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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Alcohol Withdrawal Seizures
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Accession:DOID:9004120 term browser browse the term
Definition:A condition where seizures occur in association with ethanol abuse (ALCOHOLISM) without other identifiable causes. Seizures usually occur within the first 6-48 hours after the cessation of alcohol intake, but may occur during periods of alcohol intoxication. Single generalized tonic-clonic motor seizures are the most common subtype, however, STATUS EPILEPTICUS may occur. (Adams et al., Principles of Neurology, 6th ed, p1174)
Synonyms:exact_synonym: Alcohol Withdrawal Induced Major Motor Seizure;   Alcohol Withdrawal Induced Seizure;   Alcohol Withdrawal Induced Status Epilepticus;   Alcohol Withdrawal Seizure;   Alcohol Withdrawal-Induced Seizures;   Alcoholic Seizure;   Alcoholic Seizures
 primary_id: MESH:D020270


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Alcohol Withdrawal Seizures term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit susceptibility ISO mRNA, protein:increased expression:inferior colliculus (rat) RGD PMID:25556199 RGD:152985539 NCBI chr14:29,761,898...30,213,113
Ensembl chr14:29,761,896...30,213,412 		JBrowse link
G Drd2 dopamine receptor D2 susceptibility ISO DNA:SNP:exon:A>G(human) RGD PMID:23238469 RGD:401959213 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Pdyn prodynorphin IEP mRNA:increased expression:brain RGD PMID:15869750 RGD:401850576 NCBI chr 2:129,528,469...129,541,858
Ensembl chr 2:129,528,485...129,541,764 		JBrowse link
G Slc29a1 solute carrier family 29 (nucleoside transporters), member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21283641 NCBI chr17:45,896,126...45,910,544
Ensembl chr17:45,896,126...45,910,532 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27219321 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16234
    syndrome 10776
      toxic encephalopathy 207
        Alcohol-Induced Disorders, Nervous System 61
          Alcohol Withdrawal Seizures 5
Path 2
Term Annotations click to browse term
  disease 16234
    disease of anatomical entity 15851
      nervous system disease 13784
        central nervous system disease 12292
          brain disease 11541
            disease of mental health 8326
              substance-related disorder 674
                Alcohol-Related Disorders 376
                  alcohol withdrawal syndrome 30
                    Alcohol Withdrawal Seizures 5
paths to the root