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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Chronic Allograft Nephropathy
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Accession:DOID:9002055 term browser browse the term
Definition:Chronic, progressive, and irreversible loss of function in a transplanted kidney. It is a multifactorial process associated with progressive interstitial fibrosis and tubular atrophy.


show annotations for term's descendants           Sort by:
Chronic Allograft Nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO1 aconitase 1 ISO RGD PMID:20176611 RGD:11541086 NCBI chr11:49,699,072...49,758,783
Ensembl chr11:49,699,109...49,923,257 		JBrowse link
G ALB albumin disease_progression ISO RGD PMID:24370342 RGD:11035281 NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709 		JBrowse link
G CCN2 cellular communication network factor 2 disease_progression ISO mRNA, protein:increased expression:kidney (rat) RGD PMID:19921985 RGD:150517553 NCBI chr 1:25,508,082...25,511,058
Ensembl chr 1:25,507,662...25,510,145 		JBrowse link
G CLU clusterin treatment ISO RGD PMID:22494435 RGD:9068431 NCBI chr25:29,982,811...29,999,565
Ensembl chr25:29,982,811...29,999,563 		JBrowse link
G CS citrate synthase treatment ISO RGD PMID:20005400 RGD:243048470 NCBI chr10:584,000...611,351
Ensembl chr10:584,904...611,436 		JBrowse link
G LOC480600 chemokine (C-C motif) ligand 3 ISO RGD PMID:17298994 RGD:7241819 NCBI chr 9:37,708,561...37,710,209
Ensembl chr 9:37,676,966...37,710,209 		JBrowse link
G MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) ISO RGD PMID:22845765 RGD:7241226 NCBI chr 5:28,949,631...28,957,915
Ensembl chr 5:28,949,631...28,958,222 		JBrowse link
G MMP7 matrix metallopeptidase 7 treatment ISO RGD PMID:18209025 RGD:9685339 NCBI chr 5:29,187,902...29,196,157
Ensembl chr 5:29,187,851...29,196,153 		JBrowse link
G PDGFA platelet derived growth factor subunit A ISO RGD PMID:11889420 RGD:11080974 NCBI chr 6:16,271,082...16,293,246
Ensembl chr 6:16,270,104...16,292,396 		JBrowse link
G PDGFB platelet derived growth factor subunit B ISO mRNA:increased expression:kidney: RGD PMID:11889420 PMID:15785371 RGD:10449491 RGD:11080974 NCBI chr10:25,798,877...25,819,422
Ensembl chr10:25,798,938...25,817,746 		JBrowse link
G PDGFRA platelet derived growth factor receptor alpha ISO RGD PMID:11889420 RGD:11080974 NCBI chr13:46,729,722...46,775,828
Ensembl chr13:46,730,703...46,773,278 		JBrowse link
G PDGFRB platelet derived growth factor receptor beta ISO RGD PMID:11889420 RGD:11080974 NCBI chr 4:58,925,922...58,963,639
Ensembl chr 4:58,926,351...58,962,283 		JBrowse link
G PLAU plasminogen activator, urokinase ISO protein:increased secretion:T lymphocyte (human) RGD PMID:16387096 RGD:7241259 NCBI chr 4:24,329,139...24,333,893
Ensembl chr 4:24,328,925...24,334,851 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO protein:increased expression:kidney: RGD PMID:16221712 RGD:13208600 NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981 		JBrowse link
G SERPINE1 serpin family E member 1 treatment ISO protein:increased expression:kidney: RGD PMID:16221712 PMID:18192922 RGD:13208600 RGD:13208601 NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15728
    disease of anatomical entity 15372
      immune system disease 4611
        Transplant Rejection 122
          Chronic Allograft Dysfunction 28
            Chronic Allograft Nephropathy 15
Path 2
Term Annotations click to browse term
  disease 15728
    disease of anatomical entity 15372
      Urogenital Diseases 4894
        urinary system disease 2409
          kidney disease 2168
            kidney failure 522
              acute kidney failure 307
                Kidney Reperfusion Injury 158
                  Chronic Allograft Nephropathy 15
paths to the root