RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Experimental Radiation Injuries
Accession: DOID:9000855
browse the term
Definition: Experimentally produced harmful effects of ionizing or non-ionizing RADIATION in CHORDATA animals.
Synonyms: exact_synonym: Experimental Radiation Injury
primary_id: MESH:D011833
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AGTR1
angiotensin II receptor type 1
ISO
RGD
PMID:14982483
RGD:6903857
NCBI chr15:41,957,826...42,002,776
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AGTR2
angiotensin II receptor type 2
ISO
RGD
PMID:14982483
RGD:6903857
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AIF1
allograft inflammatory factor 1
ISO
protein:decreased expression:brain (rat)
RGD
PMID:19070908
RGD:2313024
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CASP3
caspase 3
treatment
ISO
RGD
PMID:24939579
RGD:13782350
NCBI chr 7:130,589,592...130,610,845
Ensembl chr 7:130,591,166...130,610,899
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CASP8
caspase 8
treatment
ISO
RGD
PMID:24939579
RGD:13782350
NCBI chr10:86,888,654...86,944,159
Ensembl chr10:86,916,527...86,943,829
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CASP9
caspase 9
treatment
ISO
RGD
PMID:24939579
RGD:13782350
NCBI chr20:116,772,819...116,798,402
Ensembl chr20:116,772,155...116,798,930
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CCN2
cellular communication network factor 2
ISO
protein:increased expression:kidney (rat)
RGD
PMID:19080126
RGD:2314603
NCBI chr13:41,613,838...41,617,010
Ensembl chr13:41,613,798...41,617,651
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ENG
endoglin
ISO
kidney protein:decreased expression:lung (rat)
RGD
PMID:22151990 PMID:23022174
RGD:7248771 RGD:7257525
NCBI chr12:10,274,705...10,315,715
Ensembl chr12:10,275,064...10,315,040
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HIF1A
hypoxia inducible factor 1 subunit alpha
ISO
protein:increased expression:white matter of spinal cord (rat) CTD Direct Evidence: therapeutic
RGD CTD
PMID:15161688 PMID:23065176
RGD:9068912
NCBI chr24:38,873,830...38,927,657
Ensembl chr24:38,873,861...38,928,288
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HMOX1
heme oxygenase 1
treatment
ISO
RGD
PMID:22247972
RGD:10755582
NCBI chr19:18,144,466...18,157,944
Ensembl chr19:18,144,545...18,157,971
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IFNG
interferon gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473
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IGF2
insulin like growth factor 2
ISO
mRNA:increased expression:brain
RGD
PMID:11213353
RGD:5509971
NCBI chr 1:1,937,414...1,951,238
Ensembl chr 1:1,936,830...1,945,388
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IL10
interleukin 10
treatment
ISO
protein:increased expression:plasma
RGD
PMID:23788042 PMID:23968122
RGD:11049496 RGD:7365012
NCBI chr25:22,590,389...22,595,877
Ensembl chr25:22,590,962...22,594,836
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IL18
interleukin 18
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chr 1:103,485,868...103,511,632
Ensembl chr 1:103,482,083...103,510,150
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IL1B
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729
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LCN2
lipocalin 2
ISO
mRNA,protein:increased expression:liver, heart, kidney,spleen, serum,
RGD
PMID:23331620
RGD:126790570
NCBI chr12:9,976,278...9,981,087
Ensembl chr12:9,976,614...9,980,870
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MAPK1
mitogen-activated protein kinase 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:22247605
NCBI chr19:4,246,144...4,352,648
Ensembl chr19:4,246,122...4,353,325
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MAPK3
mitogen-activated protein kinase 3
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:22247605
NCBI chr 5:26,536,471...26,545,666
Ensembl chr 5:26,536,532...26,546,461
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NOS1
nitric oxide synthase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20726721
NCBI chr11:112,642,374...112,673,882
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PCNA
proliferating cell nuclear antigen
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21931560
NCBI chr 2:32,936,600...32,953,635
Ensembl chr 2:32,948,196...32,953,991
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PECAM1
platelet and endothelial cell adhesion molecule 1
ISO
mRNA:altered expression:jejunum, duodenum, ileum (rat)
RGD
PMID:22227376
RGD:6767294
NCBI chr16:56,863,763...56,947,479
Ensembl chr16:56,880,934...56,950,999
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PTGS1
prostaglandin-endoperoxide synthase 1
ISO
protein:increased expression:intestine
RGD
PMID:17699727
RGD:2290567
NCBI chr12:17,195,403...17,218,450
Ensembl chr12:17,192,628...17,218,315
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PTGS2
prostaglandin-endoperoxide synthase 2
ISO
protein:increased expression:intestine
RGD
PMID:17699727
RGD:2290567
NCBI chr25:42,733,535...42,742,463
Ensembl chr25:42,734,771...42,742,429
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SOD1
superoxide dismutase 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:22247605
NCBI chr 2:60,461,219...60,472,999
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SOD2
superoxide dismutase 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11121210 PMID:20726721
NCBI chr13:87,284,537...87,297,998
Ensembl chr13:87,280,686...87,297,974
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TNF
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11121210
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