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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Experimental Radiation Injuries
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Accession:DOID:9000855 term browser browse the term
Definition:Experimentally produced harmful effects of ionizing or non-ionizing RADIATION in CHORDATA animals.
Synonyms:exact_synonym: Experimental Radiation Injury
 primary_id: MESH:D011833


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Experimental Radiation Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:14982483 RGD:6903857 NCBI chr15:41,957,826...42,002,776 JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:14982483 RGD:6903857
G AIF1 allograft inflammatory factor 1 ISO protein:decreased expression:brain (rat) RGD PMID:19070908 RGD:2313024
G CASP3 caspase 3 treatment ISO RGD PMID:24939579 RGD:13782350 NCBI chr 7:130,589,592...130,610,845
Ensembl chr 7:130,591,166...130,610,899
JBrowse link
G CASP8 caspase 8 treatment ISO RGD PMID:24939579 RGD:13782350 NCBI chr10:86,888,654...86,944,159
Ensembl chr10:86,916,527...86,943,829
JBrowse link
G CASP9 caspase 9 treatment ISO RGD PMID:24939579 RGD:13782350 NCBI chr20:116,772,819...116,798,402
Ensembl chr20:116,772,155...116,798,930
JBrowse link
G CCN2 cellular communication network factor 2 ISO protein:increased expression:kidney (rat) RGD PMID:19080126 RGD:2314603 NCBI chr13:41,613,838...41,617,010
Ensembl chr13:41,613,798...41,617,651
JBrowse link
G ENG endoglin ISO kidney
protein:decreased expression:lung (rat)
RGD PMID:22151990 PMID:23022174 RGD:7248771 RGD:7257525 NCBI chr12:10,274,705...10,315,715
Ensembl chr12:10,275,064...10,315,040
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha ISO protein:increased expression:white matter of spinal cord (rat)
CTD Direct Evidence: therapeutic
RGD
CTD
PMID:15161688 PMID:23065176 RGD:9068912 NCBI chr24:38,873,830...38,927,657
Ensembl chr24:38,873,861...38,928,288
JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO RGD PMID:22247972 RGD:10755582 NCBI chr19:18,144,466...18,157,944
Ensembl chr19:18,144,545...18,157,971
JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:11121210 NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473
JBrowse link
G IGF2 insulin like growth factor 2 ISO mRNA:increased expression:brain RGD PMID:11213353 RGD:5509971 NCBI chr 1:1,937,414...1,951,238
Ensembl chr 1:1,936,830...1,945,388
JBrowse link
G IL10 interleukin 10 treatment ISO protein:increased expression:plasma RGD PMID:23788042 PMID:23968122 RGD:11049496 RGD:7365012 NCBI chr25:22,590,389...22,595,877
Ensembl chr25:22,590,962...22,594,836
JBrowse link
G IL18 interleukin 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11121210 NCBI chr 1:103,485,868...103,511,632
Ensembl chr 1:103,482,083...103,510,150
JBrowse link
G IL1B interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:11121210 NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729
JBrowse link
G LCN2 lipocalin 2 ISO mRNA,protein:increased expression:liver, heart, kidney,spleen, serum, RGD PMID:23331620 RGD:126790570 NCBI chr12:9,976,278...9,981,087
Ensembl chr12:9,976,614...9,980,870
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:22247605 NCBI chr19:4,246,144...4,352,648
Ensembl chr19:4,246,122...4,353,325
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 ISO CTD Direct Evidence: therapeutic CTD PMID:22247605 NCBI chr 5:26,536,471...26,545,666
Ensembl chr 5:26,536,532...26,546,461
JBrowse link
G NOS1 nitric oxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20726721 NCBI chr11:112,642,374...112,673,882 JBrowse link
G PCNA proliferating cell nuclear antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:21931560 NCBI chr 2:32,936,600...32,953,635
Ensembl chr 2:32,948,196...32,953,991
JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 ISO mRNA:altered expression:jejunum, duodenum, ileum (rat) RGD PMID:22227376 RGD:6767294 NCBI chr16:56,863,763...56,947,479
Ensembl chr16:56,880,934...56,950,999
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO protein:increased expression:intestine RGD PMID:17699727 RGD:2290567 NCBI chr12:17,195,403...17,218,450
Ensembl chr12:17,192,628...17,218,315
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO protein:increased expression:intestine RGD PMID:17699727 RGD:2290567 NCBI chr25:42,733,535...42,742,463
Ensembl chr25:42,734,771...42,742,429
JBrowse link
G SOD1 superoxide dismutase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:22247605 NCBI chr 2:60,461,219...60,472,999 JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:11121210 PMID:20726721 NCBI chr13:87,284,537...87,297,998
Ensembl chr13:87,280,686...87,297,974
JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:11121210

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  disease 15416
    Animal Diseases 1317
      Animal Disease Models 1277
        Experimental Radiation Injuries 26
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