RGD Reference Report - Irradiation-induced loss of microglia in the young brain. - Rat Genome Database

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Irradiation-induced loss of microglia in the young brain.

Authors: Kalm, M  Lannering, B  Bjork-Eriksson, T  Blomgren, K 
Citation: Kalm M, etal., J Neuroimmunol. 2009 Jan 3;206(1-2):70-5. Epub 2008 Dec 13.
RGD ID: 2313024
Pubmed: (View Article at PubMed) PMID:19070908
DOI: Full-text: DOI:10.1016/j.jneuroim.2008.11.002

Irradiation-induced loss of neural stem and progenitor cells may contribute to cognitive deficits. Furthermore, subsequent inflammation inhibits neural progenitor cell differentiation. Here we have characterized the microglia response after a single dose of 8 Gy to the brains of postnatal day 9 or 21 rats. The number of Iba-1-positive microglia increased 6 h after IR but had decreased 7 days later, below control levels, and this decrease was more pronounced in P9 rats. Active caspase-3 and TUNEL staining revealed irradiation-induced microglia death. This age-dependent IR-induced loss of microglia likely affects both the response to IR and further brain development.

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Aif1  (allograft inflammatory factor 1)

Genes (Mus musculus)
Aif1  (allograft inflammatory factor 1)

Genes (Homo sapiens)
AIF1  (allograft inflammatory factor 1)

Additional Information