The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A member of the classo of biphenyls that is the amide obtained by formal condensation of the carboxy group of 2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxylic acid with the amino group of 6-(2,6-dimethylmorpholin-4-yl)pyridin-3-amine. Used (as its phosphate salt) for treatment of locally advanced basal cell carcinoma.
sonidegib results in decreased expression of GLI2 mRNA GLI2 protein results in decreased susceptibility to sonidegib sonidegib inhibits the reaction [SUFU gene mutant form results in increased expression of GLI2 mRNA]
sonidegib inhibits the reaction [SUFU gene mutant form results in increased expression of GLI2 mRNA] SUFU gene mutant form results in decreased susceptibility to sonidegib