sonidegib - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	sonidegib	go back to main search page
Accession:	CHEBI:90863	browse the term
Definition:	A member of the classo of biphenyls that is the amide obtained by formal condensation of the carboxy group of 2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxylic acid with the amino group of 6-(2,6-dimethylmorpholin-4-yl)pyridin-3-amine. Used (as its phosphate salt) for treatment of locally advanced basal cell carcinoma.
Synonyms:	exact_synonym:	rel-N-{6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl}-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide
	related_synonym:	Erismodegib; Formula=C26H26F3N3O3; InChI=1S/C26H26F3N3O3/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29/h4-13,16-17H,14-15H2,1-3H3,(H,31,33)/t16-,17+; InChIKey=VZZJRYRQSPEMTK-CALCHBBNSA-N; LDE 225; LDE225; N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridin-3-yl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide; NVP-LDE 225; NVP-LDE225; SMILES=O1[C@H](CN(C[C@H]1C)C2=NC=C(C=C2)NC(C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F)=O)C
	xref:	CAS:956697-53-3; Drug_Central:5008; KEGG:D10119; LINCS:LSM-4938
	xref_mesh:	MESH:C561435
	xref:	PMID:23482671; PMID:23935925; PMID:24523439; PMID:24817600; PMID:25093491; PMID:25216523; PMID:25473003; PMID:25981810; PMID:26106586; PMID:26483188; PMID:26516158; PMID:26546616; Reaxys:19431762; Wikipedia:Sonidegib

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Rat (6) Mouse (6) Human (6) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) All
Genes (6)

sonidegib

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

GLI family zinc finger 1

decreases expression

sonidegib results in decreased expression of GLI1 mRNA

NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338

G

GLI family zinc finger 2

decreases expression
decreases response to substance
multiple interactions

sonidegib results in decreased expression of GLI2 mRNA
GLI2 protein results in decreased susceptibility to sonidegib
sonidegib inhibits the reaction [SUFU gene mutant form results in increased expression of GLI2 mRNA]

NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444

G

mechanistic target of rapamycin kinase

increases phosphorylation

sonidegib results in increased phosphorylation of MTOR protein

NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967

G

MYCN proto-oncogene, bHLH transcription factor

decreases response to substance

MYCN protein results in decreased susceptibility to sonidegib

NCBI chr 6:38,222,554...38,228,419
Ensembl chr 6:38,222,555...38,228,379

G

smoothened, frizzled class receptor

decreases response to substance

SMO protein mutant form results in decreased susceptibility to sonidegib

NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770

G

SUFU negative regulator of hedgehog signaling

multiple interactions
decreases response to substance

sonidegib inhibits the reaction [SUFU gene mutant form results in increased expression of GLI2 mRNA]
SUFU gene mutant form results in decreased susceptibility to sonidegib

NCBI chr 1:266,143,766...266,241,742
Ensembl chr 1:266,143,818...266,239,016

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19883
role	19833
application	19505
pharmaceutical	19375
drug	19375
antineoplastic agent	17034
sonidegib	6
sonidegib phosphate	0
Path 2
Term	Annotations
CHEBI ontology	19883
subatomic particle	19881
composite particle	19881
hadron	19881
baryon	19881
nucleon	19881
atomic nucleus	19881
atom	19881
main group element atom	19771
p-block element atom	19771
carbon group element atom	19679
carbon atom	19668
organic molecular entity	19668
organic group	18580
organic divalent group	18571
organodiyl group	18571
carbonyl group	18479
carbonyl compound	18479
carboxylic acid	18153
carboacyl group	17410
univalent carboacyl group	17410
carbamoyl group	17192
carboxamide	17192
monocarboxylic acid amide	14620
arenecarboxamide	6541
benzamides	6541
sonidegib	6
sonidegib phosphate	0

paths to the root