Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:plitidepsin
go back to main search page
Accession:CHEBI:90205 term browser browse the term
Definition:A didemnin that is didemin B in which the hydroxy group of the 1-(2-hydroxypropanoyl)-L-prolinamide moiety has been oxidised to the corresponding ketone. It was originally isolated from the Mediterranean tunicate Aplidium albicans.
Synonyms:exact_synonym: 1-(2-oxopropanoyl)-L-prolyl-N-[(3S,6R,7S,10R,11S,15S,17S,20S,25aS)-10-[(2S)-butan-2-yl]-11-hydroxy-3-(4-methoxybenzyl)-2,6,17-trimethyl-20-(2-methylpropyl)-1,4,8,13,16,18,21-heptaoxo-15-(propan-2-yl)docosahydro-15H-pyrrolo[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotricosin-7-yl]-N(2)-methyl-D-leucinamide
 related_synonym: Aplidin;   Aplidine;   Formula=C57H87N7O15;   InChI=1S/C57H87N7O15/c1-15-33(8)46-44(66)29-45(67)79-49(32(6)7)48(68)34(9)50(69)58-39(26-30(2)3)54(73)64-25-17-19-41(64)56(75)62(13)43(28-37-20-22-38(77-14)23-21-37)57(76)78-36(11)47(52(71)59-46)60-51(70)42(27-31(4)5)61(12)55(74)40-18-16-24-63(40)53(72)35(10)65/h20-23,30-34,36,39-44,46-47,49,66H,15-19,24-29H2,1-14H3,(H,58,69)(H,59,71)(H,60,70)/t33-,34-,36+,39-,40-,41-,42+,43-,44-,46+,47-,49-/m0/s1;   InChIKey=UUSZLLQJYRSZIS-LXNNNBEUSA-N;   SMILES=N1(C(=O)[C@]2(N(C([C@](NC([C@H](C([C@@](OC(C[C@@H]([C@H](NC([C@H]([C@H](OC([C@@]1(CC=3C=CC(=CC3)OC)[H])=O)C)NC([C@](N(C)C(=O)[C@]4(N(CCC4)C(=O)C(C)=O)[H])(CC(C)C)[H])=O)=O)[C@](CC)(C)[H])O)=O)(C(C)C)[H])=O)C)=O)([H])CC(C)C)=O)CCC2)[H])C;   dehydrodidemnin B;   plitidepsina;   plitidepsine;   plitidepsium
 xref: CAS:137219-37-5;   DrugBank:DB04977;   KEGG:C16862;   KNApSAcK:C00044529
 xref_mesh: MESH:C098980
 xref: PMID:16278386;   PMID:18941750;   PMID:19513942;   PMID:19687728;   PMID:21747745;   PMID:22336911;   PMID:23697951;   PMID:24287622;   PMID:24473171;   PMID:25681727;   PMID:25768401;   PMID:33495306;   Patent:WO1991004985;   Wikipedia:Plitidepsin



show annotations for term's descendants           Sort by:
plitidepsin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO AKT1 protein affects the reaction [plitidepsin results in increased activity of MAPK8 protein]; plitidepsin results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:18089842 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 increases response to substance ISO EEF1A1 protein results in increased susceptibility to plitidepsin CTD PMID:33495306 NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases activity
ISO AKT1 protein affects the reaction [plitidepsin results in increased activity of MAPK8 protein] CTD PMID:18089842 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Rac1 Rac family small GTPase 1 increases activity ISO plitidepsin results in increased activity of RAC1 protein CTD PMID:18089842 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19803
    role 19779
      biological role 19806
        antimicrobial agent 18122
          antiviral agent 11067
            anticoronaviral agent 9658
              plitidepsin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19803
    subatomic particle 19801
      composite particle 19801
        hadron 19830
          baryon 19830
            nucleon 19830
              atomic nucleus 19830
                atom 19801
                  main group element atom 19780
                    p-block element atom 19780
                      carbon group element atom 19728
                        carbon atom 19725
                          organic molecular entity 19725
                            heteroorganic entity 19479
                              organochalcogen compound 19214
                                organooxygen compound 19129
                                  carbon oxoacid 18617
                                    carboxylic acid 18578
                                      carboacyl group 17692
                                        univalent carboacyl group 17692
                                          carbamoyl group 17542
                                            carboxamide 17542
                                              peptide 11120
                                                depsipeptide 4570
                                                  cyclodepsipeptide 4559
                                                    didemnin 4
                                                      plitidepsin 4
paths to the root