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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:90205 term browser browse the term
Definition:A didemnin that is didemin B in which the hydroxy group of the 1-(2-hydroxypropanoyl)-L-prolinamide moiety has been oxidised to the corresponding ketone. It was originally isolated from the Mediterranean tunicate Aplidium albicans.
Synonyms:exact_synonym: 1-(2-oxopropanoyl)-L-prolyl-N-[(3S,6R,7S,10R,11S,15S,17S,20S,25aS)-10-[(2S)-butan-2-yl]-11-hydroxy-3-(4-methoxybenzyl)-2,6,17-trimethyl-20-(2-methylpropyl)-1,4,8,13,16,18,21-heptaoxo-15-(propan-2-yl)docosahydro-15H-pyrrolo[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotricosin-7-yl]-N(2)-methyl-D-leucinamide
 related_synonym: Aplidin;   Aplidine;   Formula=C57H87N7O15;   InChI=1S/C57H87N7O15/c1-15-33(8)46-44(66)29-45(67)79-49(32(6)7)48(68)34(9)50(69)58-39(26-30(2)3)54(73)64-25-17-19-41(64)56(75)62(13)43(28-37-20-22-38(77-14)23-21-37)57(76)78-36(11)47(52(71)59-46)60-51(70)42(27-31(4)5)61(12)55(74)40-18-16-24-63(40)53(72)35(10)65/h20-23,30-34,36,39-44,46-47,49,66H,15-19,24-29H2,1-14H3,(H,58,69)(H,59,71)(H,60,70)/t33-,34-,36+,39-,40-,41-,42+,43-,44-,46+,47-,49-/m0/s1;   InChIKey=UUSZLLQJYRSZIS-LXNNNBEUSA-N;   SMILES=N1(C(=O)[C@]2(N(C([C@](NC([C@H](C([C@@](OC(C[C@@H]([C@H](NC([C@H]([C@H](OC([C@@]1(CC=3C=CC(=CC3)OC)[H])=O)C)NC([C@](N(C)C(=O)[C@]4(N(CCC4)C(=O)C(C)=O)[H])(CC(C)C)[H])=O)=O)[C@](CC)(C)[H])O)=O)(C(C)C)[H])=O)C)=O)([H])CC(C)C)=O)CCC2)[H])C;   dehydrodidemnin B;   plitidepsina;   plitidepsine;   plitidepsium
 xref: CAS:137219-37-5;   DrugBank:DB04977;   KEGG:C16862;   KNApSAcK:C00044529
 xref_mesh: MESH:C098980
 xref: PMID:16278386;   PMID:18941750;   PMID:19513942;   PMID:19687728;   PMID:21747745;   PMID:22336911;   PMID:23697951;   PMID:24287622;   PMID:24473171;   PMID:25681727;   PMID:25768401;   PMID:33495306;   Patent:WO1991004985;   Wikipedia:Plitidepsin

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plitidepsin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO AKT1 protein affects the reaction [plitidepsin results in increased activity of MAPK8 protein]; plitidepsin results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:18089842 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 increases response to substance ISO EEF1A1 protein results in increased susceptibility to plitidepsin CTD PMID:33495306 NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases activity
ISO AKT1 protein affects the reaction [plitidepsin results in increased activity of MAPK8 protein] CTD PMID:18089842 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Rac1 Rac family small GTPase 1 increases activity ISO plitidepsin results in increased activity of RAC1 protein CTD PMID:18089842 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      biological role 19711
        antimicrobial agent 17880
          antiviral agent 10711
            anticoronaviral agent 9332
              plitidepsin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18798
                                    carbonyl compound 18798
                                      carboxylic acid 18518
                                        carboacyl group 17656
                                          univalent carboacyl group 17656
                                            carbamoyl group 17497
                                              carboxamide 17497
                                                peptide 9521
                                                  depsipeptide 382
                                                    cyclodepsipeptide 364
                                                      didemnin 4
                                                        plitidepsin 4
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