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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:didemnin
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Accession:CHEBI:90209 term browser browse the term
Definition:Any cyclic depsipeptide isolated from various species of the Trididemnu genus of sea squirts, their semi-synthetic derivatives and synthetic analogues.
Synonyms:related_synonym: didemnins
 xref: PMID:22270031;   PMID:22458477;   PMID:24284424;   PMID:25867045;   PMID:7233187;   PMID:8527098;   PMID:8709112;   Patent:US5137870;   Wikipedia:Didemnin



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plitidepsin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO AKT1 protein affects the reaction [plitidepsin results in increased activity of MAPK8 protein]; plitidepsin results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:18089842 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 increases response to substance ISO EEF1A1 protein results in increased susceptibility to plitidepsin CTD PMID:33495306 NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases activity
ISO AKT1 protein affects the reaction [plitidepsin results in increased activity of MAPK8 protein] CTD PMID:18089842 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Rac1 Rac family small GTPase 1 increases activity ISO plitidepsin results in increased activity of RAC1 protein CTD PMID:18089842 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      molecular entity 19799
        polyatomic entity 19721
          molecule 19572
            cyclic compound 19379
              macrocycle 5917
                didemnin 4
                  Didemnin B 0
                  N,N'-Methyleno-didemnin A 0
                  Nordidemnin B 0
                  plitidepsin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        carboacyl group 17469
                                          univalent carboacyl group 17469
                                            carbamoyl group 17285
                                              carboxamide 17285
                                                peptide 9455
                                                  depsipeptide 369
                                                    cyclodepsipeptide 351
                                                      didemnin 4
                                                        Didemnin B 0
                                                        N,N'-Methyleno-didemnin A 0
                                                        Nordidemnin B 0
                                                        plitidepsin 4
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