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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:didemnin
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Accession:CHEBI:90209 term browser browse the term
Definition:Any cyclic depsipeptide isolated from various species of the Trididemnu genus of sea squirts, their semi-synthetic derivatives and synthetic analogues.
Synonyms:related_synonym: didemnins
 xref: PMID:22270031;   PMID:22458477;   PMID:24284424;   PMID:25867045;   PMID:7233187;   PMID:8527098;   PMID:8709112;   Patent:US5137870;   Wikipedia:Didemnin


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plitidepsin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO AKT1 protein affects the reaction [plitidepsin results in increased activity of MAPK8 protein]; plitidepsin results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:18089842 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases activity
ISO AKT1 protein affects the reaction [plitidepsin results in increased activity of MAPK8 protein] CTD PMID:18089842 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Rac1 Rac family small GTPase 1 increases activity ISO plitidepsin results in increased activity of RAC1 protein CTD PMID:18089842 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      molecular entity 19782
        polyatomic entity 19695
          molecule 19518
            cyclic compound 19321
              macrocycle 2298
                didemnin 3
                  Didemnin B 0
                  N,N'-Methyleno-didemnin A 0
                  Nordidemnin B 0
                  plitidepsin 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            carbamoyl group 17132
                                              carboxamide 17132
                                                peptide 9391
                                                  depsipeptide 356
                                                    cyclodepsipeptide 337
                                                      didemnin 3
                                                        Didemnin B 0
                                                        N,N'-Methyleno-didemnin A 0
                                                        Nordidemnin B 0
                                                        plitidepsin 3
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