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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tiquizium bromide
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Accession:CHEBI:32232 term browser browse the term
Definition:A organic bromide salt of tiquizium. It is an antispasmodic drug used for the treatment of convulsion and hypermobility in gastritis, gastric ulcer, duodenal ulcer, enteritis, irritable bowel syndrome, gallbladder disease, biliary tract disease and urolithiasis.
Synonyms:exact_synonym: (5R,9aR)-3-[di(thiophen-2-yl)methylidene]-5-methyloctahydro-2H-quinolizinium bromide
 related_synonym: (5R,9aR)-3-[di(thiophen-2-yl)methylidene]-5-methyloctahydro-2H-quinolizin-5-ium bromide;   3-(di(2-thienyl)methylene)-5-methyldecahydroquinolizinium bromide;   3-(di-2-thienylmethylene)-5-methyl-trans-quinolizidinium bromide;   Advaston;   Aspora;   Breiful;   Formula=C19H24NS2.Br;   Gastirol;   HSR 902;   InChI=1S/C19H24NS2.BrH/c1-20-11-3-2-6-16(20)10-9-15(14-20)19(17-7-4-12-21-17)18-8-5-13-22-18;/h4-5,7-8,12-13,16H,2-3,6,9-11,14H2,1H3;1H/q+1;/p-1/t16-,20-;/m1./s1;   InChIKey=VKBNGRDAHSELMQ-KYSFMIDTSA-M;   SMILES=C(=C1C[N@+]2(C)[C@@](CC1)(CCCC2)[H])(C3=CC=CS3)C4=CC=CS4.[Br-];   Thiameron;   Thiaton;   Thiwan;   Tiapaston;   bromure de tiquizium;   bromuro de tiquizio;   tiquizii bromidum;   trans-3-(di-2-thienylmethylene)octahydro-5-methyl-2H-quinolizinium bromide
 xref: CAS:71731-58-3;   Drug_Central:2678;   KEGG:D01875
 xref_mesh: MESH:C030950
 xref: PMID:10475017;   PMID:11855677;   PMID:2881461;   PMID:2895053;   PMID:2895054;   PMID:3656779;   PMID:4090525;   PMID:6120131;   PMID:6277751;   PMID:6631675;   PMID:6677720;   PMID:7262709;   PMID:7302972;   PMID:8839659


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tiquizium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO thiaton results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP thiaton inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11855677 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP thiaton inhibits the reaction [Indomethacin results in increased activity of NOS2 protein] CTD PMID:11855677 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      application 19401
        pharmaceutical 19289
          drug 19289
            anti-ulcer drug 789
              tiquizium bromide 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    main group molecular entity 19653
                      s-block molecular entity 19418
                        hydrogen molecular entity 19411
                          hydrides 18751
                            inorganic hydride 17451
                              pnictogen hydride 17426
                                nitrogen hydride 17271
                                  ammonium 8211
                                    ammonium ion derivative 8207
                                      ammonium compound 5074
                                        organoammonium salt 424
                                          quaternary ammonium salt 307
                                            tiquizium bromide 3
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