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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tiquizium bromide
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Accession:CHEBI:32232 term browser browse the term
Definition:A organic bromide salt of tiquizium. It is an antispasmodic drug used for the treatment of convulsion and hypermobility in gastritis, gastric ulcer, duodenal ulcer, enteritis, irritable bowel syndrome, gallbladder disease, biliary tract disease and urolithiasis.
Synonyms:exact_synonym: (5R,9aR)-3-[di(thiophen-2-yl)methylidene]-5-methyloctahydro-2H-quinolizinium bromide
 related_synonym: (5R,9aR)-3-[di(thiophen-2-yl)methylidene]-5-methyloctahydro-2H-quinolizin-5-ium bromide;   3-(di(2-thienyl)methylene)-5-methyldecahydroquinolizinium bromide;   3-(di-2-thienylmethylene)-5-methyl-trans-quinolizidinium bromide;   Advaston;   Aspora;   Breiful;   Formula=C19H24NS2.Br;   Gastirol;   HSR 902;   InChI=1S/C19H24NS2.BrH/c1-20-11-3-2-6-16(20)10-9-15(14-20)19(17-7-4-12-21-17)18-8-5-13-22-18;/h4-5,7-8,12-13,16H,2-3,6,9-11,14H2,1H3;1H/q+1;/p-1/t16-,20-;/m1./s1;   InChIKey=VKBNGRDAHSELMQ-KYSFMIDTSA-M;   SMILES=C(=C1C[N@+]2(C)[C@@](CC1)(CCCC2)[H])(C3=CC=CS3)C4=CC=CS4.[Br-];   Thiameron;   Thiaton;   Thiwan;   Tiapaston;   bromure de tiquizium;   bromuro de tiquizio;   tiquizii bromidum;   trans-3-(di-2-thienylmethylene)octahydro-5-methyl-2H-quinolizinium bromide
 xref: CAS:71731-58-3;   Drug_Central:2678;   KEGG:D01875
 xref_mesh: MESH:C030950
 xref: PMID:10475017;   PMID:11855677;   PMID:2881461;   PMID:2895053;   PMID:2895054;   PMID:3656779;   PMID:4090525;   PMID:6120131;   PMID:6277751;   PMID:6631675;   PMID:6677720;   PMID:7262709;   PMID:7302972;   PMID:8839659

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tiquizium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO thiaton results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP thiaton inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11855677 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP thiaton inhibits the reaction [Indomethacin results in increased activity of NOS2 protein] CTD PMID:11855677 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link

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  CHEBI ontology 19812
    role 19784
      application 19615
        pharmaceutical 19493
          drug 19493
            anti-ulcer drug 802
              tiquizium bromide 3
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  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
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              atomic nucleus 19810
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                  main group element atom 19755
                    main group molecular entity 19755
                      s-block molecular entity 19605
                        hydrogen molecular entity 19595
                          hydrides 19072
                            inorganic hydride 17983
                              pnictogen hydride 17970
                                nitrogen hydride 17867
                                  ammonium 8306
                                    ammonium ion derivative 8301
                                      ammonium compound 5194
                                        organoammonium salt 644
                                          quaternary ammonium salt 532
                                            tiquizium bromide 3
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