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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:quaternary ammonium salt
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Accession:CHEBI:35273 term browser browse the term
Definition:Derivatives of ammonium compounds, (NH4(+))Y(-), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups.
Synonyms:exact_synonym: quaternary ammonium compounds
 related_synonym: quaternary ammonium compound;   quaternary ammonium salts
 alt_id: CHEBI:26468;   CHEBI:35268


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1,1-dimethyl-4-phenylpiperazinium iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions ISO
EXP		 Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]
1,1-dimethyl-4-phenylpiperazinium iodide affects binding competes with [Epibatidine binds to Chrna2 protein]		 CTD
RGD		 PMID:9454827 PMID:15016836 RGD:2303194 NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO
EXP		 Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]
1,1-dimethyl-4-phenylpiperazinium iodide affects binding [Epibatidine binds to Chrna3 protein]		 CTD
RGD		 PMID:9454827 PMID:15016836 RGD:2303194 NCBI chr 8:55,401,981...55,415,012
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO
EXP		 Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]
1,1-dimethyl-4-phenylpiperazinium iodide affects binding to Chrna4 protein; 1,1-dimethyl-4-phenylpiperazinium iodide competes with [Epibatidine binds to Chrna4 protein]		 CTD
RGD		 PMID:9454827 PMID:14645658 PMID:15016836 RGD:2303194 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions
increases response to substance
increases activity		 ISO Dimethylphenylpiperazinium Iodide inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]
CHRNA7 protein mutant form results in increased susceptibility to Dimethylphenylpiperazinium Iodide
Dimethylphenylpiperazinium Iodide results in increased activity of CHRNA7 protein		 CTD PMID:10082212 PMID:10216184 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO
EXP		 Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
1,1-dimethyl-4-phenylpiperazinium iodide affects binding to Chrnb2 protein; 1,1-dimethyl-4-phenylpiperazinium iodide competes with [Epibatidine binds to Chrnb2 protein]		 CTD
RGD		 PMID:14645658 PMID:15016836 RGD:2303194 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA4 protein] CTD PMID:9454827 NCBI chr 8:55,418,379...55,436,967
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Tnf tumor necrosis factor increases activity EXP TNF results in increased activity of Dimethylphenylpiperazinium Iodide CTD PMID:15086448 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
4-DAMP methiodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm3 cholinergic receptor, muscarinic 3 affects binding IDA 4-DAMP methiodide inhibits response to acetylcholine in rat aortic rings RGD PMID:8075871 RGD:2303390 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
ambenonium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Ambenonium Chloride results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G App amyloid beta precursor protein affects cleavage EXP Ambenonium Chloride affects the cleavage of APP protein CTD PMID:11099780 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
benzalkonium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aacs acetoacetyl-CoA synthetase increases expression ISO Benzalkonium Compounds results in increased expression of AACS mRNA CTD PMID:31199489 NCBI chr12:31,113,098...31,156,411
Ensembl chr12:31,113,098...31,160,954 		JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 decreases expression ISO Benzalkonium Compounds results in decreased expression of ABCA1 mRNA CTD PMID:26919959 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abca12 ATP binding cassette subfamily A member 12 increases expression ISO Benzalkonium Compounds results in increased expression of ABCA12 mRNA CTD PMID:25377654 NCBI chr 9:72,822,661...72,995,748
Ensembl chr 9:72,823,350...72,996,049 		JBrowse link
G Abca6 ATP binding cassette subfamily A member 6 decreases expression ISO Benzalkonium Compounds results in decreased expression of ABCA6 mRNA CTD PMID:20713136 NCBI chr10:95,142,805...95,212,087
Ensembl chr10:95,142,966...95,211,530 		JBrowse link
G Acod1 aconitate decarboxylase 1 increases expression ISO Benzalkonium Compounds results in increased expression of ACOD1 mRNA CTD PMID:30171875 NCBI chr15:79,871,819...79,881,101
Ensembl chr15:79,871,827...79,880,529 		JBrowse link
G Acp6 acid phosphatase 6, lysophosphatidic increases expression ISO Benzalkonium Compounds results in increased expression of ACP6 mRNA CTD PMID:31199489 NCBI chr 2:184,711,975...184,733,067
Ensembl chr 2:184,711,619...184,733,017 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 increases expression ISO Benzalkonium Compounds results in increased expression of ACSL4 mRNA CTD PMID:31199489 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427 		JBrowse link
G Ada adenosine deaminase increases expression ISO Benzalkonium Compounds results in increased expression of ADA mRNA CTD PMID:30171875 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Adh1 alcohol dehydrogenase 1C (class I), gamma polypeptide decreases expression ISO Benzalkonium Compounds results in decreased expression of ADH1 mRNA CTD PMID:31199489 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Adora1 adenosine A1 receptor decreases expression ISO Benzalkonium Compounds results in decreased expression of ADORA1 mRNA CTD PMID:30171875 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of ADRA2A mRNA CTD PMID:30171875 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of AGTR2 mRNA CTD PMID:30171875 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Benzalkonium Compounds results in increased expression of AKR1B10 mRNA CTD PMID:30806763 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Alb albumin decreases expression ISO Benzalkonium Compounds results in decreased expression of ALB mRNA CTD PMID:31199489 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Apoa1 apolipoprotein A1 decreases expression ISO Benzalkonium Compounds results in decreased expression of APOA1 mRNA CTD PMID:31199489 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoa2 apolipoprotein A2 decreases expression ISO Benzalkonium Compounds results in decreased expression of APOA2 mRNA CTD PMID:31199489 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355 		JBrowse link
G Apoc1 apolipoprotein C1 decreases expression ISO Benzalkonium Compounds results in decreased expression of APOC1 mRNA CTD PMID:31199489 NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression ISO Benzalkonium Compounds results in increased expression of AQP3 mRNA CTD PMID:30171875 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720 		JBrowse link
G Areg amphiregulin increases expression ISO Benzalkonium Compounds results in increased expression of AREG mRNA CTD PMID:30171875 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Arg2 arginase 2 increases expression ISO Benzalkonium Compounds results in increased expression of ARG2 mRNA CTD PMID:30171875 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378 		JBrowse link
G Art3 ADP-ribosyltransferase 3 decreases expression ISO Benzalkonium Compounds results in decreased expression of ART3 mRNA CTD PMID:31199489 NCBI chr14:15,637,230...15,719,442
Ensembl chr14:15,637,237...15,665,407 		JBrowse link
G Atf4 activating transcription factor 4 decreases expression ISO Benzalkonium Compounds results in decreased expression of ATF4 mRNA CTD PMID:28236482 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon decreases expression ISO Benzalkonium Compounds results in decreased expression of ATP5E mRNA CTD PMID:31199489 NCBI chr 3:163,259,072...163,261,974
Ensembl chr 3:163,260,476...163,261,450 		JBrowse link
G Atp5mg ATP synthase membrane subunit g decreases expression ISO Benzalkonium Compounds results in decreased expression of ATP5L mRNA CTD PMID:31199489 NCBI chr 8:45,226,750...45,233,582
Ensembl chr 8:45,225,686...45,233,559 		JBrowse link
G B3galt4 Beta-1,3-galactosyltransferase 4 affects response to substance ISO B3GALT4 SNP affects the susceptibility to Benzalkonium Compounds CTD PMID:27258892 NCBI chr20:4,936,089...4,937,664
Ensembl chr20:4,931,768...4,938,315 		JBrowse link
G Bambi BMP and activin membrane-bound inhibitor increases expression ISO Benzalkonium Compounds results in increased expression of BAMBI mRNA CTD PMID:20146380 NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060 		JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression ISO Benzalkonium Compounds results in increased expression of BCL3 mRNA CTD PMID:30171875 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607 		JBrowse link
G Btc betacellulin decreases expression ISO Benzalkonium Compounds results in decreased expression of BTC mRNA CTD PMID:30171875 NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049 		JBrowse link
G C1s complement C1s multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of C1S2 mRNA CTD PMID:30171875 NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303 		JBrowse link
G C3 complement C3 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of C3 mRNA CTD PMID:30171875 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions		 ISO Benzalkonium Compounds analog results in increased cleavage of CASP3 protein
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Benzalkonium Compounds analog results in increased cleavage of CASP3 protein]		 CTD PMID:31982400 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 decreases expression ISO Benzalkonium Compounds results in decreased expression of CASP8 mRNA CTD PMID:28236482 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 increases expression ISO Benzalkonium Compounds results in increased expression of CCL11 protein CTD PMID:30517752 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
increases secretion		 ISO Benzalkonium Compounds results in increased expression of CCL2 mRNA; Benzalkonium Compounds results in increased expression of CCL2 protein
Benzalkonium Compounds results in increased secretion of CCL2 protein		 CTD PMID:30171875 PMID:30517752 PMID:31707104 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO Benzalkonium Compounds results in increased expression of CCL20 mRNA CTD PMID:30806763 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccl24 C-C motif chemokine ligand 24 decreases expression ISO Benzalkonium Compounds results in decreased expression of CCL24 mRNA CTD PMID:30171875 NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression
multiple interactions		 ISO Benzalkonium Compounds results in increased expression of CCL3 protein
[IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in increased expression of CCL3 protein		 CTD PMID:30517752 PMID:31158415 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression
multiple interactions
increases expression		 ISO Benzalkonium Compounds results in decreased expression of CCL4 mRNA; Benzalkonium Compounds results in decreased expression of CCL4 protein
[IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in increased expression of CCL4 protein
Benzalkonium Compounds results in increased expression of CCL4 protein		 CTD PMID:18353026 PMID:20713136 PMID:30517752 PMID:31158415 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO Benzalkonium Compounds results in increased expression of CCL5 protein CTD PMID:30517752 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression ISO Benzalkonium Compounds results in increased expression of CCL7 mRNA; Benzalkonium Compounds results in increased expression of CCL7 protein CTD PMID:30171875 PMID:30517752 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO Benzalkonium Compounds results in decreased expression of CCN2 mRNA CTD PMID:25377654 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccn3 cellular communication network factor 3 increases expression ISO Benzalkonium Compounds results in increased expression of CCN3 mRNA CTD PMID:30171875 NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019 		JBrowse link
G Ccr4 C-C motif chemokine receptor 4 decreases expression ISO Benzalkonium Compounds results in decreased expression of CCR4 mRNA CTD PMID:30171875 NCBI chr 8:114,176,256...114,182,155
Ensembl chr 8:114,176,974...114,178,056 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression ISO Benzalkonium Compounds results in increased expression of CCR5 mRNA CTD PMID:30171875 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cd177 CD177 molecule multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of CD177 mRNA CTD PMID:30171875 NCBI chr 1:80,340,034...80,360,599
Ensembl chr 1:80,340,034...80,360,621 		JBrowse link
G Cd274 CD274 molecule multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of CD274 mRNA CTD PMID:30171875 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cd300c2 CD300C molecule 2 increases expression ISO Benzalkonium Compounds results in increased expression of CD300C2 mRNA CTD PMID:30171875 NCBI chr10:100,253,312...100,258,553
Ensembl chr10:100,253,624...100,258,323 		JBrowse link
G Cfap61 cilia and flagella associated protein 61 increases expression ISO Benzalkonium Compounds results in increased expression of CFAP61 mRNA CTD PMID:31199489 NCBI chr 3:133,354,400...133,633,310
Ensembl chr 3:133,354,197...133,633,320 		JBrowse link
G Cfd complement factor D decreases expression ISO Benzalkonium Compounds results in decreased expression of CFD mRNA CTD PMID:30171875 NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053 		JBrowse link
G Chi3l1 chitinase 3 like 1 increases expression ISO Benzalkonium Compounds results in increased expression of CHIL1 mRNA CTD PMID:30171875 NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit decreases expression ISO Benzalkonium Compounds results in decreased expression of CHRNB4 mRNA CTD PMID:30171875 NCBI chr 8:55,418,379...55,436,967
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Clcf1 cardiotrophin-like cytokine factor 1 increases expression ISO Benzalkonium Compounds results in increased expression of CLCF1 mRNA CTD PMID:30171875 NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605 		JBrowse link
G Cnfn cornifelin increases expression ISO Benzalkonium Compounds results in increased expression of CNFN mRNA; Benzalkonium Compounds results in increased expression of CNFN protein CTD PMID:25377654 NCBI chr 1:80,949,699...80,953,747
Ensembl chr 1:80,951,600...80,953,747 		JBrowse link
G Csf1 colony stimulating factor 1 increases expression ISO Benzalkonium Compounds results in increased expression of CSF1 protein CTD PMID:30517752 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO Benzalkonium Compounds results in increased expression of CSF2 protein CTD PMID:30517752 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Csf3 colony stimulating factor 3 increases expression ISO Benzalkonium Compounds results in increased expression of CSF3 protein CTD PMID:30517752 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Ctps1 CTP synthase 1 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of CTPS mRNA CTD PMID:30171875 NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression
multiple interactions		 ISO Benzalkonium Compounds results in increased expression of CXCL10 mRNA; Benzalkonium Compounds results in increased expression of CXCL10 protein
[IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in increased expression of CXCL10 protein		 CTD PMID:23445166 PMID:30517752 PMID:31158415 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
multiple interactions		 ISO Benzalkonium Compounds results in increased expression of CXCL2 mRNA; Benzalkonium Compounds results in increased expression of CXCL2 protein
[IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in increased expression of CXCL2 protein		 CTD PMID:30171875 PMID:30517752 PMID:31158415 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions
increases expression		 ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of CXCL3 mRNA
Benzalkonium Compounds results in increased expression of CXCL1 protein; Benzalkonium Compounds results in increased expression of CXCL3 mRNA		 CTD PMID:30171875 PMID:30517752 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 multiple interactions
increases expression		 ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of CXCL5 mRNA
Benzalkonium Compounds results in increased expression of CXCL5 mRNA; Benzalkonium Compounds results in increased expression of CXCL5 protein		 CTD PMID:30171875 PMID:30517752 NCBI chr14:17,310,089...17,312,303
Ensembl chr14:17,310,426...17,313,093 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases expression ISO Benzalkonium Compounds results in increased expression of CXCR1 mRNA CTD PMID:30806763 NCBI chr 9:75,768,124...75,771,122
Ensembl chr 9:75,766,770...75,771,084 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO Benzalkonium Compounds results in increased expression of CXCR4 mRNA CTD PMID:20713136 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression
increases expression		 ISO Benzalkonium Compounds results in decreased expression of CYP1A1 mRNA
Benzalkonium Compounds results in increased expression of CYP1A1 mRNA		 CTD PMID:20713136 PMID:30806763 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO Benzalkonium Compounds results in decreased expression of CYP27A1 mRNA CTD PMID:20713136 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression ISO Benzalkonium Compounds results in increased expression of CYP51 mRNA CTD PMID:31199489 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases expression ISO Benzalkonium Compounds results in increased expression of DHCR24 mRNA CTD PMID:31199489 NCBI chr 5:121,344,637...121,368,853
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases activity
increases expression		 ISO Benzalkonium Compounds results in decreased activity of DHCR7 protein
Benzalkonium Compounds results in increased expression of DHCR7 mRNA		 CTD PMID:26919959 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Benzalkonium Compounds results in decreased activity of DIO1 protein CTD PMID:30561685 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO Benzalkonium Compounds results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO Benzalkonium Compounds results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 decreases expression ISO Benzalkonium Compounds results in decreased expression of DLK1 mRNA CTD PMID:31199489 NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522 		JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Benzalkonium Compounds results in increased expression of DUSP1 mRNA CTD PMID:30806763 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Ebp EBP, cholestenol delta-isomerase increases expression ISO Benzalkonium Compounds results in increased expression of EBP mRNA CTD PMID:26919959 NCBI chr  X:14,299,427...14,305,826
Ensembl chr  X:14,299,448...14,305,826 		JBrowse link
G Egf epidermal growth factor decreases expression ISO Benzalkonium Compounds results in decreased expression of EGF mRNA CTD PMID:30171875 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egr1 early growth response 1 increases expression ISO Benzalkonium Compounds results in increased expression of EGR1 mRNA CTD PMID:25377654 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Elf3 E74 like ETS transcription factor 3 increases expression ISO Benzalkonium Compounds results in increased expression of ELF3 mRNA CTD PMID:30171875 NCBI chr13:46,690,460...46,695,394
Ensembl chr13:46,690,466...46,695,481 		JBrowse link
G Elovl1 ELOVL fatty acid elongase 1 increases expression ISO Benzalkonium Compounds results in increased expression of ELOVL1 mRNA CTD PMID:29155129 NCBI chr 5:131,961,478...131,965,961
Ensembl chr 5:131,961,322...131,965,958 		JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 increases expression ISO Benzalkonium Compounds results in increased expression of ELOVL6 mRNA CTD PMID:31199489 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186 		JBrowse link
G Endou endonuclease, poly(U)-specific increases expression ISO Benzalkonium Compounds results in increased expression of ENDOU mRNA CTD PMID:30171875 NCBI chr 7:128,845,862...128,866,542
Ensembl chr 7:128,844,862...128,866,596 		JBrowse link
G Eno1 enolase 1 decreases expression ISO Benzalkonium Compounds results in decreased expression of ENO1 mRNA CTD PMID:31199489 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G Etnk1 ethanolamine kinase 1 increases expression ISO Benzalkonium Compounds results in increased expression of ETNK1 mRNA CTD PMID:31199489 NCBI chr 4:176,126,056...176,170,325
Ensembl chr 4:176,126,180...176,193,770 		JBrowse link
G Exo1 exonuclease 1 increases expression ISO Benzalkonium Compounds results in increased expression of EXO1 mRNA CTD PMID:30171875 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Ezr ezrin increases expression ISO Benzalkonium Compounds results in increased expression of EZR mRNA; Benzalkonium Compounds results in increased expression of EZR protein CTD PMID:29893927 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G Fam83a family with sequence similarity 83, member A increases expression ISO Benzalkonium Compounds results in increased expression of FAM83A mRNA CTD PMID:30171875 NCBI chr 7:89,522,826...89,547,284
Ensembl chr 7:89,522,826...89,547,388 		JBrowse link
G Fgf2 fibroblast growth factor 2 affects response to substance ISO FGF2 SNP affects the susceptibility to Benzalkonium Compounds CTD PMID:27206134 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase increases expression ISO Benzalkonium Compounds results in increased expression of FGR mRNA CTD PMID:30171875 NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326 		JBrowse link
G Flg filaggrin increases expression ISO Benzalkonium Compounds results in increased expression of FLG mRNA CTD PMID:30171875 NCBI chr 2:178,888,688...178,912,731 JBrowse link
G Foxc1 forkhead box C1 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of FOXC1 mRNA CTD PMID:30171875 NCBI chr17:32,631,379...32,635,361
Ensembl chr17:32,633,142...32,634,803 		JBrowse link
G Foxn1 forkhead box N1 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of FOXN1 mRNA CTD PMID:30171875 NCBI chr10:63,251,400...63,273,710
Ensembl chr10:63,251,400...63,273,710 		JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of FOXP3 mRNA CTD PMID:30171875 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Gata3 GATA binding protein 3 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of GATA3 mRNA CTD PMID:30171875 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Benzalkonium Compounds results in increased expression of GCLC mRNA CTD PMID:30806763 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Benzalkonium Compounds results in increased expression of GCLM mRNA CTD PMID:30806763 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression ISO Benzalkonium Compounds results in increased expression of GPX2 mRNA CTD PMID:30171875 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO Benzalkonium Compounds results in increased expression of HBEGF mRNA CTD PMID:30171875 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of HCK mRNA CTD PMID:30171875 NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of HGF mRNA CTD PMID:30171875 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO Benzalkonium Compounds results in increased expression of HIF1A mRNA CTD PMID:30171875 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Benzalkonium Compounds results in increased expression of HMGCR mRNA CTD PMID:26919959 PMID:31199489 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression ISO Benzalkonium Compounds results in increased expression of HMGCS2 mRNA CTD PMID:31199489 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Hoxa7 homeobox A7 decreases expression ISO Benzalkonium Compounds results in decreased expression of HOXA7 mRNA CTD PMID:30171875 NCBI chr 4:81,315,730...81,317,629
Ensembl chr 4:81,314,625...81,317,659 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases expression ISO Benzalkonium Compounds results in increased expression of HSD17B7 mRNA CTD PMID:31199489 NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression ISO Benzalkonium Compounds results in decreased expression of HSPA5 mRNA CTD PMID:28236482 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Benzalkonium Compounds results in increased expression of ICAM1 mRNA; Benzalkonium Compounds results in increased expression of ICAM1 protein CTD PMID:21742781 PMID:30806763 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression ISO Benzalkonium Compounds results in increased expression of IDI1 mRNA CTD PMID:31199489 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Ifng interferon gamma increases expression ISO Benzalkonium Compounds results in increased expression of IFNG protein CTD PMID:30517752 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression		 ISO Benzalkonium Compounds results in increased expression of and results in decreased secretion of IL10 protein
[IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in decreased expression of IL10 protein
Benzalkonium Compounds results in increased expression of IL10 protein		 CTD PMID:29953848 PMID:30517752 PMID:31158415 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 increases expression ISO Benzalkonium Compounds results in increased expression of IL13RA2 mRNA CTD PMID:30171875 NCBI chr  X:111,002,590...111,074,053
Ensembl chr  X:111,002,592...111,072,381 		JBrowse link
G Il15 interleukin 15 increases expression ISO Benzalkonium Compounds results in increased expression of IL15 protein CTD PMID:30517752 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il17f interleukin 17F increases expression ISO Benzalkonium Compounds results in increased expression of IL17F mRNA CTD PMID:23445166 NCBI chr 9:23,190,094...23,201,482
Ensembl chr 9:23,190,100...23,201,482 		JBrowse link
G Il18 interleukin 18 increases expression ISO Benzalkonium Compounds results in increased expression of IL18 protein
Benzalkonium Compounds results in increased expression of IL18 mRNA		 CTD PMID:30517752 PMID:30806763 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha increases secretion
multiple interactions
increases expression		 ISO Benzalkonium Compounds results in increased secretion of IL1A protein
[IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in increased expression of IL1A protein
Benzalkonium Compounds results in increased expression of IL1A protein
Benzalkonium Compounds results in increased expression of IL1A mRNA; Benzalkonium Compounds results in increased expression of IL1A protein		 CTD PMID:8006454 PMID:12781210 PMID:25290854 PMID:30240708 PMID:30517752 More... NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 ISO Benzalkonium Compounds results in increased expression of IL1B protein
[IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in increased expression of IL1B protein		 CTD PMID:29953848 PMID:30517752 PMID:31158415 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1f10 interleukin 1 family member 10 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of IL1F10 mRNA CTD PMID:30171875 NCBI chr 3:7,072,511...7,075,439
Ensembl chr 3:7,072,511...7,075,439 		JBrowse link
G Il23a interleukin 23 subunit alpha increases expression ISO Benzalkonium Compounds results in increased expression of IL23A mRNA CTD PMID:30171875 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il27 interleukin 27 increases expression ISO Benzalkonium Compounds results in increased expression of IL27 protein CTD PMID:30517752 NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582 		JBrowse link
G Il3 interleukin 3 increases expression ISO Benzalkonium Compounds results in increased expression of IL3 protein CTD PMID:30517752 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066 		JBrowse link
G Il31 interleukin 31 increases expression ISO Benzalkonium Compounds results in increased expression of IL31 protein CTD PMID:30517752 NCBI chr12:33,095,108...33,105,026
Ensembl chr12:33,092,097...33,105,037 		JBrowse link
G Il31ra interleukin 31 receptor A decreases expression ISO Benzalkonium Compounds results in decreased expression of IL31RA mRNA CTD PMID:30171875 NCBI chr 2:44,118,748...44,189,943
Ensembl chr 2:44,122,624...44,183,767 		JBrowse link
G Il34 interleukin 34 decreases expression ISO Benzalkonium Compounds results in decreased expression of IL34 mRNA CTD PMID:30171875 NCBI chr19:38,714,990...38,782,749
Ensembl chr19:38,714,991...38,764,000 		JBrowse link
G Il36a interleukin 36, alpha increases expression ISO Benzalkonium Compounds results in increased expression of IL36A mRNA CTD PMID:30171875 NCBI chr 3:6,996,851...7,001,400
Ensembl chr 3:6,996,851...7,001,400 		JBrowse link
G Il36b interleukin 36, beta increases expression ISO Benzalkonium Compounds results in increased expression of IL36B mRNA CTD PMID:30171875 NCBI chr 3:7,024,862...7,122,489
Ensembl chr 3:7,021,973...7,031,619 		JBrowse link
G Il36g interleukin 36, gamma increases expression ISO Benzalkonium Compounds results in increased expression of IL36G mRNA CTD PMID:30171875 NCBI chr 3:6,948,323...6,954,485
Ensembl chr 3:6,948,297...6,954,480 		JBrowse link
G Il4 interleukin 4 increases expression
multiple interactions		 ISO Benzalkonium Compounds results in increased expression of IL4 protein
[IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in decreased expression of IL4 protein		 CTD PMID:30517752 PMID:31158415 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 increases expression ISO Benzalkonium Compounds results in increased expression of IL5 protein CTD PMID:30517752 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions
affects response to substance
increases expression		 ISO Benzalkonium Compounds results in increased secretion of IL6 protein
[IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of ADRA2A mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of AGTR2 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of C1S2 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of C3 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of CD177 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of CD274 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of CTPS mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of CXCL3 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of CXCL5 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of FOXC1 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of FOXN1 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of FOXP3 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of GATA3 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of GSDMA3 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of HCK mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of HGF mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of IGHA mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of IL1F10 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of KRT2 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of KRTAP14 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of KRTAP16-3 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of KRTAP19-2 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of KRTAP19-5 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of KRTAP19-9B mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of KRTAP6-1 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of KRTAP6-2 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of LTB mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of MMP25 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of MMP9 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of MRGPRA2B mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of MSX2 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of MYLK3 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of NRG2 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of PDCD1 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of PROKR2 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of PTX3 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of REG1 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of REG3G mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of RYR1 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of SAA3 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of SERPINB13 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of SIGLECE mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of SOX21 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of SRMS mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of ST14 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of TFAP2B mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of TNFRSF13C mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of TNFRSF26 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of TNFSF8 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of TSLP mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of VTCN1 mRNA; [IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in increased expression of IL6 protein
Benzalkonium Compounds results in increased expression of IL6 mRNA; Benzalkonium Compounds results in increased expression of IL6 protein
Benzalkonium Compounds results in increased expression of and results in increased secretion of IL6 protein		 CTD PMID:17763283 PMID:28214551 PMID:29953848 PMID:30171875 PMID:30517752 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor multiple interactions
increases response to substance		 ISO [IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in decreased expression of IL10 protein; [IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in decreased expression of IL4 protein; [IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in increased expression of CCL3 protein; [IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in increased expression of CCL4 protein; [IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in increased expression of CXCL10 protein; [IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in increased expression of CXCL2 protein; [IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in increased expression of IL1A protein; [IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in increased expression of IL1B protein; [IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in increased expression of IL22 protein; [IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in increased expression of IL6 protein CTD PMID:31158415 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Il7r interleukin 7 receptor increases expression ISO Benzalkonium Compounds results in increased expression of IL7R mRNA CTD PMID:20713136 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757 		JBrowse link
G Inhba inhibin subunit beta A increases expression ISO Benzalkonium Compounds results in increased expression of INHBA mRNA CTD PMID:30171875 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982 		JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO Benzalkonium Compounds results in increased expression of INSIG1 mRNA CTD PMID:31199489 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Isl1 ISL LIM homeobox 1 decreases expression ISO Benzalkonium Compounds results in decreased expression of ISL1 mRNA CTD PMID:30171875 NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584 		JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO Benzalkonium Compounds inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Benzalkonium Compounds results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kdm8 lysine demethylase 8 decreases expression ISO Benzalkonium Compounds results in decreased expression of KDM8 mRNA CTD PMID:31199489 NCBI chr 1:180,013,969...180,028,829
Ensembl chr 1:180,020,656...180,028,841 		JBrowse link
G Klk8 kallikrein related-peptidase 8 increases expression ISO Benzalkonium Compounds results in increased expression of KLK8 mRNA CTD PMID:30171875 NCBI chr 1:94,251,803...94,258,646
Ensembl chr 1:94,251,803...94,258,646 		JBrowse link
G Krt2 keratin 2 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of KRT2 mRNA CTD PMID:30171875 NCBI chr 7:132,941,275...132,947,963
Ensembl chr 7:132,940,862...132,947,963 		JBrowse link
G Krtap14 keratin associated protein 14 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of KRTAP14 mRNA CTD PMID:30171875 NCBI chr11:28,126,660...28,127,502
Ensembl chr11:28,126,660...28,127,502 		JBrowse link
G Lce3e late cornified envelope 3E increases expression ISO Benzalkonium Compounds results in increased expression of LCE3C mRNA CTD PMID:30171875 NCBI chr 2:178,579,162...178,579,458
Ensembl chr 2:178,579,162...178,579,458 		JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO Benzalkonium Compounds results in decreased expression of LDHA mRNA CTD PMID:31199489 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO Benzalkonium Compounds results in increased expression of LDLR mRNA CTD PMID:31199489 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Benzalkonium Compounds results in increased expression of LIF protein CTD PMID:30517752 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482 		JBrowse link
G LOC102551406 keratin-associated protein 20-2-like multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of KRTAP6-1 mRNA; [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of KRTAP6-2 mRNA CTD PMID:30171875 NCBI chr11:28,412,307...28,412,508
Ensembl chr11:28,481,578...28,481,748 		JBrowse link
G LOC102552326 late cornified envelope protein 5A-like decreases expression ISO Benzalkonium Compounds results in decreased expression of LCE1M mRNA CTD PMID:30171875 Ensembl chr 2:178,275,020...178,275,469 JBrowse link
G Loxl1 lysyl oxidase-like 1 decreases expression ISO Benzalkonium Compounds results in decreased expression of LOXL1 mRNA CTD PMID:31199489 NCBI chr 8:58,692,592...58,716,356
Ensembl chr 8:58,692,593...58,716,356 		JBrowse link
G Lst1 leukocyte specific transcript 1 increases expression ISO Benzalkonium Compounds results in increased expression of LST1 mRNA CTD PMID:30171875 NCBI chr20:3,634,680...3,639,731
Ensembl chr20:3,634,749...3,637,997 		JBrowse link
G Ltb lymphotoxin beta multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of LTB mRNA CTD PMID:30171875 NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO Benzalkonium Compounds results in increased phosphorylation of MAPK14 protein CTD PMID:15737199 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mesp2 mesoderm posterior bHLH transcription factor 2 decreases expression ISO Benzalkonium Compounds results in decreased expression of MESP2 mRNA CTD PMID:30171875 NCBI chr 1:133,756,601...133,759,207
Ensembl chr 1:133,756,601...133,759,198 		JBrowse link
G Mif macrophage migration inhibitory factor increases secretion ISO Benzalkonium Compounds results in increased secretion of MIF protein CTD PMID:31707104 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Mmp10 matrix metallopeptidase 10 increases expression ISO Benzalkonium Compounds results in increased expression of MMP10 mRNA CTD PMID:30806763 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748 		JBrowse link
G Mmp12 matrix metallopeptidase 12 increases expression ISO Benzalkonium Compounds results in increased expression of MMP12 mRNA CTD PMID:30171875 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611 		JBrowse link
G Mmp25 matrix metallopeptidase 25 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of MMP25 mRNA CTD PMID:30171875 NCBI chr10:12,661,297...12,676,119
Ensembl chr10:12,661,208...12,675,871 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of MMP9 mRNA CTD PMID:30171875 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression ISO Benzalkonium Compounds results in increased expression of MSMO1 mRNA CTD PMID:31199489 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016 		JBrowse link
G Msx2 msh homeobox 2 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of MSX2 mRNA CTD PMID:30171875 NCBI chr17:11,097,214...11,102,879
Ensembl chr17:11,097,103...11,102,879 		JBrowse link
G Mt2A metallothionein 2A decreases expression ISO Benzalkonium Compounds results in decreased expression of MT2 mRNA CTD PMID:31199489 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases expression ISO Benzalkonium Compounds results in decreased expression of MTHFD2 mRNA CTD PMID:31199489 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Mylk3 myosin light chain kinase 3 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of MYLK3 mRNA CTD PMID:30171875 NCBI chr19:21,685,085...21,743,587
Ensembl chr19:21,691,929...21,742,954 		JBrowse link
G Ndufa4 Ndufa4, mitochondrial complex associated decreases expression ISO Benzalkonium Compounds results in decreased expression of NDUFA4 mRNA CTD PMID:31199489 NCBI chr 4:40,002,216...40,009,384
Ensembl chr 4:40,002,216...40,023,920 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression ISO Benzalkonium Compounds results in increased expression of NR4A2 mRNA CTD PMID:25377654 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Nrg2 neuregulin 2 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of NRG2 mRNA CTD PMID:30171875 NCBI chr18:27,619,635...27,798,505
Ensembl chr18:27,619,661...27,798,505 		JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 affects response to substance ISO NTRK3 SNP affects the susceptibility to Benzalkonium Compounds CTD PMID:27206134 NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286 		JBrowse link
G Ocln occludin decreases expression ISO Benzalkonium Compounds results in decreased expression of OCLN protein CTD PMID:29514330 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression ISO Benzalkonium Compounds results in decreased expression of ODC1 mRNA CTD PMID:31199489 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Odf3l2 outer dense fiber of sperm tails 3-like 2 decreases expression ISO Benzalkonium Compounds results in decreased expression of ODF3L2 mRNA CTD PMID:30171875 NCBI chr 7:10,049,472...10,065,626
Ensembl chr 7:10,059,589...10,065,125 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression ISO Benzalkonium Compounds results in increased expression of OLR1 mRNA CTD PMID:30171875 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523 		JBrowse link
G Orm1 orosomucoid 1 decreases expression ISO Benzalkonium Compounds results in decreased expression of ORM1 mRNA CTD PMID:30171875 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO Benzalkonium Compounds analog results in increased cleavage of PARP1 protein
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Benzalkonium Compounds analog results in increased cleavage of PARP1 protein]		 CTD PMID:31982400 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pbk PDZ binding kinase increases expression ISO Benzalkonium Compounds results in increased expression of PBK mRNA CTD PMID:30171875 NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 decreases expression ISO Benzalkonium Compounds results in decreased expression of PCSK9 mRNA CTD PMID:31199489 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688 		JBrowse link
G Pdcd1 programmed cell death 1 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of PDCD1 mRNA CTD PMID:30171875 NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937 		JBrowse link
G Pfdn6 prefoldin subunit 6 affects response to substance ISO PFDN6 SNP affects the susceptibility to Benzalkonium Compounds CTD PMID:27258892 NCBI chr20:4,945,959...4,947,433
Ensembl chr20:4,945,959...4,947,433 		JBrowse link
G Pglyrp3 peptidoglycan recognition protein 3 increases expression ISO Benzalkonium Compounds results in increased expression of PGLYRP3 mRNA CTD PMID:30171875 NCBI chr 2:177,479,693...177,490,867
Ensembl chr 2:177,477,407...177,490,736 		JBrowse link
G Pgp phosphoglycolate phosphatase increases expression ISO Benzalkonium Compounds results in increased expression of PGP mRNA CTD PMID:31199489 NCBI chr10:13,495,232...13,497,858
Ensembl chr10:13,494,291...13,497,858 		JBrowse link
G Pla2g5 phospholipase A2, group V decreases expression ISO Benzalkonium Compounds results in decreased expression of PLA2G5 mRNA CTD PMID:30171875 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658 		JBrowse link
G Plcxd3 phosphatidylinositol-specific phospholipase C, X domain containing 3 increases expression ISO Benzalkonium Compounds results in increased expression of PLCXD3 mRNA CTD PMID:31199489 NCBI chr 2:53,567,022...53,746,384
Ensembl chr 2:53,567,022...53,746,384 		JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 decreases expression ISO Benzalkonium Compounds results in decreased expression of PNPLA2 mRNA CTD PMID:31199489 NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805 		JBrowse link
G Polr1d RNA polymerase I and III subunit D decreases expression ISO Benzalkonium Compounds results in decreased expression of POLR1D mRNA CTD PMID:31199489 NCBI chr12:7,970,592...8,004,157
Ensembl chr12:7,970,595...8,005,624 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Benzalkonium Compounds results in decreased expression of PPARA mRNA CTD PMID:31199489 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 increases expression ISO Benzalkonium Compounds results in increased expression of PRKAA2 mRNA CTD PMID:31199489 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 increases expression ISO Benzalkonium Compounds results in increased expression of PRKAG2 mRNA CTD PMID:31199489 NCBI chr 4:10,010,574...10,252,152
Ensembl chr 4:10,010,890...10,252,142 		JBrowse link
G Prokr2 prokineticin receptor 2 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of PROKR2 mRNA CTD PMID:30171875 NCBI chr 3:119,624,738...119,639,442
Ensembl chr 3:119,627,601...119,635,718 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Benzalkonium Compounds results in increased expression of PTGS2 mRNA CTD PMID:30806763 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptx3 pentraxin 3 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of PTX3 mRNA CTD PMID:30171875 NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323 		JBrowse link
G Reg1a regenerating family member 1 alpha multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of REG1 mRNA CTD PMID:30171875 NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570 		JBrowse link
G Reg3g regenerating family member 3 gamma multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of REG3G mRNA CTD PMID:30171875 NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723 		JBrowse link
G Rgl2 ral guanine nucleotide dissociation stimulator-like 2 affects response to substance ISO RGL2 SNP affects the susceptibility to Benzalkonium Compounds CTD PMID:27258892 NCBI chr20:4,948,495...4,956,774
Ensembl chr20:4,948,497...4,969,911 		JBrowse link
G Rps18 ribosomal protein S18 affects response to substance ISO RPS18 SNP affects the susceptibility to Benzalkonium Compounds CTD PMID:27258892 NCBI chr20:4,931,427...4,935,538
Ensembl chr10:101,204,500...101,205,146
Ensembl chr20:101,204,500...101,205,146 		JBrowse link
G RT1-DOa RT1 class II, locus DOa affects response to substance ISO HLA-DOA SNP affects the susceptibility to Benzalkonium Compounds CTD PMID:27258892 NCBI chr20:4,753,587...4,756,590
Ensembl chr20:4,753,598...4,756,577 		JBrowse link
G RT1-DOb RT1 class II, locus DOb affects response to substance ISO HLA-DOB SNP affects the susceptibility to Benzalkonium Compounds CTD PMID:27258892 NCBI chr20:4,619,599...4,625,627
Ensembl chr20:4,619,816...4,625,667 		JBrowse link
G RT1-Ha RT1 class II, locus Ha affects response to substance ISO HLA-DPA1 SNP affects the susceptibility to Benzalkonium Compounds CTD PMID:27258892 NCBI chr20:4,760,631...4,770,662
Ensembl chr20:4,760,118...4,770,244 		JBrowse link
G Ryr1 ryanodine receptor 1 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of RYR1 mRNA CTD PMID:30171875 NCBI chr 1:84,292,578...84,423,799
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression
decreases expression		 ISO Benzalkonium Compounds results in increased expression of SCD mRNA
Benzalkonium Compounds results in decreased expression of SCD1 mRNA		 CTD PMID:29155129 PMID:31199489 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Serpinb13 serpin family B member 13 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of SERPINB13 mRNA CTD PMID:30171875 NCBI chr13:23,118,584...23,150,760
Ensembl chr13:23,118,584...23,150,760 		JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Benzalkonium Compounds results in increased expression of SERPINE1 mRNA CTD PMID:30171875 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sesn2 sestrin 2 decreases expression ISO Benzalkonium Compounds results in decreased expression of SESN2 mRNA CTD PMID:31199489 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Sfn stratifin increases expression ISO Benzalkonium Compounds results in increased expression of SFN mRNA CTD PMID:30171875 Ensembl chr 5:145,826,201...145,831,314 JBrowse link
G Sfrp4 secreted frizzled-related protein 4 decreases expression ISO Benzalkonium Compounds results in decreased expression of SFRP4 mRNA CTD PMID:30171875 NCBI chr17:45,278,867...45,330,806
Ensembl chr17:45,234,097...45,330,736 		JBrowse link
G Siglec8 sialic acid binding Ig-like lectin 8 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of SIGLECE mRNA CTD PMID:30171875 NCBI chr 1:94,092,737...94,103,134
Ensembl chr 1:94,093,395...94,103,034 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 increases expression ISO Benzalkonium Compounds results in increased expression of SLC16A1 mRNA CTD PMID:31199489 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Benzalkonium Compounds results in increased expression of SLC7A11 mRNA CTD PMID:30806763 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Sox21 SRY-box transcription factor 21 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of SOX21 mRNA CTD PMID:30171875 NCBI chr15:95,292,272...95,295,316
Ensembl chr15:95,292,265...95,296,091 		JBrowse link
G Sprr1a small proline-rich protein 1A increases expression ISO Benzalkonium Compounds results in increased expression of SPRR1A mRNA CTD PMID:30171875 NCBI chr 2:178,055,096...178,057,012
Ensembl chr 2:178,055,096...178,057,063 		JBrowse link
G Sprr1b small proline-rich protein 1B increases expression ISO Benzalkonium Compounds results in increased expression of SPRR1B mRNA CTD PMID:30171875 NCBI chr 2:178,009,130...178,009,567
Ensembl chr 2:178,009,130...178,009,567 		JBrowse link
G Sprr2b small proline rich protein 2B increases expression ISO Benzalkonium Compounds results in increased expression of SPRR2B mRNA CTD PMID:30171875 NCBI chr 2:177,852,824...177,853,096
Ensembl chr 2:177,852,824...177,853,096 		JBrowse link
G Sprr2f small proline rich protein 2F increases expression ISO Benzalkonium Compounds results in increased expression of SPRR2F mRNA CTD PMID:30171875 NCBI chr 2:177,989,974...177,990,204
Ensembl chr 2:177,989,974...177,990,204 		JBrowse link
G Sqle squalene epoxidase increases expression ISO Benzalkonium Compounds results in increased expression of SQLE mRNA CTD PMID:31199489 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression ISO Benzalkonium Compounds results in increased expression of SREBF2 mRNA CTD PMID:26919959 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Srms src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of SRMS mRNA CTD PMID:30171875 NCBI chr 3:168,318,511...168,324,915
Ensembl chr 3:168,318,512...168,324,915 		JBrowse link
G St14 ST14 transmembrane serine protease matriptase multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of ST14 mRNA CTD PMID:30171875 NCBI chr 8:29,540,805...29,581,704
Ensembl chr 8:29,540,811...29,581,517 		JBrowse link
G Tapbp TAP binding protein affects response to substance ISO TAPBP SNP affects the susceptibility to Benzalkonium Compounds CTD PMID:27258892 NCBI chr20:4,956,937...4,966,191
Ensembl chr20:4,956,937...4,966,181 		JBrowse link
G Tfap2b transcription factor AP-2 beta multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of TFAP2B mRNA CTD PMID:30171875 NCBI chr 9:21,786,250...21,815,785
Ensembl chr 9:21,786,258...21,814,520 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Benzalkonium Compounds results in increased expression of TGFB1 protein CTD PMID:30517752 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgm3 transglutaminase 3 increases expression ISO Benzalkonium Compounds results in increased expression of TGM3 mRNA CTD PMID:30171875 NCBI chr 3:117,228,661...117,264,078
Ensembl chr 3:117,228,661...117,264,075 		JBrowse link
G Tgm7 transglutaminase 7 decreases expression ISO Benzalkonium Compounds results in decreased expression of TGM7 mRNA CTD PMID:30171875 NCBI chr 3:108,051,890...108,068,116
Ensembl chr 3:108,051,890...108,076,239 		JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Benzalkonium Compounds results in increased expression of THBS1 mRNA CTD PMID:30171875 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Tlr1 toll-like receptor 1 increases expression ISO Benzalkonium Compounds results in increased expression of TLR1 mRNA CTD PMID:30171875 NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125 		JBrowse link
G Tlr4 toll-like receptor 4 increases activity ISO Benzalkonium Compounds results in increased activity of TLR4 protein CTD PMID:29514330 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tmprss11b transmembrane serine protease 11B increases expression ISO Benzalkonium Compounds results in increased expression of TMPRSS11B mRNA CTD PMID:30171875 NCBI chr14:21,385,924...21,405,894
Ensembl chr14:21,383,862...21,408,817 		JBrowse link
G Tnf tumor necrosis factor decreases secretion
increases expression		 ISO Benzalkonium Compounds results in decreased secretion of TNF protein
Benzalkonium Compounds results in increased expression of TNF mRNA; Benzalkonium Compounds results in increased expression of TNF protein		 CTD PMID:29953848 PMID:30171875 PMID:30517752 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 increases expression ISO Benzalkonium Compounds results in increased expression of TNFAIP6 mRNA CTD PMID:30171875 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649 		JBrowse link
G Tnfrsf13c TNF receptor superfamily member 13C multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of TNFRSF13C mRNA CTD PMID:30171875 NCBI chr 7:113,736,046...113,738,523
Ensembl chr 7:113,736,055...113,738,517 		JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 increases expression ISO Benzalkonium Compounds results in increased expression of TNFRSF9 mRNA CTD PMID:30171875 NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000 		JBrowse link
G Tnfsf8 TNF superfamily member 8 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of TNFSF8 mRNA CTD PMID:30171875 NCBI chr 5:77,253,881...77,277,078
Ensembl chr 5:77,251,373...77,277,421 		JBrowse link
G Tp53 tumor protein p53 decreases expression ISO Benzalkonium Compounds results in decreased expression of TP53 mRNA CTD PMID:28236482 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpi1 triosephosphate isomerase 1 decreases expression ISO Benzalkonium Compounds results in decreased expression of TPI1 mRNA CTD PMID:31199489 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 increases expression ISO Benzalkonium Compounds results in increased expression of TREM2 mRNA CTD PMID:30171875 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of TSLP mRNA CTD PMID:30171875 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
G Upk3b uroplakin 3B decreases expression ISO Benzalkonium Compounds results in decreased expression of UPK3B mRNA CTD PMID:30171875 NCBI chr12:20,629,491...20,638,193
Ensembl chr12:20,631,525...20,637,724 		JBrowse link
G Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII decreases expression ISO Benzalkonium Compounds results in decreased expression of UQCRQ mRNA CTD PMID:31199489 NCBI chr10:37,585,864...37,589,328
Ensembl chr10:37,586,888...37,589,169 		JBrowse link
G Vegfd vascular endothelial growth factor D increases expression ISO Benzalkonium Compounds results in increased expression of VEGFD mRNA CTD PMID:20146380 NCBI chr  X:30,073,122...30,108,413
Ensembl chr  X:30,074,163...30,108,295 		JBrowse link
G Vtcn1 V-set domain containing T cell activation inhibitor 1 multiple interactions ISO [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of VTCN1 mRNA CTD PMID:30171875 NCBI chr 2:188,253,594...188,321,658
Ensembl chr 2:188,253,594...188,321,658 		JBrowse link
G Wdr46 WD repeat domain 46 affects response to substance ISO WDR46 SNP affects the susceptibility to Benzalkonium Compounds CTD PMID:27258892 NCBI chr20:4,937,845...4,945,796
Ensembl chr20:4,937,847...4,946,535 		JBrowse link
G Xbp1 X-box binding protein 1 decreases expression ISO Benzalkonium Compounds results in decreased expression of XBP1 mRNA alternative form CTD PMID:28236482 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Xcl1 X-C motif chemokine ligand 1 decreases expression ISO Benzalkonium Compounds results in decreased expression of XCL1 mRNA CTD PMID:30171875 NCBI chr13:77,248,865...77,252,308
Ensembl chr13:77,248,717...77,252,329 		JBrowse link
benzethonium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Benzethonium results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Benzethonium results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Benzethonium results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Benzethonium results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Benzethonium co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA CTD PMID:29594315 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Benzethonium results in decreased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Benzethonium co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Benzethonium results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Kcna3 potassium voltage-gated channel subfamily A member 3 decreases activity
multiple interactions		 ISO Benzethonium results in decreased activity of KCNA3 protein
[Benzethonium results in decreased activity of KCNA3 protein] which results in decreased import of Thallium		 CTD PMID:21362439 NCBI chr 2:194,632,360...194,633,937
Ensembl chr 2:194,632,196...194,650,138 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity		 ISO [Benzethonium results in decreased activity of KCNH2 protein] which results in decreased import of Thallium CTD PMID:21362439 PMID:23313619 PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Benzethonium inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Benzethonium results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
bretylium tosylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Bretylium Tosylate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
butylscopolamine bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Butylscopolammonium Bromide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
chlormequat chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO Chlormequat promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:25684042 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression EXP Chlormequat results in decreased expression of BGLAP protein CTD PMID:28214531 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP Chlormequat results in decreased expression of CYP11A1 protein CTD PMID:29447956 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO Chlormequat results in increased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Gh1 growth hormone 1 increases expression EXP Chlormequat results in increased expression of GH1 protein CTD PMID:31704167 PMID:32622971 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Ghr growth hormone receptor decreases expression EXP Chlormequat results in decreased expression of GHR mRNA CTD PMID:28214531 NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735 		JBrowse link
G Ghrh growth hormone releasing hormone increases expression EXP Chlormequat results in increased expression of GHRH protein CTD PMID:32622971 NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889 		JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 increases expression EXP Chlormequat results in increased expression of GNRH1 protein CTD PMID:29447956 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP Chlormequat results in decreased expression of HSD3B1 protein CTD PMID:29447956 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Igf1 insulin-like growth factor 1 affects expression
increases expression		 EXP Chlormequat affects the expression of IGF1 protein
Chlormequat results in increased expression of IGF1 protein		 CTD PMID:28214531 PMID:31704167 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Chlormequat results in increased expression of LHB protein CTD PMID:29447956 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP Chlormequat results in decreased expression of STAR protein CTD PMID:29447956 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Tnfsf11 TNF superfamily member 11 affects expression EXP Chlormequat affects the expression of TNFSF11 mRNA CTD PMID:28214531 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
colesevelam hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein decreases expression ISO Colesevelam Hydrochloride results in decreased expression of CRP protein CTD PMID:16616026 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression		 ISO Colesevelam Hydrochloride promotes the reaction [Simvastatin results in increased expression of HMGCR mRNA]
Colesevelam Hydrochloride results in increased expression of HMGCR mRNA		 CTD PMID:22120639 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO Colesevelam Hydrochloride results in increased expression of LDLR mRNA CTD PMID:22120639 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
ecothiopate iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Echothiophate Iodide results in decreased activity of ACHE protein CTD PMID:16978018 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Alb albumin affects binding ISO Echothiophate Iodide binds to ALB protein CTD PMID:15525694 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions		 ISO Echothiophate Iodide results in decreased activity of BCHE protein
Echothiophate Iodide inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]		 CTD PMID:7377577 PMID:16213467 PMID:17698511 PMID:21802514 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO Echothiophate Iodide results in decreased activity of NCEH1 protein CTD PMID:16978018 NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588 		JBrowse link
Hexamethonium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avp arginine vasopressin multiple interactions EXP Hexamethonium promotes the reaction [Dexamethasone results in increased activity of AVP protein] CTD PMID:3346065 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bdkrb2 bradykinin receptor B2 affects response to substance ISO BDKRB2 affects the susceptibility to Hexamethonium CTD PMID:10614985 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Hexamethonium affects the reaction [Nicotine results in increased expression of BIRC5 protein] CTD PMID:16601104 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO Hexamethonium inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] CTD PMID:15231866 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Hexamethonium results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:9687574 NCBI chr 8:55,401,981...55,415,012
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO Hexamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Hexamethonium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Hexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]		 CTD PMID:7756618 PMID:14645658 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO Hexamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Hexamethonium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Hexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]		 CTD PMID:7756618 PMID:14645658 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP Hexamethonium results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:9687574 NCBI chr 8:55,418,379...55,436,967
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Hexamethonium inhibits the reaction [Hydrochloric Acid results in increased expression of FOS protein] CTD PMID:12588467 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Hexamethonium inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] CTD PMID:18448488 PMID:20106947 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Hexamethonium inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] CTD PMID:18448488 PMID:20106947 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP Hexamethonium inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of MKI67 protein] CTD PMID:29501575 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Npy neuropeptide Y multiple interactions EXP Hexamethonium inhibits the reaction [Nicotine results in increased expression of NPY mRNA] CTD PMID:2233698 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO
EXP		 Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]
Hexamethonium inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of STAT3 protein modified form]		 CTD PMID:18448488 PMID:20106947 PMID:29501575 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO Hexamethonium affects the reaction [Nicotine results in increased expression of XIAP protein] CTD PMID:16601104 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
methacholine chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
increases response to substance		 ISO Cyclosporine inhibits the reaction [[AHR protein results in increased susceptibility to Antigens] which results in increased susceptibility to Methacholine Chloride]
[AHR protein results in increased susceptibility to Antigens] which results in increased susceptibility to Methacholine Chloride; AHR protein results in increased susceptibility to Methacholine Chloride		 CTD PMID:27869817 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 multiple interactions ISO BMPR2 protein affects the susceptibility to [Methacholine Chloride co-treated with Antigens, Dermatophagoides] CTD PMID:22427841 NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809 		JBrowse link
G C3 complement C3 multiple interactions ISO C3 protein affects the susceptibility to [Ozone co-treated with Methacholine Chloride] CTD PMID:14701711 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E multiple interactions EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid affects the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]; Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]; Calcium inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]; Heparin affects the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]; Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]; Ro 31-8425 inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:12663092 NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO 3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [Methacholine Chloride promotes the reaction [CFTR protein results in increased export of Chlorides]]; Methacholine Chloride promotes the reaction [CFTR protein results in increased export of Chlorides] CTD PMID:20675434 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Cpe carboxypeptidase E increases response to substance ISO CPE gene mutant form results in increased susceptibility to Methacholine Chloride CTD PMID:16002559 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions ISO Ozone promotes the reaction [CXCR2 protein affects the susceptibility to Methacholine Chloride] CTD PMID:15361358 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Fcer2 Fc epsilon receptor II increases expression ISO Methacholine Chloride results in increased expression of FCER2 protein CTD PMID:15801332 NCBI chr12:1,742,809...1,754,476
Ensembl chr12:1,742,815...1,754,476 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 affects response to substance ISO GRK3 mutant form affects the susceptibility to Methacholine Chloride CTD PMID:10198406 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262 		JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions
increases expression		 ISO IL1RN protein results in decreased susceptibility to [Ozone co-treated with Methacholine Chloride]
Methacholine Chloride results in increased expression of IL1RN protein		 CTD PMID:14754758 PMID:15801332 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Lep leptin increases response to substance ISO LEP gene mutant form results in increased susceptibility to Methacholine Chloride CTD PMID:12794034 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO NOS2 protein affects the reaction [2-chloroethyl ethyl sulfide affects the susceptibility to Methacholine Chloride] CTD PMID:22446026 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases response to substance		 ISO N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [NOS3 gene mutant form results in decreased susceptibility to Methacholine Chloride] CTD PMID:22421449 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO NR1I2 protein affects the susceptibility to [5-alpha-Dihydroprogesterone co-treated with Methacholine Chloride] CTD PMID:17159084 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride; Chlorpromazine inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride]; Cromolyn Sodium inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride] CTD PMID:22414385 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases response to substance ISO TNFRSF1A protein results in increased susceptibility to Methacholine Chloride CTD PMID:21070800 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 increases activity ISO Methacholine Chloride results in increased activity of TRPC3 protein CTD PMID:16522635 NCBI chr 2:119,481,313...119,619,333
Ensembl chr 2:119,481,400...119,558,855 		JBrowse link
methyltrioctylammonium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dio1 iodothyronine deiodinase 1 decreases activity ISO trioctylmethylammonium results in decreased activity of DIO1 protein CTD PMID:30561685 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO trioctylmethylammonium results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO trioctylmethylammonium results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660 		JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO trioctylmethylammonium inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319 		JBrowse link
tiotropium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm1 cholinergic receptor, muscarinic 1 affects binding ISO Tiotropium Bromide binds to CHRM1 protein CTD PMID:21870878 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 affects binding ISO Tiotropium Bromide binds to CHRM2 protein CTD PMID:21870878 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 affects binding ISO Tiotropium Bromide binds to CHRM3 protein CTD PMID:21870878 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 affects binding ISO Tiotropium Bromide binds to CHRM4 protein CTD PMID:21870878 NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159 		JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 affects binding ISO Tiotropium Bromide binds to CHRM5 protein CTD PMID:21870878 NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Tiotropium Bromide inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA] CTD PMID:22796455 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Tiotropium Bromide results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO Tiotropium Bromide results in decreased secretion of TNF protein CTD PMID:21352583 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
tiquizium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO thiaton results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP thiaton inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11855677 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP thiaton inhibits the reaction [Indomethacin results in increased activity of NOS2 protein] CTD PMID:11855677 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
trospium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases transport		 ISO valspodar inhibits the reaction [ABCB1 protein results in increased transport of trospium chloride] CTD PMID:25466967 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity
increases metabolic processing		 ISO trospium chloride results in decreased activity of SLC22A1 protein
SLC22A1 protein results in increased metabolism of trospium chloride		 CTD PMID:25466967 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO trospium chloride results in decreased activity of SLC22A2 protein CTD PMID:25466967 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases metabolic processing
decreases activity		 ISO SLCO1A2 protein results in increased metabolism of trospium chloride
trospium chloride results in decreased activity of SLCO1A2 protein; trospium chloride results in decreased activity of SLCO1A2 protein alternative form		 CTD PMID:25466967 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases activity ISO trospium chloride results in decreased activity of SLCO1B3 protein CTD PMID:25466967 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
vecuronium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein] CTD PMID:30036686 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein] CTD PMID:30036686 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein] CTD PMID:9846649 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:9846649 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions ISO Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein] CTD PMID:9846649 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions ISO Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein] CTD PMID:9846649 NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159 		JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 multiple interactions ISO Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein] CTD PMID:9846649 NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] CTD PMID:16931985 NCBI chr 8:55,401,981...55,415,012
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 PMID:16931985 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] CTD PMID:16931985 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 PMID:16931985 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] CTD PMID:16931985 NCBI chr 8:55,418,379...55,436,967
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 protein] CTD PMID:31846720 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 protein] CTD PMID:30959089 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 protein] CTD PMID:29486207 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of ELK1 protein] CTD PMID:29486207 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Hdac4 histone deacetylase 4 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein] CTD PMID:31846720 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hexb hexosaminidase subunit beta increases secretion ISO Vecuronium Bromide results in increased secretion of HEXB protein CTD PMID:19758318 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases expression
multiple interactions		 ISO Vecuronium Bromide results in increased expression of HSD11B2 mRNA; Vecuronium Bromide results in increased expression of HSD11B2 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]		 CTD PMID:29486207 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] CTD PMID:29486207 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] CTD PMID:29486207 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 protein] CTD PMID:30036686 NCBI chr 1:95,041,967...95,047,377
Ensembl chr 1:95,041,967...95,047,377 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 protein] CTD PMID:30036686 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein] CTD PMID:30036686 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR protein] CTD PMID:31846720 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    chemical entity 20055
      molecular entity 20054
        ion 16470
          organic ion 9184
            organic cation 8114
              quaternary ammonium ion 5123
                quaternary ammonium salt 308
                  (11)C-choline chloride 0
                  (1R,2S,1'R,2'S)-doxacurium chloride + 0
                  (1S,2R,1'S,2'R)-doxacurium chloride + 0
                  (R)-oleoylcarnitine hydrochloride 0
                  1,1'-hexadecane-1,16-diylbis(1-methylpyrrolidinium) dibromide 0
                  1,1-dimethyl-4-phenylpiperazinium iodide 7
                  2,4-D choline 0
                  2-(\{2-[Dimethyl(2-phosphanylethyl)ammonio]ethyl\}dimethylammonio)ethyl phosphinite 0
                  4-DAMP methiodide 1
                  Betaine Aldehyde Chloride 0
                  DOSPA trifluoroacetate 0
                  Dioctyldimethylammonium chloride 0
                  Diponium bromide 0
                  FM 1-43 dye 0
                  FM 4-64 dye 0
                  Heptadecyl(hexadecyl)dimethylazanium 0
                  Hexamethonium 15
                  N,N,N-Trimethylethenaminium 0
                  Nervonyl carnitine 0
                  Polidronium chloride 0
                  Polixetonium chloride 0
                  Trimethylcetylammonium pentachlorophenate 0
                  Yo-Pro-1 0
                  acetyl-beta-methylthiocholine iodide 0
                  acetylcholine bromide 0
                  acetylcholine chloride 0
                  aclidinium bromide 0
                  ambenonium chloride 2
                  anisotropine methylbromide 0
                  atracurium besylate + 0
                  benzalkonium chloride 235
                  benzethonium chloride 12
                  benzododecinium bromide 0
                  benzododecinium chloride 0
                  bethanechol chloride + 0
                  bretylium tosylate 1
                  butropium bromide 0
                  butylscopolamine bromide 1
                  carpronium chloride 0
                  cetyltrimethylammonium bromide 0
                  cetyltrimethylammonium chloride 0
                  chlormequat chloride 13
                  choline chloride 0
                  cisatracurium besylate 0
                  clidinium bromide 0
                  colesevelam + 3
                  decamethoxine 0
                  decyltrimethylammonium bromide 0
                  demecarium bromide 0
                  dimethylindole red 0
                  diphemanil methylsulfate 0
                  dodecyltrimethylammonium bromide 0
                  doxacurium chloride 0
                  ecothiopate iodide 4
                  edrophonium chloride 0
                  ethyl green 0
                  ethyltrimethylammonium iodide 0
                  fluoromethylcholine (18F) 0
                  glycopyrronium bromide + 0
                  hexafluronium 0
                  iodine green 0
                  ipratropium chloride 0
                  mepiquat chloride 0
                  meso-doxacurium chloride + 0
                  methacholine chloride 17
                  methyl green 0
                  methyltrioctylammonium chloride 4
                  octyltrimethylammonium bromide 0
                  penotonium bromide 0
                  pentamethonium bromide 0
                  poly(2-methacrylolyloxyethyltrimethylammonium chloride) macromolecule + 0
                  poly(diallyldimethylammonium chloride) macromolecule + 0
                  poly[3-(3'-N,N,N-triethylamino-1-propyloxy)-4-methylthiophene-2,5-diyl hydrochloride] macromolecule + 0
                  propyromazine bromide 0
                  quaternium-15 0
                  quaternium-52 0
                  rocuronium bromide 0
                  scopolamine methobromide 0
                  sodium green 0
                  tetrabutylammonium salt + 0
                  tetraethylammonium chloride 0
                  tetramethylammonium bromide 0
                  tetrapropylammonium bromide 0
                  tetrapropylammonium perruthenate 0
                  tiotropium bromide 8
                  tiquizium bromide 3
                  trimethylphenylammonium hydroxide 0
                  trospium chloride 5
                  umeclidinium bromide + 0
                  vecuronium bromide 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19752
                        hydrogen molecular entity 19745
                          hydrides 19114
                            inorganic hydride 17882
                              pnictogen hydride 17865
                                nitrogen hydride 17754
                                  ammonium 8235
                                    ammonium ion derivative 8231
                                      ammonium compound 5079
                                        organoammonium salt 425
                                          quaternary ammonium salt 308
                                            (11)C-choline chloride 0
                                            (1R,2S,1'R,2'S)-doxacurium chloride + 0
                                            (1S,2R,1'S,2'R)-doxacurium chloride + 0
                                            (R)-oleoylcarnitine hydrochloride 0
                                            1,1'-hexadecane-1,16-diylbis(1-methylpyrrolidinium) dibromide 0
                                            1,1-dimethyl-4-phenylpiperazinium iodide 7
                                            2,4-D choline 0
                                            2-(\{2-[Dimethyl(2-phosphanylethyl)ammonio]ethyl\}dimethylammonio)ethyl phosphinite 0
                                            4-DAMP methiodide 1
                                            Betaine Aldehyde Chloride 0
                                            DOSPA trifluoroacetate 0
                                            Dioctyldimethylammonium chloride 0
                                            Diponium bromide 0
                                            FM 1-43 dye 0
                                            FM 4-64 dye 0
                                            Heptadecyl(hexadecyl)dimethylazanium 0
                                            Hexamethonium 15
                                            N,N,N-Trimethylethenaminium 0
                                            Nervonyl carnitine 0
                                            Polidronium chloride 0
                                            Polixetonium chloride 0
                                            Trimethylcetylammonium pentachlorophenate 0
                                            Yo-Pro-1 0
                                            acetyl-beta-methylthiocholine iodide 0
                                            acetylcholine bromide 0
                                            acetylcholine chloride 0
                                            aclidinium bromide 0
                                            ambenonium chloride 2
                                            anisotropine methylbromide 0
                                            atracurium besylate + 0
                                            benzalkonium chloride 235
                                            benzethonium chloride 12
                                            benzododecinium bromide 0
                                            benzododecinium chloride 0
                                            bethanechol chloride + 0
                                            bretylium tosylate 1
                                            butropium bromide 0
                                            butylscopolamine bromide 1
                                            carpronium chloride 0
                                            cetyltrimethylammonium bromide 0
                                            cetyltrimethylammonium chloride 0
                                            chlormequat chloride 13
                                            choline chloride 0
                                            cisatracurium besylate 0
                                            clidinium bromide 0
                                            colesevelam + 3
                                            decamethoxine 0
                                            decyltrimethylammonium bromide 0
                                            demecarium bromide 0
                                            dimethylindole red 0
                                            diphemanil methylsulfate 0
                                            dodecyltrimethylammonium bromide 0
                                            doxacurium chloride 0
                                            ecothiopate iodide 4
                                            edrophonium chloride 0
                                            ethyl green 0
                                            ethyltrimethylammonium iodide 0
                                            fluoromethylcholine (18F) 0
                                            glycopyrronium bromide + 0
                                            hexafluronium 0
                                            iodine green 0
                                            ipratropium chloride 0
                                            mepiquat chloride 0
                                            meso-doxacurium chloride + 0
                                            methacholine chloride 17
                                            methyl green 0
                                            methyltrioctylammonium chloride 4
                                            octyltrimethylammonium bromide 0
                                            penotonium bromide 0
                                            pentamethonium bromide 0
                                            poly(2-methacrylolyloxyethyltrimethylammonium chloride) macromolecule + 0
                                            poly(diallyldimethylammonium chloride) macromolecule + 0
                                            poly[3-(3'-N,N,N-triethylamino-1-propyloxy)-4-methylthiophene-2,5-diyl hydrochloride] macromolecule + 0
                                            propyromazine bromide 0
                                            quaternium-15 0
                                            quaternium-52 0
                                            rocuronium bromide 0
                                            scopolamine methobromide 0
                                            sodium green 0
                                            tetrabutylammonium salt + 0
                                            tetraethylammonium chloride 0
                                            tetramethylammonium bromide 0
                                            tetrapropylammonium bromide 0
                                            tetrapropylammonium perruthenate 0
                                            tiotropium bromide 8
                                            tiquizium bromide 3
                                            trimethylphenylammonium hydroxide 0
                                            trospium chloride 5
                                            umeclidinium bromide + 0
                                            vecuronium bromide 25
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