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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:GGTI-2133
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Accession:CHEBI:101279 term browser browse the term
Definition:An organoammonium salt resulting from the mixing of equimolar amounts of GGTI-2133 free base and trifluoroacetic acid. An inhibitor of geranylgeranyltransferase type I.
Synonyms:exact_synonym: 4-{[(1S)-1-carboxy-3-methylbutyl]carbamoyl}-N-[(1H-imidazol-4-yl)methyl]-3-(naphthalen-1-yl)anilinium trifluoroacetate;   N-[4-{[(1H-imidazol-4-yl)methyl]amino}-2-(naphthalen-1-yl)benzoyl]-L-leucine trifluoroacetate
 related_synonym: Formula=C29H29F3N4O5;   InChI=1S/C27H28N4O3.C2HF3O2/c1-17(2)12-25(27(33)34)31-26(32)23-11-10-19(29-15-20-14-28-16-30-20)13-24(23)22-9-5-7-18-6-3-4-8-21(18)22;3-2(4,5)1(6)7/h3-11,13-14,16-17,25,29H,12,15H2,1-2H3,(H,28,30)(H,31,32)(H,33,34);(H,6,7)/t25-;/m0./s1;   InChIKey=FXXUNOYBYJFSRB-UQIIZPHYSA-N;   SMILES=C(C([O-])=O)(F)(F)F.C([C@H](CC(C)C)NC(=O)C1=C(C=C(C=C1)[NH2+]CC=2NC=NC2)C=3C4=C(C=CC=C4)C=CC3)(O)=O
 xref_mesh: MESH:C547856
 xref: PMID:23335799;   PMID:23415632;   PMID:23649168;   PMID:23744643;   PMID:24486886;   PMID:25882623


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GGTI-2133 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO GGTI-2133 inhibits the reaction [Smoke analog results in increased phosphorylation of AKT1 protein] CTD PMID:19299917 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO GGTI-2133 inhibits the reaction [Smoke analog results in increased phosphorylation of MAPK1 protein] CTD PMID:19299917 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO GGTI-2133 inhibits the reaction [Smoke analog results in increased phosphorylation of MAPK3 protein] CTD PMID:19299917 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions ISO GGTI-2133 inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]; GGTI-2133 inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein] CTD PMID:19299917 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G RAP1A RAP1A, member of RAS oncogene family decreases geranoylation EXP GGTI-2133 results in decreased geranoylation of RAP1A protein CTD PMID:25578243 NCBI chr 1:111,542,009...111,716,691
Ensembl chr 1:111,542,218...111,716,691 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    chemical entity 26020
      molecular entity 25998
        ion 18772
          organic ion 10240
            organic cation 9158
              GGTI-2133 free base(1+) 5
                GGTI-2133 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    main group molecular entity 25841
                      s-block molecular entity 25162
                        hydrogen molecular entity 24761
                          hydrides 22974
                            inorganic hydride 20501
                              pnictogen hydride 20442
                                nitrogen hydride 20219
                                  ammonium 8188
                                    ammonium ion derivative 8183
                                      ammonium compound 5008
                                        organoammonium salt 690
                                          GGTI-2133 5
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