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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:glycoursodeoxycholic acid
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Accession:CHEBI:89929 term browser browse the term
Definition:A bile acid glycine conjugate derived from ursoodeoxycholic acid.
Synonyms:related_synonym: 3alpha,7beta-dihydroxy-5beta-cholanoylglycine;   Formula=C26H43NO5;   GUDCA;   Glycine ursodeoxycholic acid;   Glycylursodeoxycholic acid;   InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/t15-,16+,17-,18-,19+,20+,21+,24+,25+,26-/m1/s1;   InChIKey=GHCZAUBVMUEKKP-XROMFQGDSA-N;   N-(3alpha,7beta-dihydroxy-5beta-cholan-24-oyl)glycine;   N-[(3alpha,5beta,7beta)-3,7-dihydroxy-24-oxocholan-24-yl]glycine;   SMILES=C1[C@@]2([C@]3(CC[C@]4([C@]([C@@]3([C@H](C[C@@]2(C[C@@H](C1)O)[H])O)[H])(CC[C@]4([H])[C@@H](CCC(NCC(O)=O)=O)C)[H])C)[H])C;   Ursodeoxycholylglycine
 xref: CAS:64480-66-6;   HMDB:HMDB0000708
 xref_mesh: MESH:C024033
 xref: PMID:24848512;   PMID:26009005;   PMID:26382575;   PMID:26639449;   PMID:27322559;   Reaxys:3226178
 cyclic_relationship: is_conjugate_acid_of CHEBI:132030


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glycoursodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP glycoursodeoxycholic acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA] CTD PMID:17881359 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases hydroxylation ISO CYP3A4 protein results in increased hydroxylation of glycoursodeoxycholic acid CTD PMID:36473578 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Edn1 endothelin 1 decreases expression ISO glycoursodeoxycholic acid results in decreased expression of EDN1 protein CTD PMID:15556138 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Slc4a2 solute carrier family 4 member 2 multiple interactions ISO [glycoursodeoxycholic acid co-treated with Dexamethasone] results in increased expression of SLC4A2 mRNA alternative form CTD PMID:18188457 NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP glycoursodeoxycholic acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA] CTD PMID:17881359 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
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  CHEBI ontology 19874
    role 19844
      application 19689
        pharmaceutical 19525
          drug 19525
            protective agent 18235
              neuroprotective agent 15712
                glycoursodeoxycholic acid 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic polycyclic compound 17286
                                  steroid 14717
                                    steroid fundamental parent 14511
                                      cholane 1007
                                        cholanoid 1007
                                          cholanic acids 991
                                            cholanic acid 991
                                              5beta-cholanic acid 991
                                                hydroxy-5beta-cholanic acid 991
                                                  dihydroxy-5beta-cholanic acid 842
                                                    ursodeoxycholic acid 399
                                                      glycoursodeoxycholic acid 5
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