Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:remifentanil
go back to main search page
Accession:CHEBI:8802 term browser browse the term
Definition:A piperidinecarboxylate ester that is methyl piperidine-4-carboxylate in which the hydrogen attached to the nitrogen is substituted by a 3-methoxy-3-oxopropyl group and the hydrogen at position 4 is substituted the nitrogen of N-propanoylaniline.
Synonyms:exact_synonym: methyl 1-(3-methoxy-3-oxopropyl)-4-[phenyl(propanoyl)amino]piperidine-4-carboxylate
 related_synonym: Formula=C20H28N2O5;   InChI=1S/C20H28N2O5/c1-4-17(23)22(16-8-6-5-7-9-16)20(19(25)27-3)11-14-21(15-12-20)13-10-18(24)26-2/h5-9H,4,10-15H2,1-3H3;   InChIKey=ZTVQQQVZCWLTDF-UHFFFAOYSA-N;   SMILES=CCC(=O)N(c1ccccc1)C1(CCN(CCC(=O)OC)CC1)C(=O)OC
 alt_id: CHEBI:211871
 xref: CAS:132875-61-7;   DrugBank:DB00899;   Drug_Central:2363;   HMDB:HMDB0015036;   KEGG:C08021;   KEGG:D08473
 xref_mesh: MESH:C071741
 xref: Patent:EP383579;   Patent:US5019583;   Reaxys:4358750;   Wikipedia:Remifentanil



show annotations for term's descendants           Sort by:
remifentanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CASP3 protein modified form]]; MIR205 mRNA inhibits the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]; Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CASP3 protein modified form] CTD PMID:34078833 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
increases phosphorylation
EXP Ketamine inhibits the reaction [remifentanil results in increased phosphorylation of GRIN2B protein] CTD PMID:20042082 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A affects activity ISO remifentanil affects the activity of HTR3A protein CTD PMID:18635474 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Mir205 microRNA 205 multiple interactions EXP [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PINK1 protein]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CASP3 protein modified form]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MIR205 mRNA]]; [Antagomirs results in decreased expression of MIR205 mRNA] which results in increased susceptibility to Remifentanil; MIR205 mRNA inhibits the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of MIR205 mRNA]; Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MIR205 mRNA] CTD PMID:34078833 NCBI chr13:105,035,878...105,035,985
Ensembl chr13:105,035,878...105,035,985
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions EXP [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PINK1 protein]]; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in decreased expression of PINK1 protein]; Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PINK1 protein] CTD PMID:34078833 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions
affects localization
EXP Lidocaine inhibits the reaction [remifentanil affects the localization of PRKCG protein] CTD PMID:19955894 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        pharmacological role 19026
          analgesic 14719
            opioid analgesic 667
              remifentanil 6
                remifentanil hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            inorganic hydride 18093
                              pnictogen hydride 18082
                                nitrogen hydride 17989
                                  azane 17798
                                    ammonia 17797
                                      organic amino compound 17797
                                        primary amino compound 9301
                                          primary amine 6318
                                            primary arylamine 3644
                                              aniline 3482
                                                anilide 1104
                                                  remifentanil 6
                                                    remifentanil hydrochloride 0
paths to the root