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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:opioid analgesic
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Accession:CHEBI:35482 term browser browse the term
Definition:A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood.
Synonyms:related_synonym: narcotic;   narcotic analgesic;   narcotic analgesics;   narcotics;   opioid analgesics


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(R,R)-tramadol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A increases expression EXP Tramadol results in increased expression of ADRA1A protein CTD PMID:15464068 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Tramadol results in increased expression of BAX protein CTD PMID:25550769 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bche butyrylcholinesterase decreases activity EXP Tramadol results in decreased activity of BCHE protein CTD PMID:28689766 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Casp3 caspase 3 affects activity
decreases activity
ISO
EXP
Tramadol affects the activity of CASP3 protein
Tramadol results in decreased activity of CASP3 protein
CTD PMID:27317026, PMID:28499616 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases expression
multiple interactions
EXP Tramadol results in decreased expression of CAT mRNA
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]
CTD PMID:25550769 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ckb creatine kinase B decreases expression ISO Tramadol results in decreased expression of CKB mRNA CTD PMID:27317026 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO Tramadol results in decreased activity of CYP17A1 protein CTD PMID:29100959 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
affects methylation
multiple interactions
decreases methylation
affects response to substance
decreases response to substance
increases response to substance
increases metabolic processing
ISO CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol
CYP2D6 protein affects the methylation of Tramadol
[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol
CYP2D6 protein results in decreased methylation of Tramadol
CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol
CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol
CTD PMID:12191703, PMID:12893130, PMID:14624403, PMID:16497087, PMID:16960721, PMID:17361124, PMID:17470523, PMID:17570739, PMID:18204346, PMID:18520597, PMID:18713907, PMID:29555325 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Drd2 dopamine receptor D2 increases expression EXP Tramadol results in increased expression of DRD2 protein CTD PMID:15464068 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 increases expression EXP Tramadol results in increased expression of DRD3 protein CTD PMID:15464068 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Tramadol results in increased activity of GPT protein CTD PMID:28689766 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases activity
increases expression
multiple interactions
EXP Tramadol results in increased activity of HTR2A protein
Tramadol results in increased expression of HTR2A mRNA
Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]
CTD PMID:18417104 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO Tramadol results in decreased expression of LDHA mRNA CTD PMID:27317026 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 decreases expression ISO Tramadol results in decreased expression of NDUFS1 mRNA CTD PMID:27317026 NCBI chr 9:69,919,863...69,953,182
Ensembl chr 9:69,919,867...69,953,182
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP Tramadol binds to OPRD1 protein
[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP Tramadol binds to OPRK1 protein
[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding
multiple interactions
EXP Tramadol binds to OPRM1 protein
[Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 increases expression ISO Tramadol results in increased expression of PDK3 mRNA CTD PMID:27317026 NCBI chr  X:62,836,131...62,904,114
Ensembl chr  X:62,836,131...62,903,554
JBrowse link
G Pdyn prodynorphin decreases expression EXP Tramadol results in decreased expression of PDYN mRNA CTD PMID:17401159 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:11723065 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions
EXP Tramadol results in decreased expression of SOD1 mRNA
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]
CTD PMID:25550769 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
EXP Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA]
Tramadol results in decreased expression of SOD2 mRNA
CTD PMID:25550769 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein] CTD PMID:17377112 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
alfentanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5a cytochrome b5 type A multiple interactions ISO CYB5A protein promotes the reaction [CYP3A4 protein affects the metabolism of Alfentanil]; CYB5A protein promotes the reaction [CYP3A5 protein affects the metabolism of Alfentanil] CTD PMID:15557344 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions
affects metabolic processing
ISO CYB5A protein promotes the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Ketoconazole inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Troleandomycin inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil] CTD PMID:15557344, PMID:15731592, PMID:17554244 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A affects activity ISO Alfentanil affects the activity of HTR3A protein CTD PMID:18635474 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
buprenorphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor decreases expression EXP Buprenorphine results in decreased expression of BDNF protein CTD PMID:24321744 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP
ISO
Buprenorphine results in decreased activity of CAT protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Buprenorphine] results in increased activity of CAT protein
CTD PMID:25683329, PMID:32113805 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation EXP Buprenorphine results in decreased phosphorylation of CREB1 protein CTD PMID:24321744 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects metabolic processing ISO CYP2C8 protein affects the metabolism of Buprenorphine CTD PMID:16010532 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
decreases activity
ISO CYP2D6 protein results in increased metabolism of Buprenorphine
Buprenorphine results in decreased activity of CYP2D6 protein
CTD PMID:12756210 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Buprenorphine results in increased activity of GPT protein CTD PMID:25683329 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Il2 interleukin 2 decreases expression ISO Buprenorphine results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 increases expression ISO Buprenorphine results in increased expression of IL4 mRNA CTD PMID:23965172 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Buprenorphine results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Buprenorphine results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 decreases phosphorylation EXP Buprenorphine results in decreased phosphorylation of NTRK2 protein CTD PMID:24321744 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP
ISO
Buprenorphine binds to OPRD1 protein
Buprenorphine inhibits the reaction [Enkephalin, D-Penicillamine (2,5)- analog binds to OPRD1 protein]
CTD PMID:7562497, PMID:21866885 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP
ISO
Buprenorphine binds to OPRK1 protein
Buprenorphine inhibits the reaction [U 69593 binds to OPRK1 protein]
CTD PMID:7562497, PMID:21866885 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 multiple interactions ISO Buprenorphine binds to and results in increased activity of OPRL1 protein CTD PMID:10998549 NCBI chr 3:177,223,779...177,231,663
Ensembl chr 3:177,225,737...177,231,663
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
ISO
EXP
Buprenorphine binds to and affects the activity of OPRM1 protein; Buprenorphine binds to and results in increased activity of OPRM1 protein; Buprenorphine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]
Buprenorphine binds to OPRM1 protein
CTD PMID:7562497, PMID:16010532, PMID:21866885 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha decreases activity EXP Buprenorphine results in decreased activity of PRKACA protein CTD PMID:24321744 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Buprenorphine CTD PMID:12756209 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
butorphanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects activity EXP Butorphanol affects the activity of OPRD1 protein CTD PMID:17909753 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects activity EXP Butorphanol affects the activity of OPRK1 protein CTD PMID:17909753 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 affects activity ISO
EXP
Butorphanol affects the activity of OPRM1 protein CTD PMID:17909753 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Prkcd protein kinase C, delta affects localization ISO Butorphanol affects the localization of PRKCD protein CTD PMID:29669290 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
carfentanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprm1 opioid receptor, mu 1 multiple interactions ISO Capsaicin inhibits the reaction [carfentanil binds to OPRM1 protein]; Cocaine affects the reaction [carfentanil binds to OPRM1 protein] CTD PMID:12406535, PMID:15953495 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
codeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO Codeine results in increased secretion of CCL2 protein CTD PMID:17441793 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Codeine affects the secretion of and affects the expression of CCL5 protein CTD PMID:17441793 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of Codeine analog CTD PMID:25445008 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
multiple interactions
increases metabolic processing
affects response to substance
decreases methylation
ISO CYP2D6 protein affects the metabolism of Codeine; CYP2D6 protein polymorphism affects the metabolism of Codeine
[CYP2D6 gene mutant form results in increased activity of CYP2D6 protein] which results in increased susceptibility to Codeine; [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine
[CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine
CYP2D6 protein polymorphism affects the susceptibility to Codeine
CYP2D6 protein results in decreased methylation of Codeine
CYP2D6 gene polymorphism results in increased metabolism of Codeine; CYP2D6 protein results in increased metabolism of Codeine
CTD PMID:9696456, PMID:10911933, PMID:11823760, PMID:15286053, PMID:15625333, PMID:16595712, PMID:17470523, PMID:17564651, PMID:21241245 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Codeine results in decreased activity of KCNH2 protein CTD PMID:19034038 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Codeine binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Codeine binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP Codeine binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
codeinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 6-codeinone results in increased expression of BAX protein CTD PMID:12894543 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 6-codeinone results in decreased expression of BCL2 protein CTD PMID:12894543 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
ISO 6-codeinone results in increased activity of CASP3 protein
6-codeinone results in increased cleavage of CASP3 protein
CTD PMID:12606908, PMID:12894543 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity ISO 6-codeinone results in increased activity of CASP9 protein CTD PMID:12894543 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO 6-codeinone affects the localization of CYCS protein CTD PMID:12894543 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
dextropropoxyphene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1A protein affects the susceptibility to Dextropropoxyphene CTD PMID:15502009 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Dextropropoxyphene CTD PMID:15502009 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ces1d carboxylesterase 1D affects binding ISO Dextropropoxyphene binds to CES1 protein CTD PMID:10381793 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Ces2h carboxylesterase 2H affects binding ISO Dextropropoxyphene binds to CES2 protein CTD PMID:10381793 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions
affects binding
EXP [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions
affects binding
EXP [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
EXP [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dextropropoxyphene inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
ecgonine methyl ester term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase multiple interactions
increases chemical synthesis
increases abundance
ISO [BCHE protein mutant form results in increased hydrolysis of Cocaine] which results in increased abundance of ecgonine methyl ester
[BCHE protein mutant form results in increased metabolism of Cocaine] which results in increased chemical synthesis of ecgonine methyl ester
BCHE protein mutant form results in increased chemical synthesis of ecgonine methyl ester
BCHE protein mutant form results in increased abundance of ecgonine methyl ester
CTD PMID:25814464, PMID:30080993 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
fentanyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions
increases response to substance
ISO
EXP
ABCB1 protein results in increased transport of Fentanyl
tariquidar inhibits the reaction [ABCB1 protein results in increased transport of Fentanyl]
ABCB1 protein results in increased susceptibility to Fentanyl
CTD PMID:29669042 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Arrb2 arrestin, beta 2 affects localization ISO Fentanyl affects the localization of ARRB2 protein CTD PMID:27030709 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Naloxone inhibits the reaction [Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]] CTD PMID:27030709 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Crh corticotropin releasing hormone affects expression EXP Fentanyl affects the expression of CRH mRNA CTD PMID:18819432 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Fentanyl results in increased expression of FOS protein CTD PMID:7970238 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gast gastrin multiple interactions EXP [fluanisone co-treated with Fentanyl co-treated with Midazolam] inhibits the reaction [GAST protein results in increased secretion of Histamine] CTD PMID:10864877 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484
JBrowse link
G Il2 interleukin 2 decreases expression ISO Fentanyl results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 increases expression ISO Fentanyl results in increased expression of IL4 mRNA CTD PMID:23965172 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Fentanyl results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Fentanyl results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Fentanyl results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Fentanyl results in increased expression of NFKBIA protein CTD PMID:22258905 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Oprm1 opioid receptor, mu 1 increases phosphorylation ISO Fentanyl results in increased phosphorylation of OPRM1 protein CTD PMID:17240843, PMID:21957251, PMID:23300227 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pdyn prodynorphin increases expression EXP Fentanyl results in increased expression of PDYN protein CTD PMID:19200067 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Pld2 phospholipase D2 increases activity ISO Fentanyl results in increased activity of PLD2 protein CTD PMID:23965172 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730
JBrowse link
G Pomc proopiomelanocortin decreases expression
multiple interactions
ISO Fentanyl results in decreased expression of POMC protein alternative form
[Fentanyl co-treated with Morphine] results in decreased expression of POMC protein alternative form
CTD PMID:20084599 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ren renin multiple interactions ISO [Fentanyl co-treated with Isoflurane] results in decreased expression of REN protein CTD PMID:3284271 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
heroin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases metabolic processing
ISO [ACHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine CTD PMID:30080993 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Actn2 actinin alpha 2 decreases expression ISO Heroin results in decreased expression of ACTN2 mRNA CTD PMID:16710320 NCBI chr17:66,304,530...66,397,647
Ensembl chr17:66,304,501...66,397,653
JBrowse link
G Amph amphiphysin decreases expression ISO Heroin results in decreased expression of AMPH mRNA CTD PMID:16710320 NCBI chr17:48,304,324...48,562,838
Ensembl chr17:48,304,322...48,562,905
JBrowse link
G App amyloid beta precursor protein decreases expression ISO Heroin results in decreased expression of APP mRNA CTD PMID:16710320 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bche butyrylcholinesterase multiple interactions
increases metabolic processing
ISO [BCHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine CTD PMID:30080993 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
multiple interactions
ISO
EXP
Heroin results in decreased expression of BDNF protein
Heroin results in decreased expression of BDNF mRNA
Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]
CTD PMID:17715210, PMID:25643298 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bloc1s6 biogenesis of lysosomal organelles complex 1 subunit 6 decreases expression ISO Heroin results in decreased expression of BLOC1S6 mRNA CTD PMID:16710320 NCBI chr 3:114,869,478...114,880,218
Ensembl chr 3:114,869,459...114,881,590
JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Heroin co-treated with Cocaine] results in increased activity of CASP3 protein; Heroin promotes the reaction [Cocaine results in increased activity of CASP3 protein] CTD PMID:20600547 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ces1d carboxylesterase 1D decreases acetylation
increases hydrolysis
multiple interactions
affects binding
ISO CES1 protein results in decreased acetylation of Heroin
CES1 protein results in increased hydrolysis of Heroin
Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of Heroin]
Heroin binds to CES1 protein
CTD PMID:8930175, PMID:9311626, PMID:12679808, PMID:12773168 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases hydrolysis
ISO Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of Heroin] CTD PMID:8930175, PMID:9169443, PMID:25445008 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Churc1 churchill domain containing 1 decreases expression ISO Heroin results in decreased expression of CHURC1 mRNA CTD PMID:16710320 NCBI chr 6:99,817,439...99,831,574
Ensembl chr 6:99,817,431...99,831,576
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter] CTD PMID:25643298 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Deaf1 DEAF1 transcription factor decreases expression ISO Heroin results in decreased expression of DEAF1 mRNA CTD PMID:16710320 NCBI chr 1:214,283,787...214,317,466
Ensembl chr 1:214,283,790...214,317,466
JBrowse link
G Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 decreases expression ISO Heroin results in decreased expression of DNPH1 mRNA CTD PMID:16710320 NCBI chr 9:16,845,764...16,848,514
Ensembl chr 9:16,845,525...16,848,503
JBrowse link
G Drd2 dopamine receptor D2 decreases expression ISO Heroin results in decreased expression of DRD2 protein CTD PMID:11126397 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Eif5a eukaryotic translation initiation factor 5A decreases expression ISO Heroin results in decreased expression of EIF5A mRNA CTD PMID:16710320 NCBI chr10:56,527,075...56,531,615
Ensembl chr10:56,527,085...56,531,483
JBrowse link
G Enho energy homeostasis associated decreases expression ISO Heroin results in decreased expression of ENHO mRNA CTD PMID:16710320 NCBI chr 5:58,018,039...58,019,836
Ensembl chr 5:58,018,039...58,019,836
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Heroin results in increased expression of FAS mRNA CTD PMID:16710320 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP Heroin results in increased expression of FOS mRNA; Heroin results in increased expression of FOS protein
Dronabinol affects the reaction [Heroin results in increased expression of FOS protein]
CTD PMID:16137723, PMID:19169671 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IFNG protein CTD PMID:16766138 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL10 protein CTD PMID:16766138 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL2 protein CTD PMID:16766138 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL4 protein CTD PMID:16766138 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 increases expression ISO Heroin results in increased expression of ITGB1BP1 mRNA CTD PMID:16710320 NCBI chr 6:43,348,927...43,363,633
Ensembl chr 6:43,348,958...43,363,335
JBrowse link
G Ngf nerve growth factor decreases expression ISO Heroin results in decreased expression of NGF protein CTD PMID:17715210 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression EXP Heroin results in decreased expression of NR4A2 mRNA CTD PMID:25643298 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression ISO Heroin results in increased expression of NTRK2 mRNA CTD PMID:16710320 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 decreases expression ISO Heroin results in decreased expression of NUCKS1 mRNA CTD PMID:16710320 NCBI chr13:48,679,726...48,709,663
Ensembl chr13:48,679,774...48,705,575
JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein increases expression ISO Heroin results in increased expression of PDE4DIP mRNA CTD PMID:16710320 NCBI chr 2:199,867,965...200,066,034
Ensembl chr 2:199,867,972...200,003,443
JBrowse link
G Pdyn prodynorphin decreases expression ISO Heroin results in decreased expression of PDYN mRNA CTD PMID:16710320 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 decreases expression ISO Heroin results in decreased expression of PMEPA1 mRNA CTD PMID:16710320 NCBI chr 3:171,295,630...171,342,662
Ensembl chr 3:171,294,856...171,342,646
JBrowse link
G Prepl prolyl endopeptidase-like decreases expression ISO Heroin results in decreased expression of PREPL mRNA CTD PMID:16710320 NCBI chr 6:8,316,861...8,346,293
Ensembl chr 6:8,318,979...8,346,197
JBrowse link
G Septin4 septin 4 increases expression ISO Heroin results in increased expression of SEPTIN4 mRNA CTD PMID:16710320 NCBI chr10:74,860,068...74,884,196
Ensembl chr10:74,861,714...74,884,196
JBrowse link
G Slc25a23 solute carrier family 25 member 23 decreases expression ISO Heroin results in decreased expression of SLC25A23 mRNA CTD PMID:16710320 NCBI chr 9:9,987,988...10,003,599
Ensembl chr 9:9,988,055...10,001,962
JBrowse link
G Slc25a37 solute carrier family 25 member 37 increases expression ISO Heroin results in increased expression of SLC25A37 mRNA CTD PMID:16710320 NCBI chr15:51,125,764...51,168,384
Ensembl chr15:51,128,268...51,168,384
JBrowse link
G Snap25 synaptosome associated protein 25 decreases expression ISO Heroin results in decreased expression of SNAP25 mRNA CTD PMID:16710320 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400
JBrowse link
G Stxbp1 syntaxin binding protein 1 decreases expression ISO Heroin results in decreased expression of STXBP1 mRNA CTD PMID:16710320 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417
JBrowse link
G Stxbp6 syntaxin binding protein 6 decreases expression ISO Heroin results in decreased expression of STXBP6 mRNA CTD PMID:16710320 NCBI chr 6:65,086,483...65,319,527
Ensembl chr 6:65,089,318...65,319,527
JBrowse link
G Sv2a synaptic vesicle glycoprotein 2a decreases expression ISO Heroin results in decreased expression of SV2A mRNA CTD PMID:16710320 NCBI chr 2:198,321,100...198,336,889
Ensembl chr 2:198,321,142...198,336,913
JBrowse link
G Syngr3 synaptogyrin 3 decreases expression ISO Heroin results in decreased expression of SYNGR3 mRNA CTD PMID:16710320 NCBI chr10:14,051,413...14,056,169
Ensembl chr10:14,051,415...14,056,169
JBrowse link
G Syt1 synaptotagmin 1 decreases expression ISO Heroin results in decreased expression of SYT1 mRNA CTD PMID:16710320 NCBI chr 7:50,084,063...50,638,996
Ensembl chr 7:50,084,060...50,638,798
JBrowse link
G Tfrc transferrin receptor increases expression ISO Heroin results in increased expression of TFRC mRNA CTD PMID:16710320 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of TNF protein CTD PMID:16766138 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase decreases expression ISO Heroin results in decreased expression of UGCG mRNA CTD PMID:16710320 NCBI chr 5:76,376,722...76,419,564
Ensembl chr 5:76,386,836...76,419,560
JBrowse link
G Vti1b vesicle transport through interaction with t-SNAREs 1B decreases expression ISO Heroin results in decreased expression of VTI1B mRNA CTD PMID:16710320 NCBI chr 6:102,340,261...102,353,612
Ensembl chr 6:102,339,857...102,353,403
JBrowse link
hydrocodone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects binding EXP Hydrocodone binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Hydrocodone binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP Hydrocodone binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
hydromorphone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr3a 5-hydroxytryptamine receptor 3A affects activity ISO Hydromorphone affects the activity of HTR3A protein CTD PMID:18635474 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
methadone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
affects activity
ISO Methadone results in increased expression of ABCB1 protein
Methadone affects the activity of ABCB1 protein
CTD PMID:19840843 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects activity
increases expression
EXP Methadone affects the activity of ABCB1B protein
Methadone results in increased expression of ABCB1B protein
CTD PMID:19840843 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization ISO Methadone affects the localization of BAX protein CTD PMID:20691259 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion EXP Methadone results in increased secretion of CCL2 protein CTD PMID:20178837 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion EXP Methadone results in increased secretion of CCL3 protein CTD PMID:20178837 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases secretion EXP Methadone results in increased secretion of CX3CL1 protein CTD PMID:20178837 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases secretion EXP Methadone results in increased secretion of CXCL1 protein CTD PMID:20178837 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Methadone affects the localization of CYCS protein CTD PMID:20691259 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
affects metabolic processing
ISO Aminoglutethimide inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone]; formestane inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone] CTD PMID:15242824 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
decreases activity
ISO CYP2D22 protein results in increased metabolism of Methadone
Methadone results in decreased activity of CYP2D6 protein
CTD PMID:16595712 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP Methadone affects the reaction [Cocaine affects the expression of DRD2 mRNA] CTD PMID:18990547 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Hcrt hypocretin neuropeptide precursor multiple interactions EXP Methadone affects the reaction [Cocaine affects the expression of HCRT mRNA] CTD PMID:18990547 NCBI chr10:88,669,216...88,670,430
Ensembl chr10:88,669,214...88,670,430
JBrowse link
G Il10 interleukin 10 increases secretion EXP Methadone results in increased secretion of IL10 protein CTD PMID:20178837 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1a interleukin 1 alpha increases expression EXP Methadone results in increased expression of IL1A protein CTD PMID:20178837 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta increases secretion
increases expression
EXP Methadone results in increased secretion of IL1B protein
Methadone results in increased expression of IL1B protein
CTD PMID:20178837 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 decreases expression ISO Methadone results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 increases expression
multiple interactions
ISO Methadone results in increased expression of IL4 mRNA; Methadone results in increased expression of IL4 protein
CTAP octapeptide inhibits the reaction [Methadone results in increased expression of IL4 mRNA]; SB 203580 inhibits the reaction [Methadone results in increased expression of IL4 mRNA]
CTD PMID:23965172 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 increases expression
increases secretion
EXP Methadone results in increased expression of IL6 mRNA; Methadone results in increased expression of IL6 protein
Methadone results in increased secretion of IL6 protein
CTD PMID:20178837 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 decreases response to substance ISO Methadone results in decreased susceptibility to INS protein CTD PMID:2554359 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO Chlorobutanol promotes the reaction [Methadone results in decreased activity of KCNH2 protein] CTD PMID:14527710 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Lep leptin increases expression ISO Methadone results in increased expression of LEP protein CTD PMID:15717844 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Methadone results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Methadone results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Methadone results in increased expression of NFKBIA protein CTD PMID:22258905 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP Methadone binds to OPRD1 protein
[Methadone binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRD1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP Methadone binds to OPRK1 protein
[Methadone binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRK1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
EXP [Methadone binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pld2 phospholipase D2 increases activity ISO Methadone results in increased activity of PLD2 protein CTD PMID:23965172 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730
JBrowse link
G Prl prolactin affects secretion
increases secretion
increases expression
ISO Methadone affects the secretion of PRL protein
Methadone results in increased secretion of PRL protein
Methadone results in increased expression of PRL protein
CTD PMID:2554359, PMID:16675813, PMID:21094671 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Tlr4 toll-like receptor 4 affects binding
increases expression
affects response to substance
multiple interactions
ISO
EXP
Methadone binds to TLR4 protein
Methadone results in increased expression of TLR4 mRNA; Methadone results in increased expression of TLR4 protein
Methadone affects the susceptibility to TLR4 protein
Naloxone affects the reaction [Methadone binds to TLR4 protein]
CTD PMID:20178837 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor increases secretion
increases expression
EXP Methadone results in increased secretion of TNF protein
Methadone results in increased expression of TNF protein
CTD PMID:20178837 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
morphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects metabolic processing
multiple interactions
ISO
EXP
ABCB1 affects the metabolism of Morphine
[Morphine co-treated with Naloxone] results in increased expression of ABCB1A mRNA
CTD PMID:23748253, PMID:26554626 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions EXP [Morphine co-treated with Naloxone] results in increased expression of ABCG2 mRNA CTD PMID:26554626 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 decreases expression
multiple interactions
EXP Morphine results in decreased expression of ACAT1 protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of ACAT1 protein]
CTD PMID:23056601 NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884
JBrowse link
G Ache acetylcholinesterase multiple interactions
increases chemical synthesis
ISO [ACHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine
ACHE protein results in increased chemical synthesis of Morphine
CTD PMID:30080993 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Adcy1 adenylate cyclase 1 multiple interactions ISO [ADCY8 protein co-treated with ADCY1 protein] affects the susceptibility to Morphine CTD PMID:16914643 NCBI chr14:87,311,970...87,429,880
Ensembl chr14:87,312,203...87,421,659
JBrowse link
G Adcy6 adenylate cyclase 6 affects expression EXP Morphine affects the expression of ADCY6 mRNA CTD PMID:15829634 NCBI chr 7:140,270,678...140,291,722
Ensembl chr 7:140,270,692...140,291,620
JBrowse link
G Adcy8 adenylate cyclase 8 affects response to substance
affects expression
multiple interactions
ISO
EXP
ADCY8 protein affects the susceptibility to Morphine
Morphine affects the expression of ADCY8 mRNA
[ADCY8 protein co-treated with ADCY1 protein] affects the susceptibility to Morphine
CTD PMID:15829634, PMID:16914643 NCBI chr 7:105,353,883...105,593,372
Ensembl chr 7:105,353,913...105,592,804
JBrowse link
G Adgra1 adhesion G protein-coupled receptor A1 decreases expression ISO Morphine results in decreased expression of ADGRA1 mRNA CTD PMID:21955143 NCBI chr 1:212,170,190...212,213,156
Ensembl chr 1:212,181,374...212,211,578
JBrowse link
G Adora1 adenosine A1 receptor affects response to substance
increases expression
multiple interactions
ISO
EXP
ADORA1 protein affects the susceptibility to Morphine
Morphine results in increased expression of ADORA1 mRNA; Morphine results in increased expression of ADORA1 protein
[lead acetate co-treated with Morphine] results in increased expression of ADORA1 mRNA; [lead acetate co-treated with Morphine] results in increased expression of ADORA1 protein
CTD PMID:9407998, PMID:26478469 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adora2a adenosine A2a receptor affects response to substance
increases expression
ISO ADORA2A protein affects the susceptibility to Morphine
Morphine results in increased expression of ADORA2A mRNA
CTD PMID:14756803, PMID:21955143 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Agrp agouti related neuropeptide increases expression ISO Morphine results in increased expression of AGRP mRNA CTD PMID:20144693 NCBI chr19:37,525,941...37,584,875
Ensembl chr19:37,526,419...37,528,011
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions EXP [lead acetate co-treated with Morphine] results in increased expression of AIF1 mRNA CTD PMID:26478469 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Ak5 adenylate kinase 5 decreases expression ISO Morphine results in decreased expression of AK5 mRNA CTD PMID:21955143 NCBI chr 2:257,671,772...257,864,385
Ensembl chr 2:257,671,772...257,864,385
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B decreases expression EXP Morphine results in decreased expression of AKR1B1 protein CTD PMID:23056601 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases expression
decreases expression
ISO ARRB2 protein inhibits the reaction [Morphine results in decreased expression of AKT1 protein modified form]
Morphine results in increased expression of AKT1 protein modified form
Naloxone inhibits the reaction [Morphine results in increased expression of AKT1 protein modified form]
CTD PMID:19239323, PMID:20600172 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine results in decreased expression of ALB protein] CTD PMID:23056601 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ano3 anoctamin 3 increases expression ISO Morphine results in increased expression of ANO3 mRNA CTD PMID:21955143 NCBI chr 3:101,843,516...102,203,368
Ensembl chr 3:101,840,630...102,151,489
JBrowse link
G Anxa6 annexin A6 decreases expression EXP Morphine results in decreased expression of ANXA6 protein CTD PMID:23056601 NCBI chr10:40,320,581...40,375,605
Ensembl chr10:40,320,581...40,375,605
JBrowse link
G Apoa1 apolipoprotein A1 increases expression EXP Morphine results in increased expression of APOA1 protein CTD PMID:23056601 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apob apolipoprotein B increases expression ISO Morphine results in increased expression of APOB protein CTD PMID:18980684 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Apoe apolipoprotein E increases expression
multiple interactions
EXP Morphine results in increased expression of APOE protein
Morphine deficiency affects the reaction [Morphine results in increased expression of APOE protein]
CTD PMID:23056601 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Aqp1 aquaporin 1 increases expression ISO Morphine results in increased expression of AQP1 mRNA CTD PMID:21178816 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression EXP Morphine results in increased expression of AQP3 mRNA; Morphine results in increased expression of AQP3 protein CTD PMID:25766885 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
JBrowse link
G Aqp4 aquaporin 4 decreases expression ISO Morphine results in decreased expression of AQP4 mRNA CTD PMID:21955143 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Arl4d ADP-ribosylation factor like GTPase 4D increases expression ISO Morphine results in increased expression of ARL4D mRNA CTD PMID:20144693 NCBI chr10:89,577,556...89,580,368
Ensembl chr10:89,578,212...89,580,368
JBrowse link
G Arl6ip5 ADP-ribosylation factor like GTPase 6 interacting protein 5 multiple interactions
increases expression
ISO
EXP
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]
Morphine results in increased expression of ARL6IP5 protein
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]
CTD PMID:21600884 NCBI chr 4:129,574,363...129,598,240
Ensembl chr 4:129,574,264...129,598,915
JBrowse link
G Arpp21 cAMP regulated phosphoprotein 21 increases expression ISO Morphine results in increased expression of ARPP21 mRNA CTD PMID:21955143 NCBI chr 8:120,323,895...120,492,790
Ensembl chr 8:120,323,897...120,446,507
JBrowse link
G Arrb2 arrestin, beta 2 affects response to substance
multiple interactions
ISO ARRB2 gene SNP affects the susceptibility to Morphine
ARRB2 protein affects the susceptibility to Morphine
[gp120 protein, Human immunodeficiency virus 1 co-treated with Morphine] results in decreased expression of ARRB2 mRNA; [OPRM1 protein co-treated with Morphine] results in increased activity of ARRB2 protein; ARRB2 protein inhibits the reaction [Morphine results in decreased expression of AKT1 protein modified form]; ARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form]
CTD PMID:16103897, PMID:19239323, PMID:19477204, PMID:23300227, PMID:24063433 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Art3 ADP-ribosyltransferase 3 multiple interactions
increases expression
EXP Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in increased expression of ART3 protein]]; Morphine deficiency affects the reaction [Morphine results in increased expression of ART3 protein] CTD PMID:23056601 NCBI chr14:17,143,037...17,225,389
Ensembl chr14:17,143,040...17,225,389
JBrowse link
G Asic4 acid sensing ion channel subunit family member 4 increases expression ISO Morphine results in increased expression of ASIC4 mRNA CTD PMID:21178816 NCBI chr 9:82,647,071...82,668,920
Ensembl chr 9:82,647,071...82,668,920
JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase decreases expression EXP Morphine results in decreased expression of ATIC protein CTD PMID:23056601 NCBI chr 9:78,862,013...78,882,061
Ensembl chr 9:78,862,013...78,882,060
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression ISO Morphine results in increased expression of ATRX mRNA CTD PMID:21955143 NCBI chr  X:76,820,110...76,979,155
Ensembl chr  X:76,692,970...76,708,878
Ensembl chr  X:76,692,970...76,708,878
JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression ISO Morphine results in decreased expression of AVPR1A mRNA CTD PMID:21178816 NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308
JBrowse link
G Bag3 BAG cochaperone 3 increases expression EXP Morphine results in increased expression of BAG3 protein CTD PMID:23056601 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Morphine results in increased expression of BAK1 protein CTD PMID:19070643 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression
ISO
EXP
[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BAX protein; Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]; Morphine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]]; PDGFB protein inhibits the reaction [Morphine results in increased expression of BAX protein]
Morphine results in increased expression of BAX mRNA; Morphine results in increased expression of BAX protein
Morphine results in decreased expression of BAX mRNA
Lithium inhibits the reaction [Morphine results in increased expression of BAX mRNA]
TGFB1 protein affects the reaction [Morphine results in increased expression of BAX protein]
CTD PMID:10534122, PMID:10809959, PMID:12196588, PMID:12702572, PMID:12927789, PMID:15183518, PMID:17542780, PMID:18976035, PMID:19070643, PMID:21483469 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Morphine results in increased expression of BBC3 mRNA CTD PMID:19397953 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcas1 brain enriched myelin associated protein 1 decreases expression ISO Morphine results in decreased expression of BCAS1 mRNA CTD PMID:21955143 NCBI chr 3:167,957,994...168,033,462
Ensembl chr 3:167,957,994...168,033,457
JBrowse link
G Bche butyrylcholinesterase increases chemical synthesis
multiple interactions
ISO BCHE protein results in increased chemical synthesis of Morphine
[BCHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine
CTD PMID:30080993 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl11b BAF chromatin remodeling complex subunit BCL11B increases expression ISO Morphine results in increased expression of BCL11B mRNA CTD PMID:21955143 NCBI chr 6:131,834,097...131,927,251
Ensembl chr 6:131,834,097...131,926,272
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO
EXP
[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; Morphine inhibits the reaction [BECN1 protein binds to BCL2 protein]; Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]; Morphine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]]; PDGFB protein inhibits the reaction [Morphine results in decreased expression of BCL2 protein]
Morphine results in decreased expression of BCL2 mRNA; Morphine results in decreased expression of BCL2 protein
Lithium inhibits the reaction [Morphine results in decreased expression of BCL2 mRNA]
CTD PMID:10534122, PMID:12196588, PMID:12927789, PMID:17542780, PMID:18976035, PMID:19292871, PMID:20190558, PMID:21483469 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP Morphine results in decreased expression of BCL2L1 mRNA CTD PMID:15183518 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO Morphine results in increased expression of BCL2L11 protein CTD PMID:19292871 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
decreases expression
multiple interactions
ISO
EXP
Morphine results in increased expression of BDNF mRNA
Morphine results in decreased expression of BDNF mRNA; Morphine results in decreased expression of BDNF mRNA alternative form
Morphine inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]; Morphine inhibits the reaction [NR4A2 protein binds to BDNF promoter]; Morphine inhibits the reaction [RING1 protein alternative form binds to BDNF promoter]; Morphine promotes the reaction [CREB1 protein binds to BDNF promoter]; Morphine promotes the reaction [EZH2 protein binds to BDNF promoter]; Morphine promotes the reaction [ING2 protein binds to BDNF promoter]; Morphine promotes the reaction [KMT2A protein binds to BDNF promoter]; Morphine promotes the reaction [SIN3A protein binds to BDNF promoter]; Morphine promotes the reaction [SUZ12 protein binds to BDNF promoter]
BDNF protein inhibits the reaction [NR4A2 protein affects the susceptibility to Morphine]; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA]
CTD PMID:19033880, PMID:25643298 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
ISO Morphine inhibits the reaction [BECN1 protein binds to BCL2 protein]
Morphine results in increased expression of BECN1 protein
CTD PMID:20190558 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bex4 brain expressed, X-linked 4 increases expression ISO Morphine results in increased expression of BEX4 mRNA CTD PMID:21178816
G Bok BCL2 family apoptosis regulator BOK decreases expression ISO Morphine results in decreased expression of BOK mRNA CTD PMID:21955143 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Btbd11 BTB domain containing 11 decreases expression ISO Morphine results in decreased expression of BTBD11 mRNA CTD PMID:21955143 NCBI chr 7:24,041,194...24,314,418
Ensembl chr 7:24,043,126...24,313,885
JBrowse link
G C1ql3 complement C1q like 3 increases expression ISO Morphine results in increased expression of C1QL3 mRNA CTD PMID:21178816 NCBI chr17:80,314,186...80,320,681
Ensembl chr17:80,314,186...80,320,681
JBrowse link
G Calb1 calbindin 1 increases expression ISO Morphine results in increased expression of CALB1 mRNA CTD PMID:21178816 NCBI chr 5:29,538,380...29,562,774
Ensembl chr 5:29,538,380...29,562,773
JBrowse link
G Calca calcitonin-related polypeptide alpha increases expression
multiple interactions
EXP
ISO
Morphine results in increased expression of CALCA mRNA; Morphine results in increased expression of CALCA protein
PENK protein alternative form inhibits the reaction [Morphine results in increased expression of CALCA protein]
GRIK1 protein affects the reaction [Morphine results in increased expression of CALCA protein]
CTD PMID:16935424, PMID:20359526, PMID:20568289 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha affects response to substance
increases expression
ISO CAMK2A protein affects the susceptibility to Morphine
Morphine results in increased expression of CAMK2A mRNA
CTD PMID:20053885, PMID:21955143 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Cap1 cyclase associated actin cytoskeleton regulatory protein 1 decreases expression ISO Morphine results in decreased expression of CAP1 mRNA CTD PMID:21955143 NCBI chr 5:140,559,195...140,585,494
Ensembl chr 5:140,559,206...140,585,408
JBrowse link
G Car2 carbonic anhydrase 2 increases expression ISO Morphine results in increased expression of CAR2 mRNA CTD PMID:20144693 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Carhsp1 calcium regulated heat stable protein 1 increases expression ISO Morphine results in increased expression of CARHSP1 mRNA CTD PMID:21178816 NCBI chr10:7,041,510...7,055,107
Ensembl chr10:7,041,510...7,055,101
JBrowse link
G Cartpt CART prepropeptide increases expression ISO Morphine results in increased expression of CARTPT mRNA CTD PMID:20144693 NCBI chr 2:30,125,249...30,127,408
Ensembl chr 2:30,125,249...30,127,269
JBrowse link
G Casp1 caspase 1 decreases expression EXP Morphine results in decreased expression of CASP1 mRNA CTD PMID:15183518 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
ISO
EXP
[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; Morphine inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; Morphine results in increased activity of and results in increased cleavage of CASP3 protein; PDGFB protein inhibits the reaction [Morphine results in increased activity of CASP3 protein]
Morphine results in increased expression of CASP3 protein
Minocycline inhibits the reaction [Morphine results in increased activity of CASP3 protein]
Naloxone inhibits the reaction [Morphine results in increased activity of CASP3 protein]; Naloxone inhibits the reaction [Morphine results in increased expression of CASP3 protein alternative form]; SB 203580 inhibits the reaction [Morphine results in increased activity of CASP3 protein]
Morphine results in increased expression of CASP3 protein; Morphine results in increased expression of CASP3 protein alternative form
CTD PMID:10534122, PMID:11590188, PMID:12196588, PMID:16102899, PMID:17542780, PMID:18756534, PMID:18832014, PMID:19070643, PMID:19292871, PMID:20600172, PMID:20711699, PMID:21483469 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
decreases expression
ISO ARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form]
Morphine results in increased activity of CASP8 protein
CTD PMID:11590188, PMID:19070643, PMID:19239323 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity
increases expression
ISO
EXP
Morphine results in increased activity of CASP9 protein
Morphine results in increased expression of CASP9 mRNA
CTD PMID:15183518, PMID:19292871 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Morphine results in increased abundance of Hydrogen Peroxide] CTD PMID:14871405 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbln1 cerebellin 1 precursor decreases expression ISO Morphine results in decreased expression of CBLN1 mRNA CTD PMID:21955143 NCBI chr19:20,607,507...20,611,316
Ensembl chr19:20,607,507...20,611,316
JBrowse link
G Ccdc136 coiled-coil domain containing 136 decreases expression ISO Morphine results in decreased expression of CCDC136 mRNA CTD PMID:21955143 NCBI chr 4:56,674,737...56,704,501
Ensembl chr 4:56,674,832...56,704,549
JBrowse link
G Cck cholecystokinin decreases expression ISO Morphine results in decreased expression of CCK mRNA CTD PMID:21955143 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392
JBrowse link
G Cckbr cholecystokinin B receptor affects response to substance ISO CCKBR protein affects the susceptibility to Morphine CTD PMID:11403953, PMID:11880531 NCBI chr 1:170,262,218...170,272,298
Ensembl chr 1:170,262,156...170,272,298
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion EXP Morphine results in increased secretion of CCL2 protein CTD PMID:20178837 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion EXP Morphine results in increased secretion of CCL3 protein CTD PMID:20178837 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
decreases expression
ISO beta-funaltrexamine inhibits the reaction [Morphine results in decreased expression of CCL5 protein]; Naloxone inhibits the reaction [Morphine results in decreased expression of CCL5 protein] CTD PMID:11106302 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cd38 CD38 molecule affects response to substance ISO CD38 affects the susceptibility to Morphine CTD PMID:20551293 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Cd79b CD79b molecule increases expression ISO Morphine results in increased expression of CD79B mRNA CTD PMID:20144693 NCBI chr10:94,497,445...94,500,591
Ensembl chr10:94,497,448...94,500,591
JBrowse link
G Cd9 CD9 molecule increases expression EXP Morphine results in increased expression of CD9 protein CTD PMID:23056601 NCBI chr 4:157,977,163...158,010,091
Ensembl chr 4:157,977,162...158,010,166
JBrowse link
G Cdh22 cadherin 22 increases expression ISO Morphine results in increased expression of CDH22 mRNA CTD PMID:21178816 NCBI chr 3:161,574,993...161,971,102
Ensembl chr 3:161,575,631...161,917,285
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of CDKN1A protein CTD PMID:12702572 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cep83 centrosomal protein 83 increases expression ISO Morphine results in increased expression of CEP83 mRNA CTD PMID:20144693 NCBI chr 7:35,739,553...35,847,618
Ensembl chr 7:35,773,928...35,847,617
JBrowse link
G Ces2h carboxylesterase 2H increases chemical synthesis
multiple interactions
ISO CES2 protein results in increased chemical synthesis of Morphine
Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of Morphine]
CTD PMID:8930175 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 affects response to substance ISO CHRM5 protein affects the susceptibility to Morphine CTD PMID:12154229 NCBI chr 3:103,966,451...104,018,815
Ensembl chr 3:103,966,451...104,018,861
JBrowse link
G Cirbp cold inducible RNA binding protein increases expression ISO Morphine results in increased expression of CIRBP mRNA CTD PMID:21955143 NCBI chr 7:12,400,066...12,405,054
Ensembl chr 7:12,401,207...12,405,022
JBrowse link
G Cldn2 claudin 2 increases expression ISO Morphine results in increased expression of CLDN2 mRNA CTD PMID:21178816 NCBI chr  X:111,122,552...111,133,188
Ensembl chr  X:111,122,552...111,137,769
JBrowse link
G Cmbl carboxymethylenebutenolidase homolog decreases expression EXP Morphine results in decreased expression of CMBL protein CTD PMID:23056601 NCBI chr 2:84,645,084...84,666,836
Ensembl chr 2:84,645,084...84,666,835
JBrowse link
G Cmtm5 CKLF-like MARVEL transmembrane domain containing 5 increases expression ISO Morphine results in increased expression of CMTM5 mRNA CTD PMID:21955143 NCBI chr15:33,600,016...33,602,839
Ensembl chr15:33,600,102...33,602,834
JBrowse link
G Cnbp CCHC-type zinc finger, nucleic acid binding protein multiple interactions
decreases expression
EXP Morphine deficiency affects the reaction [Morphine results in decreased expression of CNBP protein] CTD PMID:23056601 NCBI chr 4:119,747,890...119,756,787
Ensembl chr 4:119,747,911...119,756,765
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
increases expression
EXP
ISO
[Morphine results in increased expression of CNR1 mRNA] which results in increased susceptibility to Dronabinol; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]
CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Cycloheximide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]
CTD PMID:9351646, PMID:21955143, PMID:22258905 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Comt catechol-O-methyltransferase affects response to substance
multiple interactions
ISO COMT protein affects the susceptibility to Morphine
[COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine
CTD PMID:18834357, PMID:21127283 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Coq9 coenzyme Q9 decreases expression EXP Morphine results in decreased expression of COQ9 protein CTD PMID:23056601 NCBI chr19:10,583,855...10,596,848
Ensembl chr19:10,583,857...10,596,851
JBrowse link
G Cpe carboxypeptidase E increases expression ISO Morphine results in increased expression of CPE mRNA CTD PMID:20144693 NCBI chr16:26,906,716...27,014,811
Ensembl chr16:26,906,716...27,014,813
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression
increases expression
multiple interactions
decreases phosphorylation
EXP
ISO
Morphine results in decreased expression of CREB1 mRNA
Morphine results in increased expression of CREB1 protein
Morphine inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]; Morphine inhibits the reaction [CREB1 protein modified form binds to NR4A2 promoter]; Morphine promotes the reaction [CREB1 protein binds to BDNF promoter]; Morphine promotes the reaction [CREB1 protein modified form binds to GRIA1 promoter]; Morphine promotes the reaction [CREB1 protein modified form binds to TH promoter]
Morphine results in decreased phosphorylation of CREB1 protein
CTD PMID:14750654, PMID:15183518, PMID:16598705, PMID:23292329, PMID:25643298 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crem cAMP responsive element modulator increases expression ISO Morphine results in increased expression of CREM mRNA CTD PMID:22454534 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Crh corticotropin releasing hormone increases expression ISO Morphine results in increased expression of CRH mRNA CTD PMID:21955143 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 multiple interactions EXP
ISO
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency affects the abundance of Norepinephrine]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK1 protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK3 protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased secretion of POMC protein modified form]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Morphine deficiency
CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
CTD PMID:24398105, PMID:25582704 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
JBrowse link
G Crp C-reactive protein increases expression ISO Morphine results in increased expression of CRP protein CTD PMID:18980684 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cryab crystallin, alpha B decreases expression
increases expression
ISO
EXP
Morphine results in decreased expression of CRYAB mRNA
Morphine results in increased expression of CRYAB protein
CTD PMID:21955143, PMID:23056601 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Csdc2 cold shock domain containing C2 decreases expression ISO Morphine results in decreased expression of CSDC2 mRNA CTD PMID:21955143 NCBI chr 7:123,168,811...123,183,336
Ensembl chr 7:123,168,811...123,183,335
JBrowse link
G Cstb cystatin B decreases expression EXP Morphine results in decreased expression of CSTB protein CTD PMID:23056601 NCBI chr20:10,966,357...10,968,399
Ensembl chr20:10,966,331...10,968,432
JBrowse link
G Ctnnal1 catenin alpha-like 1 increases expression ISO Morphine results in increased expression of CTNNAL1 mRNA CTD PMID:21178816 NCBI chr 5:73,561,249...73,621,070
Ensembl chr 5:73,561,450...73,621,070
JBrowse link
G Ctsb cathepsin B increases expression EXP Morphine results in increased expression of CTSB mRNA CTD PMID:9429908 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Cux2 cut-like homeobox 2 increases expression ISO Morphine results in increased expression of CUX2 mRNA CTD PMID:21178816 NCBI chr12:40,016,774...40,221,067
Ensembl chr12:40,018,937...40,219,291
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 affects response to substance
increases secretion
EXP CX3CL1 protein affects the susceptibility to Morphine
Morphine results in increased secretion of CX3CL1 protein
CTD PMID:15317861, PMID:20178837 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases secretion EXP Morphine results in increased secretion of CXCL1 protein CTD PMID:20178837 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cybb cytochrome b-245 beta chain increases expression
multiple interactions
ISO Morphine results in increased expression of CYBB protein
Saquinavir inhibits the reaction [Morphine results in increased expression of CYBB protein]
CTD PMID:14871405 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cycs cytochrome c, somatic increases secretion
decreases secretion
multiple interactions
ISO
EXP
Morphine results in increased secretion of CYCS protein
Morphine results in decreased secretion of CYCS protein
Morphine inhibits the reaction [Doxorubicin affects the localization of CYCS protein]
CTD PMID:15345483, PMID:17542780, PMID:19292871 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression ISO Morphine results in increased expression of CYP27A1 mRNA CTD PMID:20144693 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects chemical synthesis
multiple interactions
ISO CYP2D6 protein affects the chemical synthesis of Morphine
[CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine
CTD PMID:15625333, PMID:16595712, PMID:21241245 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase multiple interactions
decreases expression
EXP Morphine deficiency affects the reaction [Morphine results in decreased expression of DCXR protein] CTD PMID:23056601 NCBI chr10:109,906,119...109,909,696
Ensembl chr10:109,906,815...109,909,715
JBrowse link
G Ddah2 dimethylarginine dimethylaminohydrolase 2 multiple interactions
increases expression
EXP Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in increased expression of DDAH2 protein]]; Morphine deficiency affects the reaction [Morphine results in increased expression of DDAH2 protein] CTD PMID:23056601 NCBI chr20:5,049,260...5,052,573
Ensembl chr20:5,049,496...5,052,585
JBrowse link
G Ddb2 damage specific DNA binding protein 2 increases expression
multiple interactions
ISO Morphine results in increased expression of DDB2 mRNA
Naloxone inhibits the reaction [Morphine results in increased expression of DDB2]
CTD PMID:19397953 NCBI chr 3:80,030,437...80,052,984
Ensembl chr 3:80,030,437...80,052,953
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO Morphine results in decreased expression of DHCR24 mRNA CTD PMID:21955143 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
JBrowse link
G Dhrs7b dehydrogenase/reductase 7B increases expression ISO Morphine results in increased expression of DHRS7B mRNA CTD PMID:21178816 NCBI chr10:47,065,755...47,111,089
Ensembl chr10:47,065,850...47,111,101
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression
multiple interactions
increases expression
EXP
ISO
Morphine results in decreased expression of DLG4 mRNA; Morphine results in decreased expression of DLG4 protein
Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]
Morphine results in increased expression of DLG4 mRNA
CTD PMID:15183518, PMID:16598705, PMID:21955143, PMID:22713680 NCBI chr10:56,625,845...56,655,543
Ensembl chr10:56,627,411...56,653,599
JBrowse link
G Dlx5 distal-less homeobox 5 increases expression ISO Morphine results in increased expression of DLX5 mRNA CTD PMID:21178816 NCBI chr 4:32,387,741...32,392,085
Ensembl chr 4:32,387,741...32,392,007
JBrowse link
G Dnah3 dynein, axonemal, heavy chain 3 decreases expression ISO Morphine results in decreased expression of DNAH3 mRNA CTD PMID:21178816 NCBI chr 1:189,708,985...189,865,431 JBrowse link
G Dock10 dedicator of cytokinesis 10 increases expression ISO Morphine results in increased expression of DOCK10 mRNA CTD PMID:21178816 NCBI chr 9:86,424,638...86,571,854
NCBI chr 9:86,312,470...86,423,054
Ensembl chr 9:86,312,501...86,571,870
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions
decreases expression
EXP Morphine deficiency affects the reaction [Morphine results in decreased expression of DPYSL2 protein] CTD PMID:23056601 NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 multiple interactions
decreases expression
EXP Morphine deficiency promotes the reaction [Morphine results in decreased expression of DPYSL3 protein] CTD PMID:23056601 NCBI chr18:37,716,371...37,819,347
Ensembl chr18:37,716,143...37,819,097
JBrowse link
G Drd1 dopamine receptor D1 increases expression ISO Morphine results in increased expression of DRD1 mRNA CTD PMID:21955143 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 decreases expression
multiple interactions
affects response to substance
increases expression
EXP
ISO
Morphine results in decreased expression of DRD2 mRNA
[lead acetate co-treated with Morphine] results in increased expression of DRD2 mRNA; [lead acetate co-treated with Morphine] results in increased expression of DRD2 protein
DRD2 protein affects the susceptibility to Morphine
Morphine results in increased expression of DRD2 mRNA
CTD PMID:2571179, PMID:15183518, PMID:17063042, PMID:23702354 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd4 dopamine receptor D4 increases expression EXP Morphine results in increased expression of DRD4 mRNA CTD PMID:15183518 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Dscaml1 DS cell adhesion molecule-like 1 increases expression ISO Morphine results in increased expression of DSCAML1 mRNA CTD PMID:20144693 NCBI chr 8:49,733,835...50,056,115
Ensembl chr 8:49,737,798...50,055,560
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO Morphine results in increased expression of DUSP6 mRNA CTD PMID:21955143 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 decreases expression ISO Morphine results in decreased expression of DYNC1H1 mRNA CTD PMID:21178816 NCBI chr 6:134,958,854...135,085,769
Ensembl chr 6:134,958,854...135,085,769
JBrowse link
G Ech1 enoyl-CoA hydratase 1 decreases expression EXP Morphine results in decreased expression of ECH1 protein CTD PMID:23056601 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Efhd1 EF-hand domain family, member D1 decreases expression ISO Morphine results in decreased expression of EFHD1 mRNA CTD PMID:21955143 NCBI chr 9:94,362,249...94,408,884
Ensembl chr 9:94,362,299...94,408,885
JBrowse link
G Egr1 early growth response 1 increases expression ISO Morphine results in increased expression of EGR1 mRNA CTD PMID:21955143 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Egr2 early growth response 2 increases expression ISO Morphine results in increased expression of EGR2 mRNA CTD PMID:22454534 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
JBrowse link
G Egr3 early growth response 3 increases expression ISO Morphine results in increased expression of EGR3 mRNA CTD PMID:21955143 NCBI chr15:51,756,683...51,762,080
Ensembl chr15:51,756,736...51,760,722
JBrowse link
G Egr4 early growth response 4 multiple interactions
increases expression
affects response to substance
ISO
EXP
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Morphine results in increased expression of EGR4 mRNA]; [Morphine results in increased activity of ELK1 protein] which results in increased expression of EGR4 mRNA
EGR4 protein affects the susceptibility to Morphine
CTD PMID:22454534 NCBI chr 4:117,293,620...117,296,082
Ensembl chr 4:117,293,620...117,296,082
JBrowse link
G Ehd1 EH-domain containing 1 multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine results in decreased expression of EHD1 protein] CTD PMID:23056601 NCBI chr 1:221,644,867...221,667,242
Ensembl chr 1:221,644,867...221,667,239
JBrowse link
G Eif5a eukaryotic translation initiation factor 5A increases expression ISO Morphine results in increased expression of EIF5A mRNA CTD PMID:19397953 NCBI chr10:56,527,075...56,531,615
Ensembl chr10:56,527,085...56,531,483
JBrowse link
G Elk1 ETS transcription factor ELK1 affects response to substance
increases activity
multiple interactions
ISO ELK1 protein affects the susceptibility to Morphine
Morphine results in increased activity of ELK1 protein
[Morphine results in increased activity of ELK1 protein] which results in increased expression of EGR4 mRNA
CTD PMID:22454534 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Eml2 EMAP like 2 increases expression EXP Morphine results in increased expression of EML2 protein CTD PMID:23056601 NCBI chr 1:80,087,684...80,118,784
Ensembl chr 1:80,087,684...80,119,012
JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 increases expression EXP Morphine results in increased expression of ENPP3 protein CTD PMID:23056601 NCBI chr 1:21,613,148...21,684,483
Ensembl chr 1:21,613,148...21,684,480
JBrowse link
G Ephx2 epoxide hydrolase 2 increases expression ISO Morphine results in increased expression of EPHX2 mRNA CTD PMID:21178816 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Erp44 endoplasmic reticulum protein 44 increases expression ISO Morphine results in increased expression of ERP44 mRNA CTD PMID:21178816 NCBI chr 5:63,937,866...64,030,827
Ensembl chr 5:63,937,784...64,030,901
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions EXP Morphine promotes the reaction [EZH2 protein binds to BDNF promoter] CTD PMID:25643298 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
JBrowse link
G F2 coagulation factor II increases expression
multiple interactions
EXP Morphine results in increased expression of F2 protein
Morphine deficiency affects the reaction [Morphine results in increased expression of F2 protein]
CTD PMID:23056601 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G F7 coagulation factor VII increases expression ISO Morphine results in increased expression of F7 protein CTD PMID:18980684 NCBI chr16:81,824,610...81,834,923
Ensembl chr16:81,824,111...81,834,945
JBrowse link
G Fam107a family with sequence similarity 107, member A increases expression ISO Morphine results in increased expression of FAM107A mRNA CTD PMID:21955143 NCBI chr15:18,399,145...18,415,959
Ensembl chr15:18,399,515...18,415,965
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
ISO [FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein]
[Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of FAS protein
Morphine results in increased expression of FAS mRNA
CTD PMID:12702572, PMID:16210602 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO [FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein]
Morphine results in increased expression of FASL mRNA
CTD PMID:16210602 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fblim1 filamin binding LIM protein 1 increases expression
multiple interactions
EXP Morphine results in increased expression of FBLIM1 protein
Morphine deficiency affects the reaction [Morphine results in increased expression of FBLIM1 protein]
CTD PMID:23056601 NCBI chr 5:160,122,466...160,158,921
Ensembl chr 5:160,122,425...160,158,386
JBrowse link
G Fbn1 fibrillin 1 decreases expression ISO Morphine results in decreased expression of FBN1 mRNA CTD PMID:21178816 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
JBrowse link
G Fga fibrinogen alpha chain affects secretion EXP Morphine affects the secretion of FGA protein modified form CTD PMID:24855564 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases secretion
multiple interactions
ISO Morphine results in decreased secretion of FGF2 protein
Naloxone inhibits the reaction [Morphine results in decreased secretion of FGF2 protein]; OPRM1 protein affects the reaction [Morphine results in decreased secretion of FGF2 protein]
CTD PMID:20564181 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 increases expression EXP Morphine results in increased expression of FGFR1 mRNA CTD PMID:15183518 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fh fumarate hydratase increases expression EXP Morphine results in increased expression of FH protein CTD PMID:23056601 NCBI chr13:93,651,486...93,677,371
Ensembl chr13:93,651,484...93,677,377
JBrowse link
G Fhl2 four and a half LIM domains 2 multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine deficiency inhibits the reaction [Morphine results in decreased expression of FHL2 protein]]; Morphine deficiency inhibits the reaction [Morphine results in decreased expression of FHL2 protein] CTD PMID:23056601 NCBI chr 9:49,920,611...49,994,906
Ensembl chr 9:49,920,854...49,950,093
JBrowse link
G Fn1 fibronectin 1 increases expression ISO Morphine results in increased expression of FN1 mRNA CTD PMID:20144693 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
affects expression
ISO
EXP
[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased expression of FOS protein; [Morphine co-treated with Dizocilpine Maleate] inhibits the reaction [Naloxone results in increased expression of FOS protein]; Plant Extracts inhibits the reaction [Morphine results in increased expression of FOS protein]
Morphine results in increased expression of FOS mRNA; Morphine results in increased expression of FOS protein
Morphine affects the expression of FOS mRNA
1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea inhibits the reaction [[Morphine co-treated with Naloxone] results in increased expression of FOS protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Morphine results in increased expression of FOS protein]; [Morphine co-treated with Cocaine] affects the expression of FOS; [Morphine co-treated with N-Methyl-3,4-methylenedioxyamphetamine] affects the expression of FOS; [Morphine co-treated with Naloxone] results in increased expression of FOS protein; [Naloxone co-treated with Morphine] results in increased expression of FOS protein; [SCH772984 co-treated with bilobalide] inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; Genistein inhibits the reaction [Morphine results in increased expression of FOS protein]; Morphine affects the reaction [Formaldehyde results in increased expression of FOS protein]; N-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamide inhibits the reaction [Morphine results in increased expression of FOS protein]; Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]; SCH772984 inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; U 0126 inhibits the reaction [Morphine results in increased expression of FOS protein]
CTD PMID:10521585, PMID:10814832, PMID:12821175, PMID:12934646, PMID:15183518, PMID:15196791, PMID:15196794, PMID:16935424, PMID:20727678, PMID:22258905, PMID:22590628, PMID:25308750, PMID:32319158 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP
ISO
Agmatine inhibits the reaction [Morphine results in increased expression of FOSB protein]
Morphine results in increased expression of FOSB mRNA
Morphine results in increased expression of FOSB mRNA; Morphine results in increased expression of FOSB protein; Morphine results in increased expression of FOSB protein alternative form; Morphine results in increased expression of FOSB protein modified form
CTD PMID:15899480, PMID:18293355, PMID:22454534, PMID:23185589 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Foxp1 forkhead box P1 increases expression ISO Morphine results in increased expression of FOXP1 mRNA CTD PMID:21955143 NCBI chr 4:131,362,178...131,963,466
Ensembl chr 4:131,366,744...131,694,755
JBrowse link
G Fxyd7 FXYD domain-containing ion transport regulator 7 decreases expression ISO Morphine results in decreased expression of FXYD7 mRNA CTD PMID:21955143 NCBI chr 1:89,474,601...89,484,069
Ensembl chr 1:89,474,601...89,483,988
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 decreases expression
increases expression
EXP Morphine results in decreased expression of GABRA1 mRNA
Morphine results in increased expression of GABRA1 mRNA
CTD PMID:15183518 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression ISO Morphine results in increased expression of GABRA4 mRNA CTD PMID:21178816 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta increases expression EXP Morphine results in increased expression of GABRD mRNA CTD PMID:15183518 NCBI chr 5:172,797,478...172,809,374
Ensembl chr 5:172,797,450...172,809,353
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 increases expression ISO Morphine results in increased expression of GABRG2 mRNA CTD PMID:21955143 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression EXP Morphine results in increased expression of GAD1 mRNA CTD PMID:15673448, PMID:18312583 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression ISO Morphine results in increased expression of GAD2 mRNA CTD PMID:21178816 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
JBrowse link
G Gal galanin and GMAP prepropeptide increases expression
decreases expression
ISO Morphine results in increased expression of GAL mRNA
Morphine results in decreased expression of GAL mRNA
CTD PMID:21178816, PMID:21955143 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression EXP Morphine results in decreased expression of GAPDH protein CTD PMID:23056601 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 (I blood group) increases expression ISO Morphine results in increased expression of GCNT2 mRNA CTD PMID:21955143 NCBI chr17:21,634,546...21,677,477
Ensembl chr17:21,634,551...21,739,408
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
multiple interactions
ISO
EXP
Morphine results in decreased expression of GFAP mRNA
[lead acetate co-treated with Morphine] results in increased expression of GFAP mRNA
CTD PMID:21955143, PMID:26478469 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gfm1 G elongation factor, mitochondrial 1 decreases expression EXP Morphine results in decreased expression of GFM1 protein CTD PMID:23056601 NCBI chr 2:164,601,575...164,646,478
Ensembl chr 2:164,601,586...164,646,439
JBrowse link
G Gh1 growth hormone 1 decreases expression
increases secretion
ISO
EXP
Morphine results in decreased expression of GH mRNA
Morphine results in increased secretion of GH1 protein
CTD PMID:7201058, PMID:21178816 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Gjc2 gap junction protein, gamma 2 decreases expression ISO Morphine results in decreased expression of GJC2 mRNA CTD PMID:21955143 NCBI chr10:45,526,740...45,535,520
Ensembl chr10:45,526,745...45,534,570
JBrowse link
G Glra2 glycine receptor, alpha 2 increases expression ISO Morphine results in increased expression of GLRA2 mRNA CTD PMID:21178816 NCBI chr  X:30,612,894...30,832,078
Ensembl chr  X:30,612,903...30,831,483
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression
multiple interactions
increases expression
EXP
ISO
Morphine results in decreased expression of GNAI2 mRNA
Morphine promotes the reaction [GNAI2 protein binds to RGS17 protein]
Morphine results in increased expression of GNAI2 mRNA
CTD PMID:15183518, PMID:18652891 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Gnas GNAS complex locus increases expression EXP Morphine results in increased expression of GNAS mRNA; Morphine results in increased expression of GNAS protein CTD PMID:17893922 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Gnaz G protein subunit alpha z multiple interactions ISO Morphine promotes the reaction [GNAZ protein binds to RGS17 protein] CTD PMID:18652891 NCBI chr20:14,593,072...14,644,020
Ensembl chr20:14,593,819...14,620,019
JBrowse link
G Gng11 G protein subunit gamma 11 decreases expression ISO Morphine results in decreased expression of GNG11 mRNA CTD PMID:21955143 NCBI chr 4:28,989,170...28,994,610
Ensembl chr 4:28,989,115...28,993,621
JBrowse link
G Gng2 G protein subunit gamma 2 increases expression EXP Morphine results in increased expression of GNG2 mRNA CTD PMID:15183518 NCBI chr15:4,748,242...4,853,555
Ensembl chr15:4,850,122...4,853,555
JBrowse link
G Gpr6 G protein-coupled receptor 6 decreases expression ISO Morphine results in decreased expression of GPR6 mRNA CTD PMID:21955143 NCBI chr20:45,813,169...45,815,940
Ensembl chr20:45,813,169...45,815,940
JBrowse link
G Gpr88 G-protein coupled receptor 88 increases expression ISO Morphine results in increased expression of GPR88 mRNA CTD PMID:21955143 NCBI chr 2:219,258,346...219,263,819
Ensembl chr 2:219,258,347...219,262,901
JBrowse link
G Gprc5b G protein-coupled receptor, class C, group 5, member B decreases expression ISO Morphine results in decreased expression of GPRC5B mRNA CTD PMID:21955143 NCBI chr 1:188,688,743...188,713,724
Ensembl chr 1:188,688,743...188,713,280
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 affects response to substance
multiple interactions
increases expression
decreases expression
decreases phosphorylation
ISO
EXP
GRIA1 protein affects the susceptibility to Morphine
Morphine promotes the reaction [CREB1 protein modified form binds to GRIA1 promoter]
Morphine results in increased expression of GRIA1 mRNA
Morphine results in decreased expression of GRIA1 mRNA; Morphine results in decreased expression of GRIA1 protein
Morphine results in decreased phosphorylation of GRIA1 protein
CTD PMID:11404432, PMID:15183518, PMID:15287884, PMID:23711322, PMID:25643298 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 decreases expression EXP Morphine results in decreased expression of GRIA2 protein CTD PMID:23711322 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 decreases expression EXP Morphine results in decreased expression of GRIA3 mRNA CTD PMID:15183518 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753
JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 decreases expression EXP Morphine results in decreased expression of GRIA4 mRNA CTD PMID:15183518 NCBI chr 8:1,548,145...2,045,874
Ensembl chr 8:1,548,146...2,045,817
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 multiple interactions
affects response to substance
ISO GRIK1 protein affects the reaction [Morphine results in increased expression of CALCA protein]; GRIK1 protein affects the reaction [Morphine results in increased expression of PDYN protein alternative form]
GRIK1 protein affects the susceptibility to Morphine
CTD PMID:20359526 NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions
increases expression
decreases phosphorylation
increases phosphorylation
affects phosphorylation
ISO
EXP
[Morphine results in increased activity of OPRM1 protein] which results in increased phosphorylation of GRIN1 protein; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN1 protein]
Morphine results in increased expression of GRIN1 protein
Agmatine inhibits the reaction [Morphine results in increased expression of GRIN1 protein]; Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]; resveratrol inhibits the reaction [Morphine results in increased expression of GRIN1 protein]
Morphine results in decreased phosphorylation of GRIN1 protein
Morphine affects the phosphorylation of GRIN1 protein
CTD PMID:15287884, PMID:17996026, PMID:20519536, PMID:20950603, PMID:22713680 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases expression
affects response to substance
ISO Morphine results in increased expression of GRIN2A protein
GRIN2A protein affects the susceptibility to Morphine
CTD PMID:12878694 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
increases expression
increases phosphorylation
ISO
EXP
MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN2B protein]
Morphine results in increased expression of GRIN2B protein
Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]; resveratrol inhibits the reaction [Morphine results in increased expression of GRIN2B protein]
CTD PMID:20519536, PMID:22713680 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C increases expression EXP Morphine results in increased expression of GRIN2C mRNA CTD PMID:15183518 NCBI chr10:103,798,290...103,816,923
Ensembl chr10:103,798,291...103,816,287
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 increases expression EXP Morphine results in increased expression of GRK5 mRNA CTD PMID:15183518 NCBI chr 1:282,265,371...282,467,842
Ensembl chr 1:282,265,370...282,462,605
JBrowse link
G Grm1 glutamate metabotropic receptor 1 increases expression EXP Morphine results in increased expression of GRM1 mRNA CTD PMID:15183518 NCBI chr 1:4,753,141...5,165,859
Ensembl chr 1:4,753,144...5,165,859
JBrowse link
G Grm5 glutamate metabotropic receptor 5 increases expression ISO Morphine results in increased expression of GRM5 mRNA CTD PMID:21955143 NCBI chr 1:151,207,846...151,785,038
Ensembl chr 1:151,439,409...151,783,392
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression
multiple interactions
ISO Morphine results in increased expression of GSK3B protein modified form
Naloxone inhibits the reaction [Morphine results in increased expression of GSK3B protein modified form]
CTD PMID:20600172 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hcrtr1 hypocretin receptor 1 increases expression EXP Morphine results in increased expression of HCRTR1 mRNA; Morphine results in increased expression of HCRTR1 protein CTD PMID:32319158 NCBI chr 5:148,346,029...148,355,404
Ensembl chr 5:148,346,031...148,355,406
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 multiple interactions
increases response to substance
ISO HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]
HINT1 gene mutant form results in increased susceptibility to Morphine
CTD PMID:18652891, PMID:21235400 NCBI chr10:40,208,236...40,211,981
Ensembl chr10:40,208,223...40,211,975
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression ISO Morphine results in decreased expression of HMGCS1 mRNA CTD PMID:21955143 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression ISO Morphine results in increased expression of HMGCS2 mRNA CTD PMID:20144693 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Morphine results in increased expression of HMOX1 protein CTD PMID:14871405 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hmox2 heme oxygenase 2 decreases activity
increases activity
EXP Morphine results in decreased activity of HMOX2 protein
Morphine results in increased activity of HMOX2 protein
CTD PMID:12812915 NCBI chr10:10,990,034...11,035,493
Ensembl chr10:10,990,034...11,035,484
JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like increases expression ISO Morphine results in increased expression of HNRNPDL mRNA CTD PMID:20144693 NCBI chr14:11,199,114...11,204,670
Ensembl chr14:11,198,896...11,202,669
JBrowse link
G Hnrnpl heterogeneous nuclear ribonucleoprotein L increases expression ISO Morphine results in increased expression of HNRNPL mRNA CTD PMID:21955143 NCBI chr 1:86,994,090...87,006,776
Ensembl chr 1:86,996,093...87,006,776
JBrowse link
G Homer1 homer scaffold protein 1 increases expression ISO Morphine results in increased expression of HOMER1 mRNA CTD PMID:21955143 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678
JBrowse link
G Hp haptoglobin decreases expression EXP Morphine results in decreased expression of HP protein CTD PMID:23056601 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
JBrowse link
G Hpca hippocalcin increases expression ISO Morphine results in increased expression of HPCA mRNA CTD PMID:21955143 NCBI chr 5:147,295,124...147,305,757
Ensembl chr 5:147,294,820...147,303,346
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
decreases response to substance
ISO Chlorpheniramine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]; Cimetidine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine] CTD PMID:12128009, PMID:14569158 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions
decreases response to substance
ISO [zolantidine binds to and results in decreased activity of HRH2 protein] which results in increased susceptibility to Morphine; Chlorpheniramine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]; Cimetidine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]
HRH2 protein results in decreased susceptibility to Morphine; HRH2 results in decreased susceptibility to Morphine
CTD PMID:14569158, PMID:16806305 NCBI chr17:10,912,959...10,931,389
Ensembl chr17:10,921,507...10,952,441
JBrowse link
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 increases expression ISO Morphine results in increased expression of HS6ST2 mRNA CTD PMID:21178816 NCBI chr  X:138,675,326...138,972,774
Ensembl chr  X:138,677,580...138,972,684
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Morphine results in decreased expression of HSD11B1 mRNA CTD PMID:21955143 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression EXP Morphine results in increased expression of HSP90AB1 mRNA CTD PMID:15497504 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression EXP Morphine results in decreased expression of HSP90B1 protein CTD PMID:23056601 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions
increases expression
EXP Naloxone inhibits the reaction [Morphine results in increased expression of HSPA1A mRNA]
Morphine results in increased expression of HSPA1A mRNA; Morphine results in increased expression of HSPA1A protein
CTD PMID:15497504, PMID:23056601 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Morphine results in increased expression of HSPA8 mRNA CTD PMID:15497504 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression EXP Morphine results in increased expression of HSPB1 mRNA; Morphine results in increased expression of HSPB1 protein CTD PMID:15497504, PMID:23056601 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression EXP Morphine results in increased expression of HSPE1 protein CTD PMID:23056601 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP 4-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine]; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine CTD PMID:10640309 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A increases expression ISO Morphine results in increased expression of HTR3A mRNA CTD PMID:21178816 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
EXP Morphine results in decreased expression of ICAM1 protein alternative form
Naloxone inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form]; phosphoramidon inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form]
CTD PMID:10070497 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta decreases expression
multiple interactions
EXP Morphine results in decreased expression of IDH3B protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of IDH3B protein]
CTD PMID:23056601 NCBI chr 3:122,808,564...122,813,638
Ensembl chr 3:122,808,564...122,813,583
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
ISO Morphine results in decreased expression of IFNG
OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IFNG]
CTD PMID:11590188 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igsf1 immunoglobulin superfamily, member 1 decreases expression ISO Morphine results in decreased expression of IGSF1 mRNA CTD PMID:21955143 NCBI chr  X:136,792,637...136,808,107
Ensembl chr  X:136,792,643...136,807,885
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Morphine affects the expression of [IL12A protein binds to IL12B protein] CTD PMID:16299287 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions
affects expression
ISO Morphine affects the expression of [IL12A protein binds to IL12B protein]
Morphine affects the expression of IL12B protein
CTD PMID:16299287 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il13 interleukin 13 increases expression ISO Morphine results in increased expression of IL13 protein CTD PMID:16210602 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1a interleukin 1 alpha multiple interactions
decreases expression
ISO Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]; Dexamethasone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Dexamethasone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]]; Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]; Naloxone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]] CTD PMID:12182845 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
increases secretion
EXP
ISO
Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL1B mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL1B protein]; resveratrol inhibits the reaction [Morphine results in increased expression of IL1B mRNA]
dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein]]; Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein]
Morphine results in increased expression of IL1B mRNA; Morphine results in increased expression of IL1B protein
Morphine results in increased secretion of IL1B protein
CTD PMID:12427855, PMID:20178837, PMID:21081778, PMID:22713680, PMID:24756886 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist affects response to substance ISO IL1RN protein affects the susceptibility to Morphine CTD PMID:15317861 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions
ISO Morphine results in decreased expression of IL2
Morphine results in decreased expression of IL2 mRNA
OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IL2]
CTD PMID:11590188, PMID:23965172 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
ISO [FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein]
Morphine results in increased expression of IL4 mRNA; Morphine results in increased expression of IL4 protein
CTAP octapeptide inhibits the reaction [Morphine results in increased expression of IL4 mRNA]; SB 203580 inhibits the reaction [Morphine results in increased expression of IL4 mRNA]
CTD PMID:16210602, PMID:23965172 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions
increases expression
ISO
EXP
Morphine results in increased secretion of IL6 protein
dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of IL6 protein]]; Resveratrol inhibits the reaction [Morphine results in increased expression of IL6 protein]
Morphine results in increased expression of IL6 mRNA; Morphine results in increased expression of IL6 protein
Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL6 mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL6 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of IL6 mRNA]
CTD PMID:12427855, PMID:15317861, PMID:20564181, PMID:21081778, PMID:22713680, PMID:24756886 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ing2 inhibitor of growth family, member 2 multiple interactions EXP Morphine promotes the reaction [ING2 protein binds to BDNF promoter] CTD PMID:25643298 NCBI chr16:47,714,756...47,725,836
Ensembl chr16:47,717,951...47,725,836
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Acetylcysteine inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein]; Morphine results in increased phosphorylation of and results in increased activity of JUN protein; pyrazolanthrone inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein] CTD PMID:19292871 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Morphine results in increased expression of JUNB mRNA CTD PMID:21955143 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Klf7 Kruppel like factor 7 increases expression
multiple interactions
ISO Morphine results in increased expression of KLF7 mRNA; Morphine results in increased expression of KLF7 protein
Naloxone inhibits the reaction [Morphine results in increased expression of KLF7 mRNA]
CTD PMID:14644156 NCBI chr 9:70,740,480...70,787,913
Ensembl chr 9:70,740,480...70,787,913
JBrowse link
G Klrk1 killer cell lectin like receptor K1 decreases expression ISO Morphine results in decreased expression of KLRK1 mRNA CTD PMID:20144693 NCBI chr 4:163,392,652...163,403,735
Ensembl chr 4:163,393,217...163,403,653
JBrowse link
G Kmt2a lysine methyltransferase 2A multiple interactions EXP Morphine promotes the reaction [KMT2A protein binds to BDNF promoter] CTD PMID:25643298 NCBI chr 8:49,110,407...49,185,872
Ensembl chr 8:49,114,990...49,158,971
JBrowse link
G Krt1 keratin 1 decreases expression EXP Morphine results in decreased expression of KRT1 protein CTD PMID:23056601 NCBI chr 7:143,448,318...143,453,544
Ensembl chr 7:143,448,318...143,453,544
JBrowse link
G Krt10 keratin 10 multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine results in decreased expression of KRT10 protein] CTD PMID:23056601 NCBI chr10:87,296,445...87,301,307
Ensembl chr10:87,296,451...87,300,736
JBrowse link
G Krt2 keratin 2 decreases expression
multiple interactions
EXP Morphine results in decreased expression of KRT2 protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT2 protein]
CTD PMID:23056601 NCBI chr 7:143,412,858...143,420,463
Ensembl chr 7:143,412,858...143,420,027
JBrowse link
G Krt33a keratin 33A multiple interactions
increases expression
EXP Morphine deficiency inhibits the reaction [Morphine deficiency promotes the reaction [Morphine results in increased expression of KRT33A protein]]; Morphine deficiency promotes the reaction [Morphine results in increased expression of KRT33A protein] CTD PMID:23056601
G Krt5 keratin 5 decreases expression EXP Morphine results in decreased expression of KRT5 protein CTD PMID:23056601 NCBI chr 7:143,320,142...143,324,536
Ensembl chr 7:143,316,920...143,453,546
JBrowse link
G Krt8 keratin 8 multiple interactions
decreases expression
EXP Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT8 protein]]; Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT8 protein] CTD PMID:23056601 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lcn2 lipocalin 2 increases expression ISO Morphine results in increased expression of LCN2 mRNA CTD PMID:20144693 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Lepr leptin receptor increases expression ISO Morphine results in increased expression of LEPR mRNA CTD PMID:20144693 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Morphine results in decreased expression of LHB protein CTD PMID:7022252 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lin7c lin-7 homolog C, crumbs cell polarity complex component decreases expression ISO Morphine results in decreased expression of LIN7C mRNA CTD PMID:21955143 NCBI chr 3:101,010,923...101,018,235
Ensembl chr 3:101,010,899...101,018,433
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor decreases expression ISO Morphine results in decreased expression of LITAF mRNA CTD PMID:21955143 NCBI chr10:4,753,546...4,763,272
Ensembl chr10:4,719,713...4,763,510
JBrowse link
G Lmo7 LIM domain 7 increases expression ISO Morphine results in increased expression of LMO7 mRNA CTD PMID:21955143 NCBI chr15:86,242,911...86,458,512
Ensembl chr15:86,243,148...86,457,739
JBrowse link
G Lmx1b LIM homeobox transcription factor 1 beta increases expression ISO Morphine results in increased expression of LMX1B mRNA CTD PMID:19397953 NCBI chr 3:12,608,748...12,686,937
Ensembl chr 3:12,609,574...12,686,869
JBrowse link
G LOC103690091 proSAAS increases expression ISO Morphine results in increased expression of PCSK1N mRNA CTD PMID:20144693 NCBI chr  X:15,324,261...15,328,617 JBrowse link
G Lpl lipoprotein lipase increases expression ISO Morphine results in increased expression of LPL mRNA CTD PMID:21955143 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression ISO Morphine results in decreased expression of LRP1 mRNA CTD PMID:21178816 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Lrpprc leucine-rich pentatricopeptide repeat containing increases expression ISO Morphine results in increased expression of LRPPRC mRNA CTD PMID:20144693 NCBI chr 6:7,984,043...8,066,874
Ensembl chr 6:7,984,019...8,066,868
JBrowse link
G Map2 microtubule-associated protein 2 decreases expression EXP Morphine results in decreased expression of MAP2 mRNA CTD PMID:15183518 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression
increases phosphorylation
multiple interactions
ISO
EXP
Morphine results in increased expression of MAPK1 protein modified form
Morphine results in increased phosphorylation of MAPK1 protein
[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased phosphorylation of MAPK1 protein; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]
Morphine deficiency results in increased phosphorylation of MAPK1 protein; Morphine results in increased phosphorylation of MAPK1 protein
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein]]; Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein]
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]
CTD PMID:15196791, PMID:20359526, PMID:20519536, PMID:21235400, PMID:21483469, PMID:21600884, PMID:23965172, PMID:24398105, PMID:32319158 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression EXP Morphine results in increased expression of MAPK14 protein CTD PMID:23056601 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]
Morphine deficiency results in increased phosphorylation of MAPK3 protein; Morphine results in increased phosphorylation of MAPK3 protein
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK3 protein]]; Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
CTD PMID:20519536, PMID:21235400, PMID:21483469, PMID:21600884, PMID:23965172, PMID:24398105, PMID:32319158 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapt microtubule-associated protein tau increases expression EXP Morphine results in increased expression of MAPT mRNA CTD PMID:15183518 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate decreases expression EXP Morphine results in decreased expression of MARCKS protein CTD PMID:23056601 NCBI chr20:42,966,140...42,971,838
Ensembl chr20:42,966,140...42,971,838
JBrowse link
G Mavs mitochondrial antiviral signaling protein increases expression EXP Morphine results in increased expression of MAVS protein CTD PMID:23056601 NCBI chr 3:123,776,147...123,790,572
Ensembl chr 3:123,776,181...123,790,567
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO Morphine results in increased expression of MCL1 mRNA CTD PMID:20144693 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 increases expression ISO Morphine results in increased expression of MCTP1 mRNA CTD PMID:21955143 NCBI chr 2:3,400,883...4,089,949
Ensembl chr 2:3,400,977...4,088,989
JBrowse link
G Me3 malic enzyme 3 increases expression ISO Morphine results in increased expression of ME3 mRNA CTD PMID:21178816 NCBI chr 1:153,861,535...154,058,608
Ensembl chr 1:153,861,569...154,056,654
JBrowse link
G Mir107 microRNA 107 decreases expression ISO Morphine results in decreased expression of MIR107 CTD PMID:20564181 NCBI chr 1:253,128,250...253,128,336
Ensembl chr 1:253,128,250...253,128,336
JBrowse link
G Mir132 microRNA 132 increases expression ISO Morphine results in increased expression of MIR132 CTD PMID:20564181 NCBI chr10:62,014,995...62,015,095
Ensembl chr10:62,014,995...62,015,095
JBrowse link
G Mir146a microRNA 146a increases expression ISO Morphine results in increased expression of MIR146A CTD PMID:20564181 NCBI chr10:28,962,476...28,962,570
Ensembl chr10:28,962,476...28,962,570
JBrowse link
G Mir150 microRNA 150 increases expression ISO Morphine results in increased expression of MIR150 CTD PMID:20564181 NCBI chr 1:101,115,974...101,116,058
Ensembl chr 1:101,115,974...101,116,058
JBrowse link
G Mir155 microRNA 155 increases expression ISO Morphine results in increased expression of MIR155 CTD PMID:20564181 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
JBrowse link
G Mir15b microRNA 15b increases expression ISO Morphine results in increased expression of MIR15B CTD PMID:20564181 NCBI chr 2:165,605,923...165,606,020
Ensembl chr 2:165,605,923...165,606,020
JBrowse link
G Mir191 microRNA 191 decreases expression ISO Morphine results in decreased expression of MIR191 CTD PMID:20564181 NCBI chr 8:117,354,364...117,354,454 JBrowse link
G Mir21 microRNA 21 decreases expression ISO Morphine results in decreased expression of MIR21 CTD PMID:20564181 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir221 microRNA 221 increases expression ISO Morphine results in increased expression of MIR221 CTD PMID:20564181 NCBI chr  X:3,684,480...3,684,588
Ensembl chr  X:3,684,480...3,684,588
JBrowse link
G Mir23a microRNA 23a increases expression ISO Morphine results in increased expression of MIR23A CTD PMID:20564181 NCBI chr19:25,318,582...25,318,656
Ensembl chr19:25,318,582...25,318,656
JBrowse link
G Mir23b microRNA 23b increases expression ISO Morphine results in increased expression of MIR23B CTD PMID:20564181 NCBI chr17:823,222...823,318
Ensembl chr17:823,222...823,318
JBrowse link
G Mir26a microRNA 26a decreases expression ISO Morphine results in decreased expression of MIR26A1 CTD PMID:20564181 NCBI chr 8:127,714,441...127,714,530
Ensembl chr 8:127,714,441...127,714,530
JBrowse link
G Mir26b microRNA 26b decreases expression ISO Morphine results in decreased expression of MIR26B CTD PMID:20564181 NCBI chr 9:81,675,275...81,675,359
Ensembl chr 9:81,675,275...81,675,359
JBrowse link
G Mir320a microRNA 320a decreases expression ISO Morphine results in decreased expression of MIR320A CTD PMID:20564181 NCBI chr15:52,134,276...52,134,357
Ensembl chr15:52,134,276...52,134,357
JBrowse link
G Mir423 microRNA 423 decreases expression ISO Morphine results in decreased expression of MIR423 CTD PMID:20564181 NCBI chr10:63,098,366...63,098,444
Ensembl chr10:63,098,360...63,098,453
JBrowse link
G Mir99b microRNA 99b decreases expression ISO Morphine results in decreased expression of MIR99B CTD PMID:20564181 NCBI chr 1:59,704,216...59,704,285
Ensembl chr 1:59,704,216...59,704,285
JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions
increases activity
EXP Naloxone inhibits the reaction [Morphine results in increased activity of MME protein]; phosphoramidon inhibits the reaction [Morphine results in increased activity of MME protein] CTD PMID:10070497 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases activity
ISO [7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]; [Morphine co-treated with Naloxone] results in increased activity of MMP9 protein; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN1 protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN2B protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
Morphine results in increased activity of MMP9 protein
CTD PMID:20519536 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpeg1 macrophage expressed 1 increases expression ISO Morphine results in increased expression of MPEG1 mRNA CTD PMID:21178816 NCBI chr 1:228,724,559...228,729,054
Ensembl chr 1:228,724,900...228,727,160
JBrowse link
G Myo19 myosin XIX decreases expression ISO Morphine results in decreased expression of MYO19 mRNA CTD PMID:21178816 NCBI chr10:72,198,475...72,227,892
Ensembl chr10:72,197,977...72,227,462
JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 increases expression EXP Morphine results in increased expression of NAIP mRNA CTD PMID:15183518 NCBI chr 2:30,377,505...30,418,578 JBrowse link
G Nav1 neuron navigator 1 decreases expression ISO Morphine results in decreased expression of NAV1 mRNA CTD PMID:21178816 NCBI chr13:52,260,474...52,515,016
Ensembl chr13:52,267,254...52,514,875
JBrowse link
G Ncam1 neural cell adhesion molecule 1 decreases expression EXP Morphine results in decreased expression of NCAM1 protein modified form CTD PMID:15673448 NCBI chr 8:53,836,797...54,134,881
Ensembl chr 8:53,839,098...53,901,358
JBrowse link
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 affects expression ISO Morphine affects the expression of NDUFAB1 mRNA CTD PMID:20144693 NCBI chr 1:192,044,209...192,057,644
Ensembl chr 1:192,044,216...192,057,612
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 increases expression EXP Morphine results in increased expression of NDUFV2 protein CTD PMID:23056601 NCBI chr 9:113,875,718...113,900,169
Ensembl chr 9:113,875,703...113,900,190
JBrowse link
G Nefh neurofilament heavy increases expression EXP Morphine results in increased expression of NEFH mRNA CTD PMID:15183518 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nes nestin decreases expression ISO Morphine results in decreased expression of NES mRNA CTD PMID:26877219 NCBI chr 2:187,343,109...187,352,972
Ensembl chr 2:187,344,056...187,352,969
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression EXP Morphine results in increased expression of NFKB1 mRNA CTD PMID:15183518 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
affects response to substance
increases expression
increases degradation
multiple interactions
ISO
EXP
Morphine results in increased phosphorylation of NFKBIA protein
NFKBIA protein affects the susceptibility to Morphine
Morphine results in increased expression of NFKBIA protein
Morphine results in increased degradation of NFKBIA protein
Morphine results in increased expression of NFKBIA mRNA; Morphine results in increased expression of NFKBIA protein
Calcium affects the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine results in increased expression of NFKBIA mRNA]; Cycloheximide inhibits the reaction [Morphine results in increased expression of NFKBIA mRNA]; Morphine inhibits the reaction [Doxorubicin results in increased degradation of NFKBIA protein]; Morphine inhibits the reaction [TNF protein results in increased ubiquitination of and results in increased degradation of NFKBIA protein]; USP15 mutant form inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]
CTD PMID:17542780, PMID:19070643, PMID:22258905, PMID:24068670 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ninj1 ninjurin 1 increases expression ISO Morphine results in increased expression of NINJ1 mRNA CTD PMID:19397953 NCBI chr17:15,866,235...15,881,284
Ensembl chr17:15,866,237...15,881,327
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases expression
increases expression
ISO
EXP
[7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]
Morphine results in decreased expression of NOS1 protein
PENK protein alternative form inhibits the reaction [Morphine results in increased expression of NOS1 protein]
CTD PMID:16598705, PMID:20519536, PMID:20568289 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
affects response to substance
ISO Morphine results in increased expression of NOS2 mRNA; Morphine results in increased expression of NOS2 protein
dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Resveratrol inhibits the reaction [Morphine results in increased expression of NOS2 protein]
NOS2 protein affects the susceptibility to Morphine
CTD PMID:11590188, PMID:15220775, PMID:16325209, PMID:19751225, PMID:24756886 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Npy neuropeptide Y increases expression ISO Morphine results in increased expression of NPY mRNA CTD PMID:20144693, PMID:21178816 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Npy1r neuropeptide Y receptor Y1 decreases expression ISO Morphine results in decreased expression of NPY1R mRNA CTD PMID:20144693 NCBI chr16:24,779,480...24,789,131
Ensembl chr16:24,779,477...24,788,740
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP [Mifepristone binds to and results in decreased activity of NR3C1 protein] which results in decreased susceptibility to Morphine CTD PMID:15014116 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Morphine results in increased expression of NR4A1 mRNA CTD PMID:21955143 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions
decreases expression
affects response to substance
ISO
EXP
BDNF protein inhibits the reaction [NR4A2 protein affects the susceptibility to Morphine]
Morphine results in decreased expression of NR4A2 mRNA
Morphine inhibits the reaction [CREB1 protein modified form binds to NR4A2 promoter]; Morphine inhibits the reaction [NR4A2 protein binds to BDNF promoter]
CTD PMID:25643298 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Nrcam neuronal cell adhesion molecule increases expression EXP Morphine results in increased expression of NRCAM mRNA; Morphine results in increased expression of NRCAM mRNA alternative form CTD PMID:16123759 NCBI chr 6:64,297,843...64,867,408
Ensembl chr 6:64,297,888...64,864,996
JBrowse link
G Nrn1 neuritin 1 decreases expression ISO Morphine results in decreased expression of NRN1 mRNA CTD PMID:21955143 NCBI chr17:27,925,054...28,002,946
Ensembl chr17:27,925,057...27,969,433
JBrowse link
G Nrxn3 neurexin 3 increases expression ISO Morphine results in increased expression of NRXN3 mRNA CTD PMID:21955143 NCBI chr 6:112,133,204...114,069,589
Ensembl chr 6:112,133,204...114,067,564
JBrowse link
G Ntng1 netrin G1 decreases expression ISO Morphine results in decreased expression of NTNG1 mRNA CTD PMID:21955143 NCBI chr 2:212,695,464...213,073,046
Ensembl chr 2:212,696,624...212,852,870
JBrowse link
G Ntsr1 neurotensin receptor 1 affects response to substance ISO NTSR1 protein affects the susceptibility to Morphine CTD PMID:20727387 NCBI chr 3:175,982,313...176,046,345
Ensembl chr 3:175,885,894...176,046,345
JBrowse link
G Opalin oligodendrocytic myelin paranodal and inner loop protein decreases expression ISO Morphine results in decreased expression of OPALIN mRNA CTD PMID:21955143 NCBI chr 1:260,324,028...260,341,677
Ensembl chr 1:260,324,028...260,341,723
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions
increases expression
affects binding
ISO
EXP
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]
Morphine binds to OPRD1 protein
CTD PMID:7562497, PMID:21600884 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects activity
increases activity
increases expression
affects binding
multiple interactions
ISO
EXP
Morphine affects the activity of OPRK1 protein
Morphine results in increased activity of OPRK1 protein
Morphine results in increased expression of OPRK1 mRNA
Morphine binds to OPRK1 protein
Morphine inhibits the reaction [Zymosan results in decreased expression of OPRK1 mRNA]
CTD PMID:7562497, PMID:15979727, PMID:18385270, PMID:22661197, PMID:26476280 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 multiple interactions ISO [J 113397 binds to and results in decreased activity of OPRL1 protein] which affects the susceptibility to Morphine CTD PMID:11027224 NCBI chr 3:177,223,779...177,231,663
Ensembl chr 3:177,225,737...177,231,663
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
increases phosphorylation
increases activity
decreases expression
affects response to substance
increases expression
affects binding
affects activity
decreases response to substance
ISO
EXP
[[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP; [[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP; [COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine; [OPRM1 protein co-treated with Morphine] results in increased activity of ARRB2 protein; Morphine binds to and results in increased activity of OPRM1 protein; Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]]; OPRM1 protein affects the reaction [Morphine results in decreased secretion of FGF2 protein]
Morphine results in increased phosphorylation of OPRM1 protein
Morphine results in increased activity of OPRM1 protein
Morphine results in decreased expression of OPRM1 mRNA
OPRM1 affects the susceptibility to Morphine; OPRM1 protein affects the susceptibility to Morphine
[Morphine results in increased activity of OPRM1 protein] which results in increased phosphorylation of GRIN1 protein; [phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; [Zymosan co-treated with Morphine] results in increased expression of OPRM1 mRNA; Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]; Morphine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]; Morphine binds to and affects the activity of OPRM1 protein; Morphine binds to and results in increased activity of OPRM1 protein; Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]; Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]; Naloxone inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]; OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IFNG]; OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IL2]; Tetradecanoylphorbol Acetate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; valyl-prolyl-aspartyl-prolyl-arginine inhibits the reaction [Morphine results in increased activity of OPRM1 protein]
Morphine results in increased expression of OPRM1 protein
Morphine binds to OPRM1 protein
OPRM1 affects the activity of Morphine
[beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of 3,4-Dihydroxyphenylacetic Acid]; [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of Homovanillic Acid]; [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; [naloxonazine binds to and results in decreased activity of OPRM1 protein] which affects the susceptibility to Morphine; [naloxonazine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; Morphine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]; Morphine binds to and affects the activity of OPRM1 protein
OPRM1 exon SNP results in decreased susceptibility to Morphine
Morphine affects the activity of OPRM1 protein
CTD PMID:7562497, PMID:8884884, PMID:9264103, PMID:10803207, PMID:11106302, PMID:11272841, PMID:11413242, PMID:11590188, PMID:12213227, PMID:12605406, PMID:15504181, PMID:15979727, PMID:17656655, PMID:17996026, PMID:18652891, PMID:19800397, PMID:20564181, PMID:21127283, PMID:21235400, PMID:21957251, PMID:22258905, PMID:23300227, PMID:23608241, PMID:23748253, PMID:26476280, PMID:26877219 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Oxct1 3-oxoacid CoA transferase 1 decreases expression EXP Morphine results in decreased expression of OXCT1 protein CTD PMID:23056601 NCBI chr 2:53,859,738...54,007,733
Ensembl chr 2:53,859,737...54,007,756
JBrowse link
G Patj PATJ, crumbs cell polarity complex component decreases expression ISO Morphine results in decreased expression of PATJ mRNA CTD PMID:21955143 NCBI chr 5:117,038,548...117,340,308
Ensembl chr 5:117,052,260...117,340,336
JBrowse link
G Pdcd5 programmed cell death 5 increases expression EXP Morphine results in increased expression of PDCD5 protein CTD PMID:23056601 NCBI chr 1:91,173,473...91,178,801
Ensembl chr 1:91,173,473...91,178,801
Ensembl chr 1:91,173,473...91,178,801
JBrowse link
G Pde10a phosphodiesterase 10A decreases expression ISO Morphine results in decreased expression of PDE10A mRNA CTD PMID:21955143 NCBI chr 1:52,360,296...52,544,448
Ensembl chr 1:52,360,296...52,544,450
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions
decreases response to substance
ISO PDGFB protein inhibits the reaction [Morphine results in decreased expression of BCL2 protein]; PDGFB protein inhibits the reaction [Morphine results in increased activity of CASP3 protein]; PDGFB protein inhibits the reaction [Morphine results in increased expression of BAX protein]
PDGFB protein results in decreased susceptibility to Morphine
CTD PMID:21483469 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta increases expression
multiple interactions
EXP Morphine results in increased expression of PDHB protein
Morphine deficiency affects the reaction [Morphine results in increased expression of PDHB protein]
CTD PMID:23056601 NCBI chr15:18,540,826...18,546,855
Ensembl chr15:18,539,210...18,546,854
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression EXP Morphine results in decreased expression of PDK1 protein CTD PMID:23056601 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 decreases expression EXP Morphine results in decreased expression of PDK2 protein CTD PMID:23056601 NCBI chr10:82,838,270...82,852,758
Ensembl chr10:82,839,153...82,852,660
JBrowse link
G Pdlim2 PDZ and LIM domain 2 decreases expression ISO Morphine results in decreased expression of PDLIM2 mRNA CTD PMID:21955143 NCBI chr15:51,843,562...51,856,785
Ensembl chr15:51,843,564...51,855,325
JBrowse link
G Pdyn prodynorphin increases expression
decreases expression
multiple interactions
ISO
EXP
Morphine results in increased expression of PDYN protein alternative form
Morphine results in decreased expression of PDYN mRNA
[Zymosan co-treated with Morphine] results in increased expression of PDYN mRNA; GRIK1 protein affects the reaction [Morphine results in increased expression of PDYN protein alternative form]
CTD PMID:15979727, PMID:17401159, PMID:20359526 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Penk proenkephalin multiple interactions EXP Morphine inhibits the reaction [Formaldehyde results in increased expression of PENK mRNA]; PENK protein alternative form inhibits the reaction [Morphine results in increased expression of CALCA protein]; PENK protein alternative form inhibits the reaction [Morphine results in increased expression of NOS1 protein]; PENK protein alternative form inhibits the reaction [Morphine results in increased expression of PRKCG protein] CTD PMID:7978486, PMID:20568289 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Per1 period circadian regulator 1 affects expression EXP Morphine affects the expression of PER1 mRNA CTD PMID:19383088 NCBI chr10:55,681,761...55,696,557
Ensembl chr10:55,687,050...55,695,994
JBrowse link
G Per2 period circadian regulator 2 affects response to substance
affects expression
ISO
EXP
PER2 protein affects the susceptibility to Morphine
Morphine affects the expression of PER2 mRNA
CTD PMID:19383088, PMID:20434889 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
JBrowse link
G Perm1 PPARGC1 and ESRR induced regulator, muscle 1 multiple interactions
increases expression
EXP Morphine deficiency affects the reaction [Morphine results in increased expression of PERM1 protein] CTD PMID:23056601 NCBI chr 5:173,640,780...173,646,073
Ensembl chr 5:173,640,780...173,646,073
JBrowse link
G Phldb1 pleckstrin homology-like domain, family B, member 1 decreases expression ISO Morphine results in decreased expression of PHLDB1 mRNA CTD PMID:21955143 NCBI chr 8:48,997,189...49,045,176
Ensembl chr 8:48,997,184...49,045,154
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A decreases expression ISO Morphine results in decreased expression of PIGA mRNA CTD PMID:21955143 NCBI chr  X:31,786,823...31,799,751
Ensembl chr  X:31,786,194...31,799,560
JBrowse link
G Pknox1 PBX/knotted 1 homeobox 1 increases expression ISO Morphine results in increased expression of PKNOX1 mRNA CTD PMID:21178816 NCBI chr20:10,331,608...10,358,922
Ensembl chr20:10,334,308...10,358,922
JBrowse link
G Plat plasminogen activator, tissue type affects response to substance ISO PLAT protein affects the susceptibility to Morphine CTD PMID:16619846 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plcb1 phospholipase C beta 1 affects response to substance ISO PLCB1 protein affects the susceptibility to Morphine CTD PMID:16405873 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Plcd1 phospholipase C, delta 1 multiple interactions
increases expression
EXP Morphine deficiency inhibits the reaction [Morphine results in increased expression of PLCD1 protein] CTD PMID:23056601 NCBI chr 8:127,753,514...127,782,070
Ensembl chr 8:127,753,539...127,782,070
JBrowse link
G Plcd4 phospholipase C, delta 4 decreases expression ISO Morphine results in decreased expression of PLCD4 mRNA CTD PMID:21955143 NCBI chr 9:81,816,395...81,844,364
Ensembl chr 9:81,816,872...81,844,364
JBrowse link
G Plekhg1 pleckstrin homology and RhoGEF domain containing G1 decreases expression ISO Morphine results in decreased expression of PLEKHG1 mRNA CTD PMID:21955143 NCBI chr 1:40,286,908...40,521,395
Ensembl chr 1:40,389,638...40,520,447
JBrowse link
G Plg plasminogen affects response to substance ISO PLG protein affects the susceptibility to Morphine CTD PMID:16619846 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Pllp plasmolipin decreases expression ISO Morphine results in decreased expression of PLLP mRNA CTD PMID:21955143 NCBI chr19:10,731,855...10,752,641
Ensembl chr19:10,731,855...10,752,641
JBrowse link
G Pnoc prepronociceptin decreases response to substance ISO PNOC protein results in decreased susceptibility to Morphine CTD PMID:17303110 NCBI chr15:48,805,841...48,833,071
Ensembl chr15:48,805,228...48,833,285
JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 increases expression ISO Morphine results in increased expression of PNPLA3 mRNA CTD PMID:20144693 NCBI chr 7:125,034,760...125,056,165
Ensembl chr 7:125,034,764...125,055,976
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases secretion
increases expression
ISO
EXP
[Fentanyl co-treated with Morphine] results in decreased expression of POMC protein alternative form
Morphine deficiency results in increased secretion of POMC protein modified form
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased secretion of POMC protein modified form]; [Morphine co-treated with Naloxone] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Capsaicin inhibits the reaction [[Morphine co-treated with Naloxone] results in increased secretion of POMC protein]
[Zymosan co-treated with Morphine] results in increased expression of POMC mRNA
Morphine results in increased expression of POMC mRNA
CTD PMID:2846107, PMID:15979727, PMID:20084599, PMID:20144693, PMID:24398105 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ppia peptidylprolyl isomerase A increases expression EXP Morphine results in increased expression of PPIA protein CTD PMID:23056601 NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B affects expression
multiple interactions
increases phosphorylation
EXP
ISO
Morphine affects the expression of PPP1R1B protein modified form
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]
CTD PMID:15287884, PMID:21600884 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha increases expression ISO Morphine results in increased expression of PPP3R1 mRNA CTD PMID:21955143 NCBI chr14:100,311,224...100,360,879
Ensembl chr14:100,311,173...100,360,879
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein] CTD PMID:18652891 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein] CTD PMID:18652891 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcd protein kinase C, delta decreases expression ISO Morphine results in decreased expression of PRKCD mRNA CTD PMID:21955143 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions
increases expression
EXP
ISO
PENK protein alternative form inhibits the reaction [Morphine results in increased expression of PRKCG protein]
Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]
Morphine results in increased expression of PRKCG protein modified form
CTD PMID:18652891, PMID:20359526, PMID:20568289, PMID:21235400 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions EXP Morphine inhibits the reaction [Formaldehyde results in increased expression of PRKG1 protein] CTD PMID:12620371 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Prl prolactin increases secretion EXP Morphine results in increased secretion of PRL protein CTD PMID:7201058 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Prr18 proline rich 18 decreases expression ISO Morphine results in decreased expression of PRR18 mRNA CTD PMID:21955143 NCBI chr 1:52,989,076...52,994,843
Ensembl chr 1:52,991,287...52,992,213
JBrowse link
G Psma5 proteasome 20S subunit alpha 5 increases expression EXP Morphine results in increased expression of PSMA5 protein CTD PMID:23056601 NCBI chr 2:211,050,344...211,073,706
Ensembl chr 2:211,050,360...211,073,714
JBrowse link
G Psmd2 proteasome 26S subunit, non-ATPase 2 multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine results in decreased expression of PSMD2 protein] CTD PMID:23056601 NCBI chr11:83,934,098...83,944,725
Ensembl chr11:83,934,087...83,944,763
JBrowse link
G Ptdss2 phosphatidylserine synthase 2 increases expression ISO Morphine results in increased expression of PTDSS2 mRNA CTD PMID:20144693 NCBI chr 1:214,122,981...214,148,011
Ensembl chr 1:214,123,044...214,149,729
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression
increases expression
multiple interactions
EXP Morphine results in decreased expression of PTGS1 mRNA
Morphine results in increased expression of PTGS1 mRNA
Minocycline inhibits the reaction [Morphine results in increased expression of PTGS1 mRNA]
CTD PMID:15183518, PMID:18706994 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO
EXP
Morphine results in increased expression of PTGS2 protein
[nimesulide results in decreased activity of PTGS2 protein] which results in increased susceptibility to Morphine
[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha; [Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; S-methylisothiopseudouronium inhibits the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; S-methylisothiopseudouronium inhibits the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]
CTD PMID:14511336, PMID:16325209 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pvalb parvalbumin decreases expression ISO Morphine results in decreased expression of PVALB mRNA CTD PMID:21955143 NCBI chr 7:119,428,657...119,443,674
Ensembl chr 7:119,429,019...119,441,487
JBrowse link
G Pycard PYD and CARD domain containing decreases expression ISO Morphine results in decreased expression of PYCARD mRNA CTD PMID:20144693 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Pyy peptide YY increases expression ISO Morphine results in increased expression of PYY mRNA CTD PMID:20144693 NCBI chr10:90,047,989...90,049,155
Ensembl chr10:90,047,993...90,049,112
JBrowse link
G Rab11b RAB11B, member RAS oncogene family increases expression ISO Morphine results in increased expression of RAB11B mRNA CTD PMID:21178816 NCBI chr 7:18,598,991...18,612,132
Ensembl chr 7:18,598,880...18,612,147
JBrowse link
G Rab3a RAB3A, member RAS oncogene family affects expression ISO Morphine affects the expression of RAB3A protein CTD PMID:16522322 NCBI chr16:20,435,098...20,439,206
Ensembl chr16:20,435,101...20,439,206
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase affects response to substance
multiple interactions
EXP
ISO
RAF1 protein affects the susceptibility to Morphine
HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]
CTD PMID:18976650, PMID:21235400 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Ramp3 receptor activity modifying protein 3 decreases expression ISO Morphine results in decreased expression of RAMP3 mRNA CTD PMID:21955143 NCBI chr14:86,922,223...86,939,722
Ensembl chr14:86,922,223...86,939,719
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
ISO
EXP
Morphine inhibits the reaction [Doxorubicin affects the localization of RELA protein]
Colforsin inhibits the reaction [Morphine results in increased phosphorylation of RELA protein]
CTD PMID:17542780, PMID:22258905 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Reln reelin decreases expression ISO Morphine results in decreased expression of RELN mRNA CTD PMID:21178816 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link
G Rem2 RRAD and GEM like GTPase 2 increases expression ISO Morphine results in increased expression of REM2 mRNA CTD PMID:21955143 NCBI chr15:33,121,273...33,125,752
Ensembl chr15:33,121,273...33,125,752
JBrowse link
G Rgs17 regulator of G-protein signaling 17 multiple interactions ISO Morphine promotes the reaction [GNAI2 protein binds to RGS17 protein]; Morphine promotes the reaction [GNAZ protein binds to RGS17 protein] CTD PMID:18652891 NCBI chr 1:42,491,566...42,587,735
Ensembl chr 1:42,492,761...42,587,721
JBrowse link
G Rgs4 regulator of G-protein signaling 4 decreases expression
increases expression
EXP Morphine results in decreased expression of RGS4 mRNA
Morphine results in increased expression of RGS4 mRNA
CTD PMID:12270694 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Rgs6 regulator of G-protein signaling 6 increases expression ISO Morphine results in increased expression of RGS6 mRNA CTD PMID:21178816 NCBI chr 6:106,310,442...106,598,668
Ensembl chr 6:106,496,992...106,602,139
JBrowse link
G Ring1 ring finger protein 1 multiple interactions EXP Morphine inhibits the reaction [RING1 protein alternative form binds to BDNF promoter] CTD PMID:25643298 NCBI chr20:3,812,287...3,815,834
Ensembl chr20:3,812,287...3,815,834
JBrowse link
G Rph3a rabphilin 3A decreases expression ISO Morphine results in decreased expression of RPH3A mRNA CTD PMID:21955143 NCBI chr12:41,073,296...41,149,799
Ensembl chr12:41,073,824...41,148,490
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO Morphine results in increased expression of RRM2B mRNA CTD PMID:21178816 NCBI chr 7:76,750,045...76,780,817
Ensembl chr 7:76,750,050...76,780,817
JBrowse link
G S100b S100 calcium binding protein B decreases expression ISO Morphine results in decreased expression of S100B mRNA CTD PMID:21955143 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
JBrowse link
G Sdc4 syndecan 4 increases expression ISO Morphine results in increased expression of SDC4 mRNA CTD PMID:21955143 NCBI chr 3:160,872,503...160,891,190
Ensembl chr 3:160,872,503...160,891,190
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A multiple interactions
increases expression
EXP Morphine deficiency affects the reaction [Morphine results in increased expression of SDHA protein] CTD PMID:23056601 NCBI chr 1:31,545,631...31,570,601
Ensembl chr 1:31,545,631...31,570,601
JBrowse link
G Sell selectin L decreases expression
multiple interactions
EXP Morphine results in decreased expression of SELL protein alternative form
Naloxone inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form]; phosphoramidon inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form]
CTD PMID:10070497 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Septin7 septin 7 multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine deficiency inhibits the reaction [Morphine results in decreased expression of SEPTIN7 protein]]; Morphine deficiency inhibits the reaction [Morphine results in decreased expression of SEPTIN7 protein] CTD PMID:23056601 NCBI chr 8:26,412,910...26,476,615
Ensembl chr 8:26,413,233...26,476,611
JBrowse link
G Septin8 septin 8 decreases expression ISO Morphine results in decreased expression of SEPTIN8 mRNA CTD PMID:21955143 NCBI chr10:38,877,422...38,906,480
Ensembl chr10:38,877,422...38,906,482
JBrowse link
G Serpinb1a serpin family B member 1A decreases expression ISO Morphine results in decreased expression of SERPINB1A mRNA CTD PMID:21955143 NCBI chr17:32,903,089...32,911,498
Ensembl chr17:32,904,119...32,911,495
JBrowse link
G Serpinf1 serpin family F member 1 decreases expression ISO Morphine results in decreased expression of SERPINF1 mRNA CTD PMID:21955143 NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287
JBrowse link
G Serping1 serpin family G member 1 multiple interactions
decreases expression
EXP Morphine deficiency affects the reaction [Morphine results in decreased expression of SERPING1 protein] CTD PMID:23056601 NCBI chr 3:72,161,230...72,171,109
Ensembl chr 3:72,161,189...72,171,078
JBrowse link
G Sertad4 SERTA domain containing 4 increases expression ISO Morphine results in increased expression of SERTAD4 mRNA CTD PMID:21955143 NCBI chr13:111,574,545...111,585,113
Ensembl chr13:111,574,609...111,581,019
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Morphine results in increased expression of SGK1 mRNA CTD PMID:21955143 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Shox2 short stature homeobox 2 decreases expression ISO Morphine results in decreased expression of SHOX2 mRNA CTD PMID:21955143 NCBI chr 2:164,118,175...164,126,783
Ensembl chr 2:164,118,191...164,126,783
JBrowse link
G Sin3a SIN3 transcription regulator family member A multiple interactions EXP Morphine promotes the reaction [SIN3A protein binds to BDNF promoter] CTD PMID:25643298 NCBI chr 8:61,748,590...61,803,314
Ensembl chr 8:61,762,768...61,803,099
JBrowse link
G Slc17a6 solute carrier family 17 member 6 decreases expression ISO Morphine results in decreased expression of SLC17A6 mRNA CTD PMID:21955143 NCBI chr 1:106,980,463...107,038,717
Ensembl chr 1:106,998,623...107,038,704
JBrowse link
G Slc17a7 solute carrier family 17 member 7 affects expression ISO Morphine affects the expression of SLC17A7 protein CTD PMID:16522322 NCBI chr 1:101,161,265...101,172,292
Ensembl chr 1:101,161,252...101,173,174
JBrowse link
G Slc23a2 solute carrier family 23 member 2 decreases expression EXP Morphine results in decreased expression of SLC23A2 mRNA CTD PMID:19418264 NCBI chr 3:124,632,491...124,842,225
Ensembl chr 3:124,632,492...124,724,252
JBrowse link
G Slc25a46 solute carrier family 25, member 46 multiple interactions
decreases expression
EXP Morphine deficiency promotes the reaction [Morphine results in decreased expression of SLC25A46 protein] CTD PMID:23056601 NCBI chr18:24,369,104...24,397,412
Ensembl chr18:24,369,125...24,397,551
JBrowse link
G Slc6a1 solute carrier family 6 member 1 multiple interactions
affects response to substance
ISO [NNC 711 results in decreased activity of SLC6A1 protein] which affects the susceptibility to Morphine
SLC6A1 protein affects the susceptibility to Morphine
CTD PMID:14598306 NCBI chr 4:146,258,842...146,292,176
Ensembl chr 4:146,276,862...146,292,213
JBrowse link
G Slc6a18 solute carrier family 6 member 18 increases expression ISO Morphine results in increased expression of SLC6A18 mRNA CTD PMID:20144693 NCBI chr 1:32,221,679...32,235,599
Ensembl chr 1:32,221,636...32,236,051
JBrowse link
G Slc6a7 solute carrier family 6 member 7 decreases expression ISO Morphine results in decreased expression of SLC6A7 mRNA CTD PMID:21955143 NCBI chr18:56,305,765...56,325,179
Ensembl chr18:56,305,735...56,331,991
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions
increases expression
ISO Morphine affects the reaction [SMPD1 protein affects the abundance of Ceramides]; Naloxone inhibits the reaction [Morphine results in increased expression of SMPD1 protein] CTD PMID:22825003 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524
JBrowse link
G Smpx small muscle protein, X-linked increases expression
multiple interactions
EXP Morphine results in increased expression of SMPX protein
Morphine deficiency affects the reaction [Morphine results in increased expression of SMPX protein]
CTD PMID:23056601 NCBI chr  X:40,029,200...40,086,870
Ensembl chr  X:40,030,248...40,086,870
JBrowse link
G Snca synuclein alpha increases expression EXP Morphine results in increased expression of SNCA mRNA CTD PMID:15183518 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
ISO Morphine results in increased expression of SOD2 protein
Saquinavir inhibits the reaction [Morphine results in increased expression of SOD2 protein]
CTD PMID:14871405, PMID:20564181 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sowaha sosondowah ankyrin repeat domain family member A increases expression ISO Morphine results in increased expression of SOWAHA mRNA CTD PMID:21955143 NCBI chr10:38,836,158...38,838,932
Ensembl chr10:38,836,614...38,838,272
JBrowse link
G Srf serum response factor increases expression EXP Morphine results in increased expression of SRF mRNA CTD PMID:22454534 NCBI chr 9:16,737,637...16,747,226
Ensembl chr 9:16,737,642...16,747,225
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Morphine results in increased expression of SRXN1 mRNA CTD PMID:20144693 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Sst somatostatin increases expression ISO Morphine results in increased expression of SST mRNA CTD PMID:21178816 NCBI chr11:80,358,172...80,359,449
Ensembl chr11:80,358,211...80,359,444
JBrowse link
G St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 increases expression ISO Morphine results in increased expression of ST8SIA3 mRNA CTD PMID:21955143 NCBI chr18:59,748,766...59,755,257
Ensembl chr18:59,748,444...59,755,226
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO Morphine results in increased phosphorylation of STAT3 protein CTD PMID:18385270 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stat6 signal transducer and activator of transcription 6 affects response to substance ISO STAT6 gene SNP affects the susceptibility to Morphine CTD PMID:16103897 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Strip2 striatin interacting protein 2 increases expression ISO Morphine results in increased expression of STRIP2 mRNA CTD PMID:21955143 NCBI chr 4:57,204,850...57,248,912
Ensembl chr 4:57,204,944...57,246,675
JBrowse link
G Stx12 syntaxin 12 increases expression EXP Morphine results in increased expression of STX12 mRNA CTD PMID:15183518 NCBI chr 5:151,044,050...151,072,893
Ensembl chr 5:151,044,329...151,072,904
JBrowse link
G Stx5 syntaxin 5 increases expression EXP Morphine results in increased expression of STX5A mRNA CTD PMID:15183518 NCBI chr 1:224,939,497...224,955,658
Ensembl chr 1:224,939,497...224,955,657
JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha decreases expression EXP Morphine results in decreased expression of SUCLG1 protein CTD PMID:23056601 NCBI chr 4:101,181,315...101,210,692
Ensembl chr 4:101,180,404...101,210,746
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression ISO Morphine results in increased expression of SULT1A1 mRNA CTD PMID:20144693 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Suz12 SUZ12 polycomb repressive complex 2 subunit multiple interactions EXP Morphine promotes the reaction [SUZ12 protein binds to BDNF promoter] CTD PMID:25643298 NCBI chr10:67,325,101...67,371,588
Ensembl chr10:67,325,347...67,369,668
JBrowse link
G Syne1 spectrin repeat containing nuclear envelope protein 1 increases expression ISO Morphine results in increased expression of SYNE1 mRNA CTD PMID:21955143 NCBI chr 1:41,608,287...41,763,591
NCBI chr 1:41,844,840...42,086,662
Ensembl chr 1:41,608,418...42,077,535
JBrowse link
G Syt5 synaptotagmin 5 increases expression ISO Morphine results in increased expression of SYT5 mRNA CTD PMID:21178816 NCBI chr 1:72,859,806...72,867,934
Ensembl chr 1:72,860,218...72,867,930
JBrowse link
G Syt9 synaptotagmin 9 decreases expression ISO Morphine results in decreased expression of SYT9 mRNA CTD PMID:21955143 NCBI chr 1:171,592,703...171,769,780
Ensembl chr 1:171,592,797...171,769,780
JBrowse link
G Tac1 tachykinin, precursor 1 increases expression
multiple interactions
ISO
EXP
Morphine results in increased expression of TAC1 mRNA
Morphine results in increased expression of TAC1 protein
Morphine promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]; Naloxone inhibits the reaction [Morphine results in increased expression of TAC1 protein]
CTD PMID:11976266, PMID:15964684, PMID:21178816 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions
decreases expression
increases expression
EXP [SR 140333 binds to and results in decreased activity of TACR1 protein] which results in increased susceptibility to Morphine; substance P-saporin inhibits the reaction [Morphine results in increased expression of TACR1 protein]
Morphine results in decreased expression of TACR1 protein
CTD PMID:14511336, PMID:15964684, PMID:17123731, PMID:19428329 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
JBrowse link
G Tacr2 tachykinin receptor 2 decreases expression EXP Morphine results in decreased expression of TACR2 protein CTD PMID:19428329 NCBI chr20:31,892,515...31,905,153
Ensembl chr20:31,892,515...31,905,153
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Morphine results in increased expression of and results in increased localization of TGFB1 protein; TGFB1 protein affects the reaction [Morphine results in increased expression of and results in increased localization of TGFB1 protein]; TGFB1 protein affects the reaction [Morphine results in increased expression of BAX protein] CTD PMID:10809959 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Th tyrosine hydroxylase increases expression
multiple interactions
decreases expression
increases phosphorylation
EXP
ISO
Morphine results in increased expression of TH protein
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein]; [Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein; Agmatine inhibits the reaction [Morphine results in increased expression of TH protein]; Morphine promotes the reaction [CREB1 protein modified form binds to TH promoter]
Morphine results in decreased expression of TH protein
[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein; CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
CTD PMID:15541421, PMID:24398105, PMID:25308750, PMID:25582704, PMID:25643298, PMID:26386147 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tkt transketolase decreases expression EXP Morphine results in decreased expression of TKT protein CTD PMID:23056601 NCBI chr16:6,609,670...6,634,608
Ensembl chr16:6,609,668...6,634,595
JBrowse link
G Tlr4 toll-like receptor 4 affects binding
increases expression
multiple interactions
affects response to substance
ISO
EXP
Morphine binds to TLR4 protein
Morphine results in increased expression of TLR4 protein
dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of TLR4 protein]]; Resveratrol inhibits the reaction [Morphine results in increased expression of TLR4 protein]
Morphine affects the susceptibility to TLR4 protein
Naloxone affects the reaction [Morphine binds to TLR4 protein]
CTD PMID:20178837, PMID:24756886 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tmcc3 transmembrane and coiled-coil domain family 3 decreases expression ISO Morphine results in decreased expression of TMCC3 mRNA CTD PMID:21955143 NCBI chr 7:35,266,953...35,543,770
Ensembl chr 7:35,309,265...35,543,759
JBrowse link
G Tmem125 transmembrane protein 125 decreases expression ISO Morphine results in decreased expression of TMEM125 mRNA CTD PMID:21955143 NCBI chr 5:137,371,825...137,373,229
Ensembl chr 5:137,371,825...137,373,205
Ensembl chr 5:137,371,825...137,373,205
JBrowse link
G Tmem163 transmembrane protein 163 decreases expression ISO Morphine results in decreased expression of TMEM163 mRNA CTD PMID:21955143 NCBI chr13:44,166,306...44,345,735
Ensembl chr13:44,166,306...44,345,735
JBrowse link
G Tmem63a transmembrane protein 63a decreases expression ISO Morphine results in decreased expression of TMEM63A mRNA CTD PMID:21955143 NCBI chr13:99,219,585...99,253,176
Ensembl chr13:99,220,510...99,253,316
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases secretion
EXP
ISO
Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of TNF mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of TNF protein]; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]; Resveratrol inhibits the reaction [Morphine results in increased expression of TNF mRNA]
dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of TNF protein]]; Resveratrol inhibits the reaction [Morphine results in increased expression of TNF protein]
Calcium affects the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]]; Cycloheximide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Cycloheximide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]]; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]; Morphine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Morphine inhibits the reaction [TNF protein results in increased ubiquitination of and results in increased degradation of NFKBIA protein]; USP15 mutant form inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]
Morphine results in increased expression of TNF mRNA; Morphine results in increased expression of TNF protein
Morphine results in increased secretion of TNF protein
CTD PMID:12427855, PMID:15317861, PMID:20178837, PMID:21081778, PMID:22258905, PMID:22713680, PMID:24068670, PMID:24756886 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO Morphine results in increased expression of TNFSF10 mRNA CTD PMID:16210602 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tomm70 translocase of outer mitochondrial membrane 70 decreases expression ISO Morphine results in decreased expression of TOMM70A mRNA CTD PMID:21955143 NCBI chr11:45,477,053...45,511,409
Ensembl chr11:45,480,250...45,510,961
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BAX protein; [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of CDKN1A protein; [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of FAS protein; Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]; Morphine results in increased phosphorylation of and results in increased activity of TP53 protein; Morphine results in increased phosphorylation of and results in increased stability of TP53 protein; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]]; Naloxone inhibits the reaction [Morphine results in increased expression of TP53]; Naloxone inhibits the reaction [Morphine results in increased phosphorylation of TP53 protein]
Morphine results in increased expression of TP53 mRNA
CTD PMID:12702572, PMID:12927789, PMID:19397953 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trh thyrotropin releasing hormone increases expression ISO Morphine results in increased expression of TRH mRNA CTD PMID:21178816 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trhr thyrotropin releasing hormone receptor increases expression ISO Morphine results in increased expression of TRHR mRNA CTD PMID:21178816 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
affects activity
increases expression
affects response to substance
ISO
EXP
[N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-3-(2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)acrylamide binds to and results in decreased activity of TRPV1 protein] which results in decreased susceptibility to Morphine
Morphine affects the activity of TRPV1 protein
Morphine results in increased expression of TRPV1; Morphine results in increased expression of TRPV1 protein
TRPV1 protein affects the susceptibility to Morphine
CTD PMID:18774343, PMID:20719804, PMID:22189556 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Ttll11 tubulin tyrosine ligase like11 increases expression ISO Morphine results in increased expression of TTLL11 mRNA CTD PMID:21178816 NCBI chr 3:15,084,244...15,312,312
Ensembl chr 3:15,084,634...15,278,645
JBrowse link
G Ttr transthyretin decreases expression
multiple interactions
EXP Morphine results in decreased expression of TTR protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of TTR protein]
CTD PMID:23056601 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Tubb4a tubulin, beta 4A class IVa decreases expression ISO Morphine results in decreased expression of TUBB4A mRNA CTD PMID:21955143 NCBI chr 9:9,961,020...9,968,420
Ensembl chr 9:9,961,021...9,968,486
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Morphine CTD PMID:12920162 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Morphine CTD PMID:12920162 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases expression ISO Morphine results in increased expression of UGT1A5 mRNA CTD PMID:21955143 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Morphine CTD PMID:12920162 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Morphine CTD PMID:12920162 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Morphine CTD PMID:12920162 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 affects metabolic processing
increases glucuronidation
ISO UGT2B7 affects the metabolism of Morphine; UGT2B7 protein affects the metabolism of Morphine
UGT2B7 protein results in increased glucuronidation of Morphine
CTD PMID:11186130, PMID:12756209, PMID:12920162, PMID:15286053, PMID:15611481, PMID:23748253 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Usp15 ubiquitin specific peptidase 15 multiple interactions
increases expression
ISO Calcium affects the reaction [Morphine results in increased expression of USP15 mRNA]; CTAP octapeptide inhibits the reaction [Morphine results in increased expression of USP15 mRNA]; USP15 mutant form inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]
Morphine results in increased expression of USP15 mRNA; Morphine results in increased expression of USP15 protein
CTD PMID:24068670 NCBI chr 7:66,595,707...66,687,707
Ensembl chr 7:66,595,742...66,687,278
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Morphine results in increased expression of VEGFA protein CTD PMID:19356684 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin multiple interactions
increases expression
EXP Morphine deficiency affects the reaction [Morphine results in increased expression of VIM protein] CTD PMID:23056601 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon decreases expression EXP Morphine results in decreased expression of YWHAE protein CTD PMID:23056601 NCBI chr10:63,884,338...63,921,709
Ensembl chr10:63,884,338...63,921,709
JBrowse link
G Zfp239 zinc finger protein 239 increases expression ISO Morphine results in increased expression of ZFP239 mRNA CTD PMID:21178816 NCBI chr 4:149,902,278...149,909,841
Ensembl chr 4:149,908,375...149,908,980
JBrowse link
G Zic1 Zic family member 1 increases expression ISO Morphine results in increased expression of ZIC1 mRNA CTD PMID:21955143 NCBI chr 8:98,733,715...98,738,960
Ensembl chr 8:98,734,295...98,738,446
JBrowse link
morphinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO morphinone results in increased activity of CASP3 protein CTD PMID:17094451 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
nalbuphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin increases expression ISO Nalbuphine results in increased expression of PRL protein CTD PMID:17391744 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Nalbuphine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
norcodeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CTD PMID:16595712 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
oxycodone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 increases expression EXP Oxycodone results in increased expression of ABCA8 mRNA CTD PMID:23439660 NCBI chr10:98,236,919...98,308,288
Ensembl chr10:98,237,141...98,294,522
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP Oxycodone results in increased expression of ABCB1A mRNA; Oxycodone results in increased expression of ABCB1A protein CTD PMID:23439660 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression EXP Oxycodone results in increased expression of ABCB4 mRNA CTD PMID:23439660 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression EXP Oxycodone results in decreased expression of ABCG1 mRNA CTD PMID:23439660 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP Oxycodone results in increased expression of ABCG5 mRNA CTD PMID:23439660 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Abhd6 abhydrolase domain containing 6, acylglycerol lipase increases expression EXP Oxycodone results in increased expression of ABHD6 mRNA CTD PMID:23439660 NCBI chr15:18,647,903...18,695,133
Ensembl chr15:18,647,844...18,695,133
JBrowse link
G Acsm2 acyl-CoA synthetase medium-chain family member 2 increases expression EXP Oxycodone results in increased expression of ACSM2A mRNA CTD PMID:23439660 NCBI chr 1:189,289,957...189,329,007
Ensembl chr 1:189,289,957...189,395,276
JBrowse link
G Actn1 actinin, alpha 1 decreases expression EXP Oxycodone results in decreased expression of ACTN1 mRNA CTD PMID:23439660 NCBI chr 6:103,376,557...103,470,497
Ensembl chr 6:103,375,799...103,470,555
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 decreases expression EXP Oxycodone results in decreased expression of ADAM17 mRNA CTD PMID:23439660 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression EXP Oxycodone results in increased expression of ADAMTS1 mRNA CTD PMID:23439660 NCBI chr11:25,342,119...25,350,938
Ensembl chr11:25,342,126...25,350,974
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 decreases expression EXP Oxycodone results in decreased expression of ADGRE1 mRNA CTD PMID:23439660 NCBI chr 9:9,431,888...9,585,883
Ensembl chr 9:9,431,860...9,585,865
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression EXP Oxycodone results in increased expression of AHR mRNA CTD PMID:23439660 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases expression EXP Oxycodone results in decreased expression of AKR1C3 mRNA CTD PMID:23439660 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Anxa3 annexin A3 decreases expression EXP Oxycodone results in decreased expression of ANXA3 mRNA CTD PMID:23439660 NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta decreases expression EXP Oxycodone results in decreased expression of ARHGDIB mRNA CTD PMID:23439660 NCBI chr 4:170,913,920...170,932,789
Ensembl chr 4:170,913,923...170,932,618
JBrowse link
G Asl argininosuccinate lyase increases expression EXP Oxycodone results in increased expression of ASL mRNA CTD PMID:23439660 NCBI chr12:30,160,922...30,178,348
Ensembl chr12:30,165,694...30,178,341
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO
EXP
Oxycodone results in increased expression of ATF4 protein CTD PMID:26377394 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 increases expression EXP Oxycodone results in increased expression of ATP1B1 mRNA CTD PMID:23439660 NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004
JBrowse link
G B4galnt1 beta-1,4-N-acetyl-galactosaminyl transferase 1 increases expression EXP Oxycodone results in increased expression of B4GALNT1 mRNA CTD PMID:23439660 NCBI chr 7:70,439,273...70,459,556
Ensembl chr 7:70,452,579...70,459,880
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression EXP Oxycodone results in decreased expression of BCL2A1 mRNA CTD PMID:23439660 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Blvra biliverdin reductase A decreases expression EXP Oxycodone results in decreased expression of BLVRA mRNA CTD PMID:23439660 NCBI chr 3:119,552,550...119,577,796
Ensembl chr 3:119,561,290...119,577,806
JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression EXP Oxycodone results in decreased expression of CA3 mRNA CTD PMID:23439660 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Cav2 caveolin 2 decreases expression EXP Oxycodone results in decreased expression of CAV2 mRNA CTD PMID:23439660 NCBI chr 4:44,573,264...44,580,640
Ensembl chr 4:44,573,264...44,580,638
JBrowse link
G Ccl6 chemokine (C-C motif) ligand 6 decreases expression EXP Oxycodone results in decreased expression of CCL6 mRNA CTD PMID:23439660 NCBI chr10:70,798,118...70,802,750
Ensembl chr10:70,797,124...70,802,782
JBrowse link
G Cd5l Cd5 molecule-like decreases expression EXP Oxycodone results in decreased expression of CD5L mRNA CTD PMID:23439660 NCBI chr 2:186,685,104...186,696,117
Ensembl chr 2:186,685,104...186,696,117
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Oxycodone results in increased expression of CDKN1A mRNA CTD PMID:23439660 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Ces2h carboxylesterase 2H affects expression
increases expression
EXP Oxycodone affects the expression of CES2 mRNA
Oxycodone results in increased expression of CES2 mRNA
CTD PMID:20487198, PMID:23439660 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Chd1l chromodomain helicase DNA binding protein 1-like increases expression EXP Oxycodone results in increased expression of CHD1L mRNA CTD PMID:23439660 NCBI chr 2:199,714,044...199,792,270
Ensembl chr 2:199,716,713...199,771,896
JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 decreases expression EXP Oxycodone results in decreased expression of CMTM6 mRNA CTD PMID:23439660 NCBI chr 8:122,789,208...122,807,560
Ensembl chr 8:122,789,453...122,807,560
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase decreases expression EXP Oxycodone results in decreased expression of CNP1 mRNA CTD PMID:23439660 NCBI chr10:88,490,798...88,497,357
Ensembl chr10:88,490,798...88,497,356
JBrowse link
G Cotl1 coactosin-like F-actin binding protein 1 decreases expression EXP Oxycodone results in decreased expression of COTL1 mRNA CTD PMID:23439660 NCBI chr19:52,465,074...52,499,433
Ensembl chr19:52,465,087...52,499,433
JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 decreases expression EXP Oxycodone results in decreased expression of CSRP1 mRNA CTD PMID:23439660 NCBI chr13:52,553,843...52,575,054
Ensembl chr13:52,553,775...52,575,051
JBrowse link
G Ctsc cathepsin C decreases expression EXP Oxycodone results in decreased expression of CTSC mRNA CTD PMID:23439660 NCBI chr 1:151,918,514...151,949,979
Ensembl chr 1:151,918,571...151,949,983