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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:prochlorperazine
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Accession:CHEBI:8435 term browser browse the term
Definition:A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.
Synonyms:exact_synonym: 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
 related_synonym: 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine;   3-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine;   Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine;   Formula=C20H24ClN3S;   InChI=1S/C20H24ClN3S/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24/h2-3,5-8,15H,4,9-14H2,1H3;   InChIKey=WIKYUJGCLQQFNW-UHFFFAOYSA-N;   N-(gamma-(4'-Methylpiperazinyl-1')propyl)-3-chlorophenothiazine;   Prochlorperazin;   Prochlorpermazine;   Prochlorpromazine;   Procloperazine;   SMILES=CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc23)CC1;   prochlorperazinum;   proclorperazina
 alt_id: CHEBI:59073
 xref: Beilstein:48537;   CAS:58-38-8;   DrugBank:DB00433;   Drug_Central:2274;   HMDB:HMDB0014577;   KEGG:C07403;   KEGG:D00493;   LINCS:LSM-2436
 xref_mesh: MESH:D011346
 xref: PMID:13808146;   PMID:1650428;   PMID:20825390;   PMID:4891872;   Patent:FR1167627;   Patent:GB780193;   Patent:US2902484;   Reaxys:48537;   Wikipedia:Prochlorperazine


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prochlorperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases activity ISO Prochlorperazine results in increased activity of ACHE protein CTD PMID:29614332 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Prochlorperazine binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Tfeb transcription factor EB affects localization ISO Prochlorperazine affects the localization of TFEB protein CTD PMID:28366621 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        pharmacological role 19026
          antagonist 17216
            dopamine receptor D2 antagonist 54
              prochlorperazine 3
                prochlorperazine maleate 0
                prochlorperazine methanesulfonate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            inorganic hydride 18093
                              pnictogen hydride 18082
                                nitrogen hydride 17989
                                  azane 17798
                                    ammonia 17797
                                      organic amino compound 17797
                                        tertiary amino compound 10131
                                          N-alkylpiperazine 3392
                                            N-methylpiperazine 1384
                                              prochlorperazine 3
                                                prochlorperazine maleate 0
                                                prochlorperazine methanesulfonate 0
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