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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:primidone
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Accession:CHEBI:8412 term browser browse the term
Definition:A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.
Synonyms:exact_synonym: 5-ethyl-5-phenyldihydropyrimidine-4,6(1H,5H)-dione
 related_synonym: 2-deoxyphenobarbital;   5-Phenyl-5-ethyl-Hexahydropyrimidine-4,6-dione;   Formula=C12H14N2O2;   InChI=1S/C12H14N2O2/c1-2-12(9-6-4-3-5-7-9)10(15)13-8-14-11(12)16/h3-7H,2,8H2,1H3,(H,13,15)(H,14,16);   InChIKey=DQMZLTXERSFNPB-UHFFFAOYSA-N;   SMILES=CCC1(C(=O)NCNC1=O)c1ccccc1;   primidona;   primidonum
 xref: CAS:125-33-7;   DrugBank:DB00794;   Drug_Central:2267;   HMDB:HMDB0014932;   KEGG:C07371;   KEGG:D00474;   LINCS:LSM-2700
 xref_mesh: MESH:D011324
 xref: PMID:10716065;   PMID:17253477;   PMID:24712318;   PMID:24812533;   Reaxys:218034;   Wikipedia:Primidone


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primidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases activity EXP Primidone results in decreased activity of ABCB11 protein CTD PMID:28437613 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP Primidone results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759 		JBrowse link
G IL1A interleukin 1 alpha increases expression EXP Primidone results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL24 interleukin 24 increases expression EXP Primidone results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr 1:206,897,443...206,904,139
Ensembl chr 1:206,897,443...206,904,139 		JBrowse link
G PON1 paraoxonase 1 decreases activity EXP Primidone results in decreased activity of PON1 protein CTD PMID:28032682 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532 		JBrowse link
G S100A8 S100 calcium binding protein A8 increases expression EXP Primidone results in increased expression of S100A8 mRNA CTD PMID:28138970 NCBI chr 1:153,390,032...153,422,583
Ensembl chr 1:153,390,032...153,391,073 		JBrowse link
G S100A9 S100 calcium binding protein A9 increases expression EXP Primidone results in increased expression of S100A9 mRNA CTD PMID:28138970 NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023 		JBrowse link
G SLPI secretory leukocyte peptidase inhibitor decreases expression EXP Primidone results in decreased expression of SLPI mRNA CTD PMID:32816093 NCBI chr20:45,252,239...45,254,564
Ensembl chr20:45,252,239...45,254,564 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      biological role 25935
        xenobiotic 20362
          primidone 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            organic molecule 25223
                              organic cyclic compound 24277
                                organic heterocyclic compound 22320
                                  organic heteromonocyclic compound 19213
                                    diazines 13351
                                      pyrimidines 13193
                                        pyrimidone 10508
                                          primidone 8
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