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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxaprozin
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Accession:CHEBI:7822 term browser browse the term
Definition:A monocarboxylic acid that is a propionic acid derivative having a 4,5-diphenyl-1,3-oxazol-2-yl substituent at position 3. It is non-steroidal anti-inflammatory drug commonly used to relieve the pain and inflammatory responses associated with osteoarthritis and rheumatoid arthritis.
Synonyms:exact_synonym: 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid
 related_synonym: Danoprox;   Daypro;   Dayrun;   Deflam;   Duraprox;   Formula=C18H15NO3;   InChI=1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21);   InChIKey=OFPXSFXSNFPTHF-UHFFFAOYSA-N;   SMILES=OC(=O)CCc1nc(-c2ccccc2)c(o1)-c1ccccc1;   Walix;   oxaprozina;   oxaprozine;   oxaprozinum
 xref: CAS:21256-18-8;   DrugBank:DB00991;   Drug_Central:2013;   HMDB:HMDB0015126;   KEGG:C07356;   KEGG:D00463;   LINCS:LSM-2553
 xref_mesh: MESH:C008729
 xref: PMID:1603605;   PMID:1617910;   PMID:19338579;   PMID:19672323;   PMID:20206429;   PMID:23865335;   PMID:385873;   PMID:6432657;   PMID:6611288;   PMID:6863578;   PMID:9459947;   Patent:FR2001036;   Patent:GB1206403;   Patent:US3578671;   Patent:WO2007082542;   Reaxys:1083168;   Wikipedia:Oxaprozin


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oxaprozin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsf1 heat shock transcription factor 1 increases activity ISO Oxaprozin results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO oxaprozin results in increased expression of NGFR protein CTD PMID:17409433 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO oxaprozin results in increased activity of PPARG protein CTD PMID:12065695 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Oxaprozin affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        pharmacological role 19058
          analgesic 14740
            oxaprozin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      monocarboxylic acid 18008
                                        fatty acid 16809
                                          saturated fatty acid 16535
                                            propionic acid 3803
                                              oxaprozin 4
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