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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Gly-His-Lys
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Accession:CHEBI:75430 term browser browse the term
Definition:A tripeptide composed of glycine, L-histidine and L-lysine residues joined in sequence.
Synonyms:exact_synonym: glycyl-L-histidyl-L-lysine
 related_synonym: Formula=C14H24N6O4;   GHK;   Gly-L-His-L-Lys;   Glycyl-histidyl-lysine;   InChI=1S/C14H24N6O4/c15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9/h7-8,10-11H,1-6,15-16H2,(H,17,18)(H,19,21)(H,20,22)(H,23,24)/t10-,11-/m0/s1;   InChIKey=MVORZMQFXBLMHM-QWRGUYRKSA-N;   SMILES=NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN)C(O)=O;   glycylhistidyllysine;   liver cell growth factor
 xref: CAS:49557-75-7;   CBA:545731
 xref_mesh: MESH:C020905
 xref: PMID:18644225;   PMID:20143136;   PMID:21457130;   PMID:21780203;   PMID:21898044;   PMID:22666519;   PMID:22937864;   PMID:22999295;   PMID:23019153;   PMID:23285694;   PMID:23744835;   Reaxys:965283


show annotations for term's descendants           Sort by:
Gly-His-Lys term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 multiple interactions ISO glycyl-histidyl-lysine inhibits the reaction [TNF protein results in increased secretion of IL6 protein] CTD PMID:23285694 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP [glycyl-histidyl-lysine co-treated with Copper] results in increased expression of MMP2 mRNA; [glycyl-histidyl-lysine co-treated with Copper] results in increased secretion of MMP2 protein CTD PMID:11045606 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [glycyl-histidyl-lysine co-treated with Copper] results in increased secretion of TIMP1 protein CTD PMID:11045606 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP [glycyl-histidyl-lysine co-treated with Copper] results in increased secretion of TIMP2 protein CTD PMID:11045606 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO glycyl-histidyl-lysine inhibits the reaction [TNF protein results in increased secretion of IL6 protein] CTD PMID:23285694 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          metabolite 19484
            Gly-His-Lys 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          carbamoyl group 17526
                                            carboxamide 17526
                                              peptide 11122
                                                oligopeptide 1339
                                                  tripeptide 972
                                                    Gly-His-Lys 5
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