The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A 13 amino acid peptide hormone which is found in the central nervous system and the gastrointestinal tract. It behaves as a neurotransmitter in the brain, as a hormone in the gut, and also as a neuromodulator. It is implicated in the pathophysiology of several CNS disorders (including schizophrenia, Parkinson's disease, drug abuse, pain, cancer, inflammation, eating disorders and central control of blood pressure) due to its association with a wide variety of neurotransmitter systems such as dopaminergic, sertonergic, glutamatergic, GABAergic, and cholinergic systems.
Neurotensin results in increased activity of FOS protein [Neurotensin results in increased activity of FOS protein] which results in increased expression of CXCL8 protein
Neurotensin results in increased activity of FOSL1 protein [Neurotensin results in increased activity of FOSL1 protein] which results in increased expression of CXCL8 protein
Neurotensin results in increased activity of NFKB1 protein [Neurotensin results in increased activity of NFKB1 protein] which results in increased expression of CXCL8 mRNA
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