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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:peptide hormone
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Accession:CHEBI:25905 term browser browse the term
Definition:Any peptide with hormonal activity in animals, whether endocrine, neuroendocrine, or paracrine.
Synonyms:related_synonym: peptide hormones;   polypeptide hormone


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alpha-melanocyte stimulating hormone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cartpt CART prepropeptide multiple interactions EXP alpha-MSH binds to and results in increased activity of CARTPT protein CTD PMID:15659233 NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:31,255,098...31,290,713 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO alpha-MSH results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine affects the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]]; Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]; Resveratrol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]		 CTD PMID:29486182 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein]]; Acetylcysteine affects the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein]]; Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein]; Resveratrol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein] CTD PMID:29486182 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mitf melanocyte inducing transcription factor multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [alpha-MSH results in increased expression of MITF protein]; [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein; Acetylcysteine inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]] which results in decreased ubiquitination of MITF protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]; Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]; Resveratrol inhibits the reaction [alpha-MSH results in increased expression of MITF protein] CTD PMID:29486182 NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:130,409,217...130,621,145 		JBrowse link
G Retn resistin increases expression ISO alpha-MSH analog results in increased expression of RETN mRNA CTD PMID:15522996 NCBI chr12:6,508,653...6,511,115
Ensembl chr12:1,710,881...1,712,620 		JBrowse link
G Tyr tyrosinase multiple interactions
increases activity
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of TYR protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [alpha-MSH results in increased expression of TYR protein]; alisol B inhibits the reaction [alpha-MSH results in increased activity of TYR protein]; glabridin inhibits the reaction [alpha-MSH results in increased activity of TYR protein]; Phytol inhibits the reaction [alpha-MSH results in increased expression of TYR protein]; Resveratrol inhibits the reaction [alpha-MSH results in increased expression of TYR protein] CTD PMID:28051915 PMID:29486182 NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases expression
multiple interactions		 ISO alpha-MSH results in increased expression of TYRP1 protein
Phytol inhibits the reaction [alpha-MSH results in increased expression of TYRP1 protein]		 CTD PMID:29486182 NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
angiotensin I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 affects abundance ISO [ACE2 protein affects the abundance of Angiotensin I] which affects the abundance of angiotensin I (1-7); [ACE2 protein affects the abundance of Angiotensin I] which affects the abundance of Angiotensin II; ACE2 protein affects the abundance of Angiotensin I CTD PMID:27649628 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
angiotensin II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 affects abundance ISO [ACE2 protein affects the abundance of Angiotensin I] which affects the abundance of Angiotensin II; ACE2 protein affects the abundance of Angiotensin II CTD PMID:27649628 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Agt angiotensinogen multiple interactions ISO [[Lisinopril co-treated with chymostatin] affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [Lisinopril affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II CTD PMID:27649628 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression EXP Angiotensin II results in increased expression of AGTR2 mRNA; Angiotensin II results in increased expression of AGTR2 protein CTD PMID:12969123 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in increased expression of BAX mRNA] CTD PMID:38230784 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO angiotensin II increases expression of mRNA in mouse heart RGD PMID:26873969 RGD:11526363 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp4 bone morphogenetic protein 4 increases expression ISO angiotensin II increases expression of mRNA in mouse heart RGD PMID:26873969 RGD:11526363 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in increased expression of CCL2 mRNA] CTD PMID:38230784 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of COL1A1 mRNA] CTD PMID:33746155 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression ISO Angiotensin II results in increased expression of COL3A1 mRNA CTD PMID:33746155 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions
decreases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]] CTD PMID:37269933 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Ednrb endothelin receptor type B increases expression EXP Angiotensin II results in increased expression of EDNRB protein CTD PMID:15007106 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Esrra estrogen related receptor, alpha decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of ESRRA protein
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]]		 CTD PMID:37269933 NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions
increases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in increased expression of FIS1 protein] CTD PMID:38230784 NCBI chr12:25,345,239...25,360,135
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Id1 inhibitor of DNA binding 1 increases expression ISO angiotensin II increases expression of mRNA in mouse heart RGD PMID:26873969 RGD:11526363 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 ISO Angiotensin II results in increased expression of IL1B mRNA
naoxintong inhibits the reaction [Angiotensin II results in increased expression of IL1B mRNA]		 CTD PMID:38230784 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in increased expression of IL6 protein] CTD PMID:38230784 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation ISO Angiotensin II increases phosphorylation of JAK2 protein in liver RGD PMID:22613986 RGD:127285667 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Klf4 KLF transcription factor 4 increases expression ISO angiotensin II increases expression of KLF4 mRNA and protein in vascular smooth muscle cells RGD PMID:29127880 RGD:155230825 NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 increases expression ISO Angiotensin II increases expression of MAP3K7 mRNA in cardiomyocytes RGD PMID:30854566 RGD:155791647 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
multiple interactions		 ISO Angiotensin II results in decreased expression of MCL1 protein
naoxintong inhibits the reaction [Angiotensin II results in decreased expression of MCL1 protein]		 CTD PMID:38230784 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mir143 microRNA 143 decreases expression ISO Angiotensin II decreases expression of miRNA143 RNA in vascular smooth muscle cells RGD PMID:28167124 RGD:155260287 NCBI chr18:57,371,349...57,371,453
Ensembl chr18:55,101,006...55,101,110 		JBrowse link
G Mir145 microRNA 145 decreases expression ISO angiotensin II decreases expression of MIR145a RNA in vascular smooth muscle cell
Angiotensin II decreases expression of miRNA145 RNA in vascular smooth muscle cells		 RGD PMID:29127880 PMID:28167124 RGD:155230825, RGD:155260287 NCBI chr18:57,369,983...57,370,070
Ensembl chr18:55,099,640...55,099,727 		JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions
decreases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of MYH6 mRNA alternative form] CTD PMID:37269933 NCBI chr15:32,388,102...32,413,663
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myocd myocardin decreases expression ISO angiotensin II decreases expression of MYOCD mRNA and protein in vascular smooth muscle cell RGD PMID:29127880 RGD:155230825 NCBI chr10:50,332,356...50,426,819
Ensembl chr10:49,836,641...49,927,627 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]; NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of NOX4 protein] CTD PMID:33746155 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of NOX4 protein]
Angiotensin II results in increased expression of NOX4 mRNA
naoxintong inhibits the reaction [Angiotensin II results in increased expression of NOX4 mRNA]		 CTD PMID:33746155 PMID:38230784 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions ISO angiotensin II inhibits reaction [fluvastatin increases expression of Nphs1 protein in kidney] RGD PMID:19188342 RGD:38596324 NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Nppa natriuretic peptide A increases expression
multiple interactions		 ISO
EXP		 angiotensin II increases expression of mRNA in mouse heart
Angiotensin II results in increased expression of NPPA mRNA
celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of NPPA mRNA]		 CTD
RGD		 PMID:37269933 PMID:26873969 RGD:11526363 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B increases expression
multiple interactions		 ISO
EXP		 angiotensin II increases expression of mRNA in mouse heart
Angiotensin II results in increased expression of NPPB mRNA
celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of NPPB mRNA]		 CTD
RGD		 PMID:37269933 PMID:26873969 RGD:11526363 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO Angiotensin II decreases expression of NR1H3 mRNA and protein in macrophages RGD PMID:25225013 RGD:401827926 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects response to substance ISO NR1I2 protein affects the susceptibility to Angiotensin II CTD PMID:33746155 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 multiple interactions
decreases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]] CTD PMID:37269933 NCBI chr  X:38,509,158...38,522,986
Ensembl chr  X:34,700,409...34,714,311 		JBrowse link
G Pfkm phosphofructokinase, muscle increases expression
multiple interactions		 EXP Angiotensin II results in increased expression of PFKM mRNA
celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]]		 CTD PMID:37269933 NCBI chr 7:131,100,684...131,138,250
Ensembl chr 7:129,221,653...129,259,192 		JBrowse link
G Postn periostin increases expression ISO Angiotensin II results in increased expression of POSTN mRNA; Angiotensin II results in increased expression of POSTN protein CTD PMID:33746155 NCBI chr 2:140,677,774...140,709,304
Ensembl chr 2:138,527,696...138,559,099 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]] CTD PMID:37269933 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
decreases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PPARGC1A protein] CTD PMID:37269933 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of PPARGC1B protein
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PPARGC1B protein]		 CTD PMID:37269933 NCBI chr18:57,029,264...57,131,466
Ensembl chr18:54,758,902...54,861,194 		JBrowse link
G Prkd1 protein kinase D1 affects localization EXP Angiotensin II affects localization of Prkd1 protein in cardiomyocytes RGD PMID:15652511 RGD:288084581 NCBI chr 6:73,460,640...73,774,433
Ensembl chr 6:67,725,905...68,039,042 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 increases expression EXP Angiotensin II increases expression of Ptpn1 protein in cardiac microvascular endothelial cells RGD PMID:31502193 RGD:401976382 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Rbfox2 RNA binding fox-1 homolog 2 decreases expression EXP Angiotensin II decreases expression of Rbfox2 mRNA and protein in vascular smooth muscle cells RGD PMID:28993448 RGD:329848961 NCBI chr 7:110,691,230...110,934,901
Ensembl chr 7:108,810,628...109,054,691 		JBrowse link
G Sox17 SRY-box transcription factor 17 increases expression
decreases expression 		ISO Angiotensin II increases expression of SOX17 mRNA and protein in retinal microvascular endothelial cells
Angiotensin II decreases expression of SOX17 protein in retinal endothelial cells		 RGD PMID:36200131 PMID:32078435 RGD:329853320, RGD:329853329 NCBI chr 5:19,814,345...19,819,859
Ensembl chr 5:15,016,731...15,022,228 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Angiotensin II increases expression of Spp1 protein in vascular smooth muscle cells RGD PMID:28167124 RGD:155260287 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tfam transcription factor A, mitochondrial decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of TFAM protein
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]]		 CTD PMID:37269933 NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO Angiotensin II results in increased expression of TNF mRNA
naoxintong inhibits the reaction [Angiotensin II results in increased expression of TNF mRNA]		 CTD PMID:38230784 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Traf6 TNF receptor associated factor 6 increases expression EXP Angiotensin II increases expression of Traf6 protein in rat neonatal cardiomyocytes RGD PMID:27249171 RGD:155646134 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 decreases expression EXP Angiotensin II decreases expression of Zeb2 mRNA and protein in rat renal artery endothelial cells RGD PMID:31881206 RGD:155882533 NCBI chr 3:49,624,028...49,754,323
Ensembl chr 3:29,218,301...29,345,157 		JBrowse link
argipressin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avpr1a arginine vasopressin receptor 1A multiple interactions
increases activity		 ISO vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine- inhibits the reaction [Arginine Vasopressin results in increased activity of AVPR1A protein] CTD PMID:31323226 NCBI chr 7:59,999,743...60,003,667
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression
multiple interactions		 EXP Arginine Vasopressin results in increased expression of HSPB1 mRNA; Arginine Vasopressin results in increased expression of HSPB1 protein
Pentobarbital inhibits the reaction [Arginine Vasopressin results in increased expression of HSPB1 mRNA]; Pentobarbital inhibits the reaction [Arginine Vasopressin results in increased expression of HSPB1 protein]		 CTD PMID:10839933 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity
multiple interactions		 EXP Arginine Vasopressin results in increased activity of MAPK1 protein
4'-(4,4-difluoro-5-(2-oxo-2-(4-piperidinopiperidino)ethylidene)-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)-2-methyl-3-furanilide inhibits the reaction [Arginine Vasopressin results in increased activity of MAPK1 protein]		 CTD PMID:16966841 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Myl9 myosin light chain 9 increases phosphorylation EXP Arginine Vasopressin results in increased phosphorylation of MYL9 protein CTD PMID:15347643 NCBI chr 3:165,742,020...165,748,409
Ensembl chr 3:145,281,937...145,288,333 		JBrowse link
G Nppa natriuretic peptide A decreases response to substance ISO NPPA protein results in decreased susceptibility to Arginine Vasopressin CTD PMID:8188982 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
calcitonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hcrt hypocretin neuropeptide precursor decreases expression EXP salmon calcitonin results in decreased expression of HCRT mRNA CTD PMID:12686383 NCBI chr10:86,190,289...86,191,524
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Pmch pro-melanin-concentrating hormone decreases expression EXP salmon calcitonin results in decreased expression of PMCH mRNA CTD PMID:12686383 NCBI chr 7:24,399,404...24,400,720
Ensembl chr 7:22,511,934...22,513,250 		JBrowse link
corticotropin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase increases activity ISO Adrenocorticotropic Hormone results in increased activity of ADA protein CTD PMID:8868375 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Calca calcitonin-related polypeptide alpha increases abundance EXP CALCA protein results in increased abundance of Adrenocorticotropic Hormone CTD PMID:12639925 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase decreases activity EXP Adrenocorticotropic Hormone results in decreased activity of CNP protein CTD PMID:3030154 NCBI chr10:86,011,504...86,018,063
Ensembl chr10:85,511,160...85,517,720 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases secretion		 EXP Astemizole inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]; Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]; E 4031 inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]; Tetraethylammonium promotes the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone] CTD PMID:18835572 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects abundance ISO CYP17A1 protein affects the abundance of Adrenocorticotropic Hormone CTD PMID:18645707 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Gh1 growth hormone 1 multiple interactions ISO Adrenocorticotropic Hormone inhibits the reaction [INS protein results in increased secretion of GH1 protein] CTD PMID:3008584 NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
affects expression		 EXP Bupropion inhibits the reaction [Adrenocorticotropic Hormone affects the expression of HTR2A mRNA] CTD PMID:18239281 NCBI chr15:56,360,647...56,428,703
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO Adrenocorticotropic Hormone inhibits the reaction [INS protein results in increased secretion of GH1 protein] CTD PMID:3008584 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects abundance ISO NR3C1 gene polymorphism affects the abundance of Adrenocorticotropic Hormone CTD PMID:17716631 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions ISO Cocaine promotes the reaction [PPP1R1B protein results in increased abundance of Adrenocorticotropic Hormone] CTD PMID:10516482 NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,347,731...83,356,775 		JBrowse link
G Ucn2 urocortin 2 increases abundance ISO UCN2 protein results in increased abundance of Adrenocorticotropic Hormone CTD PMID:16330704 NCBI chr 8:118,516,111...118,517,660
Ensembl chr 8:109,638,285...109,639,172 		JBrowse link
corticotropin-releasing hormone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crhr1 corticotropin releasing hormone receptor 1 increases expression
decreases activity
multiple interactions		 EXP Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA
Corticotropin-Releasing Hormone results in decreased activity of CRHR1 protein
Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in decreased activity of CRHR1 protein]; Pentobarbital inhibits the reaction [Corticotropin-Releasing Hormone results in increased expression of CRHR1 mRNA]		 CTD PMID:12093084 NCBI chr10:89,540,192...89,583,466
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
gastrin-17 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [gastrin 17 co-treated with CCKBR protein] results in decreased expression of BIRC2 CTD PMID:17704804 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO [gastrin 17 co-treated with CCKBR protein] results in decreased expression of BIRC3 CTD PMID:17704804 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Cckbr cholecystokinin B receptor multiple interactions ISO [gastrin 17 co-treated with CCKBR protein] results in decreased expression of BIRC2; [gastrin 17 co-treated with CCKBR protein] results in decreased expression of BIRC3; [gastrin 17 co-treated with CCKBR protein] results in increased expression of IER3 mRNA CTD PMID:17704804 NCBI chr 1:169,183,578...169,193,583
Ensembl chr 1:159,771,733...159,814,881 		JBrowse link
G Ier3 immediate early response 3 multiple interactions ISO [gastrin 17 co-treated with CCKBR protein] results in increased expression of IER3 mRNA CTD PMID:17704804 NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases activity ISO gastrin 17 results in decreased activity of NFKB1 protein CTD PMID:15623601 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases activity ISO gastrin 17 results in decreased activity of RELA protein CTD PMID:15623601 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sele selectin E decreases expression ISO gastrin 17 results in decreased expression of SELE protein CTD PMID:15623601 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
ghrelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnr1 cannabinoid receptor 1 multiple interactions EXP Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of CNR1 mRNA] CTD PMID:31468622 NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Glp1r glucagon-like peptide 1 receptor multiple interactions EXP Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of GLP1R mRNA] CTD PMID:31468622 NCBI chr20:8,973,393...9,011,622
Ensembl chr20:8,972,004...9,010,241 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ghrelin inhibits the reaction [High fat diet increases expression of IL1b mRNA in heart] RGD PMID:32084395 RGD:242905211 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ghrelin inhibits the reaction [High fat diet increases expression of Il6 mRNA in heart] RGD PMID:32084395 RGD:242905211 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mir33 microRNA 33 multiple interactions EXP Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of MIR33A mRNA] CTD PMID:31468622 NCBI chr 7:115,593,952...115,594,020
Ensembl chr 7:113,713,855...113,713,923 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO ghrelin inhibits the reaction [High fat diet increases expression of Tgfb1 mRNA in heart] RGD PMID:32084395 RGD:242905211 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ghrelin inhibits the reaction [high fat diet increases expression of TNF mRNA in heart] RGD PMID:32084395 RGD:242905211 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
glucagon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of ACTA2 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of ACTA2 mRNA] CTD PMID:29988851 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of and results in decreased secretion of ADIPOQ protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in decreased expression of and results in decreased secretion of ADIPOQ protein] CTD PMID:29988851 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Cat catalase multiple interactions ISO Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of CAT protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in decreased activity of CAT protein] CTD PMID:29988851 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of CCL2 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of CCL2 mRNA] CTD PMID:29988851 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of COL1A1 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of COL1A1 mRNA] CTD PMID:29988851 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CPT1A mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in decreased expression of CPT1A mRNA] CTD PMID:29988851 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP [Glucagon co-treated with Cyclic AMP] results in increased phosphorylation of CREB1 protein CTD PMID:22676303 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of FASN mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of FASN mRNA] CTD PMID:29988851 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions ISO Glucagon analog promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of FGF21 protein]; Glucagon analog promotes the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of FGF21 protein] CTD PMID:29988851 NCBI chr 1:105,219,825...105,221,376
Ensembl chr 1:96,083,441...96,090,454 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions EXP [Glucagon co-treated with Cyclic AMP] results in increased expression of G6PC1 mRNA; Fatty Acids analog inhibits the reaction [[Glucagon co-treated with Cyclic AMP] results in increased expression of G6PC1 mRNA] CTD PMID:22676303 NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gcgr glucagon receptor multiple interactions ISO Glucagon analog binds to and results in increased activity of GCGR protein CTD PMID:29988851 NCBI chr10:106,306,803...106,314,970
Ensembl chr10:105,808,473...105,816,640 		JBrowse link
G Glp1r glucagon-like peptide 1 receptor multiple interactions ISO Glucagon analog binds to and results in increased activity of GLP1R protein CTD PMID:29988851 NCBI chr20:8,973,393...9,011,622
Ensembl chr20:8,972,004...9,010,241 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of IL6 protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:29988851 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of INS1 protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of INS1 protein] CTD PMID:29988851 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Lep leptin multiple interactions ISO Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of LEP protein] CTD PMID:29988851 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lepr leptin receptor multiple interactions ISO Glucagon analog inhibits the reaction [[LEPR gene mutant form results in increased oxidation of Lipids] which results in increased abundance of Thiobarbituric Acid Reactive Substances]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in decreased activity of CAT protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in decreased expression of and results in decreased secretion of ADIPOQ protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in decreased expression of CPT1A mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in decreased expression of PPARA mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in decreased oxidation of and results in decreased metabolism of Fatty Acids]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased abundance of Cholesterol]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased abundance of Creatinine]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased abundance of Triglycerides]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased abundance of Urea]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of ACTA2 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of IL6 protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of INS1 protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of LEP protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of TNF protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of CCL2 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of COL1A1 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of FASN mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of MMP9 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of SCD1 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of SREBF1 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of TGFB1 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of TNF mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased oxidation of Lipids]; Glucagon analog promotes the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of FGF21 protein] CTD PMID:29988851 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of MMP9 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of MMP9 mRNA] CTD PMID:29988851 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions EXP [Glucagon co-treated with Cyclic AMP] results in increased expression of PCK1 mRNA; Fatty Acids analog inhibits the reaction [[Glucagon co-treated with Cyclic AMP] results in increased expression of PCK1 mRNA] CTD PMID:22676303 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of PPARA mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in decreased expression of PPARA mRNA] CTD PMID:29988851 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP [Glucagon co-treated with Cyclic AMP] results in increased expression of PPARGC1A mRNA; Fatty Acids analog inhibits the reaction [[Glucagon co-treated with Cyclic AMP] results in increased expression of PPARGC1A mRNA]; Fatty Acids analog inhibits the reaction [[Glucagon co-treated with Cyclic AMP] results in increased phosphorylation of PPARGC1A protein] CTD PMID:22676303 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SCD1 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of SCD1 mRNA] CTD PMID:29988851 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SREBF1 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of SREBF1 mRNA] CTD PMID:29988851 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of TGFB1 mRNA] CTD PMID:29988851 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of TNF protein]; Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF mRNA]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of TNF protein]; Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of TNF mRNA] CTD PMID:29988851 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
gonadorelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 multiple interactions ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gonadotropin-Releasing Hormone results in decreased expression of ESR1 protein]; Gonadotropin-Releasing Hormone results in increased ubiquitination of and results in increased degradation of and results in decreased expression of ESR1 protein CTD PMID:16055746 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Ube2d2 ubiquitin-conjugating enzyme E2D 2 increases expression ISO Gonadotropin-Releasing Hormone results in increased expression of UBE2D2 mRNA; Gonadotropin-Releasing Hormone results in increased expression of UBE2D2 protein CTD PMID:16055746 NCBI chr18:27,638,399...27,680,386
Ensembl chr18:27,364,303...27,406,181 		JBrowse link
Ile(5)-angiotensin II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 affects abundance ISO [ACE2 protein affects the abundance of Angiotensin I] which affects the abundance of Angiotensin II; ACE2 protein affects the abundance of Angiotensin II CTD PMID:27649628 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Agt angiotensinogen multiple interactions ISO [[Lisinopril co-treated with chymostatin] affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II; [Lisinopril affects the metabolism of AGT protein] which results in decreased abundance of Angiotensin II CTD PMID:27649628 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression EXP Angiotensin II results in increased expression of AGTR2 mRNA; Angiotensin II results in increased expression of AGTR2 protein CTD PMID:12969123 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in increased expression of BAX mRNA] CTD PMID:38230784 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions		 ISO Angiotensin II results in increased expression of CCL2 mRNA
naoxintong inhibits the reaction [Angiotensin II results in increased expression of CCL2 mRNA]		 CTD PMID:38230784 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions		 ISO Angiotensin II results in increased expression of COL1A1 mRNA
NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]		 CTD PMID:33746155 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression ISO Angiotensin II results in increased expression of COL3A1 mRNA CTD PMID:33746155 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of CPT1A mRNA
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]]		 CTD PMID:37269933 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Ednrb endothelin receptor type B increases expression EXP Angiotensin II results in increased expression of EDNRB protein CTD PMID:15007106 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions
decreases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]] CTD PMID:37269933 NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Fis1 fission, mitochondrial 1 increases expression
multiple interactions		 ISO Angiotensin II results in increased expression of FIS1 protein
naoxintong inhibits the reaction [Angiotensin II results in increased expression of FIS1 protein]		 CTD PMID:38230784 NCBI chr12:25,345,239...25,360,135
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in increased expression of IL1B mRNA] CTD PMID:38230784 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO Angiotensin II results in increased expression of IL6 protein
naoxintong inhibits the reaction [Angiotensin II results in increased expression of IL6 protein]		 CTD PMID:38230784 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
decreases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in decreased expression of MCL1 protein] CTD PMID:38230784 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Myh6 myosin heavy chain 6 decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of MYH6 mRNA
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of MYH6 mRNA alternative form]		 CTD PMID:37269933 NCBI chr15:32,388,102...32,413,663
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of COL1A1 mRNA]; NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of NOX4 protein] CTD PMID:33746155 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nox4 NADPH oxidase 4 increases expression
multiple interactions		 ISO Angiotensin II results in increased expression of NOX4 protein
naoxintong inhibits the reaction [Angiotensin II results in increased expression of NOX4 mRNA]
NFE2L2 protein affects the reaction [Angiotensin II results in increased expression of NOX4 protein]		 CTD PMID:33746155 PMID:38230784 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nppa natriuretic peptide A multiple interactions
increases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of NPPA mRNA] CTD PMID:37269933 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B multiple interactions
increases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of NPPB mRNA] CTD PMID:37269933 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects response to substance ISO NR1I2 protein affects the susceptibility to Angiotensin II CTD PMID:33746155 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of PDHA1 mRNA
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]]		 CTD PMID:37269933 NCBI chr  X:38,509,158...38,522,986
Ensembl chr  X:34,700,409...34,714,311 		JBrowse link
G Pfkm phosphofructokinase, muscle multiple interactions
increases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]] CTD PMID:37269933 NCBI chr 7:131,100,684...131,138,250
Ensembl chr 7:129,221,653...129,259,192 		JBrowse link
G Postn periostin increases expression ISO Angiotensin II results in increased expression of POSTN mRNA; Angiotensin II results in increased expression of POSTN protein CTD PMID:33746155 NCBI chr 2:140,677,774...140,709,304
Ensembl chr 2:138,527,696...138,559,099 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of CPT1A mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of ESRRA protein]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PDHA1 mRNA]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in increased expression of PFKM mRNA]] CTD PMID:37269933 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of PPARGC1A protein
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PPARGC1A protein]		 CTD PMID:37269933 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta multiple interactions
decreases expression		 EXP celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of PPARGC1B protein] CTD PMID:37269933 NCBI chr18:57,029,264...57,131,466
Ensembl chr18:54,758,902...54,861,194 		JBrowse link
G Tfam transcription factor A, mitochondrial decreases expression
multiple interactions		 EXP Angiotensin II results in decreased expression of TFAM protein
celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]; PPARA protein promotes the reaction [celastrol methyl ester inhibits the reaction [Angiotensin II results in decreased expression of TFAM protein]]		 CTD PMID:37269933 NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO naoxintong inhibits the reaction [Angiotensin II results in increased expression of TNF mRNA] CTD PMID:38230784 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Ile(5)-angiotensin II (1-7) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO Angiotensin-(1-7) increases expression of NR1H3 mRNA and protein in macrophages RGD PMID:25225013 RGD:401827926 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
insulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
increases activity		 ISO
EXP		 [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Insulin] results in decreased phosphorylation of AKT1 protein; [2-amino-3,4-dimethylimidazo(4,5-f)quinoline co-treated with Insulin] results in decreased phosphorylation of AKT1 protein; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Insulin] results in decreased phosphorylation of AKT1 protein
Insulin increases phosphorylation of Akt1 protein in cerebellar neurons
Insulin increases activity of Akt1 protein in adipocytes
Insulin increases activity of AKT1 protein in kidney cells		 CTD
RGD		 PMID:37005939 PMID:12088287 PMID:9112399 PMID:9202156 PMID:9065430 RGD:408345250, RGD:408345243, RGD:407987424, RGD:407420264 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Insulin] results in decreased phosphorylation of AKT2 protein; [2-amino-3,4-dimethylimidazo(4,5-f)quinoline co-treated with Insulin] results in decreased phosphorylation of AKT2 protein; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Insulin] results in decreased phosphorylation of AKT2 protein CTD PMID:37005939 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 multiple interactions ISO [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Insulin] results in decreased phosphorylation of AKT3 protein; [2-amino-3,4-dimethylimidazo(4,5-f)quinoline co-treated with Insulin] results in decreased phosphorylation of AKT3 protein; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Insulin] results in decreased phosphorylation of AKT3 protein CTD PMID:37005939 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP Insulin promotes the reaction [Ozone inhibits the reaction [Streptozocin results in increased expression of CASP1 mRNA]] CTD PMID:26614261 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Insulin promotes the reaction [Ozone inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA]] CTD PMID:26614261 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Insulin promotes the reaction [Ozone inhibits the reaction [Streptozocin results in increased expression of CASP9 mRNA]] CTD PMID:26614261 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO [Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA; cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA] CTD PMID:34575692 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA; cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA] CTD PMID:34575692 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP Insulin promotes the reaction [Ozone inhibits the reaction [Streptozocin results in increased expression of HIF1A mRNA]] CTD PMID:26614261 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Insr insulin receptor decreases expression EXP insulin decreases expression of hepatic mRNA in streptozocin treated rats RGD PMID:1280238 RGD:15036814 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 increases expression
multiple interactions		 EXP insulin increases expression of Kcnn4 mRNA and protein in vascular smooth muscle cells
2-(2-amino-3-methoxyphenyl)chromen-4-one inhibits the reaction [insulin increases expression of Kcnn4 mRNA and protein in vascular smooth muscle cells]		 RGD PMID:21463632 PMID:21463632 RGD:401794561, RGD:401794561 NCBI chr 1:89,084,306...89,102,279
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO [Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA; cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA] CTD PMID:34575692 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP [[Paraquat results in increased phosphorylation of MAPK8 protein] which results in decreased abundance of Insulin] which results in increased abundance of Glucose CTD PMID:36394833 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mir210 microRNA 210 increases expression
multiple interactions		 EXP Insulin increases expression of Mir210 miRNA in myocardial cell
LY294002 inhibits the reaction [Insulin increases expression of Mir210 miRNA in myocardial cell]		 RGD PMID:25968948 PMID:25968948 RGD:11086706, RGD:11086706 NCBI chr 1:205,755,923...205,756,032
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA; cordycepin inhibits the reaction [[Dexamethasone co-treated with Insulin co-treated with Indomethacin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA] CTD PMID:34575692 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions		 EXP
ISO		 insulin increases expression of Srebf1 mRNA in hepatoma cells
cilostazol inhibits the reaction [insulin increases expression of Srebf1 mRNA in liver cancer cells]
cilostazol inhibits the reaction [insulin increases expression of Srebf1 mRNA in primary hepatocytes]
cilostazol inhibits the reaction [insulin increases expression of Srebf1 mRNA in hepatoma cells] 		RGD PMID:24458133 PMID:24458133 PMID:24458133 PMID:24458133 PMID:24458133 More... RGD:401842379, RGD:401842379, RGD:401842379, RGD:401842379, RGD:401842379, RGD:401842379 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Insulin promotes the reaction [Ozone inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]] CTD PMID:26614261 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
insulin (human) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor increases secretion EXP Novorapid inhibits the reaction [Lipopolysaccharide increases secretion of Tnf protein in serum] RGD PMID:18078960 RGD:15023464 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
neurotensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases activity
multiple interactions		 ISO Neurotensin results in increased activity of FOS protein
[Neurotensin results in increased activity of FOS protein] which results in increased expression of CXCL8 protein		 CTD PMID:17000667 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases activity
multiple interactions		 ISO Neurotensin results in increased activity of FOSL1 protein
[Neurotensin results in increased activity of FOSL1 protein] which results in increased expression of CXCL8 protein		 CTD PMID:17000667 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases activity		 ISO [Neurotensin results in increased activity of JUNB protein] which results in increased expression of CXCL8 protein CTD PMID:17000667 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases activity
multiple interactions		 ISO Neurotensin results in increased activity of NFKB1 protein
[Neurotensin results in increased activity of NFKB1 protein] which results in increased expression of CXCL8 mRNA		 CTD PMID:17000667 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Ntsr1 neurotensin receptor 1 affects binding ISO Neurotensin binds to NTSR1 protein CTD PMID:19874804 NCBI chr 3:187,983,778...188,033,934
Ensembl chr 3:167,606,215...167,656,377 		JBrowse link
G Ntsr2 neurotensin receptor 2 affects binding ISO Neurotensin binds to NTSR2 protein CTD PMID:19874804 NCBI chr 6:39,424,297...39,431,015
Ensembl chr 6:39,424,324...39,431,014 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity		 ISO [Neurotensin results in increased activity of RELA protein] which results in increased expression of CXCL8 mRNA CTD PMID:17000667 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
oxytocin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator increases expression EXP Oxytocin results in increased expression of BCL2 protein CTD PMID:23707249 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Egfr epidermal growth factor receptor increases expression EXP Oxytocin results in increased expression of EGFR protein modified form CTD PMID:23707249 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 EXP Oxytocin results in increased expression of FOS protein
Oxytocin inhibits the reaction [Methamphetamine results in increased expression of FOS protein]		 CTD PMID:20731630 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gdf9 growth differentiation factor 9 increases expression EXP Oxytocin results in increased expression of GDF9 protein CTD PMID:23707249 NCBI chr10:38,090,021...38,100,801
Ensembl chr10:37,595,679...37,599,672 		JBrowse link
G Has2 hyaluronan synthase 2 increases expression EXP Oxytocin results in increased expression of HAS2 protein CTD PMID:23707249 NCBI chr 7:90,002,929...90,028,933
Ensembl chr 7:88,113,326...88,128,933 		JBrowse link
G Klf4 KLF transcription factor 4 multiple interactions
increases expression		 ISO KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE protein]]; KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 protein]]; MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein]; MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of KLF4 protein]
Oxytocin results in increased expression of KLF4 mRNA; Oxytocin results in increased expression of KLF4 protein		 CTD PMID:29104011 NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 multiple interactions ISO MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein] CTD PMID:29104011 NCBI chr 8:72,520,616...72,748,395
Ensembl chr 8:63,625,221...63,851,983 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression EXP Oxytocin results in increased expression of MAPK1 protein modified form CTD PMID:23707249 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression EXP Oxytocin results in increased expression of MAPK3 protein modified form CTD PMID:23707249 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mef2a myocyte enhancer factor 2a multiple interactions ISO MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein] CTD PMID:29104011 NCBI chr 1:130,258,083...130,392,819
Ensembl chr 1:120,850,080...120,981,948 		JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 multiple interactions EXP Oxytocin inhibits the reaction [Cisplatin results in increased expression of MKNK2 mRNA] CTD PMID:21993003 NCBI chr 7:9,690,385...9,701,527
Ensembl chr 7:9,039,728...9,050,827 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases response to substance EXP MMP2 protein results in decreased susceptibility to Oxytocin CTD PMID:22496348 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases response to substance EXP MMP9 protein results in decreased susceptibility to Oxytocin CTD PMID:22496348 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Noxo1 NADPH oxidase organizer 1 multiple interactions EXP Oxytocin inhibits the reaction [Cisplatin results in increased expression of NOXO1 mRNA] CTD PMID:21993003 NCBI chr10:14,226,473...14,230,541
Ensembl chr10:13,721,473...13,726,061 		JBrowse link
G Oxtr oxytocin receptor multiple interactions
increases expression		 EXP
ISO		 Oxytocin analog binds to and results in decreased activity of OXTR protein
Oxytocin results in increased expression of OXTR protein
guizhi-fuling inhibits the reaction [Oxytocin results in increased expression of OXTR protein]		 CTD PMID:9502799 PMID:27340106 NCBI chr 4:147,154,374...147,171,723
Ensembl chr 4:145,599,561...145,614,674 		JBrowse link
G Plcb1 phospholipase C beta 1 affects localization ISO Oxytocin affects the localization of PLCB1 protein CTD PMID:11579162 NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Plcb3 phospholipase C beta 3 affects localization ISO Oxytocin affects the localization of PLCB3 protein CTD PMID:11579162 NCBI chr 1:213,572,499...213,589,585
Ensembl chr 1:204,144,956...204,160,228 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 EXP
ISO		 Oxytocin results in increased expression of PTGS2 protein
guizhi-fuling inhibits the reaction [Oxytocin results in increased expression of PTGS2 protein]		 CTD PMID:23707249 PMID:27340106 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sele selectin E multiple interactions ISO KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE protein]]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE mRNA]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE protein] CTD PMID:29104011 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 increases expression EXP Oxytocin results in increased expression of TNFAIP6 protein CTD PMID:23707249 NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:36,502,188...36,521,649 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 protein]]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 mRNA]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 protein] CTD PMID:29104011 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
pasireotide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO pasireotide promotes the reaction [BMP2 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions ISO pasireotide promotes the reaction [BMP4 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO pasireotide promotes the reaction [BMP6 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions ISO pasireotide promotes the reaction [BMP7 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr 3:182,059,318...182,135,273
Ensembl chr 3:161,516,462...161,716,788 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO
EXP		 NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]] CTD PMID:23137853 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions EXP pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP19A1 mRNA] CTD PMID:23137853 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO
EXP		 NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]]
pasireotide inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]; pasireotide inhibits the reaction [FSHB protein results in increased abundance of Estradiol]; pasireotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]; pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]; pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP19A1 mRNA]; pasireotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]; pasireotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]		 CTD PMID:23137853 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions EXP pasireotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA] CTD PMID:23137853 NCBI chr 2:188,784,614...188,812,535
Ensembl chr 2:186,095,897...186,101,852 		JBrowse link
G Id1 inhibitor of DNA binding 1 multiple interactions ISO pasireotide promotes the reaction [BMP2 protein results in increased expression of ID1 mRNA]; pasireotide promotes the reaction [BMP4 protein results in increased expression of ID1 mRNA]; pasireotide promotes the reaction [BMP6 protein results in increased expression of ID1 mRNA]; pasireotide promotes the reaction [BMP7 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Nog noggin multiple interactions ISO NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]]; NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]] CTD PMID:23137853 NCBI chr10:74,625,874...74,627,501
Ensembl chr10:74,128,712...74,130,339 		JBrowse link
G Smad6 SMAD family member 6 decreases expression EXP pasireotide results in decreased expression of SMAD6 mRNA CTD PMID:23137853 NCBI chr 8:73,345,457...73,414,985
Ensembl chr 8:64,450,114...64,519,763 		JBrowse link
G Smad7 SMAD family member 7 decreases expression EXP pasireotide results in decreased expression of SMAD7 mRNA CTD PMID:23137853 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Sstr1 somatostatin receptor 1 affects binding ISO pasireotide binds to SSTR1 protein CTD PMID:16625840 NCBI chr 6:81,567,237...81,571,759
Ensembl chr 6:75,832,530...75,836,802 		JBrowse link
G Sstr2 somatostatin receptor 2 affects binding ISO pasireotide binds to SSTR2 protein CTD PMID:16625840 NCBI chr10:99,163,353...99,170,519
Ensembl chr10:98,664,216...98,674,351 		JBrowse link
G Sstr3 somatostatin receptor 3 affects binding ISO pasireotide binds to SSTR3 protein CTD PMID:16625840 NCBI chr 7:111,973,049...111,980,250
Ensembl chr 7:110,092,575...110,099,769 		JBrowse link
G Sstr4 somatostatin receptor 4 affects binding ISO pasireotide binds to SSTR4 protein CTD PMID:16625840 NCBI chr 3:156,307,992...156,309,855
Ensembl chr 3:135,854,826...135,856,689 		JBrowse link
G Sstr5 somatostatin receptor 5 affects binding ISO pasireotide binds to SSTR5 protein CTD PMID:16625840 NCBI chr10:15,010,209...15,017,469
Ensembl chr10:14,506,868...14,512,946 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO
EXP		 NOG protein inhibits the reaction [pasireotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]] CTD PMID:23137853 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
somatostatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcna5 potassium voltage-gated channel subfamily A member 5 multiple interactions EXP Somatostatin inhibits the reaction [Dexamethasone results in increased expression of KCNA5 mRNA] CTD PMID:15955845 NCBI chr 4:161,040,853...161,044,311
Ensembl chr 4:159,350,097...159,357,697 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO Somatostatin inhibits the reaction [Glucose increases expression of Ptpn1 protein in photoreceptor cells] RGD PMID:28050125 RGD:401976377 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Sstr1 somatostatin receptor 1 increases expression ISO Somatostatin results in increased expression of SSTR1 mRNA CTD PMID:18575731 NCBI chr 6:81,567,237...81,571,759
Ensembl chr 6:75,832,530...75,836,802 		JBrowse link
G Sstr2 somatostatin receptor 2 increases expression ISO Somatostatin results in increased expression of SSTR2 mRNA CTD PMID:18575731 NCBI chr10:99,163,353...99,170,519
Ensembl chr10:98,664,216...98,674,351 		JBrowse link
G Sstr3 somatostatin receptor 3 increases expression ISO Somatostatin results in increased expression of SSTR3 mRNA CTD PMID:18575731 NCBI chr 7:111,973,049...111,980,250
Ensembl chr 7:110,092,575...110,099,769 		JBrowse link
G Sstr4 somatostatin receptor 4 increases expression ISO Somatostatin results in increased expression of SSTR4 mRNA CTD PMID:18575731 NCBI chr 3:156,307,992...156,309,855
Ensembl chr 3:135,854,826...135,856,689 		JBrowse link
G Sstr5 somatostatin receptor 5 increases expression ISO Somatostatin results in increased expression of SSTR5 mRNA CTD PMID:18575731 NCBI chr10:15,010,209...15,017,469
Ensembl chr10:14,506,868...14,512,946 		JBrowse link
vasopressin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator increases activity ISO Vasopressins results in increased activity of CFTR protein CTD PMID:15513933 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Mylk myosin light chain kinase affects response to substance EXP MYLK protein affects the susceptibility to Vasopressins CTD PMID:15347643 NCBI chr11:79,288,243...79,535,450
Ensembl chr11:65,783,008...66,030,261 		JBrowse link
vasotocin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator increases activity ISO Vasotocin results in increased activity of CFTR protein CTD PMID:15685210 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        molecular messenger 18671
          hormone 18505
            peptide hormone 151
              P-factor 0
              [Hyp(3)]-bradykinin 0
              alpha-melanocyte stimulating hormone 7
              angiotensin + 46
              calcitonin 2
              corticotropin 11
              corticotropin-releasing hormone + 1
              gastrin + 7
              ghrelin 7
              glucagon 24
              gonadorelin 2
              insulin + 17
              kisspeptin-54 0
              neurotensin 7
              oxytocin + 21
              pasireotide 18
              peptide YY 0
              protirelin 0
              secretin + 0
              sermorelin 0
              somatostatin + 7
              somatostatin-28 0
              tesamorelin 0
              vasopressin + 7
              vasotocin 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            heteroorganic entity 19521
                              organochalcogen compound 19282
                                organooxygen compound 19197
                                  carbon oxoacid 18676
                                    carboxylic acid 18673
                                      carboacyl group 17700
                                        univalent carboacyl group 17700
                                          carbamoyl group 17545
                                            carboxamide 17545
                                              peptide 11445
                                                peptide hormone 151
                                                  P-factor 0
                                                  [Hyp(3)]-bradykinin 0
                                                  alpha-melanocyte stimulating hormone 7
                                                  angiotensin + 46
                                                  calcitonin 2
                                                  corticotropin 11
                                                  corticotropin-releasing hormone + 1
                                                  gastrin + 7
                                                  ghrelin 7
                                                  glucagon 24
                                                  gonadorelin 2
                                                  insulin + 17
                                                  kisspeptin-54 0
                                                  neurotensin 7
                                                  oxytocin + 21
                                                  pasireotide 18
                                                  peptide YY 0
                                                  protirelin 0
                                                  secretin + 0
                                                  sermorelin 0
                                                  somatostatin + 7
                                                  somatostatin-28 0
                                                  tesamorelin 0
                                                  vasopressin + 7
                                                  vasotocin 1
paths to the root