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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:eurycomanone
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Accession:CHEBI:65887 term browser browse the term
Definition:A quassinoid isolated from Eurycoma longifolia and has been shown to exhibit antineoplastic and antimalarial activties.
Synonyms:exact_synonym: (1beta,11beta,12alpha,15beta)-1,11,12,14,15-pentahydroxy-11,20-epoxypicrasa-3,13(21)-diene-2,16-dione
 related_synonym: Formula=C20H24O9;   InChI=1S/C20H24O9/c1-7-4-10(21)13(23)17(3)9(7)5-11-18-6-28-20(27,16(17)18)12(22)8(2)19(18,26)14(24)15(25)29-11/h4,9,11-14,16,22-24,26-27H,2,5-6H2,1,3H3/t9-,11+,12+,13+,14-,16+,17+,18+,19-,20+/m0/s1;   InChIKey=UCUWZJWAQQRCOR-AIMGAIMTSA-N;   Pasakbumin-A;   Picrasa-3,13(21)-diene-2,16-dione,11,2O-epoxy-1,11,12,14,15-pentahydroxy-,(1beta,11beta,12alpha,15beta)-,dihydrate;   SMILES=[H][C@@]12C[C@@]3([H])C(C)=CC(=O)[C@@H](O)[C@]3(C)[C@@]3([H])[C@]4(O)OC[C@@]13[C@@](O)([C@@H](O)C(=O)O2)C(=C)[C@H]4O
 xref: CAS:84633-29-4
 xref_mesh: MESH:C506425
 xref: PMID:1800638;   Reaxys:3635742


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eurycomanone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 decreases expression ISO eurycomanone results in decreased expression of ANXA1 mRNA; eurycomanone results in decreased expression of ANXA1 protein CTD PMID:21903368 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 decreases expression ISO eurycomanone results in decreased expression of ERP29 mRNA; eurycomanone results in decreased expression of ERP29 protein CTD PMID:21903368 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 decreases expression ISO eurycomanone results in decreased expression of HNRNPA2B1 protein CTD PMID:21903368 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249 		JBrowse link
G Phb1 prohibitin 1 decreases expression ISO eurycomanone results in decreased expression of PHB1 protein CTD PMID:21903368 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042 		JBrowse link
G Tp53 tumor protein p53 decreases expression ISO eurycomanone results in decreased expression of TP53 protein CTD PMID:21903368 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        biochemical role 19529
          metabolite 19515
            eurycomanone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbonyl compound 18898
                                    ketone 17187
                                      oxyketone 8905
                                        alpha-oxyketone 8905
                                          alpha-hydroxy ketone 8905
                                            secondary alpha-hydroxy ketone 1038
                                              eurycomanone 5
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