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triptorelin - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:triptorelin
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Accession:CHEBI:63633 term browser browse the term
Definition:An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-tryptophyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence. It is an agonist analogue of gonadotropin-releasing hormone.
Synonyms:exact_synonym: 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolylglycinamide
 related_synonym: (6-D-Tryptophan)luteinizing hormone-releasing hormone;   (D-Trp6)-GnRH;   Formula=C64H82N18O13;   InChI=1S/C64H82N18O13/c1-34(2)23-46(56(88)75-45(13-7-21-69-64(66)67)63(95)82-22-8-14-52(82)62(94)72-31-53(65)85)76-58(90)48(25-36-28-70-42-11-5-3-9-40(36)42)78-57(89)47(24-35-15-17-39(84)18-16-35)77-61(93)51(32-83)81-59(91)49(26-37-29-71-43-12-6-4-10-41(37)43)79-60(92)50(27-38-30-68-33-73-38)80-55(87)44-19-20-54(86)74-44/h3-6,9-12,15-18,28-30,33-34,44-52,70-71,83-84H,7-8,13-14,19-27,31-32H2,1-2H3,(H2,65,85)(H,68,73)(H,72,94)(H,74,86)(H,75,88)(H,76,90)(H,77,93)(H,78,89)(H,79,92)(H,80,87)(H,81,91)(H4,66,67,69)/t44-,45-,46-,47-,48+,49-,50-,51-,52-/m0/s1;   InChIKey=VXKHXGOKWPXYNA-PGBVPBMZSA-N;   Luteinizing hormone-releasing factor (pig), 6-D-tryptophan;   SMILES=CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O;   pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2;   triptorelina;   triptoreline;   triptorelinum
 xref: CAS:57773-63-4;   Drug_Central:2968;   KEGG:D06247
 xref_mesh: MESH:D017329
 xref: PMID:21040957;   PMID:21600174;   PMID:21693037;   PMID:21771987;   PMID:22231041;   Patent:EP1354952;   Patent:US2002111603;   Reaxys:9317315;   Wikipedia:Triptorelin

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triptorelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gnrhr gonadotropin releasing hormone receptor multiple interactions
affects expression		 ISO [Estradiol co-treated with Progesterone] inhibits the reaction [Triptorelin Pamoate affects the expression of GNRHR mRNA]; Estradiol inhibits the reaction [Triptorelin Pamoate affects the expression of GNRHR mRNA]; Progesterone promotes the reaction [Triptorelin Pamoate affects the expression of GNRHR mRNA] CTD PMID:17185802 NCBI chr14:22,211,666...22,229,654
Ensembl chr14:21,856,871...21,874,861 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression
increases expression		 EXP Triptorelin Pamoate results in decreased expression of LHB protein
Triptorelin Pamoate results in increased expression of LHB protein		 CTD PMID:3158510 PMID:20463352 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP testosterone enanthate inhibits the reaction [Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]]; testosterone enanthate inhibits the reaction [Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 protein]]; Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]; Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 protein] CTD PMID:20463352 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pde5a phosphodiesterase 5A multiple interactions EXP [testosterone enanthate co-treated with Triptorelin Pamoate] results in increased expression of PDE5A mRNA; [testosterone enanthate co-treated with Triptorelin Pamoate] results in increased expression of PDE5A protein CTD PMID:20463352 NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pde6d phosphodiesterase 6D decreases expression EXP Triptorelin Pamoate results in decreased expression of PDE6D mRNA CTD PMID:20463352 NCBI chr 9:94,640,932...94,685,918
Ensembl chr 9:87,192,983...87,237,969 		JBrowse link
G Pde9a phosphodiesterase 9A decreases expression EXP Triptorelin Pamoate results in decreased expression of PDE9A mRNA CTD PMID:20463352 NCBI chr20:9,471,136...9,564,286
Ensembl chr20:9,469,848...9,562,948 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 decreases expression
multiple interactions		 EXP Triptorelin Pamoate results in decreased expression of PRKG1 mRNA; Triptorelin Pamoate results in decreased expression of PRKG1 protein
testosterone enanthate promotes the reaction [Triptorelin Pamoate results in decreased expression of PRKG1 mRNA]; testosterone enanthate promotes the reaction [Triptorelin Pamoate results in decreased expression of PRKG1 protein]		 CTD PMID:20463352 NCBI chr 1:237,818,950...239,052,184
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Prl prolactin multiple interactions ISO
EXP		 Triptorelin Pamoate inhibits the reaction [Sulpiride results in increased abundance of PRL protein]
Triptorelin Pamoate inhibits the reaction [Haloperidol results in increased expression of PRL protein]		 CTD PMID:2954994 PMID:3158510 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
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  CHEBI ontology 19887
    role 19858
      application 19697
        pharmaceutical 19534
          drug 19534
            antineoplastic agent 17832
              triptorelin 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            heteroorganic entity 19521
                              organochalcogen compound 19282
                                organooxygen compound 19197
                                  carbon oxoacid 18676
                                    carboxylic acid 18673
                                      carboacyl group 17700
                                        univalent carboacyl group 17700
                                          carbamoyl group 17545
                                            carboxamide 17545
                                              peptide 11445
                                                oligopeptide 1360
                                                  triptorelin 8
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