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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:TCEP
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Accession:CHEBI:63213 term browser browse the term
Definition:A tertiary phosphine in which phosphane is substituted with three 2-carboxyethyl groups. It is a commonly used reducing agent.
Synonyms:exact_synonym: 3,3',3\"-phosphanetriyltripropanoic acid
 related_synonym: 3,3',3''-phosphinidynetrispropanoic acid;   Formula=C9H15O6P;   InChI=1S/C9H15O6P/c10-7(11)1-4-16(5-2-8(12)13)6-3-9(14)15/h1-6H2,(H,10,11)(H,12,13)(H,14,15);   InChIKey=PZBFGYYEXUXCOF-UHFFFAOYSA-N;   SMILES=OC(=O)CCP(CCC(O)=O)CCC(O)=O;   tris(2-carboxyethyl)phosphine
 xref: CAS:5961-85-3
 xref_mesh: MESH:C080938
 xref: Reaxys:1712644;   Wikipedia:TCEP


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TCEP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G As3mt arsenite methyltransferase multiple interactions
affects folding
increases reduction		 EXP
ISO		 tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased methylation of Arsenic]
tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased chemical synthesis of dimethylarsinous acid]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased chemical synthesis of methylarsonite]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased methylation of arsenite]
tris(2-carboxyethyl)phosphine affects the folding of AS3MT protein
tris(2-carboxyethyl)phosphine results in increased reduction of AS3MT protein		 CTD PMID:15025511 PMID:22955273 PMID:25349987 NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872 		JBrowse link
G Crygd crystallin, gamma D decreases oxidation ISO [tris(2-carboxyethyl)phosphine results in decreased oxidation of CRYGD protein] which results in decreased oxidation of CRYGD mRNA mutant form; tris(2-carboxyethyl)phosphine results in decreased oxidation of CRYGD protein CTD PMID:30242128 NCBI chr 9:66,442,057...66,443,668
Ensembl chr 9:66,442,054...66,444,067 		JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions ISO tris(2-carboxyethyl)phosphine inhibits the reaction [Cadmium promotes the reaction [MTF1 protein binds to MTF1 protein]]; tris(2-carboxyethyl)phosphine inhibits the reaction [Copper promotes the reaction [MTF1 protein binds to MTF1 protein]] CTD PMID:22057392 NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136 		JBrowse link
G Neil1 nei-like DNA glycosylase 1 multiple interactions ISO [tris(2-carboxyethyl)phosphine co-treated with Edetic Acid] inhibits the reaction [Copper results in decreased activity of NEIL1 protein]; tris(2-carboxyethyl)phosphine inhibits the reaction [Hydrogen Peroxide results in decreased activity of NEIL1 protein] CTD PMID:20622253 NCBI chr 8:57,550,142...57,556,884
Ensembl chr 8:57,550,147...57,556,258 		JBrowse link
G Slc34a1 solute carrier family 34 member 1 decreases activity EXP tris(2-carboxyethyl)phosphine results in decreased activity of SLC34A1 protein CTD PMID:10926679 NCBI chr17:9,218,876...9,233,852
Ensembl chr17:9,218,876...9,233,852 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO tris(2-carboxyethyl)phosphine inhibits the reaction [chromium hexavalent ion results in increased oxidation of TXN protein]; tris(2-carboxyethyl)phosphine inhibits the reaction [sodium chromate(VI) results in increased oxidation of TXN protein] CTD PMID:19135121 PMID:19703554 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txn2 thioredoxin 2 multiple interactions ISO tris(2-carboxyethyl)phosphine inhibits the reaction [chromium hexavalent ion results in increased oxidation of TXN2 protein] CTD PMID:19703554 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      chemical role 19498
        reducing agent 219
          TCEP 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organochalcogen compound 19290
                                organooxygen compound 19206
                                  carbon oxoacid 18675
                                    carboxylic acid 18672
                                      tricarboxylic acid 2510
                                        TCEP 7
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