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flumazenil - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:flumazenil
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Accession:CHEBI:5103 term browser browse the term
Definition:An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Synonyms:exact_synonym: ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
 related_synonym: Anexate;   Formula=C15H14FN3O3;   InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3;   InChIKey=OFBIFZUFASYYRE-UHFFFAOYSA-N;   Lanexat;   SMILES=C1=NC(=C2N1C=3C(C(N(C2)C)=O)=CC(=CC3)F)C(OCC)=O;   flumazenilo;   flumazenilum
 xref: CAS:78755-81-4;   DrugBank:DB01205;   Drug_Central:1195;   HMDB:HMDB0015336;   KEGG:C07825;   KEGG:D00697;   LINCS:LSM-4228
 xref_mesh: MESH:D005442
 xref: PMID:11881583;   PMID:23126253;   PMID:23431889;   PMID:24563235;   PMID:26324010;   PMID:26469689;   Reaxys:4763661;   Wikipedia:Flumazenil

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flumazenil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbi diazepam binding inhibitor multiple interactions ISO flumazenil inhibits the reaction [Ethanol increases expression of Dbi mRNA in cerebral cortex] RGD PMID:9526063 RGD:408346747 NCBI chr13:33,794,231...33,802,632
Ensembl chr13:31,206,988...31,268,693 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 affects binding
multiple interactions 		EXP Flumazenil binds to Gabra1 protein
Flumazenil inhibits the reaction [Ethanol deficiency results in decreased expression of GABRA1 mRNA]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]] 		CTD
RGD		 PMID:1977069 PMID:17403139 PMID:1346133 RGD:728715 NCBI chr10:27,096,731...27,152,563
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 multiple interactions EXP Flumazenil inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 mRNA]; Flumazenil inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 protein] CTD PMID:17403139 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844 		JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions
affects binding 		ISO Flumazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]
Flumazenil binds to [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein] 		CTD PMID:8632757 NCBI chr10:27,311,965...27,327,337
Ensembl chr10:26,810,423...26,825,769 		JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions EXP Flumazenil promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]] CTD PMID:1977069 NCBI chr14:36,434,339...36,917,920
Ensembl chr14:36,080,393...36,548,948 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 affects binding
multiple interactions 		ISO Flumazenil binds to [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]
Flumazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]] 		CTD PMID:8632757 NCBI chr 1:117,602,772...117,838,230
Ensembl chr 1:108,296,124...108,698,961 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions
affects binding 		ISO Flumazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]
Flumazenil binds to [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein] 		CTD PMID:8632757 NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Flumazenil inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Tspo translocator protein multiple interactions ISO [Flumazenil binds to and results in decreased activity of TSPO protein] which results in decreased susceptibility to Nicotine CTD PMID:7862733 NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:114,720,188...114,730,450 		JBrowse link
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  CHEBI ontology 19887
    role 19858
      biological role 19856
        pharmacological role 19088
          antagonist 17242
            GABA antagonist 3876
              flumazenil 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      chalcogen 19580
                        oxygen atom 19551
                          oxygen molecular entity 19551
                            hydroxides 19361
                              organic hydroxy compound 18971
                                alcohol 15766
                                  primary alcohol 14742
                                    ethanols 8967
                                      ethanol 8967
                                        ethyl ester 4453
                                          flumazenil 9
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