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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:flumazenil
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Accession:CHEBI:5103 term browser browse the term
Definition:An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Synonyms:exact_synonym: ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
 related_synonym: Anexate;   Formula=C15H14FN3O3;   InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3;   InChIKey=OFBIFZUFASYYRE-UHFFFAOYSA-N;   Lanexat;   SMILES=C1=NC(=C2N1C=3C(C(N(C2)C)=O)=CC(=CC3)F)C(OCC)=O;   flumazenilo;   flumazenilum
 xref: CAS:78755-81-4;   DrugBank:DB01205;   Drug_Central:1195;   HMDB:HMDB0015336;   KEGG:C07825;   KEGG:D00697;   LINCS:LSM-4228
 xref_mesh: MESH:D005442
 xref: PMID:11881583;   PMID:23126253;   PMID:23431889;   PMID:24563235;   PMID:26324010;   PMID:26469689;   Reaxys:4763661;   Wikipedia:Flumazenil


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flumazenil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbi diazepam binding inhibitor multiple interactions ISO flumazenil inhibits the reaction [Ethanol increases expression of Dbi mRNA in cerebral cortex] RGD PMID:9526063 RGD:408346747 NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions
affects binding		 EXP Flumazenil inhibits the reaction [Ethanol deficiency results in decreased expression of GABRA1 mRNA]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]]
Flumazenil binds to Gabra1 protein		 CTD
RGD		 PMID:1977069 PMID:17403139 PMID:1346133 RGD:728715 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 multiple interactions EXP Flumazenil inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 mRNA]; Flumazenil inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 protein] CTD PMID:17403139 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844 		JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions
affects binding		 ISO Flumazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]
Flumazenil binds to [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]		 CTD PMID:8632757 NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769 		JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions EXP Flumazenil promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]] CTD PMID:1977069 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 affects binding
multiple interactions		 ISO Flumazenil binds to [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]
Flumazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]		 CTD PMID:8632757 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions
affects binding		 ISO Flumazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]
Flumazenil binds to [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]		 CTD PMID:8632757 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Flumazenil inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Tspo translocator protein multiple interactions ISO [Flumazenil binds to and results in decreased activity of TSPO protein] which results in decreased susceptibility to Nicotine CTD PMID:7862733 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      biological role 19858
        pharmacological role 19090
          antagonist 17254
            GABA antagonist 3873
              flumazenil 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      chalcogen 19577
                        oxygen atom 19549
                          oxygen molecular entity 19529
                            hydroxides 19334
                              organic hydroxy compound 18963
                                alcohol 15714
                                  primary alcohol 14665
                                    ethanols 8821
                                      ethanol 8828
                                        ethyl ester 4147
                                          flumazenil 9
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