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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chicoric acid
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Accession:CHEBI:3594 term browser browse the term
Definition:An organooxygen compound that has formula C22H18O12.
Synonyms:exact_synonym: (2R,3R)-2,3-bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}butanedioic acid
 related_synonym: Formula=C22H18O12;   InChI=1S/C22H18O12/c23-13-5-1-11(9-15(13)25)3-7-17(27)33-19(21(29)30)20(22(31)32)34-18(28)8-4-12-2-6-14(24)16(26)10-12/h1-10,19-20,23-26H,(H,29,30)(H,31,32)/b7-3+,8-4+/t19-,20-/m1/s1;   InChIKey=YDDGKXBLOXEEMN-IABMMNSOSA-N;   SMILES=OC(=O)[C@H](OC(=O)\\C=C\\C1=CC=C(O)C(O)=C1)[C@@H](OC(=O)\\C=C\\C1=CC=C(O)C(O)=C1)C(O)=O;   dicaffeoyltartaric acid
 xref: CAS:70831-56-0;   FooDB:FDB012144;   HMDB:HMDB0002375;   KEGG:C10437;   KNApSAcK:C00002723
 xref_mesh: MESH:C100435
 xref: PDBeChem:GKP;   PMID:24244361;   PMID:30251662;   PMID:8692814;   Wikipedia:Cichoric_acid


show annotations for term's descendants           Sort by:
chicoric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation EXP chicoric acid results in increased phosphorylation of ACACA protein CTD PMID:24244361 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP chicoric acid inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein] CTD PMID:24244361 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Cs citrate synthase increases activity EXP chicoric acid results in increased activity of CS protein CTD PMID:24244361 NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:758,345...791,421 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP chicoric acid inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; chicoric acid inhibits the reaction [INS1 protein results in increased phosphorylation of MTOR protein] CTD PMID:24244361 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP chicoric acid inhibits the reaction [INS1 protein results in increased phosphorylation of MTOR protein] CTD PMID:24244361 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP chicoric acid results in increased expression of PPARGC1A mRNA CTD PMID:24244361 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP chicoric acid results in increased expression of SOD2 protein CTD PMID:24244361 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19870
      application 19713
        pharmaceutical 19549
          drug 19549
            protective agent 18260
              geroprotector 17411
                chicoric acid 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19537
                              organochalcogen compound 19297
                                organooxygen compound 19215
                                  carbon oxoacid 18693
                                    carboxylic acid 18690
                                      tetracarboxylic acid 559
                                        chicoric acid 7
paths to the root