CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: TRAM-34
Accession: CHEBI:34990
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Definition: An organochlorine compound that has formula C22H17ClN2.
Synonyms: related_synonym: 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole; Formula=C22H17ClN2; InChI=1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H; InChIKey=KBFUQFVFYYBHBT-UHFFFAOYSA-N; SMILES=Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1cccn1
xref: KEGG:C13784
xref_mesh: MESH:C411671
G
Acta2
actin alpha 2, smooth muscle
multiple interactions
EXP
TRAM 34 inhibits the reaction [Paraquat results in increased expression of ACTA2 protein]
CTD
PMID:30036685
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
G
Esr1
estrogen receptor 1
decreases expression
ISO
TRAM 34 results in decreased expression of ESR1 mRNA
CTD
PMID:20050851
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Kcnn4
potassium calcium-activated channel subfamily N member 4
decreases activity
ISO
TRAM 34 results in decreased activity of KCNN4 protein
CTD
PMID:20050851
NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
TRAM 34 binds to and results in increased activity of NR1I2 protein
CTD
PMID:20869355
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
multiple interactions
ISO
TRAM 34 binds to and results in increased activity of NR1I3 protein alternative form
CTD
PMID:20869355
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
G
Pgr
progesterone receptor
increases expression
ISO
TRAM 34 results in increased expression of PGR mRNA
CTD
PMID:20050851
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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