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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acenaphthylene
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Accession:CHEBI:33081 term browser browse the term
Definition:A ortho- and peri-fused tricyclic hydrocarbon that occurs in coal tar.
Synonyms:related_synonym: Formula=C12H8;   InChI=1S/C12H8/c1-3-9-4-2-6-11-8-7-10(5-1)12(9)11/h1-8H;   InChIKey=HXGDTGSAIMULJN-UHFFFAOYSA-N;   SMILES=c1cc2C=Cc3cccc(c1)c23;   cyclopenta[de]naphthalene
 xref: Beilstein:774092;   CAS:208-96-8;   Gmelin:102938
 xref_mesh: MESH:C042553
 xref: PMID:17824537;   PMID:24631927;   Reaxys:774092;   Wikipedia:Acenaphthylene


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acenaphthylene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 decreases expression EXP acenaphthylene results in decreased expression of CXCL8 mRNA CTD PMID:23724284 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression ISO acenaphthylene results in increased expression of CYP1A1 mRNA; acenaphthylene results in increased expression of CYP1A1 protein CTD PMID:10190573 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression
increases oxidation
multiple interactions
increases activity		 ISO
EXP		 acenaphthylene results in increased expression of CYP1A2 mRNA; acenaphthylene results in increased expression of CYP1A2 protein
CYP1A2 protein results in increased oxidation of acenaphthylene
[acenaphthylene co-treated with acenaphthene co-treated with dibenzofuran co-treated with fluorene co-treated with phenanthrene co-treated with anthracene] results in increased expression of CYP1A2 mRNA
acenaphthylene results in increased activity of CYP1A2 protein		 CTD PMID:7750161 PMID:8001243 PMID:10977129 PMID:25642975 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 increases expression
increases oxidation		 ISO
EXP		 acenaphthylene results in increased expression of CYP1B1 mRNA
CYP1B1 protein results in increased oxidation of acenaphthylene		 CTD PMID:10402558 PMID:25642975 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2A13 cytochrome P450 family 2 subfamily A member 13 increases oxidation EXP CYP2A13 protein results in increased oxidation of acenaphthylene; CYP2A13 protein results in increased oxidation of acenaphthylene metabolite CTD PMID:25642975 NCBI chr19:41,088,451...41,096,195
Ensembl chr19:41,088,451...41,096,195 		JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 increases oxidation EXP CYP2A6 protein results in increased oxidation of acenaphthylene; CYP2A6 protein results in increased oxidation of acenaphthylene metabolite CTD PMID:25642975 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases oxidation EXP CYP2C9 protein results in increased oxidation of acenaphthylene CTD PMID:25642975 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases oxidation EXP CYP3A4 protein results in increased oxidation of acenaphthylene CTD PMID:25642975 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP acenaphthylene results in increased cleavage of PARP1 protein CTD PMID:21132278 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26092
    role 26008
      biological role 25987
        aetiopathogenetic role 24625
          carcinogenic agent 22908
            polycyclic arene 19677
              ortho- and peri-fused polycyclic arene 18732
                acenaphthylene 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 26092
    subatomic particle 26067
      composite particle 26067
        hadron 26067
          baryon 26067
            nucleon 26067
              atomic nucleus 26067
                atom 26067
                  main group element atom 25894
                    main group molecular entity 25894
                      s-block molecular entity 25204
                        hydrogen molecular entity 24797
                          hydrides 22993
                            organic hydride 21946
                              organic fundamental parent 21946
                                hydrocarbon 21372
                                  cyclic hydrocarbon 20009
                                    arene 19989
                                      polycyclic arene 19677
                                        ortho- and peri-fused polycyclic arene 18732
                                          acenaphthylene 9
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