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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Siomycin A
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Accession:CHEBI:225824 term browser browse the term
Synonyms:exact_synonym: N-[3-[(3-amino-3-oxoprop-1-en-2-yl)amino]-3-oxoprop-1-en-2-yl]-2-[18-(2,3-dihydroxybutan-2-yl)-11-ethylidene-59-hydroxy-8,31-bis(1-hydroxyethyl)-26,46-dimethyl-40,43-dimethylidene-6,9,16,23,28,38,41,44,47-nonaoxo-37-propan-2-yl-27-oxa-3,13,20,56-tetrathia-7,10,17,24,36,39,42,45,48,52,58,61,62,63,64-pentadecazanonacyclo[23.23.9.329,35.12,5.112,15.119,22.154,57.01,53.032,60]tetrahexaconta-2(64),4,12(63),19(62),21,29(61),30,32(60),33,51,54,57-dodecaen-51-yl]-1,3-thiazole-4-carboxamide
 related_synonym: Formula=C71H81N19O18S5;   InChI=1S/C71H81N19O18S5/c1-14-37-64-83-44(22-109-64)61(103)89-52(70(13,107)34(12)93)67-85-43(23-112-67)59(101)88-48-33(11)108-68(106)40-19-36(31(9)91)35-15-16-38(50(94)49(35)79-40)78-46(25(2)3)62(104)77-29(7)56(98)74-27(5)55(97)75-30(8)57(99)90-71(69-86-45(24-113-69)60(102)87-47(32(10)92)63(105)81-37)18-17-39(80-51(71)41-20-111-66(48)82-41)65-84-42(21-110-65)58(100)76-28(6)54(96)73-26(4)53(72)95/h14-16,19-21,23-25,30-34,38,44,46-48,50-52,78,91-94,107H,4-7,17-18,22H2,1-3,8-13H3,(H2,72,95)(H,73,96)(H,74,98)(H,75,97)(H,76,100)(H,77,104)(H,81,105)(H,87,102)(H,88,101)(H,89,103)(H,90,99);   InChIKey=AKFVOKPQHFBYCA-UHFFFAOYSA-N;   SMILES=S1C(=NC(=C1)C(=O)NC(C(=O)NC(C(=O)N)=C)=C)C2=NC3C=4N=C(C5NC(=O)C=6N=C(C(NC(=O)C7N=C(C(NC(C(NC(C=8N=C(C3(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(C(C)C)NC9C(C=%10N=C(C(OC5C)=O)C=C(C(O)C)C%10C=C9)O)=C)=C)C)CC2)SC8)=O)C(O)C)=O)=CC)SC7)C(O)(C(O)C)C)SC6)SC4
 xref: Chemspider:17286829;   HMDB:HMDB0254959
 xref_mesh: MESH:C024711


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Siomycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 multiple interactions ISO siomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of CCND1 protein] CTD PMID:27517622 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Foxm1 forkhead box M1 multiple interactions ISO siomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of FOXM1 protein] CTD PMID:27517622 NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO siomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of CCND1 protein]; siomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of FOXM1 protein]; siomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of NFE2L2 protein]; siomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of PRDX1 protein] CTD PMID:27517622 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO siomycin A results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO siomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of NFE2L2 protein] CTD PMID:27517622 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO siomycin A inhibits the reaction [HRAS protein mutant form results in increased expression of PRDX1 protein] CTD PMID:27517622 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      group 19825
        organic group 18977
          amino-acid residue 11440
            peptide 11440
              oligopeptide 1349
                Siomycin A 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbon oxoacid 18654
                                    carboxylic acid 18651
                                      carboacyl group 17694
                                        univalent carboacyl group 17694
                                          carbamoyl group 17545
                                            carboxamide 17545
                                              peptide 11440
                                                oligopeptide 1349
                                                  Siomycin A 6
paths to the root