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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nordazepam
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Accession:CHEBI:111762 term browser browse the term
Definition:A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety.
Synonyms:related_synonym: 1-Demethyldiazepam;   7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one;   Chlordesmethyldiazepam;   Dealkylprazepam;   Desmethyldiazepam;   Formula=C15H11ClN2O;   InChI=1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19);   InChIKey=AKPLHCDWDRPJGD-UHFFFAOYSA-N;   N-Demethyldiazepam;   N-Deoxydemoxepam;   N-Desmethyldiazepam;   N1-Desmethyldiazepam;   Nordiazepam;   Norprazepam;   SMILES=Clc1ccc2NC(=O)CN=C(c3ccccc3)c2c1;   nordazepamum
 alt_id: CHEBI:7624
 xref: CAS:1088-11-5;   Drug_Central:816;   KEGG:C07486;   KEGG:D08283
 xref_mesh: MESH:D003708
 xref: PMID:16622;   PMID:19604;   PMID:360230;   PMID:364005;   PMID:367407;   PMID:4953859;   Patent:BE620020;   Patent:DE1136709;   Patent:US3051701;   Patent:US3202699;   Reaxys:751823;   Wikipedia:Desmethyldiazepam


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nordazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of Nordazepam CTD PMID:18846481 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        biophysical role 14053
          membrane transport modulator 13897
            GABA modulator 5114
              nordazepam 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            organic molecule 19686
                              organic cyclic compound 19498
                                organic heterocyclic compound 18876
                                  organonitrogen heterocyclic compound 18154
                                    benzodiazepine 912
                                      1,4-benzodiazepinone 125
                                        nordazepam 1
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