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ONTOLOGY REPORT - ANNOTATIONS


Term:GABA modulator
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Accession:CHEBI:50268 term browser browse the term
Definition:A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
Synonyms:related_synonym: GABA modulators


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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19596
    role 19539
      biological role 19537
        biophysical role 12092
          membrane transport modulator 11855
            GABA modulator 4630
              alpha-asarone 0
              barbiturates + 4370
              benzodiazepine + 527
              beta-asarone 0
              brexanolone 0
              clobazam 4
              clonazepam 6
              clorazepic acid 0
              dipotassium clorazepate 0
              estazolam 4
              isoliquiritigenin + 73
              nimetazepam 3
              nitrazepam + 7
              nordazepam 0
              pinocarveol + 0
              secobarbital 7
              secobarbital sodium 0
              valerenic acid 0
              verruculogen + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19596
    role 19539
      application 19135
        pharmaceutical 19038
          drug 19038
            neurotransmitter agent 16223
              GABA agent 15409
                GABA modulator 4630
                  alpha-asarone 0
                  barbiturates + 4370
                  benzodiazepine + 527
                  beta-asarone 0
                  brexanolone 0
                  clobazam 4
                  clonazepam 6
                  clorazepic acid 0
                  dipotassium clorazepate 0
                  estazolam 4
                  isoliquiritigenin + 73
                  nimetazepam 3
                  nitrazepam + 7
                  nordazepam 0
                  pinocarveol + 0
                  secobarbital 7
                  secobarbital sodium 0
                  valerenic acid 0
                  verruculogen + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.