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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:GABA modulator
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Accession:CHEBI:50268 term browser browse the term
Definition:A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
Synonyms:related_synonym: GABA modulators


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    • Term paths to the root
    Path 1
    Term Annotations click to browse term
      CHEBI ontology 19818
        role 19790
          biological role 19788
            biophysical role 13832
              membrane transport modulator 13668
                GABA modulator 4923
                  5alpha-dihydrodeoxycorticosterone 0
                  alpha-asarone 0
                  barbiturates + 4440
                  benzodiazepine + 903
                  beta-asarone 0
                  brexanolone 0
                  clobazam 4
                  clonazepam 6
                  clorazepic acid 0
                  dipotassium clorazepate 0
                  estazolam 6
                  isoliquiritigenin + 76
                  nimetazepam 4
                  nitrazepam + 8
                  nordazepam 1
                  pinocarveol + 0
                  secobarbital 8
                  secobarbital sodium 0
                  valerenic acid 0
                  verruculogen + 0
    Path 2
    Term Annotations click to browse term
      CHEBI ontology 19818
        role 19790
          application 19622
            pharmaceutical 19499
              drug 19499
                neurotransmitter agent 16672
                  GABA agent 15619
                    GABA modulator 4923
                      5alpha-dihydrodeoxycorticosterone 0
                      alpha-asarone 0
                      barbiturates + 4440
                      benzodiazepine + 903
                      beta-asarone 0
                      brexanolone 0
                      clobazam 4
                      clonazepam 6
                      clorazepic acid 0
                      dipotassium clorazepate 0
                      estazolam 6
                      isoliquiritigenin + 76
                      nimetazepam 4
                      nitrazepam + 8
                      nordazepam 1
                      pinocarveol + 0
                      secobarbital 8
                      secobarbital sodium 0
                      valerenic acid 0
                      verruculogen + 0
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