Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:GABA modulator
go back to main search page
Accession:CHEBI:50268 term browser browse the term
Definition:A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
Synonyms:related_synonym: GABA modulators


show annotations for term's descendants           Sort by:
 





Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        biophysical role 12651
          membrane transport modulator 12450
            GABA modulator 4658
              alpha-asarone 0
              barbiturates + 4388
              benzodiazepine + 542
              beta-asarone 0
              brexanolone 0
              clobazam 4
              clonazepam 6
              clorazepic acid 0
              dipotassium clorazepate 0
              estazolam 4
              isoliquiritigenin + 73
              nimetazepam 3
              nitrazepam + 7
              nordazepam 0
              pinocarveol + 0
              secobarbital 7
              secobarbital sodium 0
              valerenic acid 0
              verruculogen + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        pharmaceutical 19293
          drug 19293
            neurotransmitter agent 16435
              GABA agent 15429
                GABA modulator 4658
                  alpha-asarone 0
                  barbiturates + 4388
                  benzodiazepine + 542
                  beta-asarone 0
                  brexanolone 0
                  clobazam 4
                  clonazepam 6
                  clorazepic acid 0
                  dipotassium clorazepate 0
                  estazolam 4
                  isoliquiritigenin + 73
                  nimetazepam 3
                  nitrazepam + 7
                  nordazepam 0
                  pinocarveol + 0
                  secobarbital 7
                  secobarbital sodium 0
                  valerenic acid 0
                  verruculogen + 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.