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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzodiazepine
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Accession:CHEBI:22720 term browser browse the term
Definition:A group of heterocyclic compounds with a core structure containing a benzene ring fused to a diazepine ring.
Synonyms:related_synonym: benzodiazepines
 alt_id: MESH:D001569
 xref_mesh: MESH:D001569


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benzodiazepine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon decreases response to substance EXP GABRE protein results in decreased susceptibility to Benzodiazepines CTD PMID:11691872 NCBI chr  X:152,220,180...152,237,347
Ensembl chr  X:152,218,707...152,237,361
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 affects response to substance ISO GABRG2 protein affects the susceptibility to Benzodiazepines CTD PMID:7644489 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
1-hydroxymidazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases chemical synthesis ISO CYP3A5 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam CTD PMID:18191104, PMID:26958860 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Tspo translocator protein affects binding EXP 1-hydroxymethylmidazolam binds to TSPO protein; 1-hydroxymethylmidazolam metabolite binds to TSPO protein CTD PMID:7603229 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
4-hydroxymidazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases chemical synthesis
multiple interactions
ISO CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam
diosmetin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Luteolin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam]
CTD PMID:18191104 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
adinazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone multiple interactions EXP adinazolam inhibits the reaction [CRF protein results in increased secretion of beta-Endorphin] CTD PMID:1480515 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases methylation
multiple interactions
ISO CYP2C19 protein results in decreased methylation of adinazolam
Omeprazole inhibits the reaction [CYP2C19 protein results in decreased methylation of adinazolam]
CTD PMID:9600717 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A decreases expression EXP adinazolam results in decreased expression of HTR2A protein CTD PMID:1664741 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP adinazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP adinazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
alprazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Capn1 calpain 1 multiple interactions ISO [Caffeine co-treated with Alprazolam] promotes the reaction [Calcium results in increased activity of CAPN1 protein] CTD PMID:19490937 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Caffeine co-treated with Alprazolam] results in increased cleavage of CASP3 protein CTD PMID:19490937 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ctsb cathepsin B multiple interactions ISO [Caffeine co-treated with Alprazolam] results in increased secretion of CTSB protein CTD PMID:19490937 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects metabolic processing EXP CYP3A23-3A1 protein affects the metabolism of Alprazolam CTD PMID:12196913 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases hydroxylation ISO CYP3A5 protein results in increased hydroxylation of Alprazolam CTD PMID:15903124 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Il2 interleukin 2 decreases expression ISO Alprazolam results in decreased expression of IL2 protein CTD PMID:1624223 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Lhb luteinizing hormone subunit beta increases secretion ISO Alprazolam results in increased secretion of LHB protein CTD PMID:7883836 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Caffeine co-treated with Alprazolam] results in increased activity of PARP1 protein CTD PMID:19490937 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Plcb1 phospholipase C beta 1 decreases expression EXP Alprazolam results in decreased expression of PLCB1 mRNA; Alprazolam results in decreased expression of PLCB1 protein CTD PMID:12527476 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Ppia peptidylprolyl isomerase A increases hydroxylation ISO PPIA protein results in increased hydroxylation of Alprazolam CTD PMID:15806426 NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Alprazolam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP Alprazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP Alprazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
chlordiazepoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Chlordiazepoxide results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon decreases response to substance EXP GABRE protein results in decreased susceptibility to Chlordiazepoxide CTD PMID:11691872 NCBI chr  X:152,220,180...152,237,347
Ensembl chr  X:152,218,707...152,237,361
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP Chlordiazepoxide inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP Chlordiazepoxide inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
clobazam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 affects response to substance EXP ABCC2 protein affects the susceptibility to clobazam CTD PMID:22982618 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G F2 coagulation factor II multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Sele selectin E multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of SELE protein CTD PMID:16376047 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serpinc1 serpin family C member 1 multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
clonazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Clonazepam results in increased expression of BAX protein CTD PMID:17456340 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Clonazepam results in increased expression of BCL2 protein CTD PMID:17456340 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases activity EXP Clonazepam results in increased activity of CYP2B1 protein CTD PMID:1372805 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Dcx doublecortin decreases expression EXP Clonazepam results in decreased expression of DCX protein CTD PMID:19437554 NCBI chr  X:115,098,675...115,175,515
Ensembl chr  X:115,098,675...115,175,299
JBrowse link
G Ephx1 epoxide hydrolase 1 increases activity EXP Clonazepam results in increased activity of EPHX1 protein CTD PMID:1372805 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Clonazepam binds to and results in increased activity of NR1I2 protein CTD PMID:20024649 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
clozapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Clozapine results in decreased activity of ABCB11 protein CTD PMID:22646477 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity
EXP
ISO
Clozapine inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [Quinpirole results in increased expression of ABCB1 protein]
Clozapine results in decreased activity of ABCB1 protein
CTD PMID:9111066, PMID:16810505 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B multiple interactions EXP Clozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter] CTD PMID:9111066 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO Clozapine results in increased expression of ABCG1 mRNA CTD PMID:17346280 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone] CTD PMID:18834354 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Ablim2 actin binding LIM protein family, member 2 increases expression ISO Clozapine results in increased expression of ABLIM2 mRNA CTD PMID:17346280 NCBI chr14:80,044,217...80,169,491
Ensembl chr14:80,045,078...80,169,472
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 increases expression ISO Clozapine results in increased expression of ACAT2 mRNA CTD PMID:17052361 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of ACOX1 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of ACOX1 mRNA CTD PMID:23226405 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Adam1a ADAM metallopeptidase domain 1a decreases expression EXP Clozapine results in decreased expression of ADAM1A mRNA CTD PMID:16715494 NCBI chr12:40,533,731...40,536,632
Ensembl chr12:40,533,632...40,536,620
JBrowse link
G Adcy5 adenylate cyclase 5 affects response to substance
multiple interactions
ISO ADCY5 protein affects the susceptibility to Clozapine
SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Clozapine]
CTD PMID:12223546 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression
increases expression
multiple interactions
ISO
EXP
Clozapine results in decreased expression of ADIPOQ protein
Clozapine results in increased expression of ADIPOQ protein
Clozapine results in increased expression of ADIPOQ mRNA
Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA]
CTD PMID:17933447, PMID:18162013, PMID:20564506 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Clozapine results in decreased expression of ADORA2A mRNA CTD PMID:17266109 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions EXP Clozapine binds to and results in decreased activity of ADRA1A protein CTD PMID:16545797 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 decreases expression ISO Clozapine results in decreased expression of AGPAT1 mRNA CTD PMID:14647396 NCBI chr20:4,369,399...4,378,272
Ensembl chr20:4,369,178...4,378,269
JBrowse link
G Agt angiotensinogen multiple interactions ISO Clozapine inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]] CTD PMID:11549694 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
decreases expression
increases phosphorylation
ISO
EXP
Clozapine results in increased expression of AKT1 mRNA; Clozapine results in increased expression of AKT1 protein
Clozapine results in decreased expression of AKT1 mRNA
Clozapine results in increased phosphorylation of AKT1 protein
CTD PMID:15860345, PMID:19440698 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 increases expression EXP Clozapine results in increased expression of AKT2 mRNA CTD PMID:15860345 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Alb albumin multiple interactions
affects binding
EXP
ISO
Clozapine results in decreased expression of and results in decreased reduction of ALB protein
Clozapine binds to ALB protein
[[[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine] which affects the activity of ALB protein; [[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine; [stearic acid binds to ALB protein] which affects the susceptibility to Clozapine; stearic acid inhibits the reaction [Clozapine binds to ALB protein]
CTD PMID:31400341 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO Clozapine results in increased expression of ALDH1A1 mRNA CTD PMID:17266109 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Clozapine results in increased expression of ALDOA mRNA CTD PMID:15860345 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression
increases expression
ISO
EXP
Clozapine results in decreased expression of ALDOC mRNA
Clozapine results in increased expression of ALDOC mRNA
CTD PMID:15860345, PMID:16465460 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126
JBrowse link
G Alpp alkaline phosphatase, placental multiple interactions ISO Clozapine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Clozapine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA] CTD PMID:16036225 NCBI chr 9:94,189,961...94,193,054
Ensembl chr 9:94,190,067...94,192,813
JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Clozapine results in decreased expression of AP1S1 mRNA CTD PMID:17175557 NCBI chr12:22,665,128...22,676,079
Ensembl chr12:22,665,112...22,676,075
JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 increases expression EXP Clozapine results in increased expression of AP2B1 mRNA CTD PMID:15860345 NCBI chr10:70,516,462...70,621,973
Ensembl chr10:70,520,206...70,621,977
JBrowse link
G Apoa5 apolipoprotein A5 affects response to substance EXP APOA5 gene polymorphism affects the susceptibility to Clozapine CTD PMID:17726453 NCBI chr 8:50,559,079...50,561,720
Ensembl chr 8:50,559,126...50,561,736
JBrowse link
G Apod apolipoprotein D increases expression ISO Clozapine results in increased expression of APOD mRNA; Clozapine results in increased expression of APOD protein CTD PMID:11158250, PMID:14647396, PMID:17266109 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein decreases expression EXP Clozapine results in decreased expression of ARC mRNA CTD PMID:18208916 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Arhgef9 Cdc42 guanine nucleotide exchange factor 9 decreases expression ISO Clozapine results in decreased expression of ARHGEF9 mRNA CTD PMID:17266109 NCBI chr  X:64,249,576...64,428,444
Ensembl chr  X:64,248,278...64,428,592
JBrowse link
G Arpc4 actin related protein 2/3 complex, subunit 4 affects expression ISO Clozapine affects the expression of ARPC4 mRNA CTD PMID:14647396 NCBI chr 4:145,330,457...145,340,985
Ensembl chr 4:145,330,457...145,340,984
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Clozapine results in increased expression of ASAH1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Clozapine results in increased expression of ASNS mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression EXP Clozapine results in decreased expression of ATP5F1B protein CTD PMID:19441803 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 decreases expression EXP Clozapine results in decreased expression of ATP6V1B2 protein CTD PMID:19441803 NCBI chr16:22,326,537...22,350,143
Ensembl chr16:22,326,529...22,350,155
JBrowse link
G Axin2 axin 2 decreases expression EXP Clozapine results in decreased expression of AXIN2 mRNA CTD PMID:16715494 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
decreases expression
ISO
EXP
Clozapine results in increased expression of BAX mRNA; Clozapine results in increased expression of BAX protein
CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]
Clozapine results in decreased expression of BAX protein
CTD PMID:16160616, PMID:17069804 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Clozapine results in increased expression of BCL2 mRNA; Clozapine results in increased expression of BCL2 protein CTD PMID:15126120 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
increases expression
EXP Clozapine results in decreased expression of BDNF mRNA
Clozapine results in increased expression of BDNF mRNA; Clozapine results in increased expression of BDNF protein
CTD PMID:11488957, PMID:12478621, PMID:17442489 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bet1l Bet1 golgi vesicular membrane trafficking protein-like decreases expression EXP Clozapine results in decreased expression of BET1L mRNA CTD PMID:15860345 NCBI chr 1:213,602,836...213,606,507
Ensembl chr 1:213,602,850...213,605,643
JBrowse link
G Bik BCL2-interacting killer multiple interactions
increases expression
ISO CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA] CTD PMID:16160616 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447
JBrowse link
G Bptf bromodomain PHD finger transcription factor decreases expression ISO Clozapine results in decreased expression of BPTF mRNA CTD PMID:14647396 NCBI chr10:95,248,573...95,350,162
Ensembl chr10:95,250,294...95,349,789
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A decreases expression ISO
EXP
Clozapine results in decreased expression of CACNA1A mRNA CTD PMID:14647396, PMID:16715494 NCBI chr19:25,453,236...25,749,550
Ensembl chr19:25,526,751...25,749,550
JBrowse link
G Calm2 calmodulin 2 increases expression EXP Clozapine results in increased expression of CALM2 mRNA CTD PMID:19289156 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha decreases expression
increases expression
ISO
EXP
Clozapine results in decreased expression of CAMK2A mRNA
Clozapine results in increased expression of CAMK2A mRNA
Clozapine results in decreased expression of CAMK2A protein
CTD PMID:15860345, PMID:17266109, PMID:19289156 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta decreases expression EXP Clozapine results in decreased expression of CAMK2B mRNA CTD PMID:15860345 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta decreases expression EXP Clozapine results in decreased expression of CAMK2D mRNA CTD PMID:15860345 NCBI chr 2:230,900,907...231,132,207
Ensembl chr 2:230,901,126...231,132,039
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV increases expression
decreases expression
EXP Clozapine results in increased expression of CAMK4 mRNA
Clozapine results in decreased expression of CAMK4 protein
CTD PMID:15860345, PMID:19289156 NCBI chr18:25,746,878...25,975,962
Ensembl chr18:25,749,098...25,965,957
JBrowse link
G Camkk1 calcium/calmodulin-dependent protein kinase kinase 1 decreases expression EXP Clozapine results in decreased expression of CAMKK1 protein CTD PMID:19289156 NCBI chr10:59,585,023...59,608,180
Ensembl chr10:59,585,072...59,608,165
JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 decreases expression EXP Clozapine results in decreased expression of CAMKK2 protein CTD PMID:19289156 NCBI chr12:39,253,409...39,302,601
Ensembl chr12:39,253,409...39,302,601
JBrowse link
G Cartpt CART prepropeptide decreases expression EXP Clozapine results in decreased expression of CARTPT mRNA CTD PMID:14696011 NCBI chr 2:30,125,249...30,127,408
Ensembl chr 2:30,125,249...30,127,269
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
Clozapine results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP3 protein]
CTD PMID:22700542, PMID:24709159 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Clozapine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP7 protein]
CTD PMID:22700542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Cat catalase multiple interactions ISO Clozapine inhibits the reaction [Corticosterone results in increased activity of CAT protein]; Clozapine inhibits the reaction [Lipopolysaccharides inhibits the reaction [Corticosterone results in increased activity of CAT protein]] CTD PMID:14730115 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cck cholecystokinin multiple interactions
increases expression
EXP Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein]
Clozapine results in increased expression of CCK mRNA
CTD PMID:10974607, PMID:16567023 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392
JBrowse link
G Cckbr cholecystokinin B receptor increases expression ISO Clozapine results in increased expression of CCKBR mRNA CTD PMID:17266109 NCBI chr 1:170,262,218...170,272,298
Ensembl chr 1:170,262,156...170,272,298
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 decreases expression ISO Clozapine results in decreased expression of CCL1 mRNA CTD PMID:17346280 NCBI chr10:69,534,976...69,537,836
Ensembl chr10:69,534,933...69,537,882
JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP Clozapine results in decreased expression of CCND1 mRNA CTD PMID:15860345 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 increases expression EXP Clozapine results in increased expression of CCND3 mRNA CTD PMID:15860345 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccnl1 cyclin L1 increases expression EXP Clozapine results in increased expression of CCNL1 mRNA CTD PMID:15860345 NCBI chr 2:157,747,295...157,759,838
Ensembl chr 2:157,747,542...157,759,838
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression EXP Clozapine results in increased expression of CDK4 mRNA CTD PMID:15860345 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk5 cyclin-dependent kinase 5 increases expression EXP Clozapine results in increased expression of CDK5 mRNA CTD PMID:15860345 NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases expression ISO Clozapine results in increased expression of CDK5R1 mRNA CTD PMID:17266109 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
increases expression
ISO Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]
Clozapine results in increased expression of CEBPA mRNA; Clozapine results in increased expression of CEBPA protein
CTD PMID:20564506 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Chga chromogranin A decreases expression
increases expression
EXP Clozapine results in decreased expression of CHGA mRNA
Clozapine results in increased expression of CHGA mRNA
CTD PMID:12437575 NCBI chr 6:126,434,226...126,445,569
Ensembl chr 6:126,434,226...126,445,568
JBrowse link
G Chl1 cell adhesion molecule L1-like decreases expression ISO Clozapine results in decreased expression of CHL1 mRNA CTD PMID:14647396 NCBI chr 4:70,269,414...70,331,313
Ensembl chr 4:70,252,366...70,330,803
JBrowse link
G Chn1 chimerin 1 decreases expression ISO Clozapine results in decreased expression of CHN1 mRNA CTD PMID:14647396 NCBI chr 3:60,512,360...60,668,413
Ensembl chr 3:60,513,077...60,611,924
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 affects binding
increases expression
multiple interactions
ISO
EXP
Clozapine analog binds to CHRM1 protein; Clozapine binds to CHRM1 protein
Clozapine results in increased expression of CHRM1 protein
Clozapine inhibits the reaction [Dextroamphetamine results in decreased expression of CHRM1 protein]
CTD PMID:11997696, PMID:16983399, PMID:18806925 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Clock clock circadian regulator affects response to substance ISO CLOCK gene SNP affects the susceptibility to Clozapine CTD PMID:15331141 NCBI chr14:34,418,226...34,502,218
Ensembl chr14:34,446,616...34,502,218
JBrowse link
G Clta clathrin, light chain A decreases expression EXP Clozapine results in decreased expression of CLTA mRNA CTD PMID:15860345 NCBI chr 5:59,490,689...59,509,139
Ensembl chr 5:59,491,096...59,509,138
JBrowse link
G Cltb clathrin, light chain B decreases expression EXP Clozapine results in decreased expression of CLTB mRNA CTD PMID:15860345 NCBI chr17:10,537,348...10,554,999
Ensembl chr17:10,537,365...10,554,989
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase decreases expression
increases expression
ISO Clozapine results in decreased expression of CNP mRNA
Clozapine results in increased expression of CNP mRNA
CTD PMID:17266109 NCBI chr10:88,490,798...88,497,357
Ensembl chr10:88,490,798...88,497,356
JBrowse link
G Coil coilin increases expression EXP Clozapine results in increased expression of COIL mRNA CTD PMID:16715494 NCBI chr10:76,320,676...76,336,169
Ensembl chr10:76,320,041...76,341,418
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions
affects response to substance
increases response to substance
EXP
ISO
[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]
COMT protein affects the susceptibility to Clozapine
COMT gene polymorphism results in increased susceptibility to Clozapine
CTD PMID:15190105, PMID:17123785 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cplx2 complexin 2 decreases expression ISO Clozapine results in decreased expression of CPLX2 mRNA CTD PMID:17266109 NCBI chr17:10,756,871...10,828,811
Ensembl chr17:10,756,285...10,818,835
JBrowse link
G Cpn1 carboxypeptidase N subunit 1 increases expression EXP Clozapine results in increased expression of CPN1 mRNA CTD PMID:16715494 NCBI chr 1:263,733,887...263,762,758
Ensembl chr 1:263,733,519...263,762,785
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions EXP [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of CPT2 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of CPT2 mRNA CTD PMID:23226405 NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
decreases phosphorylation
ISO Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of CREB1 protein]
Clozapine results in decreased phosphorylation of CREB1 protein
CTD PMID:12871586 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Clozapine results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Crhbp corticotropin releasing hormone binding protein decreases expression EXP Clozapine results in decreased expression of CRHBP mRNA CTD PMID:16715494 NCBI chr 2:25,141,471...25,153,334
Ensembl chr 2:25,141,471...25,153,334
JBrowse link
G Crp C-reactive protein increases expression ISO Clozapine results in increased expression of CRP protein CTD PMID:17685758 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA] CTD PMID:16160616 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 decreases expression EXP Clozapine results in decreased expression of CSNK2A1 mRNA CTD PMID:16715494 NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862
JBrowse link
G Cst3 cystatin C increases expression ISO Clozapine results in increased expression of CST3 mRNA CTD PMID:14647396 NCBI chr 3:143,219,671...143,223,544
Ensembl chr 3:143,219,686...143,223,615
JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions
EXP Clozapine results in increased expression of CTNNB1 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]
CTD PMID:16144542 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctrl chymotrypsin-like increases expression EXP Clozapine results in increased expression of CTRL mRNA CTD PMID:16715494 NCBI chr19:37,905,864...37,907,714
Ensembl chr19:37,905,864...37,907,714
JBrowse link
G Ctsk cathepsin K increases expression EXP Clozapine results in increased expression of CTSK mRNA CTD PMID:16715494 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO Clozapine results in decreased expression of CXCL1 mRNA CTD PMID:17346280 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO Clozapine results in decreased expression of CXCL1 mRNA CTD PMID:17346280 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyb5b cytochrome b5 type B increases expression EXP Clozapine results in increased expression of CYB5B mRNA CTD PMID:19441803 NCBI chr19:39,357,814...39,391,680
Ensembl chr19:39,357,791...39,393,189
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases metabolic processing
EXP
ISO
Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
CYP1A1 protein results in increased metabolism of Clozapine
CTD PMID:18493746, PMID:18809730 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases response to substance
multiple interactions
increases metabolic processing
increases expression
affects metabolic processing
affects response to substance
decreases metabolic processing
ISO
EXP
CYP1A2 gene SNP results in decreased susceptibility to Clozapine
Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
CYP1A2 protein results in increased metabolism of Clozapine
Clozapine results in increased expression of CYP1A2 mRNA
CYP1A2 gene polymorphism affects the metabolism of Clozapine; CYP1A2 protein affects the metabolism of Clozapine; CYP1A2 protein polymorphism affects the metabolism of Clozapine
[Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of Clozapine; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Smoke affects the reaction [CYP1A2 gene polymorphism affects the metabolism of Clozapine]; Smoke promotes the reaction [CYP1A2 protein results in increased metabolism of Clozapine]
CYP1A2 gene SNP affects the susceptibility to Clozapine; CYP1A2 protein affects the susceptibility to Clozapine
CYP1A2 gene SNP results in increased metabolism of Clozapine; CYP1A2 protein results in increased metabolism of Clozapine
CYP1A2 gene SNP results in decreased metabolism of Clozapine
CTD PMID:11151749, PMID:11763009, PMID:12919186, PMID:12969762, PMID:15206669, PMID:15286053, PMID:15883149, PMID:15949157, PMID:16044115, PMID:18493746, PMID:18809730, PMID:23397584, PMID:27320963 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing ISO CYP1B1 protein results in increased metabolism of Clozapine CTD PMID:18809730 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
increases metabolic processing
ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine
CYP2C19 protein results in increased metabolism of Clozapine
CTD PMID:18809730, PMID:23397584, PMID:27320963 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing ISO CYP2C8 protein results in increased metabolism of Clozapine CTD PMID:18809730, PMID:27320963 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
increases metabolic processing
multiple interactions
ISO CYP2D6 protein affects the metabolism of Clozapine
CYP2D6 protein results in increased metabolism of Clozapine
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine
CTD PMID:15286053, PMID:18809730, PMID:23397584, PMID:27320963 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases metabolic processing ISO CYP2J2 protein results in increased metabolism of Clozapine CTD PMID:18809730 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of Clozapine CTD PMID:18809730 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Dab1 DAB adaptor protein 1 increases expression EXP Clozapine results in increased expression of DAB1 mRNA CTD PMID:19359144 NCBI chr 5:123,154,360...124,279,170
Ensembl chr 5:123,905,166...124,280,115
JBrowse link
G Dcaf6 DDB1 and CUL4 associated factor 6 decreases expression ISO Clozapine results in decreased expression of DCAF6 mRNA CTD PMID:14647396 NCBI chr13:83,578,730...83,680,330
Ensembl chr13:83,579,036...83,680,207
JBrowse link
G Dclk1 doublecortin-like kinase 1 increases expression ISO
EXP
Clozapine results in increased expression of DCLK1 mRNA CTD PMID:15860345, PMID:18797397 NCBI chr 2:144,646,255...144,939,389
Ensembl chr 2:144,646,308...144,936,927
JBrowse link
G Ddc dopa decarboxylase multiple interactions
increases expression
ISO Clozapine results in increased expression of and results in increased activity of DDC protein
Clozapine results in increased expression of DDC mRNA
CTD PMID:16415089 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Dennd10 DENN domain containing 10 increases expression EXP Clozapine results in increased expression of DENND10 mRNA CTD PMID:16715494 NCBI chr 1:282,188,080...282,211,588
Ensembl chr 1:282,188,110...282,210,580
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Clozapine results in increased expression of DEPP1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
JBrowse link
G Dgka diacylglycerol kinase, alpha decreases expression EXP Clozapine results in decreased expression of DGKA mRNA CTD PMID:15860345 NCBI chr 7:3,143,826...3,170,764
Ensembl chr 7:3,143,827...3,170,146
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression ISO Clozapine results in increased expression of DHCR7 mRNA CTD PMID:17052361 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
JBrowse link
G Disc1 DISC1 scaffold protein decreases response to substance
affects response to substance
ISO DISC1 gene mutant form results in decreased susceptibility to Clozapine
DISC1 protein affects the susceptibility to Clozapine
CTD PMID:20531374 NCBI chr19:57,818,838...58,069,992
Ensembl chr19:57,820,260...58,066,152
JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase decreases expression EXP Clozapine results in decreased expression of DLAT mRNA CTD PMID:15860345 NCBI chr 8:55,062,549...55,087,832
Ensembl chr 8:55,062,551...55,087,832
JBrowse link
G Dpf1 double PHD fingers 1 affects expression ISO Clozapine affects the expression of DPF1 mRNA CTD PMID:14647396 NCBI chr 1:87,248,448...87,258,070
Ensembl chr 1:87,248,489...87,258,070
JBrowse link
G Drd1 dopamine receptor D1 affects binding
decreases expression
affects response to substance
ISO
EXP
Clozapine binds to DRD1 protein
Clozapine results in decreased expression of DRD1 mRNA
Clozapine analog binds to DRD1 protein
DRD1 gene polymorphism affects the susceptibility to Clozapine; DRD1 protein affects the susceptibility to Clozapine
CTD PMID:1352677, PMID:9723970, PMID:11997696, PMID:17092969, PMID:17266109 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects binding
affects response to substance
decreases expression
increases response to substance
ISO
EXP
[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein
Clozapine binds to DRD2 protein
DRD2 protein affects the susceptibility to Clozapine
Clozapine results in decreased expression of DRD2 mRNA
Clozapine analog binds to DRD2 protein; Clozapine binds to DRD2 protein
[Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]; Clozapine binds to and results in decreased activity of DRD2 protein; Clozapine promotes the reaction [Dopamine binds to DRD2 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]
[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA
Clozapine binds to DRD2 protein alternative form
DRD2 gene SNP results in increased susceptibility to Clozapine
DRD2 gene affects the susceptibility to Clozapine; DRD2 gene polymorphism affects the susceptibility to Clozapine
CTD PMID:1352677, PMID:9723970, PMID:11997696, PMID:12476322, PMID:15286066, PMID:15716360, PMID:15781964, PMID:15830237, PMID:16033416, PMID:16144542, PMID:16278074, PMID:17266109, PMID:20375926 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 affects response to substance
multiple interactions
decreases response to substance
ISO DRD3 protein affects the susceptibility to Clozapine
DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]
DRD3 gene polymorphism results in decreased susceptibility to Clozapine
CTD PMID:15579174, PMID:20029384 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Drd4 dopamine receptor D4 affects binding
multiple interactions
affects response to substance
ISO
EXP
Clozapine binds to DRD4 protein
Clozapine inhibits the reaction [Dopamine results in increased activity of DRD4 protein]
Clozapine analog binds to DRD4 protein
DRD4 gene polymorphism affects the susceptibility to Clozapine
CTD PMID:11997696, PMID:16223700, PMID:31323226 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Drp2 dystrophin related protein 2 increases expression EXP Clozapine results in increased expression of DRP2 mRNA alternative form CTD PMID:16715494 NCBI chr  X:105,239,623...105,290,233
Ensembl chr  X:105,239,620...105,289,808
JBrowse link
G Dtnbp1 dystrobrevin binding protein 1 increases response to substance
affects response to substance
ISO DTNBP1 gene polymorphism results in increased susceptibility to Clozapine
DTNBP1 protein affects the susceptibility to Clozapine
CTD PMID:19369910 NCBI chr17:20,090,136...20,182,332
Ensembl chr17:20,090,246...20,182,206
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression EXP Clozapine results in decreased expression of DUSP1 mRNA CTD PMID:15860345 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression EXP Clozapine results in decreased expression of DUSP6 mRNA CTD PMID:15860345 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Dvl3 dishevelled segment polarity protein 3 increases expression
multiple interactions
EXP Clozapine results in increased expression of DVL3 protein
DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]
CTD PMID:16144542 NCBI chr11:84,051,177...84,068,479
Ensembl chr11:84,051,078...84,068,302
JBrowse link
G Egr1 early growth response 1 decreases expression EXP Clozapine results in decreased expression of EGR1 mRNA; Clozapine results in decreased expression of EGR1 protein CTD PMID:17028028, PMID:18208916 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Egr2 early growth response 2 affects expression
decreases expression
ISO
EXP
Clozapine affects the expression of EGR2 mRNA
Clozapine results in decreased expression of EGR2 protein
CTD PMID:17028028, PMID:19401217 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
JBrowse link
G Egr3 early growth response 3 affects response to substance ISO EGR3 protein affects the susceptibility to Clozapine CTD PMID:17637609 NCBI chr15:51,756,683...51,762,080
Ensembl chr15:51,756,736...51,760,722
JBrowse link
G Elk1 ETS transcription factor ELK1 decreases phosphorylation ISO Clozapine results in decreased phosphorylation of ELK1 protein CTD PMID:12871586 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Eno1 enolase 1 increases expression EXP Clozapine results in increased expression of ENO1 mRNA CTD PMID:15860345 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Epha7 Eph receptor A7 increases expression ISO Clozapine results in increased expression of EPHA7 mRNA CTD PMID:17266109 NCBI chr 5:43,602,744...43,761,198
Ensembl chr 5:43,603,043...43,757,549
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects phosphorylation EXP Clozapine affects the phosphorylation of ERBB2 protein CTD PMID:26961615 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions EXP Clozapine results in increased expression of and results in increased phosphorylation of ERBB4 protein CTD PMID:26961615 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Clozapine results in increased expression of FABP1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA CTD PMID:20564506 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions ISO [Clozapine analog co-treated with Hydrogen Peroxide] results in increased expression of FASLG mRNA; [Clozapine co-treated with Hydrogen Peroxide co-treated with Tretinoin] results in increased expression of FASLG mRNA CTD PMID:16510162 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase increases expression ISO Clozapine results in increased expression of FASN mRNA CTD PMID:16027736, PMID:17052361 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fdps farnesyl diphosphate synthase increases expression ISO Clozapine results in increased expression of FDPS mRNA CTD PMID:17052361 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression EXP Clozapine results in increased expression of FGF2 mRNA CTD PMID:11264663 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases metabolic processing ISO FMO1 protein results in increased metabolism of Clozapine CTD PMID:18809730 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases metabolic processing ISO FMO3 protein results in increased metabolism of Clozapine CTD PMID:18809730, PMID:27320963 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
decreases expression
EXP Clozapine affects the reaction [Haloperidol results in increased expression of FOS protein]; Cycloserine promotes the reaction [Clozapine results in increased expression of FOS mRNA]
Clozapine analog results in increased expression of FOS protein; Clozapine results in increased expression of FOS mRNA; Clozapine results in increased expression of FOS protein
Clozapine results in decreased expression of FOS protein
CTD PMID:10435392, PMID:11166331, PMID:11440804, PMID:11997696, PMID:12093589, PMID:12243769, PMID:12464447, PMID:17028028, PMID:18208916, PMID:18521575, PMID:19695244 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
decreases expression
ISO
EXP
Clozapine results in increased expression of FOSB protein alternative form
Clozapine results in increased expression of FOSB mRNA; Clozapine results in increased expression of FOSB protein
DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]
Clozapine results in decreased expression of FOSB mRNA
CTD PMID:11259127, PMID:12093589, PMID:12243769, PMID:15579174, PMID:19695244 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression EXP Clozapine results in increased expression of FOSL1 mRNA CTD PMID:18208916 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit increases expression EXP Clozapine results in increased expression of FOSL2 mRNA CTD PMID:12093589, PMID:12243769 NCBI chr 6:25,598,936...25,616,995
Ensembl chr 6:25,598,936...25,616,995
JBrowse link
G Foxp2 forkhead box P2 increases expression ISO Clozapine results in increased expression of FOXP2 mRNA CTD PMID:17266109 NCBI chr 4:41,364,441...41,944,685
Ensembl chr 4:41,364,441...41,942,023
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 decreases expression ISO Clozapine results in decreased expression of GABBR1 mRNA CTD PMID:17266109 NCBI chr20:1,955,344...1,984,907
Ensembl chr20:1,955,359...1,984,863
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 increases expression ISO Clozapine results in increased expression of GABRA1 mRNA CTD PMID:17266109 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases expression EXP Clozapine results in increased expression of GABRB3 mRNA CTD PMID:18923069 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression
decreases methylation
multiple interactions
ISO
EXP
Clozapine results in increased expression of GAD1 mRNA
Clozapine results in decreased methylation of GAD1 promoter
Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]; Valproic Acid promotes the reaction [Clozapine results in decreased methylation of GAD1 promoter]
CTD PMID:12887421, PMID:15061247, PMID:17942719, PMID:18757738, PMID:18923069 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression ISO
EXP
Clozapine results in increased expression of GAD2 mRNA CTD PMID:17266109, PMID:18923069 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression EXP Clozapine results in increased expression of GAPDH mRNA CTD PMID:15860345 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Clozapine results in increased expression of GDPD3 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 1:198,199,032...198,209,178
Ensembl chr 1:198,199,622...198,209,150
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
increases expression
EXP Clozapine results in decreased expression of GFAP protein
Clozapine results in increased expression of GFAP mRNA
CTD PMID:18585900, PMID:19441803 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gimap5 GTPase, IMAP family member 5 decreases expression EXP Clozapine results in decreased expression of GIMAP5 mRNA CTD PMID:16715494 NCBI chr 4:78,377,228...78,386,683
Ensembl chr 4:78,378,144...78,385,577
JBrowse link
G Gip gastric inhibitory polypeptide increases expression EXP Clozapine results in increased expression of GIP mRNA; Clozapine results in increased expression of GIP protein CTD PMID:16402076 NCBI chr10:83,835,080...83,848,399
Ensembl chr10:83,840,303...83,848,396
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP Clozapine results in increased expression of GJA1 protein CTD PMID:18585900 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gna12 G protein subunit alpha 12 decreases expression EXP Clozapine results in decreased expression of GNA12 mRNA CTD PMID:15860345 NCBI chr12:15,890,202...15,971,212
Ensembl chr12:15,890,170...15,971,212
JBrowse link
G Gnai1 G protein subunit alpha i1 decreases expression EXP Clozapine results in decreased expression of GNAI1 mRNA CTD PMID:15860345 NCBI chr 4:13,405,136...13,486,866
Ensembl chr 4:13,405,136...13,485,883
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression EXP Clozapine results in decreased expression of GNAI2 mRNA CTD PMID:15860345 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Gnai3 G protein subunit alpha i3 decreases expression EXP Clozapine results in decreased expression of GNAI3 mRNA CTD PMID:15860345 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749
JBrowse link
G Gnas GNAS complex locus decreases expression EXP Clozapine results in decreased expression of GNAS mRNA CTD PMID:15860345 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Gnb3 G protein subunit beta 3 decreases response to substance
increases expression
affects response to substance
increases response to substance
ISO
EXP
GNB3 gene polymorphism results in decreased susceptibility to Clozapine
Clozapine results in increased expression of GNB3 protein
GNB3 protein affects the susceptibility to Clozapine
GNB3 gene polymorphism results in increased susceptibility to Clozapine
CTD PMID:16139171, PMID:16141801, PMID:18855531 NCBI chr 4:157,352,558...157,359,237
Ensembl chr 4:157,352,372...157,358,262
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 increases expression EXP Clozapine results in increased expression of GOT2 mRNA CTD PMID:15860345 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Clozapine results in increased expression of GPX1 mRNA CTD PMID:14647396 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 increases expression EXP Clozapine results in increased expression of GRIK2 mRNA CTD PMID:18923069 NCBI chr20:53,791,428...54,517,691
Ensembl chr20:53,789,760...54,517,709
JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 affects expression
decreases expression
ISO
EXP
Clozapine affects the expression of GRIK5 mRNA
Clozapine results in decreased expression of GRIK5 mRNA
CTD PMID:14647396, PMID:18923069 NCBI chr 1:81,885,516...81,946,731
Ensembl chr 1:81,885,521...81,946,714
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression
increases expression
ISO
EXP
Clozapine results in decreased expression of GRIN1 mRNA
Clozapine results in increased expression of GRIN1 mRNA
CTD PMID:12020038, PMID:12608697, PMID:17266109, PMID:18923069 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases expression EXP Clozapine results in decreased expression of GRIN2A mRNA CTD PMID:12608697, PMID:18923069 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B decreases expression EXP Clozapine results in decreased expression of GRIN2B mRNA CTD PMID:18923069 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C decreases expression EXP Clozapine results in decreased expression of GRIN2C mRNA CTD PMID:18923069 NCBI chr10:103,798,290...103,816,923
Ensembl chr10:103,798,291...103,816,287
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 decreases expression EXP Clozapine results in decreased expression of GRK6 mRNA CTD PMID:16715494 NCBI chr17:9,705,917...9,721,921
Ensembl chr17:9,703,453...9,721,574
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha increases expression
multiple interactions
EXP Clozapine results in increased expression of GSK3A protein
DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]
CTD PMID:16144542 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
increases expression
multiple interactions
ISO
EXP
Clozapine results in increased phosphorylation of GSK3B protein
Clozapine results in increased expression of GSK3B protein
DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]
CTD PMID:16144542, PMID:19359144, PMID:19440698 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity
increases glutathionylation
ISO GSTA1 protein results in decreased activity of Clozapine
GSTA1 protein results in increased glutathionylation of Clozapine
CTD PMID:20849150 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity
increases expression
increases glutathionylation
ISO
EXP
GSTM1 protein results in decreased activity of Clozapine
Clozapine results in increased expression of GSTM1 mRNA
GSTM1 protein results in increased glutathionylation of Clozapine
CTD PMID:15860345, PMID:20849150 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Clozapine results in decreased expression of GSTM2 mRNA CTD PMID:15860345 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity
affects metabolic processing
increases glutathionylation
affects binding
ISO Clozapine metabolite results in decreased activity of GSTP1 protein; GSTP1 protein results in decreased activity of Clozapine
GSTP1 protein affects the metabolism of Clozapine metabolite
GSTP1 protein results in increased glutathionylation of Clozapine
Clozapine metabolite binds to GSTP1 protein
CTD PMID:20849150, PMID:21639118, PMID:24185126 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Higd1a HIG1 hypoxia inducible domain family, member 1A increases expression ISO Clozapine results in increased expression of HIGD1A mRNA CTD PMID:14647396 NCBI chr 8:130,482,492...130,491,888
Ensembl chr 8:130,482,493...130,491,998
JBrowse link
G Hist2h2aa2 histone cluster 2 H2A family member A2 increases expression ISO Clozapine results in increased expression of H2AC18 mRNA CTD PMID:14647396 NCBI chr 2:198,381,678...198,382,247
Ensembl chr 2:198,388,809...198,389,201
Ensembl chr 2:198,388,809...198,389,201
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression
increases activity
ISO [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol; [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides
Clozapine results in increased expression of HMGCR mRNA
CTD PMID:16027736, PMID:17052361 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Clozapine results in increased expression of HMGCS1 mRNA CTD PMID:16027736, PMID:17052361 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Clozapine results in increased expression of HMOX1 mRNA CTD PMID:18227147 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Homer1 homer scaffold protein 1 increases expression
multiple interactions
EXP Clozapine results in increased expression of HOMER1 mRNA
Cycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA]
CTD PMID:12464447, PMID:15860345 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678
JBrowse link
G Hpcal1 hippocalcin-like 1 decreases expression EXP Clozapine results in decreased expression of HPCAL1 mRNA CTD PMID:12437575 NCBI chr 6:43,001,920...43,109,083
Ensembl chr 6:43,001,948...43,109,071
JBrowse link
G Hpcal4 hippocalcin-like 4 affects expression EXP Clozapine affects the expression of HPCAL4 mRNA CTD PMID:12437575 NCBI chr 5:140,870,127...140,882,242
Ensembl chr 5:140,870,140...140,882,244
JBrowse link
G Hpn hepsin increases expression ISO Clozapine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
JBrowse link
G Hrh1 histamine receptor H 1 affects binding ISO Clozapine binds to HRH1 protein CTD PMID:16983399 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions
affects binding
ISO
EXP
Clozapine binds to and affects the activity of HTR1A protein
Clozapine binds to HTR1A protein
CTD PMID:9723970, PMID:15482641 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr1d 5-hydroxytryptamine receptor 1D decreases expression EXP Clozapine results in decreased expression of HTR1D mRNA CTD PMID:16715494 NCBI chr 5:154,780,958...154,801,505
Ensembl chr 5:154,800,226...154,801,350
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases response to substance
affects binding
multiple interactions
decreases expression
decreases activity
affects response to substance
increases expression
ISO
EXP
HTR2A gene SNP results in increased susceptibility to Clozapine
Clozapine analog binds to HTR2A protein; Clozapine binds to HTR2A protein
Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine inhibits the reaction [Ketanserin binds to HTR2A protein]
Clozapine results in decreased expression of HTR2A mRNA; Clozapine results in decreased expression of HTR2A protein
Clozapine results in decreased activity of HTR2A protein
[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]; Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein]
HTR2A protein affects the susceptibility to Clozapine
Clozapine results in increased expression of HTR2A mRNA
CTD PMID:7520908, PMID:9723970, PMID:11997696, PMID:14751426, PMID:15380371, PMID:15542763, PMID:16314884, PMID:16983399, PMID:17868938, PMID:18976543, PMID:20521326 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding
decreases expression
affects response to substance
ISO
EXP
Clozapine binds to HTR2C protein
Clozapine results in decreased expression of HTR2C mRNA
HTR2C gene polymorphism affects the susceptibility to Clozapine; HTR2C gene SNP affects the susceptibility to Clozapine; HTR2C promoter SNP affects the susceptibility to Clozapine; HTR2C protein affects the susceptibility to Clozapine
CTD PMID:9723970, PMID:12668355, PMID:15635667, PMID:16983399, PMID:17868938, PMID:19142101, PMID:19142110 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions
affects response to substance
ISO Clozapine binds to and results in decreased activity of HTR3A protein
HTR3A protein affects the susceptibility to Clozapine
CTD PMID:19696922, PMID:20168265 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 multiple interactions
affects binding
ISO Clozapine binds to and results in decreased activity of HTR6 protein
Clozapine binds to HTR6 protein
CTD PMID:11406289, PMID:16983399 NCBI chr 5:157,501,202...157,518,870
Ensembl chr 5:157,503,040...157,518,631
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 affects binding
multiple interactions
ISO Clozapine binds to HTR7 protein
[Clozapine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; Clozapine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]
CTD PMID:14578406, PMID:20827463 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression EXP Clozapine results in increased expression of ID2 mRNA CTD PMID:12437575 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Ifng interferon gamma affects expression
decreases expression
ISO Clozapine affects the expression of IFNG protein
Clozapine results in decreased expression of IFNG mRNA
CTD PMID:17346280 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO Clozapine results in decreased expression of IGF1 protein CTD PMID:11769361 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il10 interleukin 10 decreases expression EXP Clozapine results in decreased expression of IL10 protein CTD PMID:24709159 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases secretion ISO Clozapine results in increased secretion of IL2RA protein CTD PMID:8067274 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il5 interleukin 5 affects expression ISO Clozapine affects the expression of IL5 protein CTD PMID:17346280 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Ilkap ILK associated serine/threonine phosphatase decreases expression EXP Clozapine results in decreased expression of ILKAP mRNA CTD PMID:15860345 NCBI chr 9:98,514,599...98,536,586
Ensembl chr 9:98,514,584...98,536,581
JBrowse link
G Inha inhibin subunit alpha decreases expression EXP Clozapine results in decreased expression of INHA mRNA CTD PMID:16715494 NCBI chr 9:82,700,482...82,703,383
Ensembl chr 9:82,700,468...82,703,400
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Clozapine results in increased expression of INHBE mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Ins2 insulin 2 affects secretion
increases expression
ISO Clozapine affects the secretion of INS protein
Clozapine results in increased expression of INS protein
CTD PMID:11769361, PMID:16601995 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP [[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein] CTD PMID:18976543 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
increases expression
EXP Clozapine results in decreased expression of JUN mRNA
Clozapine results in increased expression of JUN mRNA
CTD PMID:12093589, PMID:15860345, PMID:18208916 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Clozapine results in increased expression of JUNB mRNA CTD PMID:12093589, PMID:19695244 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Clozapine results in decreased expression of JUND mRNA CTD PMID:12093589 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Kcna1 potassium voltage-gated channel subfamily A member 1 increases expression ISO Clozapine results in increased expression of KCNA1 mRNA CTD PMID:18797397 NCBI chr 4:159,190,781...159,192,526
Ensembl chr 4:159,190,804...159,192,526
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Clozapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnip3 potassium voltage-gated channel interacting protein 3 decreases expression
increases expression
ISO Clozapine results in decreased expression of KCNIP3 mRNA
Clozapine results in increased expression of KCNIP3 mRNA
CTD PMID:17266109, PMID:18797397 NCBI chr 3:120,023,062...120,087,650
Ensembl chr 3:120,023,917...120,087,136
JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 decreases expression ISO Clozapine results in decreased expression of KCNK2 mRNA CTD PMID:15542763 NCBI chr13:107,690,111...107,886,476
Ensembl chr13:107,690,087...107,886,476
JBrowse link
G Kmt2a lysine methyltransferase 2A increases expression
decreases expression
multiple interactions
ISO Clozapine results in increased expression of KMT2A mRNA
Clozapine results in decreased expression of KMT2A mRNA
Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]
CTD PMID:14647396, PMID:17942719 NCBI chr 8:49,110,407...49,185,872
Ensembl chr 8:49,114,990...49,158,971
JBrowse link
G Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 increases expression ISO Clozapine results in increased expression of LAMTOR3 mRNA CTD PMID:14647396 NCBI chr 2:243,160,821...243,173,057
Ensembl chr 2:243,160,917...243,173,048
JBrowse link
G Ldhb lactate dehydrogenase B increases expression EXP Clozapine results in increased expression of LDHB mRNA CTD PMID:15860345 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
JBrowse link
G Ldlr low density lipoprotein receptor increases expression
multiple interactions
ISO Clozapine results in increased expression of LDLR mRNA
Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]
CTD PMID:17052361, PMID:20564506 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lep leptin affects response to substance
increases expression
ISO
EXP
LEP protein affects the susceptibility to Clozapine
Clozapine results in increased expression of LEP protein
CTD PMID:16402076, PMID:17502770 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G LOC103690091 proSAAS affects expression ISO Clozapine affects the expression of PCSK1N mRNA CTD PMID:14647396 NCBI chr  X:15,324,261...15,328,617 JBrowse link
G Lpl lipoprotein lipase decreases expression
increases expression
ISO Clozapine results in decreased expression of LPL mRNA; Clozapine results in decreased expression of LPL protein
Clozapine results in increased expression of LPL mRNA
CTD PMID:17266109, PMID:19682446 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lss lanosterol synthase increases expression ISO Clozapine results in increased expression of LSS mRNA CTD PMID:15342952, PMID:17175557 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Mal mal, T-cell differentiation protein decreases expression ISO Clozapine results in decreased expression of MAL mRNA CTD PMID:17266109, PMID:18797397 NCBI chr 3:120,209,647...120,233,655
Ensembl chr 3:120,209,647...120,233,655
JBrowse link
G Maob monoamine oxidase B increases expression ISO Clozapine results in increased expression of MAOB mRNA CTD PMID:17266109 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Map1a microtubule-associated protein 1A increases expression EXP Clozapine results in increased expression of MAP1A mRNA CTD PMID:15860345 NCBI chr 3:113,251,918...113,272,193
Ensembl chr 3:113,251,778...113,272,186
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases expression EXP Clozapine results in decreased expression of MAP2K1 mRNA CTD PMID:15860345 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases expression
decreases expression
ISO
EXP
Clozapine results in increased expression of MAP2K2 mRNA
Clozapine results in decreased expression of MAP2K2 mRNA
CTD PMID:14647396, PMID:15860345 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 decreases expression EXP Clozapine results in decreased expression of MAP2K5 mRNA CTD PMID:15860345 NCBI chr 8:68,055,976...68,282,656
Ensembl chr 8:68,055,972...68,282,590
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression EXP Clozapine results in increased expression of MAP3K1 mRNA CTD PMID:15860345 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207
JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 increases expression EXP Clozapine results in increased expression of MAP3K12 mRNA CTD PMID:15860345 NCBI chr 7:144,102,275...144,120,306
Ensembl chr 7:144,102,680...144,109,116
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases expression
decreases phosphorylation
ISO
EXP
Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]
Clozapine results in decreased expression of MAPK1 mRNA
Clozapine results in decreased phosphorylation of MAPK1 protein
CTD PMID:12871586, PMID:15860345 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 affects expression EXP Clozapine affects the expression of MAPK14 mRNA CTD PMID:15860345 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO Clozapine results in decreased phosphorylation of MAPK3 protein
Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]
CTD PMID:12871586 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk6 mitogen-activated protein kinase 6 affects expression EXP Clozapine affects the expression of MAPK6 mRNA CTD PMID:15860345 NCBI chr 8:82,328,013...82,351,108
Ensembl chr 8:82,328,020...82,351,108
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 increases expression ISO Clozapine results in increased expression of MAPK8IP1 mRNA CTD PMID:17266109 NCBI chr 3:81,295,023...81,304,181
Ensembl chr 3:81,295,024...81,304,181
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 affects expression EXP Clozapine affects the expression of MAPK9 mRNA CTD PMID:15860345 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor decreases expression EXP Clozapine results in decreased expression of MAS1 mRNA CTD PMID:16715494 NCBI chr 1:48,076,761...48,108,218
Ensembl chr 1:48,077,033...48,108,216
JBrowse link
G Mbp myelin basic protein increases expression ISO Clozapine results in increased expression of MBP mRNA CTD PMID:17266109, PMID:17346280 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mc1r melanocortin 1 receptor increases expression ISO Clozapine results in increased expression of MC1R mRNA CTD PMID:17346280 NCBI chr19:56,215,420...56,219,987 JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase increases expression ISO Clozapine results in increased expression of MLKL protein CTD PMID:31220554 NCBI chr19:43,508,416...43,535,050
Ensembl chr19:43,506,976...43,528,851
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO Clozapine results in decreased expression of MMP10 mRNA CTD PMID:17346280 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO Clozapine results in decreased expression of MMP7 mRNA CTD PMID:17346280 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Mobp myelin-associated oligodendrocyte basic protein increases expression ISO Clozapine results in increased expression of MOBP mRNA CTD PMID:15542763, PMID:17266109 NCBI chr 8:128,824,420...128,854,492
Ensembl chr 8:128,824,508...128,850,358
JBrowse link
G Mpo myeloperoxidase affects response to substance ISO MPO protein affects the susceptibility to Clozapine CTD PMID:24588327 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mpp3 membrane palmitoylated protein 3 decreases expression ISO Clozapine results in decreased expression of MPP3 mRNA CTD PMID:17266109 NCBI chr10:89,930,270...89,959,462
Ensembl chr10:89,930,241...89,959,176
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Clozapine affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841
JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR gene polymorphism affects the susceptibility to Clozapine; MTHFR protein affects the susceptibility to Clozapine CTD PMID:20547447 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Ncan neurocan decreases expression ISO Clozapine results in decreased expression of NCAN mRNA CTD PMID:18797397 NCBI chr16:21,050,243...21,076,707
Ensembl chr16:21,050,243...21,076,707
JBrowse link
G Ncl nucleolin increases expression ISO Clozapine results in increased expression of NCL mRNA CTD PMID:14647396 NCBI chr 9:93,369,119...93,377,643
Ensembl chr 9:93,368,932...93,377,643
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 increases expression EXP Clozapine results in increased expression of NDUFV2 mRNA CTD PMID:19441803 NCBI chr 9:113,875,718...113,900,169
Ensembl chr 9:113,875,703...113,900,190
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase decreases expression ISO Clozapine results in decreased expression of NEDD4 mRNA CTD PMID:18797397 NCBI chr 8:79,323,408...79,408,842
Ensembl chr 8:79,323,408...79,408,833
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to Clozapine CTD PMID:21540358 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression EXP Clozapine results in decreased expression of NFKB1 protein CTD PMID:16500086 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Ngfr nerve growth factor receptor decreases expression ISO
EXP
Clozapine results in decreased expression of NGFR protein; Clozapine results in decreased expression of NGFR protein alternative form
Clozapine results in decreased expression of NGFR mRNA
CTD PMID:12111809, PMID:14598305, PMID:16513140 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nop53 NOP53 ribosome biogenesis factor affects expression ISO Clozapine affects the expression of NOP53 mRNA CTD PMID:14647396 NCBI chr 1:77,836,522...77,843,991
Ensembl chr 1:77,836,196...77,844,189
JBrowse link
G Nptn neuroplastin increases expression ISO Clozapine results in increased expression of NPTN mRNA CTD PMID:18797397 NCBI chr 8:63,379,062...63,445,694
Ensembl chr 8:63,379,087...63,445,686
JBrowse link
G Nptx2 neuronal pentraxin 2 decreases expression EXP Clozapine results in decreased expression of NPTX2 mRNA CTD PMID:18208916 NCBI chr12:12,014,638...12,025,547
Ensembl chr12:12,013,911...12,025,549
JBrowse link
G Npy neuropeptide Y decreases expression EXP Clozapine results in decreased expression of NPY mRNA CTD PMID:16516965 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 affects response to substance
increases reduction
multiple interactions
ISO NQO2 gene SNP affects the susceptibility to Clozapine
NQO2 protein results in increased reduction of Clozapine metabolite
Clozapine inhibits the reaction [NQO2 protein results in increased reduction of Vitamin K 3]
CTD PMID:14617031, PMID:29281794 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Clozapine results in increased expression of NR0B2 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] CTD PMID:21402137 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Clozapine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein] CTD PMID:16581232 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression
decreases expression
EXP Clozapine results in increased expression of NR4A1 mRNA
Clozapine results in decreased expression of NR4A1 mRNA
CTD PMID:10987852, PMID:11564422, PMID:19695244 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression ISO Clozapine results in increased expression of NR4A2 mRNA CTD PMID:17266109 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Nrg1 neuregulin 1 increases expression
affects expression
affects response to substance
ISO
EXP
Clozapine results in increased expression of NRG1 mRNA
Clozapine affects the expression of NRG1 protein
NRG1 protein affects the susceptibility to Clozapine
CTD PMID:15706234, PMID:18184445, PMID:19502011 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Ntng2 netrin G2 increases expression EXP Clozapine results in increased expression of NTNG2 mRNA CTD PMID:17507910 NCBI chr 3:7,742,511...7,800,834
Ensembl chr 3:7,742,531...7,796,385
JBrowse link
G Nts neurotensin increases expression EXP Clozapine results in increased expression of NTS mRNA CTD PMID:12887421 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
JBrowse link
G Numbl NUMB-like, endocytic adaptor protein decreases expression ISO Clozapine results in decreased expression of NUMBL mRNA CTD PMID:18797397 NCBI chr 1:84,067,841...84,091,659
Ensembl chr 1:84,067,938...84,091,671
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Clozapine results in increased expression of NUPR1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Osbpl8 oxysterol binding protein-like 8 increases expression ISO Clozapine results in increased expression of OSBPL8 mRNA CTD PMID:14647396 NCBI chr 7:53,878,906...54,030,110
Ensembl chr 7:53,878,610...54,027,892
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide affects response to substance ISO OXT protein affects the susceptibility to Clozapine CTD PMID:20196918 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
JBrowse link
G Park7 Parkinsonism associated deglycase increases expression ISO Clozapine results in increased expression of PARK7 mRNA CTD PMID:14647396 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Pcm1 pericentriolar material 1 decreases expression ISO Clozapine results in decreased expression of PCM1 mRNA CTD PMID:19048012 NCBI chr16:54,040,721...54,137,675
Ensembl chr16:54,040,721...54,137,660
JBrowse link
G Pde10a phosphodiesterase 10A increases expression ISO
EXP
Clozapine results in increased expression of PDE10A mRNA
Clozapine results in increased expression of PDE10A mRNA; Clozapine results in increased expression of PDE10A protein
CTD PMID:17266109, PMID:18222493 NCBI chr 1:52,360,296...52,544,448
Ensembl chr 1:52,360,296...52,544,450
JBrowse link
G Pde1b phosphodiesterase 1B increases expression ISO Clozapine results in increased expression of PDE1B mRNA CTD PMID:14647396 NCBI chr 7:145,117,951...145,147,711
Ensembl chr 7:145,117,951...145,145,376
JBrowse link
G Pde4a phosphodiesterase 4A decreases expression EXP Clozapine results in decreased expression of PDE4A protein CTD PMID:20222156 NCBI chr 8:22,189,533...22,234,036
Ensembl chr 8:22,189,600...22,233,748
JBrowse link
G Pde4b phosphodiesterase 4B decreases expression
increases expression
EXP Clozapine results in decreased expression of PDE4B protein
Clozapine results in increased expression of PDE4B mRNA; Clozapine results in increased expression of PDE4B protein
CTD PMID:18222493, PMID:20222156 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
G Penk proenkephalin decreases expression
increases expression
EXP Clozapine results in decreased expression of PENK mRNA
Clozapine results in increased expression of PENK mRNA
CTD PMID:1635659, PMID:12887421 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Pfdn5 prefoldin subunit 5 increases expression ISO Clozapine results in increased expression of PFDN5 mRNA CTD PMID:14647396 NCBI chr 7:143,924,662...143,929,400
Ensembl chr 7:143,924,662...143,929,397
JBrowse link
G Pfkp phosphofructokinase, platelet increases expression EXP Clozapine results in increased expression of PFKP mRNA CTD PMID:15860345 NCBI chr17:68,510,765...68,574,387
Ensembl chr17:68,511,064...68,559,471
JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression EXP Clozapine results in increased expression of PGK1 mRNA CTD PMID:15860345 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367
JBrowse link
G Phactr1 phosphatase and actin regulator 1 increases expression ISO Clozapine results in increased expression of PHACTR1 mRNA CTD PMID:14647396 NCBI chr17:23,245,423...23,761,207 JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 decreases expression EXP Clozapine results in decreased expression of PIK3R3 mRNA CTD PMID:16715494 NCBI chr 5:135,069,972...135,145,633
Ensembl chr 5:135,074,297...135,142,488
JBrowse link
G Pkib cAMP-dependent protein kinase inhibitor beta decreases expression EXP Clozapine results in decreased expression of PKIB mRNA CTD PMID:15860345 NCBI chr20:40,616,868...40,712,598
Ensembl chr20:40,618,128...40,712,592
JBrowse link
G Pkm pyruvate kinase M1/2 increases expression EXP Clozapine results in increased expression of PKM mRNA CTD PMID:15860345 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Plcb1 phospholipase C beta 1 increases expression ISO Clozapine results in increased expression of PLCB1 mRNA CTD PMID:16465460 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Plp1 proteolipid protein 1 decreases expression
increases expression
ISO Clozapine results in decreased expression of PLP1 mRNA
Clozapine results in increased expression of PLP1 mRNA
CTD PMID:17266109, PMID:18797397 NCBI chr  X:107,494,326...107,511,355
Ensembl chr  X:107,496,072...107,511,348
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
ISO Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein]
Clozapine results in increased expression of PPARG mRNA; Clozapine results in increased expression of PPARG protein
CTD PMID:20564506 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A decreases expression EXP Clozapine results in decreased expression of PPM1A mRNA CTD PMID:15860345 NCBI chr 6:94,433,658...94,484,979
Ensembl chr 6:94,429,068...94,484,351
JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B decreases expression EXP Clozapine results in decreased expression of PPM1B mRNA CTD PMID:15860345 NCBI chr 6:8,219,385...8,280,127
Ensembl chr 6:8,218,696...8,280,124
JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta decreases expression EXP Clozapine results in decreased expression of PPP1CB mRNA CTD PMID:15860345 NCBI chr 6:23,548,507...23,581,136
Ensembl chr 6:23,549,317...23,581,052
JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma decreases expression EXP Clozapine results in decreased expression of PPP1CC mRNA CTD PMID:15860345 NCBI chr12:39,864,302...39,882,030
Ensembl chr12:39,864,295...39,882,030
JBrowse link
G Ppp1r1a protein phosphatase 1, regulatory (inhibitor) subunit 1A decreases expression EXP Clozapine results in decreased expression of PPP1R1A mRNA CTD PMID:15860345 NCBI chr 7:145,146,480...145,154,131
Ensembl chr 7:145,146,481...145,154,131
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions
increases phosphorylation
ISO Clozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein]
Clozapine results in increased phosphorylation of PPP1R1B protein
CTD PMID:11880652, PMID:12871586 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 decreases expression EXP Clozapine results in decreased expression of PPP1R2 mRNA CTD PMID:15860345 NCBI chr11:72,748,789...73,034,683
Ensembl chr11:73,022,063...73,034,682
JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B increases expression EXP Clozapine results in increased expression of PPP1R9B protein CTD PMID:16844384 NCBI chr10:82,800,704...82,816,735
Ensembl chr10:82,800,704...82,816,731
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha decreases expression EXP Clozapine results in decreased expression of PPP2CA mRNA CTD PMID:15860345 NCBI chr10:37,534,449...37,554,861
Ensembl chr10:37,535,871...37,554,664
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta decreases expression EXP Clozapine results in decreased expression of PPP2CB mRNA CTD PMID:15860345 NCBI chr16:62,273,276...62,294,767
Ensembl chr16:62,273,276...62,294,769
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha increases expression EXP Clozapine results in increased expression of PPP2R1A mRNA CTD PMID:15860345 NCBI chr 1:60,717,386...60,736,629
Ensembl chr 1:60,717,386...60,736,609
JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha decreases expression EXP Clozapine results in decreased expression of PPP2R2A mRNA CTD PMID:15860345 NCBI chr15:43,673,958...43,733,182
Ensembl chr15:43,673,960...43,733,182
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha multiple interactions
increases expression
decreases expression
EXP [Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein
Clozapine results in increased expression of PPP3CA mRNA
Clozapine results in decreased expression of PPP3CA mRNA; Clozapine results in decreased expression of PPP3CA protein
CTD PMID:12437575, PMID:16033416 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit affects expression ISO Clozapine affects the expression of PPP5C mRNA CTD PMID:14647396 NCBI chr 1:78,944,054...78,968,361
Ensembl chr 1:78,944,040...78,968,329
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases expression EXP Clozapine results in increased expression of PRKACA mRNA CTD PMID:15860345 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta decreases expression
increases expression
EXP Clozapine results in decreased expression of PRKACB mRNA; Clozapine results in decreased expression of PRKACB protein
Clozapine results in increased expression of PRKACB mRNA
CTD PMID:11907174, PMID:15860345 NCBI chr 2:252,602,197...252,691,886
Ensembl chr 2:252,605,307...252,691,886
JBrowse link
G Prkar2a protein kinase cAMP-dependent type II regulatory subunit alpha multiple interactions
decreases expression
EXP Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2A protein]
Clozapine results in decreased expression of PRKAR2A mRNA; Clozapine results in decreased expression of PRKAR2A protein
CTD PMID:11907174 NCBI chr 8:117,486,085...117,548,768
Ensembl chr 8:117,486,083...117,546,370
JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta decreases expression
multiple interactions
EXP Clozapine results in decreased expression of PRKAR2B mRNA; Clozapine results in decreased expression of PRKAR2B protein
Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2B protein]
CTD PMID:11907174, PMID:15860345 NCBI chr 6:51,265,509...51,356,383
Ensembl chr 6:51,265,515...51,356,383
JBrowse link
G Prkcb protein kinase C, beta affects expression
increases expression
EXP Clozapine affects the expression of PRKCB protein
Clozapine results in increased expression of PRKCB mRNA
CTD PMID:15860345, PMID:15967061 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkce protein kinase C, epsilon increases expression EXP Clozapine results in increased expression of PRKCE mRNA CTD PMID:15860345 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Prkcz protein kinase C, zeta increases expression EXP Clozapine results in increased expression of PRKCZ mRNA CTD PMID:15860345 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Prl prolactin increases secretion
increases expression
multiple interactions
ISO
EXP
Clozapine results in increased secretion of PRL protein
Clozapine analog results in increased expression of PRL protein
[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein; [Risperidone co-treated with Clozapine] results in increased expression of PRL protein
CTD PMID:11155212, PMID:11997696, PMID:15286066, PMID:18562423 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa increases expression ISO Clozapine results in increased expression of PROC protein CTD PMID:20126316 NCBI chr18:24,918,402...24,928,822
Ensembl chr18:24,918,398...24,929,091
JBrowse link
G Prpf38b pre-mRNA processing factor 38B decreases expression ISO Clozapine results in decreased expression of PRPF38B mRNA CTD PMID:14647396 NCBI chr 2:211,706,245...211,715,271
Ensembl chr 2:211,706,228...211,715,311
JBrowse link
G Prrc2a proline-rich coiled-coil 2A decreases expression ISO Clozapine results in decreased expression of PRRC2A mRNA CTD PMID:18797397 NCBI chr20:5,139,881...5,155,371
Ensembl chr20:5,139,882...5,155,293
JBrowse link
G Ptgds prostaglandin D2 synthase decreases expression
increases expression
ISO Clozapine results in decreased expression of PTGDS mRNA
Clozapine results in increased expression of PTGDS mRNA
CTD PMID:15542763, PMID:17266109 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Ptms parathymosin increases expression ISO Clozapine results in increased expression of PTMS mRNA CTD PMID:14647396 NCBI chr 4:157,435,371...157,439,507
Ensembl chr 4:157,435,373...157,439,507
JBrowse link
G Pvalb parvalbumin multiple interactions EXP Clozapine inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA] CTD PMID:12589379 NCBI chr 7:119,428,657...119,443,674
Ensembl chr 7:119,429,019...119,441,487
JBrowse link
G Rab12 RAB12, member RAS oncogene family decreases expression EXP Clozapine results in decreased expression of RAB12 mRNA CTD PMID:12437575 NCBI chr 9:114,683,985...114,709,613
Ensembl chr 9:114,684,039...114,709,546
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 decreases expression ISO Clozapine results in decreased expression of RAPGEF4 mRNA CTD PMID:18797397 NCBI chr 3:58,632,338...58,925,127
Ensembl chr 3:58,632,476...58,924,038
JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 affects expression EXP Clozapine affects the expression of RASGRF1 mRNA CTD PMID:12437575 NCBI chr 8:97,277,250...97,405,095
Ensembl chr 8:97,277,456...97,405,102
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression EXP Clozapine results in decreased expression of RELA protein CTD PMID:16500086 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Reln reelin decreases expression
multiple interactions
decreases methylation
ISO
EXP
Clozapine results in decreased expression of RELN mRNA
Clozapine results in decreased expression of RELN protein
Valproic Acid promotes the reaction [Clozapine results in decreased methylation of RELN promoter]
CTD PMID:17266109, PMID:18757738, PMID:19359144 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression EXP
ISO
Clozapine results in increased expression of RGS4 mRNA CTD PMID:15860345, PMID:17266109 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Rgs7 regulator of G-protein signaling 7 multiple interactions
increases expression
EXP [[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]
Clozapine results in increased expression of RGS7 mRNA
CTD PMID:18976543 NCBI chr13:93,095,659...93,534,452
Ensembl chr13:93,095,200...93,307,199
JBrowse link
G Rgs8 regulator of G-protein signaling 8 increases expression EXP Clozapine results in increased expression of RGS8 mRNA CTD PMID:15860345 NCBI chr13:71,086,654...71,141,820
Ensembl chr13:71,086,745...71,141,075
JBrowse link
G Rorb RAR-related orphan receptor B decreases expression EXP Clozapine results in decreased expression of RORB mRNA CTD PMID:11564422 NCBI chr 1:234,252,757...234,442,597
Ensembl chr 1:234,252,757...234,435,839
JBrowse link
G Rplp2 ribosomal protein lateral stalk subunit P2 increases expression ISO Clozapine results in increased expression of RPLP2 mRNA CTD PMID:14647396 NCBI chr 1:214,428,280...214,430,551
Ensembl chr 1:214,428,526...214,430,515
JBrowse link
G Rps10 ribosomal protein S10 increases expression ISO Clozapine results in increased expression of RPS10 mRNA CTD PMID:14647396 NCBI chr20:7,215,762...7,220,331
Ensembl chr20:7,215,774...7,219,548
JBrowse link
G Rtn4 reticulon 4 increases expression ISO Clozapine results in increased expression of RTN4 mRNA CTD PMID:17266109 NCBI chr14:114,126,931...114,174,459
Ensembl chr14:114,126,943...114,174,458
JBrowse link
G Rxrg retinoid X receptor gamma decreases expression EXP Clozapine results in decreased expression of RXRG mRNA alternative form CTD PMID:11564422 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552
JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression ISO Clozapine results in decreased expression of S100A9 mRNA CTD PMID:18797397 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO Clozapine results in increased expression of SC5D mRNA CTD PMID:17052361 NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Clozapine results in increased expression of SCD mRNA CTD PMID:16027736, PMID:17052361 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Serpina3m serpin family A member 3M increases expression ISO Clozapine results in increased expression of SERPINA3 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 6:127,808,785...127,816,067
Ensembl chr 6:127,808,785...127,816,055
JBrowse link
G Serpine2 serpin family E member 2 increases expression EXP Clozapine results in increased expression of SERPINE2 mRNA; Clozapine results in increased expression of SERPINE2 protein CTD PMID:15354176 NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO
EXP
Clozapine results in increased expression of SGK1 mRNA CTD PMID:17266109, PMID:18208916 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Slc17a6 solute carrier family 17 member 6 increases expression ISO Clozapine results in increased expression of SLC17A6 mRNA; Clozapine results in increased expression of SLC17A6 protein CTD PMID:17266109, PMID:18155072 NCBI chr 1:106,980,463...107,038,717
Ensembl chr 1:106,998,623...107,038,704
JBrowse link
G Slc17a7 solute carrier family 17 member 7 increases expression ISO Clozapine results in increased expression of SLC17A7 mRNA; Clozapine results in increased expression of SLC17A7 protein CTD PMID:16111724 NCBI chr 1:101,161,265...101,172,292
Ensembl chr 1:101,161,252...101,173,174
JBrowse link
G Slc18a2 solute carrier family 18 member A2 increases expression EXP Clozapine results in increased expression of SLC18A2 mRNA; Clozapine results in increased expression of SLC18A2 protein CTD PMID:12007678 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases expression EXP Clozapine results in decreased expression of SLC1A1 mRNA CTD PMID:12873733 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Slc1a2 solute carrier family 1 member 2 decreases activity
decreases expression
EXP Clozapine results in decreased activity of SLC1A2 protein
Clozapine results in decreased expression of SLC1A2 mRNA; Clozapine results in decreased expression of SLC1A2 protein
CTD PMID:11443521, PMID:12873733 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Clozapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Clozapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:30465787 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Clozapine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Slc39a7 solute carrier family 39 member 7 increases expression ISO Clozapine results in increased expression of SLC39A7 mRNA CTD PMID:14647396 NCBI chr20:3,819,416...3,822,788
Ensembl chr20:3,819,414...3,822,778
JBrowse link
G Slc6a2 solute carrier family 6 member 2 decreases expression EXP Clozapine results in decreased expression of SLC6A2 mRNA CTD PMID:18923069 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274
JBrowse link
G Slc6a3 solute carrier family 6 member 3 affects response to substance ISO SLC6A3 5' UTR affects the susceptibility to Clozapine CTD PMID:20580759 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions
increases expression
affects response to substance
ISO
EXP
[SLC6A4 gene polymorphism results in decreased uptake of Serotonin] which results in decreased susceptibility to Clozapine
Clozapine results in increased expression of SLC6A4
SLC6A4 protein affects the susceptibility to Clozapine
CTD PMID:12007678, PMID:20452607 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Snap25 synaptosome associated protein 25 increases expression
affects response to substance
EXP
ISO
Clozapine results in increased expression of SNAP25 mRNA
SNAP25 gene SNP affects the susceptibility to Clozapine
CTD PMID:15823421, PMID:15860345 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400
JBrowse link
G Snrpd2 small nuclear ribonucleoprotein D2 polypeptide increases expression ISO Clozapine results in increased expression of SNRPD2 mRNA CTD PMID:14647396 NCBI chr 1:80,057,140...80,059,990
Ensembl chr 1:80,056,755...80,059,996
JBrowse link
G Sod1 superoxide dismutase 1 increases expression
multiple interactions
EXP Clozapine results in increased expression of SOD1 mRNA
Clozapine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA]; Clozapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]
CTD PMID:12111809, PMID:12752374, PMID:16564057 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression EXP Clozapine results in decreased expression of SOD2 mRNA CTD PMID:15860345 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sod3 superoxide dismutase 3 increases expression EXP Clozapine results in increased expression of SOD3 mRNA CTD PMID:15860345 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression
increases expression
EXP Clozapine results in decreased expression of SOS1 mRNA
Clozapine results in increased expression of SOS1 mRNA
CTD PMID:12437575 NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO Clozapine results in decreased expression of SPP1 mRNA CTD PMID:17346280 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions
ISO Clozapine results in increased expression of SREBF1 mRNA
Clozapine results in increased expression of SREBF1 mRNA; Clozapine results in increased expression of SREBF1 protein
Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein]
CTD PMID:17052361, PMID:19682446, PMID:20564506 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions
increases expression
ISO Clozapine inhibits the reaction [25-hydroxycholesterol results in decreased activity of SREBF2 protein]; Clozapine results in increased cleavage of and results in increased activity of SREBF2 protein
Clozapine results in increased expression of SREBF2 mRNA
CTD PMID:17052361 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G Sst somatostatin multiple interactions EXP Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST protein] CTD PMID:16567023 NCBI chr11:80,358,172...80,359,449
Ensembl chr11:80,358,211...80,359,444
JBrowse link
G Strn4 striatin 4 increases expression ISO Clozapine results in increased expression of STRN4 mRNA CTD PMID:14647396 NCBI chr 1:78,739,930...78,765,696
Ensembl chr 1:78,735,678...78,765,692
JBrowse link
G Stx1a syntaxin 1A increases expression EXP Clozapine results in increased expression of STX1A mRNA CTD PMID:15860345 NCBI chr12:24,682,050...24,710,002
Ensembl chr12:24,682,041...24,710,019
JBrowse link
G Stx1b syntaxin 1B increases expression EXP Clozapine results in increased expression of STX1B mRNA CTD PMID:15860345 NCBI chr 1:199,251,842...199,270,465
Ensembl chr 1:199,251,844...199,270,627
JBrowse link
G Stx4 syntaxin 4 increases expression EXP Clozapine results in increased expression of STX4 mRNA CTD PMID:15860345 NCBI chr 1:199,287,384...199,295,606
Ensembl chr 1:199,287,710...199,294,979
JBrowse link
G Stx8 syntaxin 8 affects expression EXP Clozapine affects the expression of STX8 mRNA CTD PMID:15860345 NCBI chr10:54,512,922...54,753,302
Ensembl chr10:54,512,983...54,753,302
JBrowse link
G Stxbp1 syntaxin binding protein 1 affects expression EXP Clozapine affects the expression of STXBP1 mRNA CTD PMID:12437575 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417
JBrowse link
G Supt3h SPT3 homolog, SAGA and STAGA complex component increases expression EXP Clozapine results in increased expression of SUPT3H mRNA CTD PMID:16715494 NCBI chr 9:18,249,565...18,604,814
Ensembl chr 9:18,319,246...18,371,856
JBrowse link
G Syn2 synapsin II decreases expression
increases expression
ISO
EXP
Clozapine results in decreased expression of SYN2 mRNA
Clozapine results in increased expression of SYN2 mRNA
CTD PMID:15860345, PMID:17266109 NCBI chr 4:147,037,179...147,195,096
Ensembl chr 4:147,037,179...147,195,096
JBrowse link
G Syt11 synaptotagmin 11 increases expression EXP Clozapine results in increased expression of SYT11 mRNA CTD PMID:15860345 NCBI chr 2:188,112,301...188,138,180
Ensembl chr 2:188,112,286...188,138,177
JBrowse link
G Syt2 synaptotagmin 2 increases expression ISO Clozapine results in increased expression of SYT2 mRNA CTD PMID:17266109 NCBI chr13:51,569,248...51,577,824
Ensembl chr13:51,534,025...51,578,052
JBrowse link
G Syt4 synaptotagmin 4 increases expression EXP Clozapine results in increased expression of SYT4 mRNA CTD PMID:15860345 NCBI chr18:24,172,580...24,181,989
Ensembl chr18:24,172,587...24,182,012
JBrowse link
G Syt5 synaptotagmin 5 decreases expression EXP Clozapine results in decreased expression of SYT5 mRNA CTD PMID:12437575 NCBI chr 1:72,859,806...72,867,934
Ensembl chr 1:72,860,218...72,867,930
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression ISO
EXP
Clozapine results in decreased expression of TAC1 mRNA CTD PMID:10974607, PMID:17266109 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tagln transgelin decreases expression ISO Clozapine results in decreased expression of TAGLN mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tatdn1 TatD DNase domain containing 1 increases expression ISO Clozapine results in increased expression of TATDN1 mRNA CTD PMID:14647396 NCBI chr 7:98,782,164...98,813,001
Ensembl chr 7:98,782,178...98,804,499
JBrowse link
G Th tyrosine hydroxylase decreases activity
multiple interactions
increases expression
decreases expression
increases activity
EXP
ISO
Clozapine results in decreased activity of TH protein
Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein]
Clozapine results in increased expression of TH protein
Clozapine results in decreased expression of TH mRNA; Clozapine results in decreased expression of TH protein
Clozapine results in increased activity of TH protein
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine]; [Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine
CTD PMID:12645084, PMID:15983997, PMID:16402076, PMID:16415089, PMID:17028028 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Thra thyroid hormone receptor alpha decreases expression
increases expression
EXP Clozapine results in decreased expression of THRA mRNA alternative form
Clozapine results in increased expression of THRA mRNA alternative form
CTD PMID:11564422 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta decreases expression EXP Clozapine results in decreased expression of THRB mRNA alternative form CTD PMID:11564422 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tnf tumor necrosis factor affects response to substance
increases expression
ISO
EXP
TNF protein affects the susceptibility to Clozapine
Clozapine results in increased expression of TNF protein
CTD PMID:20521320, PMID:24709159 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf15 TNF superfamily member 15 decreases expression ISO Clozapine results in decreased expression of TNFSF15 mRNA CTD PMID:17346280 NCBI chr 5:79,553,935...79,569,974
Ensembl chr 5:79,553,742...79,570,073
JBrowse link
G Tnik TRAF2 and NCK interacting kinase decreases expression ISO Clozapine results in decreased expression of TNIK mRNA CTD PMID:14647396 NCBI chr 2:113,984,599...114,391,805
Ensembl chr 2:113,984,646...114,384,894
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO Clozapine results in increased expression of TP53 mRNA
CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA]
CTD PMID:16160616 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression EXP Clozapine results in increased expression of TPI1 mRNA CTD PMID:15860345 NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905
JBrowse link
G Trim2 tripartite motif-containing 2 decreases expression ISO Clozapine results in decreased expression of TRIM2 mRNA CTD PMID:14647396 NCBI chr 2:183,145,096...183,223,819
Ensembl chr 2:183,145,089...183,213,228
JBrowse link
G Ttr transthyretin decreases expression
increases expression
ISO
EXP
Clozapine results in decreased expression of TTR mRNA
Clozapine results in increased expression of TTR mRNA; Clozapine results in increased expression of TTR protein
CTD PMID:15927202, PMID:17266109 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 increases expression ISO Clozapine results in increased expression of UBA52 mRNA CTD PMID:14647396 NCBI chr16:20,668,925...20,671,127
Ensembl chr16:20,668,971...20,671,127
JBrowse link
G Ube2r2 ubiquitin-conjugating enzyme E2R 2 affects expression ISO Clozapine affects the expression of UBE2R2 mRNA CTD PMID:14647396 NCBI chr 5:57,472,315...57,530,973
Ensembl chr 5:57,472,315...57,530,987
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO Clozapine results in increased expression of UGT1A1 mRNA CTD PMID:18227147 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein SNP results in increased glucuronidation of Clozapine CTD PMID:15708967 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Unc13a unc-13 homolog A decreases expression EXP Clozapine results in decreased expression of UNC13A mRNA CTD PMID:15860345 NCBI chr16:20,056,398...20,103,951
Ensembl chr16:20,056,765...20,097,287
JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI affects expression ISO Clozapine affects the expression of UQCR11 mRNA CTD PMID:14647396 NCBI chr 7:12,171,146...12,175,838
Ensembl chr 7:12,171,185...12,175,835
JBrowse link
G Vamp1 vesicle-associated membrane protein 1 increases expression EXP Clozapine results in increased expression of VAMP1 mRNA CTD PMID:15860345 NCBI chr 4:157,726,941...157,733,644
Ensembl chr 4:157,726,941...157,733,643
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 increases expression EXP Clozapine results in increased expression of VAMP2 mRNA CTD PMID:15860345 NCBI chr10:55,675,171...55,679,405
Ensembl chr10:55,675,575...55,679,450
JBrowse link
G Vsnl1 visinin-like 1 decreases expression EXP Clozapine results in decreased expression of VSNL1 mRNA CTD PMID:12437575 NCBI chr 6:37,001,360...37,121,969
Ensembl chr 6:37,001,356...37,122,023
JBrowse link
G Wbp1l WW domain binding protein 1-like decreases expression ISO Clozapine results in decreased expression of WBP1L mRNA CTD PMID:14647396 NCBI chr 1:266,358,728...266,415,296
Ensembl chr 1:266,358,728...266,415,296
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Clozapine results in increased expression of WIPI1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta decreases expression ISO Clozapine results in decreased expression of YWHAB mRNA CTD PMID:17266109 NCBI chr 3:160,391,108...160,399,931
Ensembl chr 3:160,391,106...160,399,931
JBrowse link
devazepide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cckar cholecystokinin A receptor multiple interactions ISO Devazepide inhibits the reaction [CCKAR protein results in increased susceptibility to denatonium] CTD PMID:18003792 NCBI chr14:59,610,939...59,619,786
Ensembl chr14:59,611,434...59,619,783
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Devazepide inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased expression of FOS protein] CTD PMID:9372230 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
diazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Diazepam results in decreased activity of AKR1C4 protein CTD PMID:11995921, PMID:12604236 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Diazepam results in decreased activity of AKR1C2 protein CTD PMID:11995921, PMID:12604236 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Diazepam results in decreased activity of AKR1C3 protein CTD PMID:11995921, PMID:12604236 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Alb albumin affects binding ISO Diazepam binds to ALB protein CTD PMID:10506189, PMID:20956006 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA] CTD PMID:21971501 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
affects expression
increases expression
EXP
ISO
[Diazepam co-treated with Pentobarbital] promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; [Pilocarpine co-treated with Diazepam co-treated with Pentobarbital] results in increased expression of BDNF protein; Diazepam inhibits the reaction [Lithium results in increased expression of BDNF mRNA]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]
Diazepam inhibits the reaction [Pentylenetetrazole results in decreased expression of BDNF protein]
Diazepam affects the expression of BDNF mRNA
Diazepam results in increased expression of BDNF protein
CTD PMID:9073163, PMID:11259499, PMID:17442489, PMID:31324950, PMID:32450180 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bgn biglycan increases expression ISO Diazepam results in increased expression of BGN mRNA CTD PMID:19114084 NCBI chr  X:157,319,042...157,331,204
Ensembl chr  X:157,319,046...157,331,204
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP
ISO
Diazepam results in decreased activity of CAT protein
Diazepam inhibits the reaction [Pentylenetetrazole results in decreased activity of CAT protein]
Simvastatin inhibits the reaction [Diazepam results in decreased activity of CAT protein]
CTD PMID:27111380, PMID:32450180 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccn3 cellular communication network factor 3 affects expression EXP Diazepam affects the expression of CCN3 mRNA CTD PMID:31324950 NCBI chr 7:94,375,134...94,382,154
Ensembl chr 7:94,375,020...94,383,024
JBrowse link
G Cnr1 cannabinoid receptor 1 affects response to substance ISO CNR1 protein affects the susceptibility to Diazepam CTD PMID:17442049 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Diazepam results in increased expression of COL1A1 mRNA CTD PMID:19114084 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col7a1 collagen type VII alpha 1 chain decreases expression ISO Diazepam results in decreased expression of COL7A1 mRNA CTD PMID:19114084 NCBI chr 8:117,694,441...117,726,844
Ensembl chr 8:117,694,605...117,726,844
JBrowse link
G Cort cortistatin affects expression EXP Diazepam affects the expression of CORT mRNA CTD PMID:31324950 NCBI chr 5:165,942,780...165,944,221 JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases expression
ISO
EXP
Plant Extracts inhibits the reaction [Diazepam results in increased expression of CREB1 protein modified form]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein]
CTD PMID:18585439, PMID:21971501 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO
EXP
Diazepam results in increased expression of CYP2B10 protein
Diazepam results in increased expression of CYP2B1 protein
CTD PMID:16684660 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Diazepam results in increased expression of CYP2B2 protein CTD PMID:16684660 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects metabolic processing
increases metabolic processing
ISO
EXP
CYP2C19 protein affects the metabolism of Diazepam
CYP2C19 protein results in increased metabolism of Diazepam
CTD PMID:12464242, PMID:15286053, PMID:15801540 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Diazepam results in increased expression of FGF2 mRNA CTD PMID:19114084 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression ISO Diazepam results in decreased expression of FGFR2 mRNA CTD PMID:19114084 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fmod fibromodulin decreases expression ISO Diazepam results in decreased expression of FMOD mRNA CTD PMID:19114084 NCBI chr13:50,874,886...50,885,503
Ensembl chr13:50,873,605...50,885,563
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP
Diazepam inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; Diazepam inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
CTD PMID:1710164, PMID:3037702, PMID:7984056, PMID:8417141, PMID:21971501 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 increases expression EXP Diazepam results in increased expression of GABBR1 mRNA CTD PMID:15802192 NCBI chr20:1,955,344...1,984,907
Ensembl chr20:1,955,359...1,984,863
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 affects activity
multiple interactions
decreases expression
increases activity
ISO
EXP
Diazepam affects the activity of GABRA1 protein
Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]
Diazepam results in decreased expression of GABRA1 mRNA
Diazepam promotes the reaction [Ethanol deficiency results in decreased expression of GABRA1 mRNA]
Diazepam results in increased activity of GABRA1 protein
Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]
CTD PMID:1712603, PMID:11804615, PMID:14684873, PMID:15613639, PMID:15802192, PMID:15864560, PMID:26344803, PMID:29038840 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 increases response to substance
multiple interactions
increases activity
affects response to substance
ISO
EXP
GABRA2 protein results in increased susceptibility to Diazepam
Diazepam results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]
Diazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA2 mRNA]
Diazepam results in increased activity of GABRA2 protein
GABRA2 protein affects the susceptibility to Diazepam
CTD PMID:14684873, PMID:15613639, PMID:16284244, PMID:18313124, PMID:21632935, PMID:29038840 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 decreases expression
multiple interactions
increases activity
EXP Diazepam results in decreased expression of GABRA3 mRNA
Diazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA3 mRNA]
Diazepam results in increased activity of GABRA3 protein
CTD PMID:14684873, PMID:15613639, PMID:15802192 NCBI chr  X:152,414,332...152,642,607
Ensembl chr  X:152,414,615...152,642,531
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression
multiple interactions
EXP Diazepam deficiency results in increased expression of GABRA4 mRNA; Diazepam results in increased expression of GABRA4 mRNA
Diazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 mRNA]; Diazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 protein]
CTD PMID:11804615, PMID:14684873, PMID:15802192 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 increases activity EXP Diazepam results in increased activity of GABRA5 protein CTD PMID:15613639 NCBI chr 1:112,833,941...112,947,482
Ensembl chr 1:112,833,944...112,947,451
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 increases expression
decreases response to substance
EXP
ISO
Diazepam results in increased expression of GABRA6 mRNA
GABRA6 gene results in decreased susceptibility to Diazepam; GABRA6 protein results in decreased susceptibility to Diazepam
CTD PMID:9281599, PMID:9987027, PMID:15802192 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions
increases expression
ISO
EXP
Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]
Diazepam results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]
Diazepam results in increased expression of GABRB1 mRNA
CTD PMID:1712603, PMID:11804615, PMID:29038840 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 decreases expression
multiple interactions
EXP
ISO
Diazepam results in decreased expression of GABRB2 mRNA
Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]
CTD PMID:11804615, PMID:26344803, PMID:29038840 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases expression
multiple interactions
EXP
ISO
Diazepam results in increased expression of GABRB3 mRNA
Diazepam results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]
CTD PMID:15802192, PMID:29038840 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta increases expression EXP Diazepam results in increased expression of GABRD mRNA CTD PMID:15802192 NCBI chr 5:172,797,478...172,809,374
Ensembl chr 5:172,797,450...172,809,353
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions
decreases expression
affects response to substance
affects binding
increases activity
ISO
EXP
Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of GABRG2 protein]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]
Diazepam affects the reaction [Ethanol deficiency results in decreased expression of GABRG2 mRNA]
Diazepam results in decreased expression of GABRG2 mRNA
GABRG2 protein affects the susceptibility to Diazepam
GABRG2 protein mutant form binds to Diazepam
Diazepam results in increased activity of GABRG2 protein
Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]
CTD PMID:1712603, PMID:7748319, PMID:10797553, PMID:10880692, PMID:11804615, PMID:14684873, PMID:15613639, PMID:26344803, PMID:29038840 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gabrq gamma-aminobutyric acid type A receptor subunit theta increases expression EXP Diazepam results in increased expression of GABRQ mRNA CTD PMID:15802192 NCBI chr  X:152,852,230...152,869,012
Ensembl chr  X:152,852,506...152,864,975
JBrowse link
G Gad1 glutamate decarboxylase 1 decreases expression EXP Diazepam results in decreased expression of GAD1 mRNA CTD PMID:15802192 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gad2 glutamate decarboxylase 2 decreases expression EXP Diazepam results in decreased expression of GAD2 mRNA CTD PMID:15802192 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A affects response to substance ISO GRIN2A protein affects the susceptibility to Diazepam CTD PMID:15731593 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 multiple interactions EXP [Pilocarpine co-treated with Diazepam] results in increased expression of HCN1 mRNA CTD PMID:12890777 NCBI chr 2:50,099,576...50,499,799
Ensembl chr 2:50,099,576...50,499,799
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Diazepam inhibits the reaction [Pentylenetetrazole results in decreased expression of HMOX1 protein] CTD PMID:32450180 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Itga5 integrin subunit alpha 5 increases expression ISO Diazepam results in increased expression of ITGA5 mRNA CTD PMID:19114084 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression ISO Diazepam results in decreased expression of ITGA6 mRNA CTD PMID:19114084 NCBI chr 3:58,442,904...58,515,124
Ensembl chr 3:58,443,101...58,515,124
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein]; Diazepam inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of JUN mRNA] CTD PMID:7984056, PMID:8417141, PMID:21971501 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Diazepam inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] CTD PMID:7984056 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity
multiple interactions
ISO
EXP
Diazepam results in increased activity of MAPK1 protein
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein]
Plant Extracts inhibits the reaction [Diazepam results in increased activity of MAPK1 protein]
CTD PMID:18585439, PMID:21971501 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein] CTD PMID:21971501 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity
multiple interactions
ISO
EXP
Diazepam results in increased activity of MAPK3 protein
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein]
Plant Extracts inhibits the reaction [Diazepam results in increased activity of MAPK3 protein]
CTD PMID:18585439, PMID:21971501 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein] CTD PMID:21971501 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Nefh neurofilament heavy affects expression EXP Diazepam affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Diazepam inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of NFKB1 protein] CTD PMID:10700573 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO
EXP
Diazepam results in increased expression of NOS2 protein
Plant Extracts inhibits the reaction [Diazepam results in increased expression of NOS2 protein]
Diazepam results in increased expression of NOS2 mRNA
CTD PMID:12429386, PMID:18585439 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Diazepam promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Diazepam promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] CTD PMID:21402137 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions EXP Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased activity of ODC1 protein]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of ODC1 mRNA] CTD PMID:1710164 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Pdyn prodynorphin multiple interactions EXP Diazepam inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA] CTD PMID:8417141 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Penk proenkephalin multiple interactions EXP Diazepam inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA] CTD PMID:8417141 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
Diazepam inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of RELA protein]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein]
CTD PMID:10700573, PMID:21971501 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc12a5 solute carrier family 12 member 5 increases response to substance ISO SLC12A5 protein results in increased susceptibility to Diazepam CTD PMID:16936706 NCBI chr 3:161,433,303...161,465,078
Ensembl chr 3:161,425,988...161,462,879
JBrowse link
G Slc1a3 solute carrier family 1 member 3 increases oxidation EXP Diazepam results in increased oxidation of SLC1A3 mRNA CTD PMID:18506841 NCBI chr 2:57,860,881...57,935,363
Ensembl chr 2:57,860,834...57,935,363
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Diazepam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Diazepam inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO Diazepam inhibits the reaction [SLC2A1 protein results in increased transport of Glucose] CTD PMID:18455367 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc6a11 solute carrier family 6 member 11 increases expression EXP Diazepam results in increased expression of SLC6A11 mRNA CTD PMID:15802192 NCBI chr 4:146,106,386...146,223,228
Ensembl chr 4:146,106,386...146,223,228
JBrowse link
G Slc6a12 solute carrier family 6 member 12 increases expression EXP Diazepam results in increased expression of SLC6A12 mRNA CTD PMID:15802192 NCBI chr 4:153,921,199...153,941,333
Ensembl chr 4:153,921,115...153,941,391
JBrowse link
G Tac1 tachykinin, precursor 1 decreases response to substance EXP TAC1 protein modified form results in decreased susceptibility to Diazepam CTD PMID:20600432 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tat tyrosine aminotransferase multiple interactions EXP [Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein] CTD PMID:7761789 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression ISO Diazepam results in decreased expression of TGFB3 mRNA CTD PMID:19114084 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression ISO Diazepam results in increased expression of TGFBR1 mRNA CTD PMID:19114084 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression ISO Diazepam results in increased expression of TGFBR2 mRNA CTD PMID:19114084 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 decreases expression ISO Diazepam results in decreased expression of TGFBR3 mRNA CTD PMID:19114084 NCBI chr14:3,506,416...3,680,508
Ensembl chr14:3,506,339...3,682,545
JBrowse link
G Tnc tenascin C decreases expression ISO Diazepam results in decreased expression of TNC mRNA CTD PMID:19114084 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP Diazepam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP Diazepam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
G Tspo translocator protein affects response to substance ISO TSPO protein affects the susceptibility to Diazepam CTD PMID:19782064 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Diazepam inhibits the reaction [Pentylenetetrazole results in increased expression of VEGFA protein] CTD PMID:32450180 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vtn vitronectin decreases expression ISO Diazepam results in decreased expression of VTN mRNA CTD PMID:19114084 NCBI chr10:65,767,960...65,771,040
Ensembl chr10:65,767,053...65,771,038
JBrowse link
estazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Estazolam results in decreased activity of AKR1C2 protein CTD PMID:11995921 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Estazolam results in decreased activity of AKR1C3 protein CTD PMID:11995921 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP Estazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP Estazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
flumazenil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP Flumazenil inhibits the reaction [Ethanol deficiency results in decreased expression of GABRA1 mRNA]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]] CTD PMID:1977069, PMID:17403139 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 multiple interactions EXP Flumazenil inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 mRNA]; Flumazenil inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 protein] CTD PMID:17403139 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions
affects binding
ISO Flumazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]
Flumazenil binds to [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]
CTD PMID:8632757 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions EXP Flumazenil promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]] CTD PMID:1977069 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 affects binding
multiple interactions
ISO Flumazenil binds to [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]
Flumazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]
CTD PMID:8632757 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions
affects binding
ISO Flumazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]
Flumazenil binds to [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]
CTD PMID:8632757 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Flumazenil inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tspo translocator protein multiple interactions ISO [Flumazenil binds to and results in decreased activity of TSPO protein] which results in decreased susceptibility to Nicotine CTD PMID:7862733 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
flunitrazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Flunitrazepam results in decreased activity of AKR1C4 protein CTD PMID:11995921 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Flunitrazepam results in decreased activity of AKR1C2 protein CTD PMID:11995921 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Flunitrazepam results in decreased activity of AKR1C3 protein CTD PMID:11995921 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Casp3 caspase 3 multiple interactions ISO CYP3A4 protein affects the reaction [Flunitrazepam results in increased activity of CASP3 protein] CTD PMID:19005028 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO CYP3A4 protein affects the reaction [Flunitrazepam results in increased activity of CASP7 protein] CTD PMID:19005028 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Crp C-reactive protein multiple interactions ISO [bromperidol co-treated with Flunitrazepam] results in increased expression of CRP protein CTD PMID:15298663 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of Flunitrazepam CTD PMID:10911933 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases hydroxylation ISO CYP3A5 protein results in increased hydroxylation of Flunitrazepam CTD PMID:15383492 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions
affects binding
ISO
EXP
2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Flunitrazepam binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]
Flunitrazepam binds to GABRA1 protein
alphaxalone promotes the reaction [Flunitrazepam binds to GABRA1 protein]; Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA1 protein]
CTD PMID:8397295, PMID:8632757, PMID:22029276 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 affects binding
multiple interactions
EXP Flunitrazepam binds to GABRA2 protein
alphaxalone promotes the reaction [Flunitrazepam binds to GABRA2 protein]; Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA2 protein]
CTD PMID:8397295 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions
affects binding
ISO 2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Flunitrazepam binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:8632757, PMID:22029276 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions
affects binding
ISO 2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Flunitrazepam binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:8632757, PMID:22029276 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Sstr3 somatostatin receptor 3 affects expression EXP Flunitrazepam affects the expression of SSTR3 mRNA CTD PMID:16162846 NCBI chr 7:119,760,881...119,768,082
Ensembl chr 7:119,760,888...119,768,082
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases activity ISO Flunitrazepam results in decreased activity of UGT1A1 protein CTD PMID:15334623 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity ISO Flunitrazepam results in decreased activity of UGT1A3 protein CTD PMID:15334623 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
flurazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 affects response to substance ISO GABRA1 protein affects the susceptibility to Flurazepam CTD PMID:12490572 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 affects response to substance ISO GABRB2 protein affects the susceptibility to Flurazepam CTD PMID:12490572 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Flurazepam results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP Flurazepam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP Flurazepam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
GYKI 52466 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP GYKI 52466 inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased phosphorylation of CREB1 protein] CTD PMID:14622123 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO GYKI 52466 inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein] CTD PMID:16686654 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
Lorazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 decreases expression EXP Lorazepam results in decreased expression of GABRA1 mRNA CTD PMID:16107249 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 affects expression EXP Lorazepam affects the expression of GABRA2 mRNA CTD PMID:16107249 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 increases expression EXP Lorazepam results in increased expression of GABRA3 mRNA CTD PMID:16107249 NCBI chr  X:152,414,332...152,642,607
Ensembl chr  X:152,414,615...152,642,531
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 affects expression
affects response to substance
EXP Lorazepam affects the expression of GABRA4 mRNA
GABRA4 protein affects the susceptibility to Lorazepam
CTD PMID:12522171, PMID:16107249 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 decreases expression EXP Lorazepam results in decreased expression of GABRG2 mRNA alternative form CTD PMID:16107249 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
midazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Midazolam results in decreased activity of ABCB11 protein
Midazolam inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:20829430, PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Midazolam results in increased expression of ABCB1 protein CTD PMID:8632764 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 multiple interactions
decreases metabolic processing
ISO [ABCB6 gene mutant form results in decreased expression of CYP3A11 mRNA] inhibits the reaction [CYP3A11 protein results in increased metabolism of Midazolam]; [ABCB6 gene mutant form results in decreased expression of CYP3A11 protein] inhibits the reaction [CYP3A11 protein results in increased metabolism of Midazolam]
ABCB6 gene mutant form results in decreased metabolism of Midazolam
CTD PMID:25623066 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Midazolam results in increased expression of BCL2 CTD PMID:17715682 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Midazolam results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Midazolam results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity ISO Midazolam results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Midazolam results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Midazolam results in decreased activity of CYP2D6 protein CTD PMID:18420780 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of Midazolam CTD PMID:17590308 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases hydroxylation
affects metabolic processing
multiple interactions
EXP CYP3A2 protein results in increased hydroxylation of Midazolam
CYP3A4 protein affects the metabolism of Midazolam
shikonin inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Midazolam]
CTD PMID:11911841, PMID:15801540, PMID:28941798 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases hydroxylation EXP CYP3A23-3A1 protein results in increased hydroxylation of Midazolam CTD PMID:11911841 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing
increases metabolic processing
multiple interactions
increases hydroxylation
ISO
EXP
CYP3A5 gene polymorphism affects the metabolism of Midazolam; CYP3A5 protein affects the metabolism of Midazolam
CYP3A5 protein results in increased metabolism of Midazolam
fructus schizandrae, radix ginseng, radix ophiopogonis drug combination affects the reaction [CYP3A5 protein affects the metabolism of Midazolam]
CYP3A5 protein results in increased hydroxylation of Midazolam
CTD PMID:15383492, PMID:15499178, PMID:15801540, PMID:15900284, PMID:19557931, PMID:26958860 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression ISO Midazolam results in increased expression of GABRA4 mRNA CTD PMID:16733821 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 decreases response to substance ISO GABRA6 protein mutant form results in decreased susceptibility to Midazolam CTD PMID:12031754 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases response to substance ISO GABRB3 protein results in increased susceptibility to Midazolam CTD PMID:9523823 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon decreases response to substance EXP GABRE protein results in decreased susceptibility to Midazolam CTD PMID:11691872 NCBI chr  X:152,220,180...152,237,347
Ensembl chr  X:152,218,707...152,237,361
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 affects response to substance
affects binding
ISO GABRG2 protein alternative form affects the susceptibility to Midazolam
GABRG2 protein mutant form binds to Midazolam
CTD PMID:10880692 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gast gastrin multiple interactions EXP [fluanisone co-treated with Fentanyl co-treated with Midazolam] inhibits the reaction [GAST protein results in increased secretion of Histamine] CTD PMID:10864877 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A affects response to substance ISO GRIN2A protein affects the susceptibility to Midazolam CTD PMID:15731593 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Midazolam results in increased activity of NR1I2 protein
NR1I2 gene promotes the reaction [Rifampin results in increased metabolism of Midazolam]
CTD PMID:18799805, PMID:20080160 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases metabolic processing ISO NR1I3 gene mutant form results in decreased metabolism of Midazolam CTD PMID:27434302 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO Midazolam results in increased expression of STAR protein CTD PMID:19857560 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Syn1 synapsin I decreases expression EXP Midazolam results in decreased expression of SYN1 protein CTD PMID:21920406 NCBI chr  X:1,321,315...1,379,202
Ensembl chr  X:1,321,315...1,379,198
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP Midazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP Midazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
G Tspo translocator protein increases expression
affects binding
ISO
EXP
Midazolam results in increased expression of TSPO protein
Midazolam binds to TSPO protein
CTD PMID:7603229, PMID:19857560 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
nimetazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP3 protein] CTD PMID:19005028 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP7 protein] CTD PMID:19005028 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO nimetazepam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
nitrazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Nitrazepam results in decreased activity of AKR1C4 protein CTD PMID:11995921 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Nitrazepam results in decreased activity of AKR1C2 protein CTD PMID:11995921 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Nitrazepam results in decreased activity of AKR1C3 protein CTD PMID:11995921 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Casp3 caspase 3 multiple interactions ISO CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP3 protein] CTD PMID:19005028 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP7 protein] CTD PMID:19005028 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Nitrazepam binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
olanzapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A1bg alpha-1-B glycoprotein affects phosphorylation ISO olanzapine affects the phosphorylation of A1BG protein CTD PMID:25821032 NCBI chr 7:102,294,805...102,298,522
Ensembl chr 7:102,294,797...102,298,522
JBrowse link
G A2m alpha-2-macroglobulin affects phosphorylation ISO olanzapine affects the phosphorylation of A2M protein CTD PMID:25821032 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO olanzapine results in decreased activity of ABCB11 protein CTD PMID:22646477 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO olanzapine results in decreased activity of ABCB1 protein CTD PMID:16810505 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO olanzapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone] CTD PMID:18834354 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression
multiple interactions
ISO Olanzapine results in decreased expression of ACACA mRNA
capsazepine inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA]; Metformin inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA]
CTD PMID:32652086 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of ACOX1 protein; [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of ACOX1 mRNA CTD PMID:23226405 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Adcyap1r1 ADCYAP receptor type I affects expression ISO olanzapine affects the expression of ADCYAP1R1 mRNA CTD PMID:27900577 NCBI chr 4:85,662,809...85,711,696
Ensembl chr 4:85,662,892...85,711,696
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
decreases expression
multiple interactions
ISO olanzapine results in increased expression of ADIPOQ mRNA
Olanzapine results in decreased expression of ADIPOQ protein
capsazepine inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]; Metformin inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]
CTD PMID:17651982, PMID:32652086 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Afm afamin affects phosphorylation ISO olanzapine affects the phosphorylation of AFM protein CTD PMID:25821032 NCBI chr14:19,078,678...19,132,212
Ensembl chr14:19,078,680...19,132,208
JBrowse link
G Agrp agouti related neuropeptide increases expression
multiple interactions
EXP
ISO
olanzapine results in increased expression of AGRP protein
Metformin inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA]
CTD PMID:21695181, PMID:32652086 NCBI chr19:37,525,941...37,584,875
Ensembl chr19:37,526,419...37,528,011
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
decreases expression
multiple interactions
increases response to substance
increases phosphorylation
ISO Olanzapine results in increased expression of AKT1 mRNA; Olanzapine results in increased expression of AKT1 protein
Olanzapine results in decreased expression of AKT1 mRNA
capsazepine inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]; Metformin inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]
AKT1 gene SNP results in increased susceptibility to olanzapine
olanzapine results in increased phosphorylation of AKT1 protein
CTD PMID:19440698, PMID:21187413, PMID:32652086 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin affects phosphorylation ISO olanzapine affects the phosphorylation of ALB protein CTD PMID:25821032 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Apoa1 apolipoprotein A1 increases phosphorylation ISO olanzapine results in increased phosphorylation of APOA1 protein CTD PMID:25821032 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoa4 apolipoprotein A4 affects phosphorylation ISO olanzapine affects the phosphorylation of APOA4 protein CTD PMID:25821032 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Apob apolipoprotein B increases phosphorylation ISO olanzapine results in increased phosphorylation of APOB protein CTD PMID:25821032 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Apoc3 apolipoprotein C3 affects response to substance EXP APOC3 gene polymorphism affects the susceptibility to olanzapine CTD PMID:17726453 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498
JBrowse link
G Apoh apolipoprotein H affects phosphorylation ISO olanzapine affects the phosphorylation of APOH protein CTD PMID:25821032 NCBI chr10:96,640,013...96,653,939
Ensembl chr10:96,639,924...96,653,938
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP olanzapine inhibits the reaction [APP protein modified form affects the activity of CAT protein]; olanzapine inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species] CTD PMID:15948179 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Aqp4 aquaporin 4 affects response to substance
increases response to substance
ISO AQP4 gene polymorphism affects the susceptibility to olanzapine
AQP4 protein results in increased susceptibility to olanzapine
CTD PMID:22544010 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP olanzapine results in increased expression of BAX protein CTD PMID:16462815 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
EXP olanzapine inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]
olanzapine results in increased expression of BCL2 mRNA; olanzapine results in increased expression of BCL2 protein
CTD PMID:15126120, PMID:15276877 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP
ISO
olanzapine results in increased expression of BDNF mRNA; olanzapine results in increased expression of BDNF protein
Olanzapine results in increased expression of BDNF mRNA; Olanzapine results in increased expression of BDNF protein
CTD PMID:12478621, PMID:17442489, PMID:29182611 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bik BCL2-interacting killer increases expression ISO olanzapine results in increased expression of BIK mRNA CTD PMID:16160616 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447
JBrowse link
G C3 complement C3 affects phosphorylation ISO olanzapine affects the phosphorylation of C3 protein CTD PMID:25821032 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G C4a complement C4A decreases phosphorylation ISO olanzapine results in decreased phosphorylation of C4A protein CTD PMID:25821032 NCBI chr20:2,651,599...2,678,183
Ensembl chr20:2,651,599...2,678,141
JBrowse link
G C4b complement C4B (Chido blood group) affects phosphorylation ISO olanzapine affects the phosphorylation of C4B protein CTD PMID:25821032 NCBI chr20:4,302,344...4,316,752
Ensembl chr20:4,302,344...4,316,715
JBrowse link
G C5 complement C5 affects phosphorylation ISO olanzapine affects the phosphorylation of C5 protein CTD PMID:25821032 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G C6 complement C6 affects phosphorylation ISO olanzapine affects the phosphorylation of C6 protein CTD PMID:25821032 NCBI chr 2:54,460,333...54,533,801
Ensembl chr 2:54,466,280...54,533,797
JBrowse link
G C9 complement C9 affects phosphorylation ISO olanzapine affects the phosphorylation of C9 protein CTD PMID:25821032 NCBI chr 2:55,775,562...55,823,807
Ensembl chr 2:55,775,274...55,823,826
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP olanzapine results in decreased expression of and results in decreased phosphorylation of CAMK2A protein CTD PMID:18061412 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Cat catalase multiple interactions EXP olanzapine inhibits the reaction [APP protein modified form affects the activity of CAT protein] CTD PMID:15948179 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cfb complement factor B affects phosphorylation ISO olanzapine affects the phosphorylation of CFB protein CTD PMID:25821032 NCBI chr20:4,536,206...4,542,073
Ensembl chr20:4,536,203...4,561,066
Ensembl chr20:4,536,203...4,561,066
JBrowse link
G Cfh complement factor H decreases phosphorylation ISO olanzapine results in decreased phosphorylation of CFH protein CTD PMID:25821032 NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 affects binding ISO olanzapine binds to CHRM1 protein CTD PMID:16983399 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Clu clusterin affects phosphorylation ISO olanzapine affects the phosphorylation of CLU protein CTD PMID:25821032 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases phosphorylation ISO olanzapine results in decreased phosphorylation of COL1A1 protein CTD PMID:25821032 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Comt catechol-O-methyltransferase increases expression EXP olanzapine results in increased expression of COMT mRNA CTD PMID:15964593 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cp ceruloplasmin affects phosphorylation ISO olanzapine affects the phosphorylation of CP protein CTD PMID:25821032 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions EXP [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of CPT2 mRNA; [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of CPT2 protein; [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of CPT2 mRNA CTD PMID:23226405 NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP [Fluoxetine co-treated with olanzapine] results in decreased phosphorylation of CREB1 protein CTD PMID:14556240 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
increases expression
multiple interactions
ISO olanzapine results in decreased expression of CTNNB1 mRNA
Olanzapine results in increased expression of CTNNB1 mRNA
Olanzapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA]
CTD PMID:18797397, PMID:31563592 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
multiple interactions
ISO CYP1A2 protein affects the metabolism of olanzapine
Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of olanzapine]
CTD PMID:15545309, PMID:15883149 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Dab1 DAB adaptor protein 1 decreases expression EXP olanzapine results in decreased expression of DAB1 protein CTD PMID:19359144 NCBI chr 5:123,154,360...124,279,170
Ensembl chr 5:123,905,166...124,280,115
JBrowse link
G Dclk1 doublecortin-like kinase 1 increases expression ISO olanzapine results in increased expression of DCLK1 mRNA CTD PMID:18797397 NCBI chr 2:144,646,255...144,939,389
Ensembl chr 2:144,646,308...144,936,927
JBrowse link
G Drd1 dopamine receptor D1 affects binding ISO olanzapine binds to DRD1 protein CTD PMID:24389121 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 increases response to substance
affects binding
multiple interactions
decreases activity
affects activity
ISO
EXP
DRD2 gene SNP results in increased susceptibility to olanzapine; DRD2 intron SNP results in increased susceptibility to olanzapine
olanzapine binds to DRD2 protein
olanzapine promotes the reaction [Dopamine binds to DRD2 protein]
olanzapine results in decreased activity of DRD2 protein
olanzapine affects the activity of DRD2 protein
CTD PMID:10482380, PMID:10831489, PMID:11198054, PMID:15716360, PMID:20361897, PMID:20375926, PMID:21187413, PMID:24389121 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions ISO DRD3 protein results in increased susceptibility to [olanzapine co-treated with Fluoxetine] CTD PMID:20021991 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G F2 coagulation factor II affects phosphorylation ISO olanzapine affects the phosphorylation of F2 protein CTD PMID:25821032 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Olanzapine results in increased expression of FABP1 mRNA CTD PMID:31437515 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fasn fatty acid synthase increases expression ISO olanzapine results in increased expression of FASN mRNA CTD PMID:17651982 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP [Fluoxetine co-treated with olanzapine] results in increased expression of FGF2 mRNA CTD PMID:15158429 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fn1 fibronectin 1 affects phosphorylation ISO olanzapine affects the phosphorylation of FN1 protein CTD PMID:25821032 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Fluoxetine co-treated with olanzapine] results in decreased expression of FOS protein CTD PMID:14556240 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions EXP olanzapine inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOSL1 protein] CTD PMID:11425506 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Gad1 glutamate decarboxylase 1 decreases expression EXP olanzapine results in decreased expression of GAD1 mRNA; olanzapine results in decreased expression of GAD1 protein CTD PMID:14519413, PMID:19359144 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
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G Gad2 glutamate decarboxylase 2 decreases expression EXP olanzapine results in decreased expression of GAD2 protein CTD PMID:19359144 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
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G Gc GC, vitamin D binding protein affects phosphorylation ISO olanzapine affects the phosphorylation of GC protein CTD PMID:25821032 NCBI chr14:20,267,023...20,302,577
Ensembl chr14:20,266,891...20,302,581
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G Gfap glial fibrillary acidic protein multiple interactions
increases expression
ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA]; Metformin inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA] CTD PMID:32652086 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
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G Ghrl ghrelin and obestatin prepropeptide multiple interactions
increases expression
ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of GHRL protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of GHRL protein]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHRL protein] CTD PMID:32652086 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
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G Ghsr growth hormone secretagogue receptor increases expression
multiple interactions
ISO Olanzapine results in increased expression of GHSR mRNA
capsazepine inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA]; Metformin inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA]
CTD PMID:32652086 NCBI chr 2:113,065,953...113,071,265
Ensembl chr 2:113,066,885...113,070,261
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G Gria2 glutamate ionotropic receptor AMPA type subunit 2 increases expression EXP olanzapine results in increased expression of GRIA2 mRNA CTD PMID:11526992 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
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G Gria3 glutamate ionotropic receptor AMPA type subunit 3 increases expression EXP olanzapine results in increased expression of GRIA3 mRNA CTD PMID:11526992 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753
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G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
decreases expression
ISO olanzapine results in increased phosphorylation of GSK3B protein
Olanzapine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]
Olanzapine results in decreased expression of GSK3B mRNA
CTD PMID:19440698, PMID:31563592 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression
decreases expression
multiple interactions
ISO
EXP
olanzapine results in increased expression of HMGCR mRNA
olanzapine results in decreased expression of HMGCR mRNA
1-(carboxymethylthio)tetradecane promotes the reaction [olanzapine results in decreased expression of HMGCR mRNA]; olanzapine promotes the reaction [1-(carboxymethylthio)tetradecane results in decreased expression of HMGCR mRNA]
CTD PMID:17052361, PMID:23226405 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO olanzapine results in increased expression of HMGCS1 mRNA CTD PMID:17052361 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hpx hemopexin affects phosphorylation ISO olanzapine affects the phosphorylation of HPX protein CTD PMID:25821032 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073
JBrowse link
G Hrg histidine-rich glycoprotein affects phosphorylation ISO olanzapine affects the phosphorylation of HRG protein CTD PMID:25821032 NCBI chr11:81,621,274...81,639,938
Ensembl chr11:81,621,283...81,639,952
JBrowse link
G Hrh1 histamine receptor H 1 affects binding
multiple interactions
ISO olanzapine binds to HRH1 protein
HRH1 protein results in increased susceptibility to [olanzapine co-treated with Fluoxetine]
CTD PMID:16983399, PMID:20021991, PMID:24389121 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
affects binding
decreases activity
ISO
EXP
olanzapine binds to and results in decreased activity of HTR2A protein
olanzapine binds to HTR2A protein
olanzapine results in decreased activity of HTR2A protein
[[olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in decreased activity of HTR2A protein]; [olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; olanzapine binds to and results in decreased activity of HTR2A protein
CTD PMID:16983399, PMID:18976543, PMID:19304867, PMID:20521326, PMID:24389121 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C increases response to substance
affects binding
affects response to substance
ISO HTR2C gene polymorphism results in increased susceptibility to olanzapine
olanzapine binds to HTR2C protein
HTR2C gene polymorphism affects the susceptibility to Olanzapine; HTR2C gene SNP affects the susceptibility to Olanzapine; HTR2C protein affects the susceptibility to Olanzapine
CTD PMID:15666332, PMID:16983399, PMID:19142110, PMID:19434072,