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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,4-benzodiazepinone
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Accession:CHEBI:35500 term browser browse the term
Synonyms:related_synonym: 1,4-benzodiazepinones


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clobazam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 affects response to substance EXP ABCC2 protein affects the susceptibility to clobazam CTD PMID:22982618 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G F2 coagulation factor II multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Sele selectin E multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of SELE protein CTD PMID:16376047 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serpinc1 serpin family C member 1 multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
clonazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Clonazepam results in increased expression of BAX protein CTD PMID:17456340 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Clonazepam results in increased expression of BCL2 protein CTD PMID:17456340 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases activity EXP Clonazepam results in increased activity of CYP2B1 protein CTD PMID:1372805 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Dcx doublecortin decreases expression EXP Clonazepam results in decreased expression of DCX protein CTD PMID:19437554 NCBI chr  X:115,098,675...115,175,515
Ensembl chr  X:115,098,675...115,175,299
JBrowse link
G Ephx1 epoxide hydrolase 1 increases activity EXP Clonazepam results in increased activity of EPHX1 protein CTD PMID:1372805 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Clonazepam binds to and results in increased activity of NR1I2 protein CTD PMID:20024649 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
devazepide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cckar cholecystokinin A receptor multiple interactions ISO Devazepide inhibits the reaction [CCKAR protein results in increased susceptibility to denatonium] CTD PMID:18003792 NCBI chr14:59,610,939...59,619,786
Ensembl chr14:59,611,434...59,619,783
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Devazepide inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased expression of FOS protein] CTD PMID:9372230 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
diazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Diazepam results in decreased activity of AKR1C4 protein CTD PMID:11995921, PMID:12604236 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Diazepam results in decreased activity of AKR1C2 protein CTD PMID:11995921, PMID:12604236 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Diazepam results in decreased activity of AKR1C3 protein CTD PMID:11995921, PMID:12604236 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Alb albumin affects binding ISO Diazepam binds to ALB protein CTD PMID:10506189, PMID:20956006 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA] CTD PMID:21971501 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
affects expression
increases expression
EXP
ISO
[Diazepam co-treated with Pentobarbital] promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; [Pilocarpine co-treated with Diazepam co-treated with Pentobarbital] results in increased expression of BDNF protein; Diazepam inhibits the reaction [Lithium results in increased expression of BDNF mRNA]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]
Diazepam inhibits the reaction [Pentylenetetrazole results in decreased expression of BDNF protein]
Diazepam affects the expression of BDNF mRNA
Diazepam results in increased expression of BDNF protein
CTD PMID:9073163, PMID:11259499, PMID:17442489, PMID:31324950, PMID:32450180 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bgn biglycan increases expression ISO Diazepam results in increased expression of BGN mRNA CTD PMID:19114084 NCBI chr  X:157,319,042...157,331,204
Ensembl chr  X:157,319,046...157,331,204
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP
ISO
Diazepam results in decreased activity of CAT protein
Diazepam inhibits the reaction [Pentylenetetrazole results in decreased activity of CAT protein]
Simvastatin inhibits the reaction [Diazepam results in decreased activity of CAT protein]
CTD PMID:27111380, PMID:32450180 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccn3 cellular communication network factor 3 affects expression EXP Diazepam affects the expression of CCN3 mRNA CTD PMID:31324950 NCBI chr 7:94,375,134...94,382,154
Ensembl chr 7:94,375,020...94,383,024
JBrowse link
G Cnr1 cannabinoid receptor 1 affects response to substance ISO CNR1 protein affects the susceptibility to Diazepam CTD PMID:17442049 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Diazepam results in increased expression of COL1A1 mRNA CTD PMID:19114084 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col7a1 collagen type VII alpha 1 chain decreases expression ISO Diazepam results in decreased expression of COL7A1 mRNA CTD PMID:19114084 NCBI chr 8:117,694,441...117,726,844
Ensembl chr 8:117,694,605...117,726,844
JBrowse link
G Cort cortistatin affects expression EXP Diazepam affects the expression of CORT mRNA CTD PMID:31324950 NCBI chr 5:165,942,780...165,944,221 JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases expression
ISO
EXP
Plant Extracts inhibits the reaction [Diazepam results in increased expression of CREB1 protein modified form]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein]
CTD PMID:18585439, PMID:21971501 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO
EXP
Diazepam results in increased expression of CYP2B10 protein
Diazepam results in increased expression of CYP2B1 protein
CTD PMID:16684660 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Diazepam results in increased expression of CYP2B2 protein CTD PMID:16684660 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects metabolic processing
increases metabolic processing
ISO
EXP
CYP2C19 protein affects the metabolism of Diazepam
CYP2C19 protein results in increased metabolism of Diazepam
CTD PMID:12464242, PMID:15286053, PMID:15801540 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Diazepam results in increased expression of FGF2 mRNA CTD PMID:19114084 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression ISO Diazepam results in decreased expression of FGFR2 mRNA CTD PMID:19114084 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fmod fibromodulin decreases expression ISO Diazepam results in decreased expression of FMOD mRNA CTD PMID:19114084 NCBI chr13:50,874,886...50,885,503
Ensembl chr13:50,873,605...50,885,563
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP
Diazepam inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; Diazepam inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
CTD PMID:1710164, PMID:3037702, PMID:7984056, PMID:8417141, PMID:21971501 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 increases expression EXP Diazepam results in increased expression of GABBR1 mRNA CTD PMID:15802192 NCBI chr20:1,955,344...1,984,907
Ensembl chr20:1,955,359...1,984,863
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 affects activity
multiple interactions
decreases expression
increases activity
ISO
EXP
Diazepam affects the activity of GABRA1 protein
Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]
Diazepam results in decreased expression of GABRA1 mRNA
Diazepam promotes the reaction [Ethanol deficiency results in decreased expression of GABRA1 mRNA]
Diazepam results in increased activity of GABRA1 protein
Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]
CTD PMID:1712603, PMID:11804615, PMID:14684873, PMID:15613639, PMID:15802192, PMID:15864560, PMID:26344803, PMID:29038840 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 increases response to substance
multiple interactions
increases activity
affects response to substance
ISO
EXP
GABRA2 protein results in increased susceptibility to Diazepam
Diazepam results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]
Diazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA2 mRNA]
Diazepam results in increased activity of GABRA2 protein
GABRA2 protein affects the susceptibility to Diazepam
CTD PMID:14684873, PMID:15613639, PMID:16284244, PMID:18313124, PMID:21632935, PMID:29038840 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 decreases expression
multiple interactions
increases activity
EXP Diazepam results in decreased expression of GABRA3 mRNA
Diazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA3 mRNA]
Diazepam results in increased activity of GABRA3 protein
CTD PMID:14684873, PMID:15613639, PMID:15802192 NCBI chr  X:152,414,332...152,642,607
Ensembl chr  X:152,414,615...152,642,531
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression
multiple interactions
EXP Diazepam deficiency results in increased expression of GABRA4 mRNA; Diazepam results in increased expression of GABRA4 mRNA
Diazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 mRNA]; Diazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 protein]
CTD PMID:11804615, PMID:14684873, PMID:15802192 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 increases activity EXP Diazepam results in increased activity of GABRA5 protein CTD PMID:15613639 NCBI chr 1:112,833,941...112,947,482
Ensembl chr 1:112,833,944...112,947,451
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 increases expression
decreases response to substance
EXP
ISO
Diazepam results in increased expression of GABRA6 mRNA
GABRA6 gene results in decreased susceptibility to Diazepam; GABRA6 protein results in decreased susceptibility to Diazepam
CTD PMID:9281599, PMID:9987027, PMID:15802192 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions
increases expression
ISO
EXP
Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]
Diazepam results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]
Diazepam results in increased expression of GABRB1 mRNA
CTD PMID:1712603, PMID:11804615, PMID:29038840 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 decreases expression
multiple interactions
EXP
ISO
Diazepam results in decreased expression of GABRB2 mRNA
Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]
CTD PMID:11804615, PMID:26344803, PMID:29038840 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases expression
multiple interactions
EXP
ISO
Diazepam results in increased expression of GABRB3 mRNA
Diazepam results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]
CTD PMID:15802192, PMID:29038840 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta increases expression EXP Diazepam results in increased expression of GABRD mRNA CTD PMID:15802192 NCBI chr 5:172,797,478...172,809,374
Ensembl chr 5:172,797,450...172,809,353
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions
decreases expression
affects response to substance
affects binding
increases activity
ISO
EXP
Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of GABRG2 protein]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]
Diazepam affects the reaction [Ethanol deficiency results in decreased expression of GABRG2 mRNA]
Diazepam results in decreased expression of GABRG2 mRNA
GABRG2 protein affects the susceptibility to Diazepam
GABRG2 protein mutant form binds to Diazepam
Diazepam results in increased activity of GABRG2 protein
Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]
CTD PMID:1712603, PMID:7748319, PMID:10797553, PMID:10880692, PMID:11804615, PMID:14684873, PMID:15613639, PMID:26344803, PMID:29038840 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gabrq gamma-aminobutyric acid type A receptor subunit theta increases expression EXP Diazepam results in increased expression of GABRQ mRNA CTD PMID:15802192 NCBI chr  X:152,852,230...152,869,012
Ensembl chr  X:152,852,506...152,864,975
JBrowse link
G Gad1 glutamate decarboxylase 1 decreases expression EXP Diazepam results in decreased expression of GAD1 mRNA CTD PMID:15802192 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gad2 glutamate decarboxylase 2 decreases expression EXP Diazepam results in decreased expression of GAD2 mRNA CTD PMID:15802192 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A affects response to substance ISO GRIN2A protein affects the susceptibility to Diazepam CTD PMID:15731593 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 multiple interactions EXP [Pilocarpine co-treated with Diazepam] results in increased expression of HCN1 mRNA CTD PMID:12890777 NCBI chr 2:50,099,576...50,499,799
Ensembl chr 2:50,099,576...50,499,799
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Diazepam inhibits the reaction [Pentylenetetrazole results in decreased expression of HMOX1 protein] CTD PMID:32450180 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Itga5 integrin subunit alpha 5 increases expression ISO Diazepam results in increased expression of ITGA5 mRNA CTD PMID:19114084 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression ISO Diazepam results in decreased expression of ITGA6 mRNA CTD PMID:19114084 NCBI chr 3:58,442,904...58,515,124
Ensembl chr 3:58,443,101...58,515,124
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein]; Diazepam inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of JUN mRNA] CTD PMID:7984056, PMID:8417141, PMID:21971501 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Diazepam inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] CTD PMID:7984056 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity
multiple interactions
ISO
EXP
Diazepam results in increased activity of MAPK1 protein
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein]
Plant Extracts inhibits the reaction [Diazepam results in increased activity of MAPK1 protein]
CTD PMID:18585439, PMID:21971501 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein] CTD PMID:21971501 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity
multiple interactions
ISO
EXP
Diazepam results in increased activity of MAPK3 protein
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein]
Plant Extracts inhibits the reaction [Diazepam results in increased activity of MAPK3 protein]
CTD PMID:18585439, PMID:21971501 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein] CTD PMID:21971501 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Nefh neurofilament heavy affects expression EXP Diazepam affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Diazepam inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of NFKB1 protein] CTD PMID:10700573 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO
EXP
Diazepam results in increased expression of NOS2 protein
Plant Extracts inhibits the reaction [Diazepam results in increased expression of NOS2 protein]
Diazepam results in increased expression of NOS2 mRNA
CTD PMID:12429386, PMID:18585439 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Diazepam promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Diazepam promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] CTD PMID:21402137 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions EXP Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased activity of ODC1 protein]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of ODC1 mRNA] CTD PMID:1710164 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Pdyn prodynorphin multiple interactions EXP Diazepam inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA] CTD PMID:8417141 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Penk proenkephalin multiple interactions EXP Diazepam inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA] CTD PMID:8417141 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
Diazepam inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of RELA protein]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein]
CTD PMID:10700573, PMID:21971501 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc12a5 solute carrier family 12 member 5 increases response to substance ISO SLC12A5 protein results in increased susceptibility to Diazepam CTD PMID:16936706 NCBI chr 3:161,433,303...161,465,078
Ensembl chr 3:161,425,988...161,462,879
JBrowse link
G Slc1a3 solute carrier family 1 member 3 increases oxidation EXP Diazepam results in increased oxidation of SLC1A3 mRNA CTD PMID:18506841 NCBI chr 2:57,860,881...57,935,363
Ensembl chr 2:57,860,834...57,935,363
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Diazepam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Diazepam inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO Diazepam inhibits the reaction [SLC2A1 protein results in increased transport of Glucose] CTD PMID:18455367 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc6a11 solute carrier family 6 member 11 increases expression EXP Diazepam results in increased expression of SLC6A11 mRNA CTD PMID:15802192 NCBI chr 4:146,106,386...146,223,228
Ensembl chr 4:146,106,386...146,223,228
JBrowse link
G Slc6a12 solute carrier family 6 member 12 increases expression EXP Diazepam results in increased expression of SLC6A12 mRNA CTD PMID:15802192 NCBI chr 4:153,921,199...153,941,333
Ensembl chr 4:153,921,115...153,941,391
JBrowse link
G Tac1 tachykinin, precursor 1 decreases response to substance EXP TAC1 protein modified form results in decreased susceptibility to Diazepam CTD PMID:20600432 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tat tyrosine aminotransferase multiple interactions EXP [Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein] CTD PMID:7761789 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression ISO Diazepam results in decreased expression of TGFB3 mRNA CTD PMID:19114084 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression ISO Diazepam results in increased expression of TGFBR1 mRNA CTD PMID:19114084 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression ISO Diazepam results in increased expression of TGFBR2 mRNA CTD PMID:19114084 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 decreases expression ISO Diazepam results in decreased expression of TGFBR3 mRNA CTD PMID:19114084 NCBI chr14:3,506,416...3,680,508
Ensembl chr14:3,506,339...3,682,545
JBrowse link
G Tnc tenascin C decreases expression ISO Diazepam results in decreased expression of TNC mRNA CTD PMID:19114084 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP Diazepam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP Diazepam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
G Tspo translocator protein affects response to substance ISO TSPO protein affects the susceptibility to Diazepam CTD PMID:19782064 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Diazepam inhibits the reaction [Pentylenetetrazole results in increased expression of VEGFA protein] CTD PMID:32450180 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vtn vitronectin decreases expression ISO Diazepam results in decreased expression of VTN mRNA CTD PMID:19114084 NCBI chr10:65,767,960...65,771,040
Ensembl chr10:65,767,053...65,771,038
JBrowse link
flunitrazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Flunitrazepam results in decreased activity of AKR1C4 protein CTD PMID:11995921 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Flunitrazepam results in decreased activity of AKR1C2 protein CTD PMID:11995921 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Flunitrazepam results in decreased activity of AKR1C3 protein CTD PMID:11995921 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Casp3 caspase 3 multiple interactions ISO CYP3A4 protein affects the reaction [Flunitrazepam results in increased activity of CASP3 protein] CTD PMID:19005028 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO CYP3A4 protein affects the reaction [Flunitrazepam results in increased activity of CASP7 protein] CTD PMID:19005028 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Crp C-reactive protein multiple interactions ISO [bromperidol co-treated with Flunitrazepam] results in increased expression of CRP protein CTD PMID:15298663 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of Flunitrazepam CTD PMID:10911933 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases hydroxylation ISO CYP3A5 protein results in increased hydroxylation of Flunitrazepam CTD PMID:15383492 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions
affects binding
ISO
EXP
2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Flunitrazepam binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]
Flunitrazepam binds to GABRA1 protein
alphaxalone promotes the reaction [Flunitrazepam binds to GABRA1 protein]; Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA1 protein]
CTD PMID:8397295, PMID:8632757, PMID:22029276 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 affects binding
multiple interactions
EXP Flunitrazepam binds to GABRA2 protein
alphaxalone promotes the reaction [Flunitrazepam binds to GABRA2 protein]; Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA2 protein]
CTD PMID:8397295 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions
affects binding
ISO 2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Flunitrazepam binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:8632757, PMID:22029276 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions
affects binding
ISO 2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Flunitrazepam binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:8632757, PMID:22029276 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Sstr3 somatostatin receptor 3 affects expression EXP Flunitrazepam affects the expression of SSTR3 mRNA CTD PMID:16162846 NCBI chr 7:119,760,881...119,768,082
Ensembl chr 7:119,760,888...119,768,082
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases activity ISO Flunitrazepam results in decreased activity of UGT1A1 protein CTD PMID:15334623 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity ISO Flunitrazepam results in decreased activity of UGT1A3 protein CTD PMID:15334623 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
flurazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 affects response to substance ISO GABRA1 protein affects the susceptibility to Flurazepam CTD PMID:12490572 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 affects response to substance ISO GABRB2 protein affects the susceptibility to Flurazepam CTD PMID:12490572 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Flurazepam results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP Flurazepam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP Flurazepam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
nimetazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP3 protein] CTD PMID:19005028 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP7 protein] CTD PMID:19005028 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO nimetazepam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
nitrazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Nitrazepam results in decreased activity of AKR1C4 protein CTD PMID:11995921 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Nitrazepam results in decreased activity of AKR1C2 protein CTD PMID:11995921 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Nitrazepam results in decreased activity of AKR1C3 protein CTD PMID:11995921 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Casp3 caspase 3 multiple interactions ISO CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP3 protein] CTD PMID:19005028 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP7 protein] CTD PMID:19005028 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Nitrazepam binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
oxazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arf2 ADP-ribosylation factor 2 decreases expression ISO Oxazepam results in decreased expression of ARF2 mRNA CTD PMID:12727805 NCBI chr10:92,018,562...92,040,335
Ensembl chr10:92,018,562...92,040,333
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Oxazepam results in increased expression of CDKN1A mRNA CTD PMID:15618236 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO Oxazepam results in increased expression of CES1D mRNA CTD PMID:12727805 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Cidea cell death-inducing DFFA-like effector a decreases expression ISO Oxazepam results in decreased expression of CIDEA mRNA CTD PMID:12727805 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051
JBrowse link
G Cish cytokine inducible SH2-containing protein decreases expression ISO Oxazepam results in decreased expression of CISH mRNA CTD PMID:15618236 NCBI chr 8:116,054,547...116,059,494
Ensembl chr 8:116,054,465...116,060,723
JBrowse link
G Ctnnb1 catenin beta 1 increases mutagenesis ISO Oxazepam results in increased mutagenesis of CTNNB1 gene CTD PMID:10467420 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP
ISO
Oxazepam results in increased expression of CYP2B1 protein
Oxazepam results in increased expression of CYP2B10 mRNA; Oxazepam results in increased expression of CYP2B10 protein
CTD PMID:12727805, PMID:15618236, PMID:16684660 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Oxazepam results in increased expression of CYP2B2 protein CTD PMID:16684660 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO Oxazepam results in decreased expression of EGFR mRNA; Oxazepam results in decreased expression of EGFR protein CTD PMID:15618236 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 decreases expression ISO Oxazepam results in decreased expression of EGR1 mRNA CTD PMID:15618236 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO Oxazepam results in increased expression of GADD45B mRNA; Oxazepam results in increased expression of GADD45B protein CTD PMID:12727805, PMID:15618236, PMID:17533171 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO Oxazepam results in increased expression of IGFBP1 mRNA; Oxazepam results in increased expression of IGFBP1 protein CTD PMID:12727805, PMID:15618236 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Inhba inhibin subunit beta A decreases expression ISO Oxazepam results in decreased expression of INHBA mRNA CTD PMID:15618236 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Oxazepam results in decreased expression of JUNB mRNA CTD PMID:15618236 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Lzts2 leucine zipper tumor suppressor 2 increases expression ISO Oxazepam results in increased expression of LZTS2 mRNA CTD PMID:12727805, PMID:15618236 NCBI chr 1:264,765,256...264,776,553
Ensembl chr 1:264,768,105...264,776,616
JBrowse link
G Maf MAF bZIP transcription factor increases expression ISO Oxazepam results in increased expression of MAF mRNA CTD PMID:12727805 NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO Oxazepam results in increased expression of MAFF mRNA CTD PMID:15618236 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 increases expression ISO Oxazepam results in increased expression of MAP3K7 mRNA CTD PMID:12727805 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO Oxazepam results in increased activity of NFE2L2 protein CTD PMID:30114225, PMID:30203046 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Oxazepam results in increased activity of NR1I3 protein CTD PMID:30203046 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Oxazepam results in decreased expression of PPARA protein CTD PMID:12727805 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G St6gal1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 increases expression ISO Oxazepam results in increased expression of ST6GAL1 mRNA CTD PMID:12727805 NCBI chr11:80,927,601...80,981,424
Ensembl chr11:80,927,601...80,981,422
JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases activity ISO Oxazepam results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link
G Tff1 trefoil factor 1 decreases expression ISO Oxazepam results in decreased expression of TFF1 mRNA CTD PMID:12727805 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tnfaip2 TNF alpha induced protein 2 increases expression ISO Oxazepam results in increased expression of TNFAIP2 mRNA; Oxazepam results in increased expression of TNFAIP2 protein CTD PMID:12727805 NCBI chr 6:135,890,869...135,903,647
Ensembl chr 6:135,890,931...135,903,647
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression ISO Oxazepam results in decreased expression of TSC22D1 mRNA; Oxazepam results in decreased expression of TSC22D1 protein CTD PMID:15618236, PMID:17533171 NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases metabolic processing ISO UGT1A9 protein results in increased metabolism of Oxazepam CTD PMID:12386133 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation
increases metabolic processing
ISO UGT2B7 protein results in increased glucuronidation of Oxazepam
UGT2B7 protein results in increased metabolism of Oxazepam
CTD PMID:7773302, PMID:12386133 NCBI chr14:22,597,103...22,619,968 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biophysical role 12642
          membrane transport modulator 12441
            GABA modulator 4655
              benzodiazepine 542
                1,4-benzodiazepinone 116
                  2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-3-carboxylic acid 0
                  5-(2-chlorophenyl)-7-(dihydroxyamino)-1,3-dihydro-1,4-benzodiazepin-2-one 0
                  Ro 5-3335 0
                  cinolazepam 0
                  clobazam 4
                  clonazepam 6
                  clorazepic acid 0
                  compound E 0
                  cyclopeptine + 0
                  dehydrocyclopeptine + 0
                  devazepide 2
                  diazepam + 74
                  didesethylflurazepam 0
                  fludiazepam 0
                  flunitrazepam 15
                  flurazepam + 5
                  hydroxyethylflurazepam 0
                  lormetazepam 0
                  nimetazepam 3
                  nitrazepam + 7
                  nordazepam 0
                  oxazepam 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organonitrogen heterocyclic compound 17485
                                    benzodiazepine 542
                                      1,4-benzodiazepinone 116
                                        2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-3-carboxylic acid 0
                                        5-(2-chlorophenyl)-7-(dihydroxyamino)-1,3-dihydro-1,4-benzodiazepin-2-one 0
                                        Ro 5-3335 0
                                        cinolazepam 0
                                        clobazam 4
                                        clonazepam 6
                                        clorazepic acid 0
                                        compound E 0
                                        cyclopeptine + 0
                                        dehydrocyclopeptine + 0
                                        devazepide 2
                                        diazepam + 74
                                        didesethylflurazepam 0
                                        fludiazepam 0
                                        flunitrazepam 15
                                        flurazepam + 5
                                        hydroxyethylflurazepam 0
                                        lormetazepam 0
                                        nimetazepam 3
                                        nitrazepam + 7
                                        nordazepam 0
                                        oxazepam 28
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.