Ccdc121 (coiled-coil domain containing 121) - Rat Genome Database

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Gene: Ccdc121 (coiled-coil domain containing 121) Rattus norvegicus
Analyze
Symbol: Ccdc121
Name: coiled-coil domain containing 121
RGD ID: 1560110
Description: Orthologous to human CCDC121 (coiled-coil domain containing 121); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; indole-3-methanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ccdc121l1; coiled-coil domain containing 121 like 1; coiled-coil domain-containing protein 121; LOC366565; RGD1560110; similar to RIKEN cDNA 4930548H24
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8630,690,831 - 30,693,437 (-)NCBIGRCr8
mRatBN7.2624,970,845 - 24,973,451 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl624,970,833 - 24,973,478 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,271,697 - 25,274,309 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0625,587,594 - 25,590,206 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,066,826 - 25,069,446 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,278,440 - 26,281,788 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,278,500 - 26,281,300 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,101,969 - 36,105,260 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,031,161 - 25,033,504 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera624,465,107 - 24,468,460 (-)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Ccdc121
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8630,690,831 - 30,693,437 (-)NCBIGRCr8
mRatBN7.2624,970,845 - 24,973,451 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl624,970,833 - 24,973,478 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,271,697 - 25,274,309 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0625,587,594 - 25,590,206 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,066,826 - 25,069,446 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,278,440 - 26,281,788 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,278,500 - 26,281,300 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,101,969 - 36,105,260 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,031,161 - 25,033,504 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera624,465,107 - 24,468,460 (-)NCBICelera
Cytogenetic Map6q14NCBI
CCDC121
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38227,625,638 - 27,629,012 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl227,625,638 - 27,629,012 (-)EnsemblGRCh38hg38GRCh38
GRCh37227,848,505 - 27,851,879 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,702,010 - 27,705,383 (-)NCBINCBI36Build 36hg18NCBI36
Celera227,693,962 - 27,697,354 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef227,590,152 - 27,593,544 (-)NCBIHuRef
CHM1_1227,779,242 - 27,782,634 (-)NCBICHM1_1
T2T-CHM13v2.0227,668,723 - 27,672,097 (-)NCBIT2T-CHM13v2.0
Ccdc121
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,643,205 - 31,645,820 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,643,084 - 31,645,820 (+)EnsemblGRCm39 Ensembl
GRCm38531,485,859 - 31,488,262 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl531,485,740 - 31,488,476 (+)EnsemblGRCm38mm10GRCm38
MGSCv37531,788,232 - 31,790,635 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36531,762,440 - 31,764,843 (+)NCBIMGSCv36mm8
Celera528,964,610 - 28,967,013 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.27NCBI

Variants

.
Variants in Ccdc121
22 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)61653614027261739Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 6 1
Below cutoff 1 4 5 1 1 4 2 6 6 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000078750   ⟹   ENSRNOP00000074668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl624,970,833 - 24,973,478 (-)Ensembl
Rnor_6.0 Ensembl626,278,500 - 26,281,300 (-)Ensembl
RefSeq Acc Id: NM_001401944   ⟹   NP_001388873
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8630,690,831 - 30,693,437 (-)NCBI
mRatBN7.2624,970,845 - 24,973,451 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001388873 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM02908 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074668
  ENSRNOP00000074668.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000074668   ⟸   ENSRNOT00000078750
RefSeq Acc Id: NP_001388873   ⟸   NM_001401944
- UniProtKB: A0A0G2K8M8 (UniProtKB/TrEMBL),   A6HA53 (UniProtKB/TrEMBL)
Protein Domains
DUF4515

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K8M8-F1-model_v2 AlphaFold A0A0G2K8M8 1-391 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560110 AgrOrtholog
BioCyc Gene G2FUF-38361 BioCyc
Ensembl Genes ENSRNOG00000055899 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078750 ENTREZGENE
  ENSRNOT00000078750.2 UniProtKB/TrEMBL
InterPro DUF4515 UniProtKB/TrEMBL
NCBI Gene 366565 ENTREZGENE
PANTHER COILED-COIL DOMAIN-CONTAINING 166 UniProtKB/TrEMBL
  RIKEN CDNA 4930548H24 GENE UniProtKB/TrEMBL
Pfam DUF4515 UniProtKB/TrEMBL
PhenoGen Ccdc121 PhenoGen
RatGTEx ENSRNOG00000055899 RatGTEx
UniProt A0A0G2K8M8 ENTREZGENE, UniProtKB/TrEMBL
  A6HA53 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-21 Ccdc121  coiled-coil domain containing 121  Ccdc121l1  coiled-coil domain containing 121 like 1  Name and Symbol changed 629549 APPROVED
2022-12-27 Ccdc121l1  coiled-coil domain containing 121 like 1  Ccdc121  coiled-coil domain containing 121  Name and Symbol changed 629549 APPROVED
2022-03-24 Ccdc121  coiled-coil domain containing 121  CCDC121  coiled-coil domain containing 121  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-03-07 CCDC121  coiled-coil domain containing 121  RGD1560110  similar to RIKEN cDNA 4930548H24  Name and Symbol changed 629549 APPROVED
2008-04-30 RGD1560110  similar to RIKEN cDNA 4930548H24   RGD1560110_predicted  similar to RIKEN cDNA 4930548H24 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560110_predicted  similar to RIKEN cDNA 4930548H24 (predicted)  LOC366565  similar to RIKEN cDNA 4930548H24  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC366565  similar to RIKEN cDNA 4930548H24      Symbol and Name status set to provisional 70820 PROVISIONAL