Hdac2 (histone deacetylase 2) - Rat Genome Database

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Gene: Hdac2 (histone deacetylase 2) Rattus norvegicus
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Symbol: Hdac2
Name: histone deacetylase 2
RGD ID: 619976
Description: Enables several functions, including DNA-binding transcription factor binding activity; heat shock protein binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including behavioral response to ethanol; positive regulation of cell differentiation; and regulation of gene expression. Located in chromatin. Used to study Peyronie's disease; alcohol use disorder; and anxiety disorder. Biomarker of anxiety disorder; bronchitis; chronic obstructive pulmonary disease (multiple); endometriosis; and fetal alcohol spectrum disorder. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human HDAC2 (histone deacetylase 2); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; Hedgehog signaling pathway; histone modification pathway; INTERACTS WITH (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82042,101,815 - 42,126,486 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2042,102,861 - 42,126,311 (+)EnsemblGRCr8
mRatBN7.22040,548,244 - 40,571,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2040,548,250 - 40,571,609 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2042,287,370 - 42,310,647 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02041,946,582 - 41,969,860 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02042,695,816 - 42,719,094 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02043,084,870 - 43,108,198 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2043,084,870 - 43,108,198 (-)Ensemblrn6Rnor6.0
Rnor_5.02044,811,967 - 44,835,337 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42041,162,093 - 41,186,492 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2041,298,790 - 41,322,159 (+)NCBICelera
RGSC_v3.12041,204,917 - 41,209,275 (+)NCBI
Cytogenetic Map20q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic AMP  (EXP)
3,3'-diindolylmethane  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acetic acid  (ISO)
aconitine  (EXP)
acrolein  (ISO)
adenine  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
biphenyl-4-amine  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Brodifacoum  (EXP)
butanal  (ISO)
butyric acid  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcium oxalate  (EXP)
capsaicin  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
coumarin  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethylene glycol  (EXP)
fenpyroximate  (ISO)
fenthion  (ISO)
fluoxetine  (EXP,ISO)
folic acid  (ISO)
FR900359  (ISO)
fumaraldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
glafenine  (EXP)
Honokiol  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
hydroxyurea  (ISO)
indole-3-methanol  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
manganese(II) chloride  (EXP)
mechlorethamine  (EXP)
menadione  (ISO)
methoxyacetic acid  (ISO)
mifepristone  (EXP,ISO)
mocetinostat  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nefazodone  (EXP)
nickel subsulfide  (EXP)
nicotine  (EXP,ISO)
nimesulide  (EXP)
Nonylphenol  (ISO)
okadaic acid  (ISO)
oxalic acid  (ISO)
oxybenzone  (EXP)
ozone  (EXP,ISO)
pelargonidin  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
picoxystrobin  (ISO)
Plantamajoside  (EXP,ISO)
resveratrol  (EXP,ISO)
romidepsin  (EXP)
rotenone  (ISO)
sevoflurane  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium propionate  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tangeretin  (ISO)
tartrazine  (ISO)
tebufenpyrad  (ISO)
tetrachloromethane  (ISO)
theophylline  (ISO)
titanium dioxide  (ISO)
trichostatin A  (EXP,ISO)
Triptolide  (EXP)
triptonide  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vorinostat  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to ethanol  (IEP)
cardiac muscle cell development  (ISO)
cardiac muscle hypertrophy  (IEP)
cellular response to dopamine  (IEP)
cellular response to heat  (IEP)
cellular response to hydrogen peroxide  (IDA)
cellular response to retinoic acid  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to trichostatin A  (ISO)
chromatin organization  (IEA)
chromatin remodeling  (IEA,ISO)
circadian regulation of gene expression  (ISO)
dendrite development  (ISO)
embryonic digit morphogenesis  (ISO)
epidermal cell differentiation  (ISO)
eyelid development in camera-type eye  (ISO)
fungiform papilla formation  (ISO)
hair follicle placode formation  (ISO)
heterochromatin formation  (IBA,IEA,ISO)
hippocampus development  (ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle cell proliferation  (ISO)
negative regulation of cell communication  (IEA)
negative regulation of dendritic spine development  (IMP)
negative regulation of DNA binding  (IMP)
negative regulation of DNA-templated transcription  (IMP,ISO)
negative regulation of gene expression, epigenetic  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (ISO)
negative regulation of miRNA transcription  (ISO)
negative regulation of neuron projection development  (IMP,ISO)
negative regulation of peptidyl-lysine acetylation  (IMP)
negative regulation of signaling  (IEA)
negative regulation of transcription by competitive promoter binding  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neuron differentiation  (ISO)
obsolete positive regulation of DNA-binding transcription factor activity  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
positive regulation of cell population proliferation  (IEA,IMP,ISO)
positive regulation of epithelial to mesenchymal transition  (IMP)
positive regulation of interleukin-1 production  (IMP)
positive regulation of intracellular estrogen receptor signaling pathway  (ISO)
positive regulation of male mating behavior  (IMP)
positive regulation of oligodendrocyte differentiation  (IEA,IMP,ISO)
positive regulation of protein modification process  (IMP)
positive regulation of proteolysis  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IMP)
progesterone receptor signaling pathway  (ISO)
protein modification process  (IMP)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
regulation of protein deacetylation  (ISO)
regulation of sarcomere organization  (ISO)
response to alcohol  (IEP)
response to amphetamine  (IEP)
response to amyloid-beta  (IEP)
response to caffeine  (IEP)
response to cocaine  (IEP)
response to hyperoxia  (IEP)
response to lipopolysaccharide  (IEP)
response to nicotine  (IEP)
response to xenobiotic stimulus  (IEP)
rhythmic process  (IEA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Upregulation of class II histone deacetylases mRNA during neural differentiation of cultured rat hippocampal progenitor cells. Ajamian F, etal., Neurosci Lett 2003 Jul 31;346(1-2):57-60.
2. Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer. Backlund MG, etal., Cancer Res. 2008 Nov 15;68(22):9331-7. doi: 10.1158/0008-5472.CAN-08-2893.
3. DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2. Bai S, etal., Mol Cell Biol. 2005 Jan;25(2):751-66.
4. Regulation of neuronal traits by a novel transcriptional complex. Ballas N, etal., Neuron. 2001 Aug 16;31(3):353-65.
5. The nucleosome remodeling and deacetylase complex in development and disease. Basta J and Rauchman M, Transl Res. 2014 May 10. pii: S1931-5244(14)00166-2. doi: 10.1016/j.trsl.2014.05.003.
6. Epigenetic suppression of neuroligin 1 underlies amyloid-induced memory deficiency. Bie B, etal., Nat Neurosci. 2014 Feb;17(2):223-31. doi: 10.1038/nn.3618. Epub 2014 Jan 19.
7. Fluoxetine and cocaine induce the epigenetic factors MeCP2 and MBD1 in adult rat brain. Cassel S, etal., Mol Pharmacol. 2006 Aug;70(2):487-92. Epub 2006 May 2.
8. Regulation of acetylation of histone deacetylase 2 by p300/CBP-associated factor/histone deacetylase 5 in the development of cardiac hypertrophy. Eom GH, etal., Circ Res. 2014 Mar 28;114(7):1133-43. doi: 10.1161/CIRCRESAHA.114.303429. Epub 2014 Feb 13.
9. Inhibition of HDAC2 protects the retina from ischemic injury. Fan J, etal., Invest Ophthalmol Vis Sci. 2013 Jun 12;54(6):4072-80. doi: 10.1167/iovs.12-11529.
10. Fetal Alcohol Exposure Reduces Dopamine Receptor D2 and Increases Pituitary Weight and Prolactin Production via Epigenetic Mechanisms. Gangisetty O, etal., PLoS One. 2015 Oct 28;10(10):e0140699. doi: 10.1371/journal.pone.0140699. eCollection 2015.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Graff J, etal., Nature. 2012 Feb 29;483(7388):222-6. doi: 10.1038/nature10849.
14. The expression of histone deacetylase 4 is associated with prednisone poor-response in childhood acute lymphoblastic leukemia. Gruhn B, etal., Leuk Res. 2013 Oct;37(10):1200-7. doi: 10.1016/j.leukres.2013.07.016. Epub 2013 Aug 12.
15. alpha2-Adrenoceptor agonist dexmedetomidine protects septic acute kidney injury through increasing BMP-7 and inhibiting HDAC2 and HDAC5. Hsing CH, etal., Am J Physiol Renal Physiol. 2012 Nov 15;303(10):F1443-53. doi: 10.1152/ajprenal.00143.2012. Epub 2012 Aug 29.
16. Increased expression of histone deacetylases 2 in temporal lobe epilepsy: a study of epileptic patients and rat models. Huang Y, etal., Synapse. 2012 Feb;66(2):151-9. doi: 10.1002/syn.20995. Epub 2011 Nov 3.
17. Histone deacetylase expression in white matter oligodendrocytes after stroke. Kassis H, etal., Neurochem Int. 2014 Nov;77:17-23. doi: 10.1016/j.neuint.2014.03.006. Epub 2014 Mar 19.
18. Activation of histone deacetylase 2 by inducible heat shock protein 70 in cardiac hypertrophy. Kee HJ, etal., Circ Res. 2008 Nov 21;103(11):1259-69. Epub 2008 Oct 10.
19. HDAC inhibition suppresses cardiac hypertrophy and fibrosis in DOCA-salt hypertensive rats via regulation of HDAC6/HDAC8 enzyme activity. Kee HJ, etal., Kidney Blood Press Res. 2013;37(4-5):229-39. doi: 10.1159/000350148. Epub 2013 Jul 8.
20. Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy. Khabele D, etal., Cancer Biol Ther. 2007 May;6(5):795-801. Epub 2007 Feb 14.
21. Clinically relevant concentrations of valproic acid modulate melatonin MT(1) receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells. Kim B, etal., Eur J Pharmacol. 2008 Jul 28;589(1-3):45-8. Epub 2008 May 7.
22. Targeted inactivation of HDAC2 restores p16INK4a activity and exerts antitumor effects on human gastric cancer. Kim JK, etal., Mol Cancer Res. 2013 Jan;11(1):62-73. doi: 10.1158/1541-7786.MCR-12-0332. Epub 2012 Nov 21.
23. Silencing histone deacetylase 2 using small hairpin RNA induces regression of fibrotic plaque in a rat model of Peyronie's disease. Kwon KD, etal., BJU Int. 2014 May 19. doi: 10.1111/bju.12812.
24. Effect of Quanzhenyiqitang on apoptosis of alveolar macrophages and expression of histone deacetylase 2 in rats with chronic obstructive pulmonary disease. Li DZ, etal., Exp Ther Med. 2014 May;7(5):1327-1331. Epub 2014 Feb 25.
25. Intravenous antagomiR-494 lessens brain-infiltrating neutrophils by increasing HDAC2-mediated repression of multiple MMPs in experimental stroke. Li F, etal., FASEB J. 2020 May;34(5):6934-6949. doi: 10.1096/fj.201903127R. Epub 2020 Apr 2.
26. Inhibition of histone deacetylase 2 expression by elevated glucocorticoid receptor beta in steroid-resistant asthma. Li LB, etal., Am J Respir Crit Care Med. 2010 Oct 1;182(7):877-83. doi: 10.1164/rccm.201001-0015OC. Epub 2010 Jun 10.
27. Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment. Lin Z, etal., Clin Cancer Res. 2009 Jan 15;15(2):570-7.
28. Epigenetic mechanisms in the dopamine D2 receptor-dependent inhibition of the prolactin gene. Liu JC, etal., Mol Endocrinol. 2005 Jul;19(7):1904-17. Epub 2005 Feb 24.
29. Angiotensin II induces cardiomyocyte hypertrophy probably through histone deacetylases. Lu Y and Yang S, Tohoku J Exp Med. 2009 Sep;219(1):17-23.
30. Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children. Lundh M, etal., Diabetologia. 2012 Sep;55(9):2421-31. doi: 10.1007/s00125-012-2615-0. Epub 2012 Jul 7.
31. Methamphetamine causes differential alterations in gene expression and patterns of histone acetylation/hypoacetylation in the rat nucleus accumbens. Martin TA, etal., PLoS One. 2012;7(3):e34236. doi: 10.1371/journal.pone.0034236. Epub 2012 Mar 28.
32. Histone deacetylation during brain development is essential for permanent masculinization of sexual behavior. Matsuda KI, etal., Endocrinology. 2011 Jul;152(7):2760-7. doi: 10.1210/en.2011-0193. Epub 2011 May 17.
33. All-trans retinoic acid increases KLF4 acetylation by inducing HDAC2 phosphorylation and its dissociation from KLF4 in vascular smooth muscle cells. Meng F, etal., Biochem Biophys Res Commun. 2009 Sep 11;387(1):13-8. doi: 10.1016/j.bbrc.2009.05.112. Epub 2009 May 30.
34. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
35. Aberrant histone deacetylase2-mediated histone modifications and synaptic plasticity in the amygdala predisposes to anxiety and alcoholism. Moonat S, etal., Biol Psychiatry. 2013 Apr 15;73(8):763-73. doi: 10.1016/j.biopsych.2013.01.012. Epub 2013 Feb 26.
36. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
37. Lipopolysaccharide induces up-regulation of TGF-alpha through HDAC2 in a rat model of bronchopulmonary dysplasia. Ni W, etal., PLoS One. 2014 Mar 4;9(3):e91083. doi: 10.1371/journal.pone.0091083. eCollection 2014.
38. Characteristic comparison of three rat models induced by cigarette smoke or combined with LPS: to establish a suitable model for study of airway mucus hypersecretion in chronic obstructive pulmonary disease. Nie YC, etal., Pulm Pharmacol Ther. 2012 Oct;25(5):349-56. doi: 10.1016/j.pupt.2012.06.004. Epub 2012 Jun 23.
39. Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury. Noh H, etal., Am J Physiol Renal Physiol. 2009 Sep;297(3):F729-39. doi: 10.1152/ajprenal.00086.2009. Epub 2009 Jun 24.
40. HDAC2 provides a critical support to malignant progression of hepatocellular carcinoma through feedback control of mTORC1 and AKT. Noh JH, etal., Cancer Res. 2014 Mar 15;74(6):1728-38. doi: 10.1158/0008-5472.CAN-13-2109. Epub 2014 Jan 21.
41. S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons. Nott A, etal., Nature. 2008 Sep 18;455(7211):411-5. Epub 2008 Aug 27.
42. Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood. Pandey SC, etal., Neurobiol Dis. 2015 Oct;82:607-619. doi: 10.1016/j.nbd.2015.03.019. Epub 2015 Mar 24.
43. Histone deacetylase 1/2 mediates proliferation of renal interstitial fibroblasts and expression of cell cycle proteins. Pang M, etal., J Cell Biochem. 2011 Aug;112(8):2138-48. doi: 10.1002/jcb.23135.
44. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
45. Prenatal caffeine ingestion induces aberrant DNA methylation and histone acetylation of steroidogenic factor 1 and inhibits fetal adrenal steroidogenesis. Ping J, etal., Toxicology. 2014 Jul 3;321:53-61. doi: 10.1016/j.tox.2014.03.011. Epub 2014 Apr 6.
46. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
47. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
48. Chemopreventive effects of an HDAC2-selective inhibitor on rat colon carcinogenesis and APCmin/+ mouse intestinal tumorigenesis. Ravillah D, etal., J Pharmacol Exp Ther. 2014 Jan;348(1):59-68. doi: 10.1124/jpet.113.208645. Epub 2013 Nov 11.
49. GOA pipeline RGD automated data pipeline
50. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
51. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
52. A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition. Ropero S, etal., Nat Genet. 2006 May;38(5):566-9. Epub 2006 Apr 16.
53. Increased expression of histone deacetylase 2 is found in human gastric cancer. Song J, etal., APMIS. 2005 Apr;113(4):264-8.
54. HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure. Stypula-Cyrus Y, etal., PLoS One. 2013 May 28;8(5):e64600. doi: 10.1371/journal.pone.0064600. Print 2013.
55. Low-dose theophylline restores corticosteroid responsiveness in rats with smoke-induced airway inflammation. Sun X, etal., Can J Physiol Pharmacol. 2012 Jul;90(7):895-902. doi: 10.1139/y2012-079. Epub 2012 Jun 18.
56. Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy. Wang X, etal., Kidney Int. 2014 Oct;86(4):712-25. doi: 10.1038/ki.2014.111. Epub 2014 Apr 9.
57. Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy. Weichert W, etal., Br J Cancer. 2008 Feb 12;98(3):604-10. Epub 2008 Jan 22.
58. Expression of class I histone deacetylases indicates poor prognosis in endometrioid subtypes of ovarian and endometrial carcinomas. Weichert W, etal., Neoplasia. 2008 Sep;10(9):1021-7.
59. A comprehensive analysis of oxidative stress in the ozone-induced lung inflammation mouse model. Wiegman CH, etal., Clin Sci (Lond). 2014 Mar;126(6):425-40. doi: 10.1042/CS20130039.
60. Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation. Wu M, etal., J Neurosci. 2012 May 9;32(19):6651-64. doi: 10.1523/JNEUROSCI.4876-11.2012.
61. Prenatal nicotinic exposure suppresses fetal adrenal steroidogenesis via steroidogenic factor 1 (SF-1) deacetylation. Yan YE, etal., Toxicol Appl Pharmacol. 2014 Jun 15;277(3):231-41. doi: 10.1016/j.taap.2014.03.019. Epub 2014 Apr 5.
62. Fenretinide causes emphysema, which is prevented by sphingosine 1-phoshate. Yasuo M, etal., PLoS One. 2013;8(1):e53927. doi: 10.1371/journal.pone.0053927. Epub 2013 Jan 11.
63. DeltaNp73 modulates nerve growth factor-mediated neuronal differentiation through repression of TrkA. Zhang J and Chen X, Mol Cell Biol. 2007 May;27(10):3868-80. Epub 2007 Mar 12.
64. Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast*. Zhang Z, etal., Breast Cancer Res Treat. 2005 Nov;94(1):11-6.
65. Silencing of microRNA-494 inhibits the neurotoxic Th1 shift via regulating HDAC2-STAT4 cascade in ischaemic stroke. Zhao H, etal., Br J Pharmacol. 2020 Jan;177(1):128-144. doi: 10.1111/bph.14852. Epub 2019 Nov 8.
66. Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. Zhao L, etal., Circulation. 2012 Jul 24;126(4):455-67. doi: 10.1161/CIRCULATIONAHA.112.103176. Epub 2012 Jun 18.
67. Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata. Zhao M, etal., Br J Dermatol. 2012 Feb;166(2):226-73. doi: 10.1111/j.1365-2133.2011.10646.x. Epub 2012 Jan 9.
68. Levo-tetrahydropalmatine retards the growth of ectopic endometrial implants and alleviates generalized hyperalgesia in experimentally induced endometriosis in rats. Zhao T, etal., Reprod Sci. 2011 Jan;18(1):28-45. doi: 10.1177/1933719110381928. Epub 2010 Sep 30.
69. HDAC2 phosphorylation-dependent Klf5 deacetylation and RARalpha acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs. Zheng B, etal., Cell Res. 2011 Oct;21(10):1487-508. doi: 10.1038/cr.2011.34. Epub 2011 Mar 8.
70. Hyperoxia arrests alveolar development through suppression of histone deacetylases in neonatal rats. Zhu L, etal., Pediatr Pulmonol. 2012 Mar;47(3):264-74. doi: 10.1002/ppul.21540. Epub 2011 Sep 8.
Additional References at PubMed
PMID:8889548   PMID:10431247   PMID:10888872   PMID:11062478   PMID:11641274   PMID:12007404   PMID:12403844   PMID:12477932   PMID:12975471   PMID:14519686   PMID:14643676   PMID:14966270  
PMID:15051733   PMID:15226430   PMID:16217013   PMID:17182846   PMID:17322895   PMID:17392792   PMID:17785205   PMID:17827154   PMID:18316616   PMID:18347167   PMID:18458156   PMID:18768922  
PMID:19041327   PMID:19139378   PMID:19276356   PMID:19372552   PMID:19380719   PMID:19503085   PMID:19644445   PMID:20075857   PMID:20720167   PMID:20833366   PMID:20972425   PMID:21093383  
PMID:21166804   PMID:21177534   PMID:22391310   PMID:22681889   PMID:22770845   PMID:22926524   PMID:23516383   PMID:23980619   PMID:24111946   PMID:24137001   PMID:24675724   PMID:24936141  
PMID:24970816   PMID:25241747   PMID:25380525   PMID:26962001   PMID:26998823   PMID:28046085   PMID:28053041   PMID:28177689   PMID:29257262   PMID:30177751   PMID:30213210   PMID:30452948  
PMID:30483749   PMID:31022463   PMID:31108155   PMID:31493239   PMID:32847971   PMID:33378103   PMID:33750441   PMID:35263606   PMID:35902549   PMID:35926274   PMID:36156740   PMID:37021908  
PMID:39192337  


Genomics

Comparative Map Data
Hdac2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82042,101,815 - 42,126,486 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2042,102,861 - 42,126,311 (+)EnsemblGRCr8
mRatBN7.22040,548,244 - 40,571,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2040,548,250 - 40,571,609 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2042,287,370 - 42,310,647 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02041,946,582 - 41,969,860 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02042,695,816 - 42,719,094 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02043,084,870 - 43,108,198 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2043,084,870 - 43,108,198 (-)Ensemblrn6Rnor6.0
Rnor_5.02044,811,967 - 44,835,337 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42041,162,093 - 41,186,492 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2041,298,790 - 41,322,159 (+)NCBICelera
RGSC_v3.12041,204,917 - 41,209,275 (+)NCBI
Cytogenetic Map20q12NCBI
HDAC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386113,933,028 - 113,971,148 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6113,933,028 - 114,011,308 (-)Ensemblhg38GRCh38
GRCh376114,254,192 - 114,292,312 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366114,364,019 - 114,399,047 (-)NCBIBuild 36Build 36hg18NCBI36
Build 346114,368,619 - 114,398,967NCBI
Celera6114,998,693 - 115,033,733 (-)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6111,834,121 - 111,869,161 (-)NCBIHuRef
CHM1_16114,520,179 - 114,555,225 (-)NCBICHM1_1
T2T-CHM13v2.06115,116,117 - 115,154,233 (-)NCBIT2T-CHM13v2.0
Hdac2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391036,850,293 - 36,877,885 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1036,850,540 - 36,877,885 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381036,974,297 - 37,001,889 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1036,974,544 - 37,001,889 (+)Ensemblmm10GRCm38
MGSCv371036,694,350 - 36,721,694 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361036,663,960 - 36,691,304 (+)NCBIMGSCv36mm8
Celera1037,867,952 - 37,895,247 (+)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1019.44NCBI
Hdac2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555262,728,377 - 2,759,707 (+)Ensembl
ChiLan1.0NW_0049555262,739,099 - 2,759,640 (+)NCBIChiLan1.0ChiLan1.0
HDAC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25133,936,717 - 133,967,655 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16131,832,186 - 131,863,124 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06111,731,139 - 111,761,826 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16115,802,367 - 115,833,004 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6115,802,367 - 115,833,004 (-)EnsemblpanPan2panpan1.1
HDAC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11270,053,822 - 70,083,491 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1270,053,297 - 70,103,578 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1269,799,259 - 69,828,714 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01270,933,049 - 70,962,557 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1270,932,535 - 70,961,523 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11270,285,352 - 70,314,769 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01270,123,758 - 70,153,135 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01270,454,633 - 70,484,021 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hdac2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946105,216,548 - 105,242,461 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366792,448,390 - 2,474,641 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366792,448,676 - 2,474,641 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HDAC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl179,863,094 - 79,901,585 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1179,867,713 - 79,901,597 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2189,929,206 - 89,962,996 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HDAC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11359,873,248 - 59,904,542 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1359,873,767 - 59,905,742 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604032,233,290 - 32,264,328 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hdac2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248564,834,217 - 4,861,592 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248564,834,197 - 4,861,546 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Hdac2
339 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:382
Count of miRNA genes:232
Interacting mature miRNAs:261
Transcripts:ENSRNOT00000000742
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202668936256021148Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202679235356021148Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202668936256021148Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202668936256021148Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203215696745978663Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202668936256021148Rat

Markers in Region
RH127658  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map4649.61UniSTS
Cytogenetic Map20q12UniSTS
RH136178  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22040,571,152 - 40,571,386 (-)MAPPERmRatBN7.2
Rnor_6.02043,085,093 - 43,085,326NCBIRnor6.0
Rnor_5.02044,812,190 - 44,812,423UniSTSRnor5.0
Cytogenetic Map20q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000000742   ⟹   ENSRNOP00000000742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2042,103,127 - 42,126,311 (+)Ensembl
mRatBN7.2 Ensembl2040,548,250 - 40,571,609 (+)Ensembl
Rnor_6.0 Ensembl2043,084,870 - 43,108,198 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100766   ⟹   ENSRNOP00000094992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2042,102,861 - 42,123,731 (+)Ensembl
mRatBN7.2 Ensembl2040,548,250 - 40,568,854 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000156139   ⟹   ENSRNOP00000108011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2042,102,861 - 42,126,311 (+)Ensembl
RefSeq Acc Id: NM_053447   ⟹   NP_445899
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82042,103,127 - 42,126,486 (+)NCBI
mRatBN7.22040,548,244 - 40,571,609 (+)NCBI
Rnor_6.02043,084,870 - 43,108,198 (-)NCBI
Rnor_5.02044,811,967 - 44,835,337 (-)NCBI
RGSC_v3.42041,162,093 - 41,186,492 (+)RGD
Celera2041,298,790 - 41,322,159 (+)RGD
Sequence:
RefSeq Acc Id: XM_063279578   ⟹   XP_063135648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82042,101,815 - 42,126,312 (+)NCBI
RefSeq Acc Id: XM_063279579   ⟹   XP_063135649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82042,106,303 - 42,126,312 (+)NCBI
RefSeq Acc Id: NP_445899   ⟸   NM_053447
- UniProtKB: F7ENH8 (UniProtKB/TrEMBL),   A6KID6 (UniProtKB/TrEMBL),   A0A8I6AP99 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000742   ⟸   ENSRNOT00000000742
Ensembl Acc Id: ENSRNOP00000094992   ⟸   ENSRNOT00000100766
RefSeq Acc Id: XP_063135648   ⟸   XM_063279578
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP99 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135649   ⟸   XM_063279579
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AP99 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108011   ⟸   ENSRNOT00000156139
Protein Domains
Histone deacetylase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7ENH8-F1-model_v2 AlphaFold F7ENH8 1-488 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701645
Promoter ID:EPDNEW_R12169
Type:multiple initiation site
Name:Hdac2_1
Description:histone deacetylase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02043,108,204 - 43,108,264EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619976 AgrOrtholog
BioCyc Gene G2FUF-3523 BioCyc
Ensembl Genes ENSRNOG00000000604 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000742.7 UniProtKB/TrEMBL
  ENSRNOT00000100766.2 UniProtKB/TrEMBL
  ENSRNOT00000156139 ENTREZGENE
  ENSRNOT00000156139.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.800.20 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9023326 IMAGE-MGC_LOAD
InterPro His_deacetylse UniProtKB/TrEMBL
  His_deacetylse_1 UniProtKB/TrEMBL
  His_deacetylse_dom UniProtKB/TrEMBL
  His_deacetylse_dom_sf UniProtKB/TrEMBL
  Ureohydrolase_domain UniProtKB/TrEMBL
KEGG Report rno:84577 UniProtKB/TrEMBL
MGC_CLONE MGC:187727 IMAGE-MGC_LOAD
NCBI Gene 84577 ENTREZGENE
PANTHER HISTONE DEACETYLASE 2 UniProtKB/TrEMBL
  HISTONE DEACETYLASE HDAC1-RELATED UniProtKB/TrEMBL
Pfam Hist_deacetyl UniProtKB/TrEMBL
PhenoGen Hdac2 PhenoGen
PIRSF His_deacetylse_1 UniProtKB/TrEMBL
PRINTS HDASUPER UniProtKB/TrEMBL
  HISDACETLASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000604 RatGTEx
Superfamily-SCOP SSF52768 UniProtKB/TrEMBL
UniProt A0A8I6AP99 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LVE7_RAT UniProtKB/TrEMBL
  A6KID6 ENTREZGENE, UniProtKB/TrEMBL
  B1WBY8_RAT UniProtKB/TrEMBL
  F7ENH8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-08-07 Hdac2  histone deacetylase 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in embryonic rat hippocampal progenitors 704464