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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619976
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdac2
Name: histone deacetylase 2
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdac2multiple interactionsEXP 6480464CTDValproic Acid inhibits the reaction [Mechlorethamine results in increased expression of HDAC2 protein]PMID:28184907
Hdac2decreases activityISOHDAC2 (Homo sapiens)6480464CTDValproic Acid results in decreased activity of HDAC2 proteinPMID:15103026
Hdac2decreases expressionISOHDAC2 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of HDAC2 mRNA; Valproic Acid results in decreased expression of HDAC2 proteinPMID:17653085 PMID:24200999
Hdac2increases degradationISOHDAC2 (Homo sapiens)6480464CTDValproic Acid results in increased degradation of HDAC2 proteinPMID:16294345
Hdac2multiple interactionsISOHDAC2 (Homo sapiens)6480464CTDHydroxyurea promotes the reaction [Valproic Acid results in decreased expression of HDAC2 protein]PMID:17653085
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