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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619976
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdac2
Name: histone deacetylase 2
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdac2increases expressionEXP 6480464CTDNicotine results in increased expression of HDAC2 mRNA; Nicotine results in increased expression of HDAC2 proteinPMID:24709674 PMID:31846720 PMID:34245815
Hdac2multiple interactionsEXP 6480464CTDSNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 protein]PMID:34245815
Hdac2decreases expressionISOHdac2 (Mus musculus)6480464CTDNicotine results in decreased expression of HDAC2 proteinPMID:31507073
Hdac2increases expressionISOHDAC2 (Homo sapiens)6480464CTDNicotine results in increased expression of HDAC2 mRNAPMID:24709674
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