Pgf (placental growth factor) - Rat Genome Database

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Gene: Pgf (placental growth factor) Rattus norvegicus
Analyze
Symbol: Pgf
Name: placental growth factor
RGD ID: 619850
Description: Enables identical protein binding activity. Involved in several processes, including positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; and sprouting angiogenesis. Located in extracellular space. Used to study congestive heart failure and myocardial infarction. Biomarker of diabetic retinopathy; end stage renal disease; pre-eclampsia; and status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including brain ischemia; diabetic neuropathy; glioblastoma; myocardial infarction; and pancreatic endocrine carcinoma. Orthologous to human PGF (placental growth factor); PARTICIPATES IN vascular endothelial growth factor signaling pathway; ceramide signaling pathway; mTOR signaling pathway; INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93298; placenta growth factor; Plgf
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,547,165 - 110,557,747 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6110,547,153 - 110,557,747 (-)EnsemblGRCr8
mRatBN7.26104,816,102 - 104,826,685 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,816,104 - 104,826,685 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6104,985,728 - 104,996,309 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,284,901 - 105,295,482 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,654,265 - 104,664,846 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06108,994,016 - 109,004,598 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,994,018 - 109,004,598 (-)Ensemblrn6Rnor6.0
Rnor_5.06116,552,660 - 116,563,242 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46109,215,540 - 109,226,122 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6102,639,061 - 102,649,643 (-)NCBICelera
RGSC_v3.16109,218,997 - 109,229,578 (-)NCBI
RH 3.4 Map6731.99RGD
Cytogenetic Map6q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
Cannabidivarin  (ISO)
cannabigerol  (ISO)
cantharidin  (ISO)
capsazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
corn oil  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
curcumin  (EXP)
cyclosporin A  (ISO)
cyfluthrin  (EXP)
DDT  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
furosemide  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
GSK2656157  (ISO)
isoflurane  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
N-nitrosodimethylamine  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicotine  (EXP)
nitrogen dioxide  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
organoselenium compound  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
Pf-06840003  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thimerosal  (ISO)
thiram  (ISO)
thyroxine  (EXP)
titanium dioxide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Contribution of angiogenic factors in a rat model of pre-eclampsia. Agunanne EE, etal., Am J Nephrol. 2010;32(4):332-9. Epub 2010 Aug 19.
2. Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction. Bahtiyar MO, etal., Am J Obstet Gynecol. 2007 Jan;196(1):72.e1-6.
3. Biomarkers of inflammation and placental dysfunction are associated with subsequent preterm birth. Bastek JA, etal., J Matern Fetal Neonatal Med. 2011 Apr;24(4):600-5. Epub 2010 Sep 7.
4. Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. Batchelor TT, etal., J Clin Oncol. 2010 Jun 10;28(17):2817-23. Epub 2010 May 10.
5. Cell type-specific expression of neuropilins in an MCA-occlusion model in mice suggests a potential role in post-ischemic brain remodeling. Beck H, etal., J Neuropathol Exp Neurol. 2002 Apr;61(4):339-50.
6. Elevated levels of plasma angiogenic factors are associated with human lymphatic filarial infections. Bennuru S, etal., Am J Trop Med Hyg. 2010 Oct;83(4):884-90.
7. Intramyocardial sustained delivery of placental growth factor using nanoparticles as a vehicle for delivery in the rat infarct model. Binsalamah ZM, etal., Int J Nanomedicine. 2011;6:2667-78. Epub 2011 Oct 31.
8. Placental Growth Factor Contributes to Bronchial Neutrophilic Inflammation and Edema in Allergic Asthma. Bobic S, etal., Am J Respir Cell Mol Biol. 2012 Feb 3.
9. Placenta growth factor in sickle cell disease: association with hemolysis and inflammation. Brittain JE, etal., Blood. 2010 Mar 11;115(10):2014-20. Epub 2009 Dec 29.
10. Placental growth factor regulates cardiac inflammation through the tissue inhibitor of metalloproteinases-3/tumor necrosis factor-alpha-converting enzyme axis: crucial role for adaptive cardiac remodeling during cardiac pressure overload. Carnevale D, etal., Circulation. 2011 Sep 20;124(12):1337-50. Epub 2011 Sep 6.
11. Involvement of placental growth factor in Wallerian degeneration. Chaballe L, etal., Glia. 2011 Mar;59(3):379-96. doi: 10.1002/glia.21108. Epub 2010 Dec 6.
12. Acute pyelonephritis during pregnancy changes the balance of angiogenic and anti-angiogenic factors in maternal plasma. Chaiworapongsa T, etal., J Matern Fetal Neonatal Med. 2010 Feb;23(2):167-78.
13. Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Chang JD, etal., Proc Natl Acad Sci U S A. 2007 May 8;104(19):8077-82. Epub 2007 May 2.
14. Titanium dioxide nanoparticles induce emphysema-like lung injury in mice. Chen HW, etal., FASEB J. 2006 Nov;20(13):2393-5. Epub 2006 Oct 5.
15. Anti-chemorepulsive effects of vascular endothelial growth factor and placental growth factor-2 in dorsal root ganglion neurons are mediated via neuropilin-1 and cyclooxygenase-derived prostanoid production. Cheng L, etal., J Biol Chem. 2004 Jul 16;279(29):30654-61. Epub 2004 May 4.
16. Differential expression of placenta growth factors and their receptors in the normal and pregnancy-induced hypertensive human placentas. Cho GJ, etal., J Korean Med Sci. 2003 Jun;18(3):402-8.
17. Expression of placenta growth factor mRNA in the rat placenta during mid-late pregnancy. Choi WS, etal., J Vet Sci. 2005 Sep;6(3):179-83.
18. Purification and characterization of a naturally occurring vascular endothelial growth factor.placenta growth factor heterodimer. DiSalvo J, etal., J Biol Chem 1995 Mar 31;270(13):7717-23.
19. Analysis of soluble angiogenic factors in Crohn's disease: a preliminary study. Duenas Pousa I, etal., Gastroenterol Hepatol. 2007 Nov;30(9):518-24.
20. Circulating angiopoietin and Tie-2 levels in systemic sclerosis. Dunne JV, etal., Rheumatol Int. 2012 Mar 30.
21. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
22. Improvement of cardiac function in the failing rat heart after transfer of skeletal myoblasts engineered to overexpress placental growth factor. Gmeiner M, etal., J Thorac Cardiovasc Surg. 2011 May;141(5):1238-45. Epub 2011 Feb 16.
23. A translocation involving the placental growth factor gene is identified in an epithelioid hemangioendothelioma. He M, etal., Cancer Genet Cytogenet. 2006 Jul 15;168(2):150-4.
24. Placental growth factor supports neuroendocrine tumor growth and predicts disease prognosis in patients. Hilfenhaus G, etal., Endocr Relat Cancer. 2013 May 20;20(3):305-19. doi: 10.1530/ERC-12-0223. Print 2013 Jun.
25. Subclinical gut inflammation in spondyloarthritis is associated with a pro-angiogenic intestinal mucosal phenotype. Hindryckx P, etal., Ann Rheum Dis. 2011 Nov;70(11):2044-8. Epub 2011 Aug 26.
26. Absence of placental growth factor blocks dextran sodium sulfate-induced colonic mucosal angiogenesis, increases mucosal hypoxia and aggravates acute colonic injury. Hindryckx P, etal., Lab Invest. 2010 Apr;90(4):566-76. Epub 2010 Feb 8.
27. PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in Obesity. Incio J, etal., Clin Cancer Res. 2016 Jun 15;22(12):2993-3004. doi: 10.1158/1078-0432.CCR-15-1839. Epub 2016 Feb 9.
28. Darbepoetin-mediated cardioprotection after myocardial infarction involves multiple mechanisms independent of erythropoietin receptor-common beta-chain heteroreceptor. Kanellakis P, etal., Br J Pharmacol. 2010 Aug;160(8):2085-96.
29. Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation. Khurana R, etal., Circulation. 2005 May 31;111(21):2828-36. Epub 2005 May 23.
30. Streptozotocin-induced diabetes decreases placenta growth factor (PlGF) levels in rat placenta. Koh PO, etal., J Vet Med Sci. 2007 Sep;69(9):877-80.
31. The functional deficiency of bone marrow mesenchymal stromal cells in ALS patients is proportional to disease progression rate. Koh SH, etal., Exp Neurol. 2012 Jan;233(1):472-80. Epub 2011 Nov 19.
32. Placental growth factor contributes to micro-vascular abnormalization and blood-retinal barrier breakdown in diabetic retinopathy. Kowalczuk L, etal., PLoS One. 2011 Mar 7;6(3):e17462.
33. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
34. Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemia. Liu H, etal., Brain. 2006 Oct;129(Pt 10):2734-45. Epub 2006 Aug 10.
35. Prognostic impact of placenta growth factor and vascular endothelial growth factor A in patients with breast cancer. Maae E, etal., Breast Cancer Res Treat. 2012 May;133(1):257-65. Epub 2012 Jan 22.
36. Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair. Maes C, etal., J Clin Invest. 2006 May;116(5):1230-42. Epub 2006 Apr 13.
37. Prognostic significance of plasma placental growth factor levels in renal cell cancer: an association with clinical characteristics and vascular endothelial growth factor levels. Matsumoto K, etal., Anticancer Res. 2003 Nov-Dec;23(6D):4953-8.
38. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
39. Serum heat shock protein 70 levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in women with preeclampsia. Molvarec A, etal., Clin Chim Acta. 2011 Oct 9;412(21-22):1957-62. Epub 2011 Jul 6.
40. Placental growth factor-2 gene transfer by electroporation restores diabetic sensory neuropathy in mice. Murakami T, etal., Exp Neurol. 2011 Jan;227(1):195-202. Epub 2010 Nov 5.
41. Elevation of plasma placental growth factor in the patients with ischemic cardiomyopathy. Nakamura T, etal., Int J Cardiol. 2009 Jan 9;131(2):186-91. Epub 2008 Jan 14.
42. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
43. VEGF receptor signalling - in control of vascular function. Olsson AK, etal., Nat Rev Mol Cell Biol. 2006 May;7(5):359-71.
44. Placenta growth factor expression in human atherosclerotic carotid plaques is related to plaque destabilization. Pilarczyk K, etal., Atherosclerosis. 2008 Jan;196(1):333-40. Epub 2006 Dec 8.
45. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
46. GOA pipeline RGD automated data pipeline
47. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
48. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
49. Circulating endothelial cells and angiogenic proteins in patients with systemic lupus erythematosus. Robak E, etal., Lupus. 2009 Apr;18(4):332-41.
50. Short-term delivery of anti-PlGF antibody delays progression of atherosclerotic plaques to vulnerable lesions. Roncal C, etal., Cardiovasc Res. 2010 Apr 1;86(1):29-36. Epub 2009 Dec 1.
51. Comparison of endothelial biomarkers according to reversibility of pulmonary hypertension secondary to congenital heart disease. Smadja DM, etal., Pediatr Cardiol. 2010 Jul;31(5):657-62. Epub 2010 Feb 27.
52. Hypoadiponectinemia and circulating angiogenic factors in overweight patients complicated with pre-eclampsia. Suwaki N, etal., Am J Obstet Gynecol. 2006 Dec;195(6):1687-92. Epub 2006 Jun 12.
53. Evaluation of placental growth factor and soluble Fms-like tyrosine kinase 1 as predictors of all-cause and cardiovascular mortality in patients with Type 1 diabetes with and without diabetic nephropathy. Theilade S, etal., Diabet Med. 2012 Mar;29(3):337-44. doi: 10.1111/j.1464-5491.2011.03482.x.
54. Antiangiogenic treatment with Sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats. Tugues S, etal., Hepatology. 2007 Dec;46(6):1919-26.
55. Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice. Van Steenkiste C, etal., Hepatology. 2011 May;53(5):1629-40. doi: 10.1002/hep.24238.
56. Expression of placental growth factor in regenerating livers after partial hepatectomy in the rat. Vanheule E, etal., Eur J Gastroenterol Hepatol. 2011 Jan;23(1):66-75.
57. Upregulation of the angiogenic factors PlGF, VEGF and their receptors (Flt-1, Flk-1/KDR) by TSH in cultured thyrocytes and in the thyroid gland of thiouracil-fed rats suggest a TSH-dependent paracrine mechanism for goiter hypervascularization. Viglietto G, etal., Oncogene. 1997 Nov 27;15(22):2687-98.
58. Modulation of angiogenesis during adipose tissue development in murine models of obesity. Voros G, etal., Endocrinology. 2005 Oct;146(10):4545-54. Epub 2005 Jul 14.
59. Inhibitory effect of atractylenolide I on angiogenesis in chronic inflammation in vivo and in vitro. Wang C, etal., Eur J Pharmacol. 2009 Jun 10;612(1-3):143-52. Epub 2009 Apr 6.
60. Microvasculature change and placenta growth factor expression in the early stage of a rat remnant kidney model. Wu Q, etal., Am J Nephrol. 2006;26(1):97-104. Epub 2006 Mar 14.
61. Increased expression of placental growth factor in patients with temporal lobe epilepsy and a rat model. Xu Y, etal., Brain Res. 2012 Jan 6;1429:124-33. Epub 2011 Oct 6.
62. Increased placental growth factor in cerebrospinal fluid of patients with epilepsy. Xu Y, etal., Neurochem Res. 2012 Mar;37(3):665-70. Epub 2011 Dec 8.
63. Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. Yano K, etal., J Exp Med. 2006 Jun 12;203(6):1447-58. Epub 2006 May 15.
64. Role of placenta growth factor and its receptor flt-1 in rheumatoid inflammation: a link between angiogenesis and inflammation. Yoo SA, etal., Arthritis Rheum. 2009 Feb;60(2):345-54.
65. Chimeric VEGF-ENZ7/PlGF specifically binding to VEGFR-2 accelerates skin wound healing via enhancement of neovascularization. Zheng Y, etal., Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):503-11. Epub 2006 Dec 28.
66. Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure. Zimpfer D, etal., J Thorac Cardiovasc Surg. 2009 Apr;137(4):963-70.
Additional References at PubMed
PMID:12477932   PMID:13678594   PMID:15489334   PMID:17997886   PMID:18421240   PMID:19048427   PMID:20860549   PMID:21123739   PMID:21215706   PMID:21266048   PMID:21911594   PMID:21969865  
PMID:23691181   PMID:24001991   PMID:25184477   PMID:25515701   PMID:26192016   PMID:27280587   PMID:29933759   PMID:30361676   PMID:33379399   PMID:34530740   PMID:37424113  


Genomics

Comparative Map Data
Pgf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,547,165 - 110,557,747 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6110,547,153 - 110,557,747 (-)EnsemblGRCr8
mRatBN7.26104,816,102 - 104,826,685 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,816,104 - 104,826,685 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6104,985,728 - 104,996,309 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,284,901 - 105,295,482 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,654,265 - 104,664,846 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06108,994,016 - 109,004,598 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,994,018 - 109,004,598 (-)Ensemblrn6Rnor6.0
Rnor_5.06116,552,660 - 116,563,242 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46109,215,540 - 109,226,122 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6102,639,061 - 102,649,643 (-)NCBICelera
RGSC_v3.16109,218,997 - 109,229,578 (-)NCBI
RH 3.4 Map6731.99RGD
Cytogenetic Map6q31NCBI
PGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381474,941,830 - 74,955,764 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1474,941,830 - 74,955,626 (-)Ensemblhg38GRCh38
GRCh371475,408,533 - 75,422,467 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,478,290 - 74,492,044 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341474,478,292 - 74,492,044NCBI
Celera1455,446,919 - 55,460,674 (-)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,576,546 - 55,590,481 (-)NCBIHuRef
CHM1_11475,347,700 - 75,361,635 (-)NCBICHM1_1
T2T-CHM13v2.01469,150,944 - 69,164,879 (-)NCBIT2T-CHM13v2.0
Pgf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391285,213,413 - 85,224,087 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1285,213,409 - 85,224,564 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381285,166,637 - 85,177,785 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1285,166,635 - 85,177,790 (-)Ensemblmm10GRCm38
MGSCv371286,507,591 - 86,518,235 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361286,055,744 - 86,066,388 (-)NCBIMGSCv36mm8
Celera1286,623,655 - 86,634,299 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.58NCBI
Pgf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523616,154 - 627,713 (+)Ensembl
ChiLan1.0NW_004955523616,196 - 627,055 (+)NCBIChiLan1.0ChiLan1.0
PGF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21576,024,811 - 76,038,594 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11475,241,311 - 75,255,228 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,494,152 - 55,508,066 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11474,338,976 - 74,352,964 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1474,338,976 - 74,352,964 (-)EnsemblpanPan2panpan1.1
PGF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1848,059,554 - 48,110,534 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl848,059,552 - 48,075,170 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha847,743,752 - 47,795,118 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0848,287,229 - 48,338,603 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl848,287,229 - 48,300,619 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1847,958,057 - 48,009,418 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0847,979,365 - 48,030,910 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0848,377,990 - 48,429,367 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pgf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864027,957,791 - 27,970,740 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364884,098,225 - 4,111,142 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364884,098,187 - 4,111,108 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl798,148,994 - 98,162,741 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1798,149,510 - 98,162,784 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27103,993,598 - 104,006,849 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PGF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12452,160,904 - 52,174,493 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2452,161,787 - 52,173,989 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605340,391,564 - 40,405,145 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pgf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473426,751,530 - 26,764,242 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473426,751,986 - 26,764,154 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pgf
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1799,276,864 - 99,287,624 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pgf
176 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:370
Count of miRNA genes:191
Interacting mature miRNAs:218
Transcripts:ENSRNOT00000007790
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)699708426112483760Rat

Markers in Region
RH94485  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86110,547,803 - 110,547,910 (+)Marker Load Pipeline
mRatBN7.26104,816,740 - 104,816,847 (+)MAPPERmRatBN7.2
Rnor_6.06108,994,655 - 108,994,761NCBIRnor6.0
Rnor_5.06116,562,497 - 116,562,603UniSTSRnor5.0
RGSC_v3.46109,216,179 - 109,216,285UniSTSRGSC3.4
Celera6102,639,700 - 102,639,806UniSTS
RH 3.4 Map6731.99UniSTS
Cytogenetic Map6q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 157 82 81 50 74 50 6 326 174 11 136 78 91 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000007790   ⟹   ENSRNOP00000007790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6110,547,167 - 110,557,747 (-)Ensembl
mRatBN7.2 Ensembl6104,816,104 - 104,826,685 (-)Ensembl
Rnor_6.0 Ensembl6108,994,018 - 109,004,598 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142885   ⟹   ENSRNOP00000103020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6110,547,153 - 110,557,747 (-)Ensembl
RefSeq Acc Id: NM_053595   ⟹   NP_446047
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86110,547,165 - 110,557,747 (-)NCBI
mRatBN7.26104,816,102 - 104,826,685 (-)NCBI
Rnor_6.06108,994,016 - 109,004,598 (-)NCBI
Rnor_5.06116,552,660 - 116,563,242 (+)NCBI
RGSC_v3.46109,215,540 - 109,226,122 (-)RGD
Celera6102,639,061 - 102,649,643 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446047 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA97426 (Get FASTA)   NCBI Sequence Viewer  
  AAH87006 (Get FASTA)   NCBI Sequence Viewer  
  EDL81554 (Get FASTA)   NCBI Sequence Viewer  
  EDL81555 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007790
GenBank Protein Q63434 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446047   ⟸   NM_053595
- Peptide Label: precursor
- UniProtKB: Q63434 (UniProtKB/Swiss-Prot),   A6JE11 (UniProtKB/TrEMBL),   A0A8L2Q2Z4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007790   ⟸   ENSRNOT00000007790
Ensembl Acc Id: ENSRNOP00000103020   ⟸   ENSRNOT00000142885
Protein Domains
Platelet-derived growth factor (PDGF) family

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63434-F1-model_v2 AlphaFold Q63434 1-158 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694736
Promoter ID:EPDNEW_R5261
Type:single initiation site
Name:Pgf_1
Description:placental growth factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06109,004,612 - 109,004,672EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619850 AgrOrtholog
BioCyc Gene G2FUF-36794 BioCyc
Ensembl Genes ENSRNOG00000005650 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000007790 ENTREZGENE
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7193034 IMAGE-MGC_LOAD
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  PD_growth_factor_CS UniProtKB/Swiss-Prot
  PDGF/VEGF_dom UniProtKB/Swiss-Prot
  PDGF/VEGF_growth_factor UniProtKB/Swiss-Prot
KEGG Report rno:94203 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93298 IMAGE-MGC_LOAD
NCBI Gene 94203 ENTREZGENE
PANTHER PLACENTA GROWTH FACTOR UniProtKB/Swiss-Prot
  VASCULAR ENDOTHELIAL GROWTH FACTOR UniProtKB/Swiss-Prot
Pfam PDGF UniProtKB/Swiss-Prot
PhenoGen Pgf PhenoGen
PROSITE PDGF_1 UniProtKB/Swiss-Prot
  PDGF_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005650 RatGTEx
SMART PDGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt A0A8L2Q2Z4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LCQ9_RAT UniProtKB/TrEMBL
  A6JE10_RAT UniProtKB/TrEMBL
  A6JE11 ENTREZGENE, UniProtKB/TrEMBL
  PLGF_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Pgf  placental growth factor      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Pgf  placental growth factor      Symbol and Name status set to provisional 70820 PROVISIONAL