RGD Reference Report - Elevated levels of plasma angiogenic factors are associated with human lymphatic filarial infections. - Rat Genome Database

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Elevated levels of plasma angiogenic factors are associated with human lymphatic filarial infections.

Authors: Bennuru, S  Maldarelli, G  Kumaraswami, V  Klion, AD  Nutman, TB 
Citation: Bennuru S, etal., Am J Trop Med Hyg. 2010 Oct;83(4):884-90.
RGD ID: 6483608
Pubmed: PMID:20889885   (View Abstract at PubMed)
PMCID: PMC2946762   (View Article at PubMed Central)
DOI: DOI:10.4269/ajtmh.2010.10-0039   (Journal Full-text)

Lymphatic dilatation, dysfunction, and lymphangiogenesis are hallmarks of patent lymphatic filariasis, observed even in those with subclinical microfilaremia, through processes associated, in part, by vascular endothelial growth factors (VEGFs). A panel of pro-angiogenic factors was measured in the plasma of subjects from filaria-endemic regions using multiplexed immunological assays. Compared with endemic normal control subjects, those with both subclinical microfilaremia, and those with longstanding lymphedema had significantly elevated levels of VEGF-A, VEGF-C, VEGF-D, and angiopoietins (Ang-1/Ang-2), with only levels of basic fibroblast growth factor (bFGF) and placental growth factor (PlGF) being elevated only if lymphedema was evident. Furthermore, levels of these factors 1-year post-treatment with doxycycline were similar to pretreatment levels suggesting a minimal role, if any, for Wolbachia. Our data support the concept that filarial infection per se is associated with elevated levels of most of the known pro-angiogenic factors, with only a few being associated with the serious pathologic consequences associated with Wuchereria bancrofti infection.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PGFHumanlymphedema  IEP associated with Elephantiasis more ...RGD 
PgfRatlymphedema  ISOPGF (Homo sapiens)associated with Elephantiasis more ...RGD 
PgfMouselymphedema  ISOPGF (Homo sapiens)associated with Elephantiasis more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pgf  (placental growth factor)

Genes (Mus musculus)
Pgf  (placental growth factor)

Genes (Homo sapiens)
PGF  (placental growth factor)


Additional Information