RGD Reference Report - Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation. - Rat Genome Database

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Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation.

Authors: Khurana, R  Moons, L  Shafi, S  Luttun, A  Collen, D  Martin, JF  Carmeliet, P  Zachary, IC 
Citation: Khurana R, etal., Circulation. 2005 May 31;111(21):2828-36. Epub 2005 May 23.
RGD ID: 1642386
Pubmed: PMID:15911697   (View Abstract at PubMed)
DOI: DOI:10.1161/CIRCULATIONAHA.104.495887   (Journal Full-text)

BACKGROUND: Placental growth factor (PlGF) has been implicated in the pathophysiological angiogenesis and monocyte recruitment that underlie chronic inflammatory disease, but its role in atherosclerosis has not been examined. We investigated the effects of exogenous PlGF, delivered by adenoviral gene transfer, on atherogenic intimal thickening and macrophage accumulation induced by collar placement around the rabbit carotid artery and examined the effects of PlGF deficiency on atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice. METHODS AND RESULTS: Periadventitial transfer of PlGF2-encoding adenoviruses significantly increased intimal thickening, macrophage accumulation, endothelial vascular cell adhesion molecule-1 expression, and adventitial neovascularization in the collared arteries of hypercholesterolemic rabbits and increased the intima-to-media ratio in rabbits fed a normal diet. Neointimal macrophages were associated with increased expression of the PlGF receptor Flt-1. The size and macrophage content of early atherosclerotic lesions were reduced in mice deficient in both apoE and PlGF compared with apoE-deficient mice. CONCLUSIONS: Local adenoviral PlGF2 delivery promotes atherogenic neointima formation in hypercholesterolemic rabbits, and PlGF is required for macrophage infiltration in early atherosclerotic lesions in apoE(-/-) mice. These findings support a novel role for PlGF in the pathogenesis of atherosclerotic disease.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PGFHumanInflammation severityISOPgf (Mus musculus) RGD 
PgfRatInflammation severityISOPgf (Mus musculus) RGD 
PgfMouseInflammation severityIAGP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pgf  (placental growth factor)

Genes (Mus musculus)
Pgf  (placental growth factor)

Genes (Homo sapiens)
PGF  (placental growth factor)


Additional Information