RGD Reference Report - Increased placental growth factor in cerebrospinal fluid of patients with epilepsy. - Rat Genome Database

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Increased placental growth factor in cerebrospinal fluid of patients with epilepsy.

Authors: Xu, Y  Zhang, Y  Guo, Z  Yin, H  Zeng, K  Wang, L  Luo, J  Zhu, Q  Wu, L  Zhang, X  Chen, D 
Citation: Xu Y, etal., Neurochem Res. 2012 Mar;37(3):665-70. Epub 2011 Dec 8.
RGD ID: 6483572
Pubmed: PMID:22160787   (View Abstract at PubMed)
DOI: DOI:10.1007/s11064-011-0646-4   (Journal Full-text)

Recent studies suggest that angiogenesis and vascular endothelial growth factor (VEGF) are involved in the pathophysiology of epilepsy. However, relatively little data are available linking placenta growth factor (PIGF) with epilepsy. In this study, we assessed concentrations of PIGF in cerebrospinal fluid (CSF) of 60 epileptic patients and 24 non-seizure subjects using sandwich enzyme-linked immunosorbent assays. Epileptic patients in general had higher concentration of CSF-PIGF than controls (7.95 +/- 0.88 ng/l vs. 5.87 +/- 0.79 ng/l, P < 0.01). CSF-PIGF level in secondary epileptic patients (8.59 +/- 1.26 ng/l) was higher than that in idiopathic epileptic patients (7.62 +/- 0.20 ng/l) (P < 0.05). In idiopathic epilepsy, CSF-PIGF level in patients with high seizure frequency was higher than those in patients with low seizure frequency and seizure-free in recent 3 years (7.78 +/- 0.23 ng/l vs. 7.49 +/- 0.09 ng/l and 7.59 +/- 0.10 ng/l, P < 0.05). Concentration of CSF-PIGF in patients with a disease duration of > 5 years was higher than those in patients with durations of 1-5 years and <1 year (7.72 +/- 0.20 ng/l vs. 7.52 +/- 0.09 ng/l and 7.41 +/- 0.07 ng/l, P < 0.05). These results indicate that preexisting brain damage, seizure frequency and disease duration are important factors contributing to elevated PIGF.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PGFHumanepilepsy  IEP protein:increased expression:cerebrospinal fluidRGD 
PgfRatepilepsy  ISOPGF (Homo sapiens)protein:increased expression:cerebrospinal fluidRGD 
PgfMouseepilepsy  ISOPGF (Homo sapiens)protein:increased expression:cerebrospinal fluidRGD 

Objects Annotated

Genes (Rattus norvegicus)
Pgf  (placental growth factor)

Genes (Mus musculus)
Pgf  (placental growth factor)

Genes (Homo sapiens)
PGF  (placental growth factor)


Additional Information