Prkcb (protein kinase C, beta) - Rat Genome Database

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Gene: Prkcb (protein kinase C, beta) Rattus norvegicus
Analyze
Symbol: Prkcb
Name: protein kinase C, beta
RGD ID: 3396
Description: Predicted to enable several functions, including histone binding activity; nuclear androgen receptor binding activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of insulin receptor signaling pathway; positive regulation of odontogenesis of dentin-containing tooth; and response to angiotensin. Located in brush border membrane; centrosome; and cytosol. Used to study hyperglycemia; hypertension; and silicosis. Biomarker of congestive heart failure; obesity; and status epilepticus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta); PARTICIPATES IN insulin signaling pathway; interleukin-2 signaling pathway; protein kinase C (PKC) signaling pathway; INTERACTS WITH (+)-pilocarpine; (9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: PKC-beta; Pkcb; Prkcb1; Protein kinase C beta; protein kinase C beta I; protein kinase C beta II; protein kinase C beta type; protein kinase C, beta 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81186,263,397 - 186,594,743 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1186,263,447 - 186,594,740 (+)EnsemblGRCr8
mRatBN7.21176,832,173 - 177,163,539 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,832,226 - 177,163,536 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1185,160,371 - 185,491,641 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01192,346,335 - 192,677,604 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,030,688 - 185,362,219 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01192,233,569 - 192,575,339 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1192,233,910 - 192,574,831 (+)Ensemblrn6Rnor6.0
Rnor_5.01199,295,067 - 199,639,140 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41181,117,512 - 181,459,856 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1174,677,501 - 174,871,327 (+)NCBICelera
RGSC_v3.11181,257,931 - 181,599,763 (+)NCBI
Cytogenetic Map1q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
(9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione  (EXP,ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-amanitin  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-naphthoflavone  (EXP)
alpha-Zearalanol  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
Bandrowski's base  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bryostatin  (ISO)
bryostatin 1  (ISO)
bupivacaine  (EXP)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
choline  (EXP,ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clopidogrel  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
daidzein  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (EXP)
dexmedetomidine  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dicofol  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etomoxir  (EXP)
fenvalerate  (EXP)
flavonoids  (EXP)
fluorescein 5-isothiocyanate  (ISO)
fluvoxamine  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (EXP,ISO)
haloperidol  (EXP)
hydrogen peroxide  (EXP)
indometacin  (ISO)
inulin  (ISO)
ionomycin  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lactacystin  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
losartan  (EXP)
mercury dibromide  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
Mezerein  (ISO)
ML-7  (EXP)
morphine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel subsulfide  (EXP)
nicotine  (ISO)
nitrates  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenethyl isothiocyanate  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
pterostilbene  (ISO)
puerarin  (EXP)
quercetin  (EXP,ISO)
quercitrin  (ISO)
resveratrol  (ISO)
Riluzole  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
sotrastaurin  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
T-2 toxin  (EXP)
tamibarotene  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
tetrodotoxin  (EXP)
thapsigargin  (ISO)
thenoyltrifluoroacetone  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vanillic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
apoptotic process  (IEA)
B cell activation  (ISO,ISS)
B cell receptor signaling pathway  (ISO,ISS)
calcium ion transport  (ISO)
cellular response to carbohydrate stimulus  (ISO)
chromatin organization  (IEA)
chromatin remodeling  (IEA)
dibenzo-p-dioxin metabolic process  (IEP)
immune system process  (IEA)
intracellular calcium ion homeostasis  (ISO)
intracellular signal transduction  (IBA)
learning or memory  (IEA)
negative regulation of D-glucose transmembrane transport  (ISO,ISS)
negative regulation of insulin receptor signaling pathway  (IDA)
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway  (ISO)
positive regulation of angiogenesis  (ISO,ISS)
positive regulation of canonical NF-kappaB signal transduction  (ISO,ISS)
positive regulation of developmental process  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of ferroptosis  (ISO,ISS)
positive regulation of multicellular organismal process  (IEA)
positive regulation of odontogenesis of dentin-containing tooth  (IEP)
positive regulation of signal transduction  (IEA)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (ISO,ISS)
protein kinase C signaling  (ISO,ISS)
protein phosphorylation  (ISO)
regulation of cell communication  (IEA)
regulation of D-glucose transmembrane transport  (ISO,ISS)
regulation of dopamine secretion  (IMP)
regulation of exocytosis  (IEA)
regulation of growth  (IMP)
regulation of secretion by cell  (IEA)
regulation of signal transduction  (IEA)
regulation of signaling  (IEA)
regulation of synaptic vesicle exocytosis  (ISO)
regulation of transcription by RNA polymerase II  (ISO,ISS)
response to angiotensin  (IDA)
response to ethanol  (IEP)
response to glucose  (IEP)
response to hypoxia  (ISO)
response to vitamin D  (IEP)
response to xenobiotic stimulus  (IMP)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Role of protein kinase C beta in phorbol ester-induced c-fos gene expression in neurons of normotensive and spontaneously hypertensive rat brains. Amemiya T, etal., Brain Res. 2005 Apr 8;1040(1-2):129-36.
2. Age-dependent activation of PKC isoforms by angiotensin II in the proximal nephron. Boesch DM and Garvin JL, Am J Physiol Regul Integr Comp Physiol 2001 Sep;281(3):R861-7.
3. Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart. Bowling N, etal., Circulation. 1999 Jan 26;99(3):384-91.
4. Centrosomal anchoring of protein kinase C betaII by pericentrin controls microtubule organization, spindle function, and cytokinesis. Chen D, etal., J Biol Chem. 2004 Feb 6;279(6):4829-39. Epub 2003 Nov 1.
5. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. Chen D, etal., J Biol Chem. 2007 Nov 16;282(46):33776-87. Epub 2007 Sep 24.
6. Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells. Corsini E, etal., Br J Dermatol. 2009 Jan;160(1):16-25. Epub 2008 Oct 11.
7. Resistance to acute silicosis in senescent rats: role of alveolar macrophages. Corsini E, etal., Chem Res Toxicol. 2003 Dec;16(12):1520-7.
8. Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-{alpha} and -{beta}. Devaraj S, etal., Diabetes. 2005 Jan;54(1):85-91.
9. Effect of ageing on the expression of protein kinase C and its activation by 1,25(OH)2-vitamin D3 in rat skeletal muscle. Facchinetti MM and de Boland AR, Cell Signal. 1999 Jan;11(1):39-44.
10. Altered protein kinase C activation associated with rat embryonic dysmorphogenesis. Gareskog M and Wentzel P, Pediatr Res. 2004 Dec;56(6):849-57. Epub 2004 Oct 20.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Role of inflammatory mediators in the suppression of insulin receptor phosphorylation in circulating mononuclear cells of obese subjects. Ghanim H, etal., Diabetologia. 2007 Feb;50(2):278-85. Epub 2006 Dec 16.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. The hexosamine pathway regulates the plasminogen activator inhibitor-1 gene promoter and Sp1 transcriptional activation through protein kinase C-beta I and -delta. Goldberg HJ, etal., J Biol Chem 2002 Sep 13;277(37):33833-41.
15. Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Holmes K, etal., Cell Signal. 2007 Oct;19(10):2003-12. Epub 2007 Jun 12.
16. Overproduction of protein kinase C causes disordered growth control in rat fibroblasts. Housey GM, etal., Cell 1988 Feb 12;52(3):343-54.
17. Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family. Housey GM, etal., Proc Natl Acad Sci U S A 1987 Feb;84(4):1065-9.
18. Agents that act by different mechanisms modulate the activity of protein kinase CbetaII isozyme in the rat spinal cord during peripheral inflammation. Igwe OJ Neuroscience. 2006;138(1):313-28. Epub 2005 Dec 19.
19. Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta. Inagaki K, etal., J Mol Cell Cardiol. 2002 Oct;34(10):1377-85.
20. Regulation of amphetamine-stimulated dopamine efflux by protein kinase C beta. Johnson LA, etal., J Biol Chem. 2005 Mar 25;280(12):10914-9. Epub 2005 Jan 12.
21. Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells. Kaneto H, etal., J Biol Chem. 2002 Feb 1;277(5):3680-5. Epub 2001 Nov 19.
22. Inhibition of PKCbeta improves glucocorticoid-induced insulin resistance in rat adipocytes. Kawai Y, etal., IUBMB Life. 2002 Dec;54(6):365-70.
23. Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension. Kelly DJ, etal., Diabetes 2003 Feb;52(2):512-8.
24. Cloning and expression of multiple protein kinase C cDNAs. Knopf JL, etal., Cell 1986 Aug 15;46(4):491-502.
25. Differential induction of protein kinase C isoforms at the cardiac hypertrophy stage and congestive heart failure stage in Dahl salt-sensitive rats. Koide Y, etal., Hypertens Res. 2003 May;26(5):421-6.
26. Differential effects of systemic ethanol administration on protein kinase cepsilon, gamma, and beta isoform expression, membrane translocation, and target phosphorylation: reversal by chronic ethanol exposure. Kumar S, etal., J Pharmacol Exp Ther. 2006 Dec;319(3):1366-75. Epub 2006 Sep 22.
27. Protein-protein interaction of zinc finger LIM domains with protein kinase C. Kuroda S, etal., J Biol Chem 1996 Dec 6;271(49):31029-32.
28. Translocation of PKC-betaII is mediated via RACK-1 in the neuronal cells following dioxin exposure. Lee HG, etal., Neurotoxicology. 2007 Mar;28(2):408-14. Epub 2006 May 5.
29. Diagnostic role of Wnt pathway gene promoter methylation in non small cell lung cancer. Liu S, etal., Oncotarget. 2017 May 30;8(22):36354-36367. doi: 10.18632/oncotarget.16754.
30. Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure. Mahadev K and Vemuri MC, Arch Biochem Biophys. 1998 Aug 15;356(2):249-57.
31. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
32. Eukaryotic initiation factor 6 mediates a continuum between 60S ribosome biogenesis and translation. Miluzio A, etal., EMBO Rep. 2009 May;10(5):459-65. doi: 10.1038/embor.2009.70. Epub 2009 Apr 17.
33. Apical GLUT2 and Cav1.3: regulation of rat intestinal glucose and calcium absorption. Morgan EL, etal., J Physiol. 2007 Apr 15;580(Pt. 2):593-604. Epub 2007 Feb 1.
34. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
35. Protein kinase C: poised to signal. Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24.
36. Protein kinase C betaII peptide inhibitor exerts cardioprotective effects in rat cardiac ischemia/reperfusion injury. Omiyi D, etal., J Pharmacol Exp Ther. 2005 Aug;314(2):542-51. Epub 2005 May 5.
37. Cloning of rat brain protein kinase C complementary DNA. Ono Y, etal., FEBS Lett 1986 Jul 28;203(2):111-5.
38. Two types of complementary DNAs of rat brain protein kinase C. Heterogeneity determined by alternative splicing. Ono Y, etal., FEBS Lett 1986 Oct 6;206(2):347-52.
39. High glucose-induced membrane translocation of PKC betaI is associated with Arf6 in glomerular mesangial cells. Padival AK, etal., Mol Cell Biochem. 2004 Mar;258(1-2):129-35.
40. Phosphoinositide 3-kinase mediates protein kinase C beta II mRNA destabilization in rat A10 smooth muscle cell cultures exposed to high glucose. Patel NA, etal., Arch Biochem Biophys 2002 Jul 1;403(1):111-20.
41. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
42. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Characterization of the binding and phosphorylation of cardiac calsequestrin by epsilon protein kinase C. Rodriguez MM, etal., FEBS Lett 1999 Jul 9;454(3):240-6.
46. Expression of protein kinase C isoforms in cardiac hypertrophy and heart failure due to volume overload. Sentex E, etal., Can J Physiol Pharmacol. 2006 Feb;84(2):227-38.
47. Signal transduction mechanisms in Alzheimer disease. Shimohama S and Matsushima H, Alzheimer Dis Assoc Disord. 1995;9 Suppl 2:15-22.
48. PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. Su TT, etal., Nat Immunol 2002 Aug;3(8):780-6.
49. Expression of different isoforms of protein kinase C in the rat hippocampus after pilocarpine-induced status epilepticus with special reference to CA1 area and the dentate gyrus. Tang FR, etal., Hippocampus. 2004;14(1):87-98.
50. The receptor-like protein-tyrosine phosphatase, RPTP alpha, is phosphorylated by protein kinase C on two serines close to the inner face of the plasma membrane. Tracy S, etal., J Biol Chem. 1995 May 5;270(18):10587-94.
51. RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function. Vallentin A and Mochly-Rosen D, J Biol Chem. 2007 Jan 19;282(3):1650-7. Epub 2006 Nov 22.
52. Evidence for the involvement of a phospholipase C--protein kinase C signaling pathway in insulin stimulated glucose transport in skeletal muscle. Wright DC, etal., Life Sci 2003 May 23;73(1):61-71.
53. N-acetylcysteine attenuates PKCbeta2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats. Xia Z, etal., Cardiovasc Res. 2007 Mar 1;73(4):770-82. Epub 2006 Nov 30.
54. Obligatory role of protein kinase Cbeta and MARCKS in vesicular trafficking in living neurons. Yang H, etal., Hypertension 2002 Feb;39(2 Pt 2):567-72.
55. In vivo expression of classic PKC isoforms in the rat dental follicle as related to tooth eruption. Yao S and Wise G, Connect Tissue Res. 2004;45(4-5):216-21.
56. Changes in protein kinase C (PKC) activity, isozyme translocation, and GAP-43 phosphorylation in the rat hippocampal formation after a single-trial contextual fear conditioning paradigm. Young E, etal., Hippocampus 2002;12(4):457-64.
57. Regulation of insulin receptor function. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91.
58. Integrated Analysis of Multiple Microarray Studies to Identify Core Gene-Expression Signatures Involved in Tubulointerstitial Injury in Diabetic Nephropathy. Zhou H, etal., Biomed Res Int. 2022 May 10;2022:9554658. doi: 10.1155/2022/9554658. eCollection 2022.
Additional References at PubMed
PMID:1299012   PMID:3576226   PMID:7929424   PMID:7961692   PMID:8034726   PMID:8327493   PMID:8631738   PMID:8749392   PMID:8889548   PMID:9514928   PMID:9817842   PMID:10365161  
PMID:10499500   PMID:10534118   PMID:10617144   PMID:10722046   PMID:10871288   PMID:11118818   PMID:11123317   PMID:11278415   PMID:11306676   PMID:11738801   PMID:11805327   PMID:11880265  
PMID:12391145   PMID:12551925   PMID:12618484   PMID:12766174   PMID:12826667   PMID:12904329   PMID:14613966   PMID:14682474   PMID:14715497   PMID:15037605   PMID:15042584   PMID:15322124  
PMID:15545601   PMID:15632189   PMID:15737652   PMID:15741241   PMID:16051606   PMID:16131649   PMID:16179609   PMID:16301747   PMID:16585392   PMID:16837815   PMID:17118565   PMID:17363743  
PMID:17531159   PMID:17678882   PMID:17694297   PMID:17711990   PMID:18001287   PMID:18056970   PMID:18315563   PMID:18323529   PMID:18440322   PMID:18497307   PMID:19057126   PMID:19091746  
PMID:19351495   PMID:19587355   PMID:19605547   PMID:19854265   PMID:19900507   PMID:20197783   PMID:20228790   PMID:20458337   PMID:20599775   PMID:20874717   PMID:21071702   PMID:21215369  
PMID:21228767   PMID:21424759   PMID:21575103   PMID:21658591   PMID:21700703   PMID:21704734   PMID:22479367   PMID:22531886   PMID:22587992   PMID:22797313   PMID:22865386   PMID:22871113  
PMID:23295407   PMID:23403203   PMID:23686852   PMID:23775122   PMID:24151077   PMID:24269213   PMID:24355769   PMID:24466133   PMID:25659900   PMID:25678708   PMID:25849791   PMID:25915883  
PMID:25982116   PMID:26199377   PMID:26660275   PMID:27402227   PMID:28534945   PMID:30053369   PMID:30701683   PMID:32048876   PMID:32357304   PMID:32866516   PMID:35192161   PMID:36066426  


Genomics

Comparative Map Data
Prkcb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81186,263,397 - 186,594,743 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1186,263,447 - 186,594,740 (+)EnsemblGRCr8
mRatBN7.21176,832,173 - 177,163,539 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,832,226 - 177,163,536 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1185,160,371 - 185,491,641 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01192,346,335 - 192,677,604 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,030,688 - 185,362,219 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01192,233,569 - 192,575,339 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1192,233,910 - 192,574,831 (+)Ensemblrn6Rnor6.0
Rnor_5.01199,295,067 - 199,639,140 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41181,117,512 - 181,459,856 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1174,677,501 - 174,871,327 (+)NCBICelera
RGSC_v3.11181,257,931 - 181,599,763 (+)NCBI
Cytogenetic Map1q36NCBI
PRKCB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381623,835,983 - 24,220,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1623,835,959 - 24,220,611 (+)Ensemblhg38GRCh38
GRCh371623,847,304 - 24,231,932 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361623,754,823 - 24,139,063 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341623,754,822 - 24,139,063NCBI
Celera1622,625,642 - 23,009,889 (+)NCBICelera
Cytogenetic Map16p12.2-p12.1NCBI
HuRef1621,938,281 - 22,322,666 (+)NCBIHuRef
CHM1_11624,859,040 - 25,244,985 (+)NCBICHM1_1
T2T-CHM13v2.01624,111,361 - 24,497,130 (+)NCBIT2T-CHM13v2.0
Prkcb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397121,888,327 - 122,233,625 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7121,887,974 - 122,233,625 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387122,289,104 - 122,634,402 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7122,288,751 - 122,634,402 (+)Ensemblmm10GRCm38
MGSCv377129,432,639 - 129,777,916 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367122,080,445 - 122,419,795 (+)NCBIMGSCv36mm8
Celera7122,177,656 - 122,520,472 (+)NCBICelera
Cytogenetic Map7F2NCBI
cM Map765.75NCBI
Prkcb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554932,395,109 - 2,710,934 (+)Ensembl
ChiLan1.0NW_0049554932,395,494 - 2,710,522 (+)NCBIChiLan1.0ChiLan1.0
PRKCB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21825,253,309 - 25,633,275 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11629,772,855 - 30,153,604 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01613,888,936 - 14,268,759 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11624,091,284 - 24,466,701 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1624,091,289 - 24,466,203 (+)EnsemblpanPan2panpan1.1
PRKCB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1621,742,970 - 22,064,360 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl621,742,973 - 22,065,185 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha623,304,828 - 23,630,068 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0621,880,650 - 22,206,417 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl621,880,653 - 22,206,393 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1621,685,773 - 22,010,753 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0621,587,647 - 21,912,745 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0621,982,425 - 22,308,075 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prkcb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344120,339,861 - 120,631,378 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365018,437,715 - 8,728,716 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365018,410,273 - 8,729,238 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKCB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl321,995,231 - 22,383,264 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1321,995,227 - 22,383,628 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2322,949,682 - 23,174,763 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKCB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1521,558,608 - 21,940,536 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl521,558,441 - 21,943,864 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660687,834,678 - 8,241,859 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkcb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247828,974,765 - 9,287,702 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247828,974,995 - 9,287,609 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Prkcb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1279,220,402 - 79,556,347 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prkcb
1793 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:412
Count of miRNA genes:221
Interacting mature miRNAs:275
Transcripts:ENSRNOT00000016418, ENSRNOT00000016442
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1182383862191260518Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat

Markers in Region
D1Smu9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,061,421 - 177,061,592 (+)MAPPERmRatBN7.2
Rnor_6.01192,471,881 - 192,472,051NCBIRnor6.0
Rnor_5.01199,535,728 - 199,535,898UniSTSRnor5.0
RGSC_v3.41181,356,209 - 181,356,379UniSTSRGSC3.4
Celera1174,768,747 - 174,768,917UniSTS
Cytogenetic Map1q36UniSTS
D1Rat170  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81186,492,652 - 186,492,768 (+)Marker Load Pipeline
mRatBN7.21177,061,447 - 177,061,563 (+)MAPPERmRatBN7.2
Rnor_6.01192,471,907 - 192,472,022NCBIRnor6.0
Rnor_5.01199,535,754 - 199,535,869UniSTSRnor5.0
RGSC_v3.41181,356,235 - 181,356,350UniSTSRGSC3.4
RGSC_v3.41181,356,234 - 181,356,350RGDRGSC3.4
Celera1174,768,773 - 174,768,888UniSTS
RGSC_v3.11181,496,149 - 181,496,265RGD
SHRSP x BN Map189.1199UniSTS
SHRSP x BN Map189.1199RGD
Cytogenetic Map1q36UniSTS
D1Got399  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21176,968,788 - 176,968,947 (+)MAPPERmRatBN7.2
Rnor_6.01192,379,361 - 192,379,519NCBIRnor6.0
Rnor_5.01199,443,417 - 199,443,575UniSTSRnor5.0
RGSC_v3.41181,263,910 - 181,264,068UniSTSRGSC3.4
Celera1174,676,987 - 174,677,145UniSTS
Cytogenetic Map1q36UniSTS
RH144428  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21176,900,557 - 176,900,794 (+)MAPPERmRatBN7.2
Rnor_6.01192,303,475 - 192,303,711NCBIRnor6.0
Rnor_5.01199,367,739 - 199,367,975UniSTSRnor5.0
Rnor_5.01199,012,168 - 199,012,404UniSTSRnor5.0
RGSC_v3.41181,195,201 - 181,195,437UniSTSRGSC3.4
Celera1174,609,316 - 174,609,552UniSTS
Cytogenetic Map1q36UniSTS
BE108217  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,157,000 - 177,157,150 (+)MAPPERmRatBN7.2
Rnor_6.01192,568,801 - 192,568,950NCBIRnor6.0
Rnor_5.01199,632,602 - 199,632,751UniSTSRnor5.0
RGSC_v3.41181,453,321 - 181,453,470UniSTSRGSC3.4
Celera1174,864,789 - 174,864,938UniSTS
Cytogenetic Map1q36UniSTS
AI044240  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,163,226 - 177,163,429 (+)MAPPERmRatBN7.2
Rnor_6.01192,575,027 - 192,575,229NCBIRnor6.0
Rnor_5.01199,638,828 - 199,639,030UniSTSRnor5.0
RGSC_v3.41181,459,547 - 181,459,749UniSTSRGSC3.4
Celera1174,871,015 - 174,871,217UniSTS
RH 3.4 Map11378.39UniSTS
Cytogenetic Map1q36UniSTS
RH94487  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,163,390 - 177,163,490 (+)MAPPERmRatBN7.2
Rnor_6.01192,575,191 - 192,575,290NCBIRnor6.0
Rnor_5.01199,638,992 - 199,639,091UniSTSRnor5.0
RGSC_v3.41181,459,711 - 181,459,810UniSTSRGSC3.4
Celera1174,871,179 - 174,871,278UniSTS
Cytogenetic Map1q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001172305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH002228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM383786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB576043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK838368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M13706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U62762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000016418   ⟹   ENSRNOP00000016417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1186,263,826 - 186,594,740 (+)Ensembl
mRatBN7.2 Ensembl1176,832,730 - 177,163,528 (+)Ensembl
Rnor_6.0 Ensembl1192,233,910 - 192,568,687 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000016442   ⟹   ENSRNOP00000016442
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1186,303,830 - 186,594,740 (+)Ensembl
mRatBN7.2 Ensembl1176,832,815 - 177,129,783 (+)Ensembl
Rnor_6.0 Ensembl1192,233,910 - 192,574,831 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078705   ⟹   ENSRNOP00000073511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1186,263,447 - 186,594,740 (+)Ensembl
mRatBN7.2 Ensembl1176,832,226 - 177,163,536 (+)Ensembl
Rnor_6.0 Ensembl1192,379,543 - 192,568,745 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094409   ⟹   ENSRNOP00000081034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1186,263,447 - 186,594,740 (+)Ensembl
mRatBN7.2 Ensembl1176,832,226 - 177,163,536 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096083   ⟹   ENSRNOP00000077705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1186,263,826 - 186,594,740 (+)Ensembl
mRatBN7.2 Ensembl1176,832,815 - 177,163,536 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110215   ⟹   ENSRNOP00000082450
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1186,263,447 - 186,594,740 (+)Ensembl
mRatBN7.2 Ensembl1176,832,226 - 177,163,536 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116223   ⟹   ENSRNOP00000094736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1186,263,447 - 186,594,740 (+)Ensembl
mRatBN7.2 Ensembl1176,832,226 - 177,125,024 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117718   ⟹   ENSRNOP00000077459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1186,263,826 - 186,594,740 (+)Ensembl
mRatBN7.2 Ensembl1176,832,730 - 177,163,528 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000141500   ⟹   ENSRNOP00000111645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1186,263,835 - 186,589,270 (+)Ensembl
RefSeq Acc Id: NM_001172305   ⟹   NP_001165776
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81186,263,906 - 186,594,743 (+)NCBI
mRatBN7.21176,832,685 - 177,163,539 (+)NCBI
Rnor_6.01192,233,780 - 192,575,339 (+)NCBI
Rnor_5.01199,295,067 - 199,639,140 (+)NCBI
Celera1174,677,501 - 174,871,327 (+)NCBI
Sequence:
RefSeq Acc Id: NM_012713   ⟹   NP_036845
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81186,263,906 - 186,588,950 (+)NCBI
mRatBN7.21176,832,685 - 177,157,748 (+)NCBI
Rnor_6.01192,233,780 - 192,569,544 (+)NCBI
Rnor_5.01199,295,067 - 199,639,140 (+)NCBI
RGSC_v3.41181,117,512 - 181,459,856 (+)RGD
Celera1174,677,501 - 174,865,532 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101232   ⟹   XP_038957160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81186,263,399 - 186,594,743 (+)NCBI
mRatBN7.21176,832,174 - 177,163,539 (+)NCBI
RefSeq Acc Id: XM_039101234   ⟹   XP_038957162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81186,263,397 - 186,594,743 (+)NCBI
mRatBN7.21176,832,173 - 177,163,539 (+)NCBI
RefSeq Acc Id: XM_039101236   ⟹   XP_038957164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81186,391,509 - 186,594,743 (+)NCBI
mRatBN7.21176,960,297 - 177,163,539 (+)NCBI
RefSeq Acc Id: NP_036845   ⟸   NM_012713
- Peptide Label: isoform 1
- UniProtKB: F1LS42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001165776   ⟸   NM_001172305
- Peptide Label: isoform 2
- UniProtKB: F1LS42 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016442   ⟸   ENSRNOT00000016442
Ensembl Acc Id: ENSRNOP00000016417   ⟸   ENSRNOT00000016418
Ensembl Acc Id: ENSRNOP00000073511   ⟸   ENSRNOT00000078705
RefSeq Acc Id: XP_038957162   ⟸   XM_039101234
- Peptide Label: isoform X2
- UniProtKB: P68403 (UniProtKB/Swiss-Prot),   F1LS42 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957160   ⟸   XM_039101232
- Peptide Label: isoform X1
- UniProtKB: F1LS42 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957164   ⟸   XM_039101236
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K5Q0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081034   ⟸   ENSRNOT00000094409
Ensembl Acc Id: ENSRNOP00000082450   ⟸   ENSRNOT00000110215
Ensembl Acc Id: ENSRNOP00000094736   ⟸   ENSRNOT00000116223
Ensembl Acc Id: ENSRNOP00000077459   ⟸   ENSRNOT00000117718
Ensembl Acc Id: ENSRNOP00000077705   ⟸   ENSRNOT00000096083
Ensembl Acc Id: ENSRNOP00000111645   ⟸   ENSRNOT00000141500
Protein Domains
AGC-kinase C-terminal   C2   Phorbol-ester/DAG-type   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P68403-F1-model_v2 AlphaFold P68403 1-671 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690386
Promoter ID:EPDNEW_R903
Type:multiple initiation site
Name:Prkcb_1
Description:protein kinase C, beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01192,379,538 - 192,379,598EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3396 AgrOrtholog
BIND 134040
BioCyc Gene G2FUF-57541 BioCyc
Ensembl Genes ENSRNOG00000012061 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016418 ENTREZGENE
  ENSRNOT00000016418.7 UniProtKB/Swiss-Prot
  ENSRNOT00000016442 ENTREZGENE
  ENSRNOT00000078705 ENTREZGENE
  ENSRNOT00000078705.2 UniProtKB/Swiss-Prot
  ENSRNOT00000141500 ENTREZGENE
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot
  3.30.60.20 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  C1-like_sf UniProtKB/Swiss-Prot
  C2_dom UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  cPKC_beta UniProtKB/Swiss-Prot
  DAG/PE-bd UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PE/DAG-bd UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Protein_kinase_C_a/b/g UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:25023 UniProtKB/Swiss-Prot
NCBI Gene 25023 ENTREZGENE
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot
Pfam C1_1 UniProtKB/Swiss-Prot
  PF00168 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
PhenoGen Prkcb PhenoGen
PIRSF PKC_alpha UniProtKB/Swiss-Prot
PRINTS C2DOMAIN UniProtKB/Swiss-Prot
  DAGPEDOMAIN UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  PS50004 UniProtKB/Swiss-Prot
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012061 RatGTEx
SMART S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
  SM00109 UniProtKB/Swiss-Prot
  SM00239 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
  SSF57889 UniProtKB/Swiss-Prot
UniProt A0A0G2K5Q0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5XW57_RAT UniProtKB/TrEMBL
  A0A8I5Y861_RAT UniProtKB/TrEMBL
  A0A8I5ZQS9_RAT UniProtKB/TrEMBL
  A0A8I5ZUY0_RAT UniProtKB/TrEMBL
  A0A8I6AM65_RAT UniProtKB/TrEMBL
  A0ABK0M331_RAT UniProtKB/TrEMBL
  F1LS36_RAT UniProtKB/TrEMBL
  F1LS42 ENTREZGENE, UniProtKB/TrEMBL
  KPCB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P04410 UniProtKB/Swiss-Prot
  P04411 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-24 Prkcb  protein kinase C, beta  Prkcb1  protein kinase C, beta 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Prkcb1  protein kinase C, beta 1    Protein kinase C beta  Name updated 629478 APPROVED
2002-06-10 Prkcb1  Protein kinase C beta      Symbol and Name status set to approved 70586 APPROVED