RGD Reference Report - Cloning and expression of multiple protein kinase C cDNAs. - Rat Genome Database

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Cloning and expression of multiple protein kinase C cDNAs.

Authors: Knopf, JL  Lee, MH  Sultzman, LA  Kriz, RW  Loomis, CR  Hewick, RM  Bell, RM 
Citation: Knopf JL, etal., Cell 1986 Aug 15;46(4):491-502.
RGD ID: 633713
Pubmed: PMID:3755379   (View Abstract at PubMed)

Three different protein kinase C related cDNA clones were isolated from a rat brain cDNA library and designated PKC-I, PKC-II, and PKC-III. These each encode very similar, but distinct, polypeptides that contain a region homologous with other protein kinases. COS cells transfected with either PKC-I or PKC-II specifically bind at least 5-fold more 3H-PDBu (phorbol ester) than control cells. An increase in Ca2+, phosphatidylserine, and diacylglycerol/phorbol-ester-dependent protein kinase activity is also observed in COS cells transfected with either PKC-I or PKC-II. The physiological implications of the discovery of three protein-kinase-C-related cDNAs are discussed.

Objects referenced in this article
Gene Prkcb protein kinase C, beta Rattus norvegicus
Gene Prkcg protein kinase C, gamma Rattus norvegicus

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