Fgf2 (fibroblast growth factor 2) - Rat Genome Database

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Gene: Fgf2 (fibroblast growth factor 2) Rattus norvegicus
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Symbol: Fgf2
Name: fibroblast growth factor 2
RGD ID: 2609
Description: Enables fibroblast growth factor receptor binding activity and histone H3K9me2/3 reader activity. Involved in several processes, including behavioral response to ethanol; positive regulation of cell population proliferation; and regulation of intracellular signal transduction. Acts upstream of or within fibroblast growth factor receptor signaling pathway. Located in extracellular space. Used to study alcohol use disorder and pulmonary hypertension. Biomarker of several diseases, including cocaine abuse; decubitus ulcer; hypertension; middle cerebral artery infarction; and retinal vascular disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; corneal neovascularization; diabetic neuropathy; gastric ulcer; and impotence. Orthologous to human FGF2 (fibroblast growth factor 2); PARTICIPATES IN cerium oxide nanoparticle response pathway; fibroblast growth factor signaling pathway; glypican signaling pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-colchicine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: angiogenesis promoting growth factor; basic fibroblast growth factor; bFGF; Fgf-2; Fgf2a; fibroblast growth factor 2a; HBGF-2; heparin binding growth factor; heparin-binding growth factor 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   LEW
Candidate Gene For: Cm49
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82122,164,454 - 122,218,796 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2122,164,454 - 122,224,493 (+)EnsemblGRCr8
mRatBN7.22120,236,328 - 120,290,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,236,328 - 120,291,221 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2126,799,241 - 126,853,523 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,911,739 - 124,966,029 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,540,703 - 119,594,985 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02124,081,072 - 124,134,133 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2124,081,072 - 124,134,681 (+)Ensemblrn6Rnor6.0
Rnor_5.02143,689,407 - 143,742,070 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42123,893,314 - 123,947,136 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2115,183,003 - 115,237,310 (+)NCBICelera
RGSC_v3.12123,838,275 - 123,897,453 (+)NCBI
RH 3.4 Map2677.29RGD
Cytogenetic Map2q25NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
alcohol use disorder  (IMP)
Animal Mammary Neoplasms  (ISO)
Arteriovenous Fistula  (ISO)
biliary tract disease  (ISO)
bladder disease  (IEP)
bone disease  (ISO)
Bone Fractures  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Cardiomegaly  (IEP,ISO)
cataract  (ISO)
cholangiocarcinoma  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (IEP)
chronic ulcer of skin  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
cocaine abuse  (IEP)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
decubitus ulcer  (IEP)
Delayed Hypersensitivity  (ISO)
demyelinating disease  (ISO)
depressive disorder  (ISO)
dermatitis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (IEP,ISO)
Diaphragmatic Hernia  (ISO)
Disease Progression  (ISO)
endometrial cancer  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
esophageal cancer  (ISO)
essential thrombocythemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (ISO)
Eye Injuries  (IEP,ISO)
Femoral Fractures  (IEP)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (ISO)
gestational diabetes  (ISO)
Gliosis  (ISO)
high grade glioma  (ISO)
Hypercholesterolemia  (ISO)
Hyperoxic Lung Injury  (IMP)
hypertension  (IEP)
Hypoglossal Nerve Injuries  (IEP)
impotence  (ISO)
Inflammation  (IEP,ISO)
Invasive Pulmonary Aspergillosis  (ISO)
Kaposiform Hemangioendothelioma  (ISO)
kidney disease  (ISO)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
long QT syndrome  (ISO)
macular retinal edema  (ISO)
Mesothelioma  (ISO)
middle cerebral artery infarction  (IEP)
multiple endocrine neoplasia type 1  (ISO)
Myocardial Ischemia  (ISO)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Neointima  (IEP)
neovascular inflammatory vitreoretinopathy  (ISO)
nephrosclerosis  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
Optic Nerve Injuries  (ISO)
oral submucous fibrosis  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinsonism  (ISO)
Penetrating Eye Injuries  (ISO)
periapical periodontitis  (ISO)
polyarteritis nodosa  (ISO)
Pregnancy in Diabetics  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
prostate adenocarcinoma  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Infections  (ISO)
pterygium  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IMP,ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (IEP,ISO)
retinal vein occlusion  (IEP)
Spinal Cord Compression  (IEP)
Spinal Cord Injuries  (IEP)
Surgical Wound  (IMP)
transitional cell carcinoma  (ISO)
Tympanic Membrane Perforation  (IEP,ISO)
type 2 diabetes mellitus  (ISO)
Ulcer  (IEP)
urinary bladder cancer  (ISO)
Wound Infection  (ISO)
Wounds and Injuries  (IEP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
14,15-EET  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxyethyl methacrylate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-dihydroxybenzaldehyde  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-fluorouracil  (ISO)
6-aminonicotinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (ISO)
albuterol  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alliin  (ISO)
alpha-D-galactose  (EXP)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
apigenin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
bathocuproine disulfonic acid  (ISO)
BAY 60-6583  (ISO)
beclomethasone  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
boric acid  (ISO)
brequinar  (ISO)
bucladesine  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
Calcitonin gene-related peptide 1  (EXP)
Calphostin C  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
cerivastatin  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
chondroitin sulfate  (ISO)
cilazapril monohydrate  (EXP)
cilnidipine  (EXP)
cisplatin  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDT  (ISO)
deguelin  (ISO)
dermatan sulfate  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
diazinon  (EXP,ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dieldrin  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
diprotium oxide  (ISO)
divanadium pentaoxide  (ISO)
dizocilpine maleate  (EXP)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
Erionite  (ISO)
ethanol  (ISO)
etoposide  (ISO)
famotidine  (ISO)
fenoldopam  (EXP)
fenpyroximate  (ISO)
finasteride  (EXP)
fluoranthene  (ISO)
fluoxetine  (EXP)
flutamide  (EXP,ISO)
folic acid  (ISO)
formoterol fumarate  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
furosemide  (EXP)
galactose  (EXP)
gamma-tocopherol  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
glucose  (EXP,ISO)
glycidol  (EXP)
gossypol  (ISO)
haloperidol  (ISO)
heparan sulfate  (ISO)
heparin  (EXP,ISO)
hexadecanoic acid  (ISO)
Hexadimethrine bromide  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
iloprost  (ISO)
imiquimod  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
irinotecan  (ISO)
Isradipine  (ISO)
kaempferol  (EXP)
kainic acid  (EXP)
lansoprazole  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
leflunomide  (ISO)
leukotriene B4  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
Mecamylamine  (EXP)
melittin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methoxychlor  (EXP)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
MK-2206  (EXP)
monosodium L-glutamate  (ISO)
morphine  (ISO)
Morroniside  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
naled  (ISO)
naloxone  (ISO)
naringin  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicotine  (EXP,ISO)
nifedipine  (ISO)
nitrofen  (EXP)
nitroprusside  (EXP,ISO)
O-(chloroacetylcarbamoyl)fumagillol  (ISO)
olanzapine  (EXP)
Oxadiazon  (ISO)
oxilofrine  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
permethrin  (EXP)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
piroxicam  (ISO)
platycodin D  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
prostaglandin F2alpha  (EXP)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
Rutecarpine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH772984  (EXP)
scutellarin  (EXP)
serpentine asbestos  (EXP,ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
Sodium oleate  (ISO)
Soman  (EXP)
Sucralfate  (ISO)
sucrose  (ISO)
suramin  (ISO)
Swertiamarin  (EXP)
tamoxifen  (ISO)
temozolomide  (EXP,ISO)
teniposide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (EXP,ISO)
thyroxine  (ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
topotecan  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trifluoroacetic acid  (ISO)
triphenylstannane  (EXP,ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
water  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
angiogenesis involved in coronary vascular morphogenesis  (IMP)
behavioral response to ethanol  (IMP)
branching involved in ureteric bud morphogenesis  (IEA,ISO,ISS)
cell differentiation  (IEA)
cell migration involved in sprouting angiogenesis  (IEA,ISO)
cellular response to mechanical stimulus  (IEP)
chondroblast differentiation  (IEA,ISO)
chromatin organization  (IEA)
corticotropin hormone secreting cell differentiation  (ISO)
embryo development ending in birth or egg hatching  (IMP)
fibroblast growth factor receptor signaling pathway  (IBA,IEA,IPI,ISO)
glial cell differentiation  (ISO)
growth factor dependent regulation of skeletal muscle satellite cell proliferation  (IEA,ISO)
hyaluronan catabolic process  (IEA,ISO)
lung development  (ISO)
mammary gland epithelial cell differentiation  (ISO)
negative regulation of blood vessel endothelial cell migration  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of fibroblast migration  (IEA,ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IMP)
negative regulation of wound healing  (IEA,ISO)
neurogenesis  (IBA)
organ induction  (ISO)
paracrine signaling  (IDA)
positive chemotaxis  (IEA)
positive regulation of angiogenesis  (IEA,ISO,ISS)
positive regulation of blood vessel branching  (IEA,ISO)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO,ISS)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cardiac muscle cell proliferation  (IDA,IEA,ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cell division  (IEA)
positive regulation of cell fate specification  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (IEA,ISO,ISS)
positive regulation of cell population proliferation  (IBA,IDA,IEA,ISO)
positive regulation of cerebellar granule cell precursor proliferation  (ISO)
positive regulation of DNA biosynthetic process  (IEA,ISO)
positive regulation of endothelial cell chemotaxis  (IEA,ISO)
positive regulation of endothelial cell chemotaxis to fibroblast growth factor  (IEA,ISO)
positive regulation of endothelial cell migration  (IEA,ISO)
positive regulation of endothelial cell proliferation  (IEA,ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial tube formation  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA,IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of lens fiber cell differentiation  (IEA,ISO,ISS)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (IBA,IEA,ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of sprouting angiogenesis  (IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
positive regulation of vascular endothelial cell proliferation  (IEA,ISO)
regulation of cell cycle  (ISO)
regulation of cell migration  (IBA)
regulation of endothelial cell chemotaxis to fibroblast growth factor  (IEA,ISO)
regulation of retinal cell programmed cell death  (ISO)
release of sequestered calcium ion into cytosol  (IEA,ISO)
response to axon injury  (ISO)
response to ethanol  (IMP)
response to wortmannin  (IMP)
signal transduction  (IEA)
stem cell development  (IEA,ISO)
substantia nigra development  (ISO)
thyroid-stimulating hormone-secreting cell differentiation  (ISO)
wound healing  (IEA,ISO)

Cellular Component
cytoplasm  (IBA)
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)
nuclear body  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mechanical load induced by glass microspheres releases angiogenic factors from neonatal rat ventricular myocytes cultures and causes arrhythmias. Barac DY, etal., J Cell Mol Med. 2008 Oct;12(5B):2037-51. doi: 10.1111/j.1582-4934.2008.00193.x.
2. Proangiogenic growth factors potentiate in situ angiogenesis and enhance antifungal drug activity in murine invasive aspergillosis. Ben-Ami R, etal., J Infect Dis. 2013 Apr;207(7):1066-74. doi: 10.1093/infdis/jis940. Epub 2013 Jan 9.
3. Genetic variation and plasma level of the basic fibroblast growth factor in proliferative diabetic retinopathy. Beranek M, etal., Diabetes Res Clin Pract. 2008 Feb;79(2):362-7. Epub 2007 Nov 7.
4. Cell surface heparan sulfate proteoglycans: target and partners of the basic fibroblast growth factor in rat Sertoli cells. Brucato S, etal., Eur J Biochem 2002 Jan;269(2):502-11.
5. Acidic and basic fibroblast growth factor messenger RNA and protein show increased expression in adult compared to developing normal and dystrophic rat retina. Bugra K and Hicks D, J Mol Neurosci. 1997 Aug;9(1):13-25.
6. Influence of maternal diabetes on placental fibroblast growth factor-2 expression, proliferation, and apoptosis. Burleigh DW, etal., J Soc Gynecol Investig. 2004 Jan;11(1):36-41.
7. Mechanical injury increases bFGF and CNTF mRNA expression in the mouse retina. Cao W, etal., Exp Eye Res. 1997 Aug;65(2):241-8.
8. Functional components of basic fibroblast growth factor signaling that inhibit lung elastin gene expression. Carreras I, etal., Am J Physiol Lung Cell Mol Physiol 2001 Oct;281(4):L766-75.
9. Platelet derived growth factor and fibroblast growth factor basic levels in the vitreous of patients with vitreoretinal disorders. Cassidy L, etal., Br J Ophthalmol. 1998 Feb;82(2):181-5.
10. FGF2-Targeted adenovirus encoding platelet-derived growth factor-B enhances de novo tissue formation. Chandler LA, etal., Mol Ther. 2000 Aug;2(2):153-60. doi: 10.1006/mthe.2000.0102.
11. FGF2 is a target and a trigger of epigenetic mechanisms associated with differences in emotionality: partnership with H3K9me3. Chaudhury S, etal., Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11834-9. doi: 10.1073/pnas.1411618111. Epub 2014 Jul 28.
12. The importance of vascular endothelial growth factor in the healing of acute tympanic membrane perforation. Cho KS, etal., Am J Otolaryngol. 2010 Sep-Oct;31(5):309-14. doi: 10.1016/j.amjoto.2009.03.005. Epub 2009 Jun 4.
13. Coordination of fibroblast growth factor receptor 1 (FGFR1) and fibroblast growth factor-2 (FGF-2) trafficking to nuclei of reactive astrocytes around cerebral lesions in adult rats.PG - 17-30 Clarke WE, etal., Mol Cell Neurosci 2001 Jan;17(1):17-30.
14. Differential intranuclear localization of fibroblast growth factor-2 isoforms and specific interaction with the survival of motoneuron protein. Claus P, etal., J Biol Chem 2003 Jan 3;278(1):479-85.
15. Fibroblast growth factor-2 binds to small heparin-derived oligosaccharides and stimulates a sustained phosphorylation of p42/44 mitogen-activated protein kinase and proliferation of rat mammary fibroblasts. Delehedde M, etal., Biochem J 2002 Aug 15;366(Pt 1):235-44.
16. Growth factor expression in ophthalmic pterygia and normal conjunctiva. Detorakis ET, etal., Int J Mol Med. 2010 Apr;25(4):513-6.
17. Responses of reactive astrocytes containing S100beta protein and fibroblast growth factor-2 in the border and in the adjacent preserved tissue after a contusion injury of the spinal cord in rats: implications for wound repair and neuroregeneration. do Carmo Cunha J, etal., Wound Repair Regen. 2007 Jan-Feb;15(1):134-46.
18. Intranasal Calcitonin Gene-Related Peptide Protects Against Focal Cerebral Ischemic Injury in Rats Through the Wnt/β-Catenin Pathway. Du Z, etal., Med Sci Monit. 2018 Dec 7;24:8860-8869. doi: 10.12659/MSM.913777.
19. Sequence analysis of the fibroblast growth factor 2 gene from the spontaneously hypertensive and hypertrophic heart rats. Dwyer JP, etal., Clin Exp Hypertens 2004 Apr;26(3):209-18.
20. Cellular distribution, subcellular localization and possible functions of basic and acidic fibroblast growth factors. Eckenstein FP, etal., Biochem Pharmacol. 1994 Jan 13;47(1):103-10.
21. Inhibition of FGF Receptor-1 Suppresses Alcohol Consumption: Role of PI3 Kinase Signaling in Dorsomedial Striatum. Even-Chen O and Barak S, J Neurosci. 2019 Oct 2;39(40):7947-7957. doi: 10.1523/JNEUROSCI.0805-19.2019. Epub 2019 Aug 2.
22. Fibroblast Growth Factor 2 in the Dorsomedial Striatum Is a Novel Positive Regulator of Alcohol Consumption. Even-Chen O, etal., J Neurosci. 2017 Sep 6;37(36):8742-8754. doi: 10.1523/JNEUROSCI.0890-17.2017. Epub 2017 Aug 8.
23. Immunolocalization and temporal distribution of cytokine expression during the development of vein graft intimal hyperplasia in an experimental model. Faries PL, etal., J Vasc Surg. 1996 Sep;24(3):463-71.
24. A comparative study of recombinant human basic fibroblast growth factor (bFGF) and erythropoietin (EPO) in prevention of skin flap ischemic necrosis in rats. Fayazzadeh E, etal., Arch Iran Med. 2012 Sep;15(9):553-6. doi: 012159/AIM.008.
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28. Gastric mucosal injury activates bFGF gene expression and triggers preferential translation of high molecular weight bFGF isoforms through CUG-initiated, non-canonical codons. Florkiewicz RZ, etal., Biochem Biophys Res Commun. 2011 Jun 10;409(3):494-9. doi: 10.1016/j.bbrc.2011.05.033. Epub 2011 May 11.
29. Expressions of the fibroblast growth factor family (FGF-1, -2 and -4) mRNA in endometrial cancers. Fujimoto J, etal., Tumour Biol. 1996;17(4):226-33.
30. Increased serum levels of basic fibroblast growth factor in patients with renal cell carcinoma. Fujimoto K, etal., Biochem Biophys Res Commun. 1991 Oct 15;180(1):386-92.
31. Prenatal stress elicits regionally selective changes in basal FGF-2 gene expression in adulthood and alters the adult response to acute or chronic stress. Fumagalli F, etal., Neurobiol Dis. 2005 Dec;20(3):731-7. Epub 2005 Jun 20.
32. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
33. Differential expression of fibroblast growth factor-2 and receptor by glial cells in experimental autoimmune encephalomyelitis (EAE) Gehrmann J, etal., Glia. 1996 Feb;16(2):93-100.
34. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
35. Strain-dependent anterior segment neovascularization following intravitreal gene transfer of basic fibroblast growth factor (bFGF). Gupta AR, etal., J Gene Med. 2001 May-Jun;3(3):252-9.
36. Time-dependent increase in basic fibroblast growth factor protein in limbic regions following electroshock seizures. Gwinn RP, etal., Neuroscience 2002;114(2):403-9.
37. A new method for closing tympanic membrane perforations using basic fibroblast growth factor. Hakuba N, etal., Laryngoscope. 2003 Aug;113(8):1352-5.
38. Alterations in protein tyrosine kinase pathways following retinal vein occlusion in the rat. Hayashi A, etal., Curr Eye Res. 1999 Mar;18(3):231-9.
39. Parallel up-regulation of FGF-2 and hyaluronan during development of cardiac hypertrophy in rat. Hellman U, etal., Cell Tissue Res. 2008 Jan 15;.
40. Increased levels of serum fibroblast growth factor-2 in diabetic pregnant women with retinopathy. Hill DJ, etal., J Clin Endocrinol Metab. 1997 May;82(5):1452-7.
41. High expression of heparanase is significantly associated with dedifferentiation and lymph node metastasis in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA and via HIF1a to HB-EGF and bFGF. Hoffmann AC, etal., J Gastrointest Surg. 2008 Oct;12(10):1674-81; discussion 1681-2. Epub 2008 Aug 13.
42. High basic fibroblast growth factor levels in nipple aspirate fluid are correlated with breast cancer. Hsiung R, etal., Cancer J. 2002 Jul-Aug;8(4):303-10.
43. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
44. Expression of fibroblast growth factor-2 in hypoglossal motoneurons is stimulated by peripheral nerve injury. Huber K, etal., J Comp Neurol. 1997 Jun 2;382(2):189-98.
45. Induction of KGF, basic FGF, and TGFalpha mRNA expression during healing of experimental TM perforations. Ishibashi T, etal., Acta Otolaryngol. 1998 Sep;118(5):701-4.
46. Inhibitory effect of TNP-470 on experimental choroidal neovascularization in a rat model. Ishida K, etal., Invest Ophthalmol Vis Sci. 1999 Jun;40(7):1512-9.
47. Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents. Izikki M, etal., J Clin Invest. 2009 Mar;119(3):512-23. doi: 10.1172/JCI35070. Epub 2009 Feb 9.
48. Fibroblast growth factor receptor-1 and neonatal compensatory lung growth after exposure to 95% oxygen. Jankov RP, etal., Am J Respir Crit Care Med. 2003 Jun 1;167(11):1554-61. Epub 2003 Mar 5.
49. Vascular endothelial growth factor and basic fibroblast growth factor in exudative age-related macular degeneration and diffuse diabetic macular edema. Jonas JB and Neumaier M, Ophthalmic Res. 2007;39(3):139-42. Epub 2007 May 15.
50. Basic fibroblast growth factor in an animal model of spontaneous mammary tumor progression. Kao S, etal., Oncol Rep. 2012 Jun;27(6):1807-14. doi: 10.3892/or.2012.1710. Epub 2012 Mar 7.
51. Stimulation of fracture repair by recombinant human basic fibroblast growth factor in normal and streptozotocin-diabetic rats. Kawaguchi H, etal., Endocrinology. 1994 Aug;135(2):774-81.
52. Site-dependent angiogenic cytokine production in human tumor xenografts. Keyes KA, etal., Cytokine. 2003 Jan 21;21(2):98-104.
53. Angiogenic cytokines in serum and cutaneous lesions of patients with polyarteritis nodosa. Kikuchi K, etal., J Am Acad Dermatol. 2005 Jul;53(1):57-61.
54. Expression of acidic fibroblast growth factor and basic fibroblast growth factor in nasal polyps. Kim HJ, etal., Acta Otolaryngol. 2006 Jun;126(6):600-5.
55. Strain-dependent increases in retinal inflammatory proteins and photoreceptor FGF-2 expression in streptozotocin-induced diabetic rats. Kirwin SJ, etal., Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5396-404. Epub 2009 May 27.
56. Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes. Konishi M, etal., J Biol Chem. 2000 Apr 21;275(16):12119-22.
57. Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma. Kuniyasu H, etal., Int J Oncol. 2001 Oct;19(4):681-5.
58. Expressions of angiogenic factors in pancreatic ductal carcinoma: a correlative study with clinicopathologic parameters and patient survival. Kuwahara K, etal., Pancreas. 2003 May;26(4):344-9.
59. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
60. NP603, a novel and potent inhibitor of FGFR1 tyrosine kinase, inhibits hepatic stellate cell proliferation and ameliorates hepatic fibrosis in rats. Lin N, etal., Am J Physiol Cell Physiol. 2011 Aug;301(2):C469-77. doi: 10.1152/ajpcell.00452.2010. Epub 2011 May 4.
61. Prognostic correlation of basic fibroblast growth factor and vascular endothelial growth factor in 1307 primary breast cancers. Linderholm BK, etal., Clin Breast Cancer. 2003 Dec;4(5):340-7.
62. Basic FGF and FGF receptor 1 are expressed in microglia during experimental autoimmune encephalomyelitis: temporally distinct expression of midkine and pleiotrophin. Liu X, etal., Glia. 1998 Dec;24(4):390-7.
63. Fibrin-based scaffold incorporating VEGF- and bFGF-loaded nanoparticles stimulates wound healing in diabetic mice. Losi P, etal., Acta Biomater. 2013 Aug;9(8):7814-21. doi: 10.1016/j.actbio.2013.04.019. Epub 2013 Apr 17.
64. Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination. Messersmith DJ, etal., J Neurosci Res. 2000 Oct 15;62(2):241-56.
65. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
66. Expression of basic fibroblast growth factor and its receptor mRNA in retinal tissue following ischemic injury in the rat. Miyashiro M, etal., Graefes Arch Clin Exp Ophthalmol. 1998 Apr;236(4):295-300.
67. Effects of basic fibroblast growth factor on experimental diabetic neuropathy in rats. Nakae M, etal., Diabetes. 2006 May;55(5):1470-7.
68. Spatial and temporal gene expression for fibroblast growth factor type I receptor (FGFR1) during fracture healing in the rat. Nakajima A, etal., Bone. 2001 Nov;29(5):458-66.
69. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
70. Kit ligand and basic fibroblast growth factor interactions in the induction of ovarian primordial to primary follicle transition. Nilsson EE and Skinner MK, Mol Cell Endocrinol 2004 Feb 12;214(1-2):19-25.
71. Therapeutic effect of bFGF on retina ischemia-reperfusion injury. Niu YJ, etal., Chin Med J (Engl). 2004 Feb;117(2):252-7.
72. Basic fibroblast growth factor evokes a rapid glutamate release through activation of the MAPK pathway in cultured cortical neurons. Numakawa T, etal., J Biol Chem 2002 Aug 9;277(32):28861-9.
73. Acceleration of wound healing in healing-impaired db/db mice with a photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2. Obara K, etal., Wound Repair Regen. 2005 Jul-Aug;13(4):390-7.
74. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
75. Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor. Owczarek S, etal., FASEB J. 2010 Apr;24(4):1139-50. Epub 2009 Dec 1.
76. Hypercholesterolemia impairs angiogenesis in patients with breast carcinoma and, therefore, lowers the risk of metastases. Ozdemir BH, etal., Am J Clin Pathol. 2004 Nov;122(5):696-703.
77. Fibroblast growth factors and their specific binding sites in normal urothelium and transitional cell carcinoma (TCC) of the human bladder. Palcy S, etal., Cell Mol Biol (Noisy-le-grand). 1995 Jun;41(4):565-75.
78. Angiogenesis and capillary maturation phenotypes associated with the Edpm3 locus on rat chromosome 3. Pandey J and Wendell DL, Mamm Genome. 2006 Jan;17(1):49-57. Epub 2006 Jan 13.
79. Peripheral monocytes from diabetic patients with coronary artery disease display increased bFGF and VEGF mRNA expression. Panutsopulos D, etal., J Transl Med. 2003 Oct 6;1(1):6.
80. High and low molecular weight fibroblast growth factor-2 increase proliferation of neonatal rat cardiac myocytes but have differential effects on binucleation and nuclear morphology. Evidence for both paracrine and intracrine actions of fibroblast growth factor-2. Pasumarthi KB, etal., Circ Res. 1996 Jan;78(1):126-36.
81. Polymorphisms in the promoter region of the basic fibroblast growth factor gene and proliferative diabetic retinopathy in Caucasians with type 2 diabetes. Petrovic MG, etal., Clin Experiment Ophthalmol. 2008 Mar;36(2):168-72. Epub 2008 Feb 13.
82. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
83. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
84. Fibroblast growth factor 2 promotes tumor progression in an autochthonous mouse model of prostate cancer. Polnaszek N, etal., Cancer Res. 2003 Sep 15;63(18):5754-60.
85. carboxypeptidase E-ΔN, a neuroprotein transiently expressed during development protects embryonic neurons against glutamate neurotoxicity. Qin XY, etal., PLoS One. 2014 Nov 26;9(11):e112996. doi: 10.1371/journal.pone.0112996. eCollection 2014.
86. Suppression of smooth muscle cell proliferation after experimental PTFE arterial grafting: a role for polyclonal anti-basic fibroblast growth factor (bFGF) antibody. Randone B, etal., Eur J Vasc Endovasc Surg. 1998 Nov;16(5):401-7.
87. GOA pipeline RGD automated data pipeline
88. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
89. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
90. Assessment of the VEGF, bFGF, aFGF and IL8 angiogenic activity in urinary bladder carcinoma, using the mice cutaneous angiogenesis test. Rogala E, etal., Anticancer Res. 2001 Nov-Dec;21(6B):4259-63.
91. Controlled release of fibroblast growth factor 2 stimulates bone healing in an animal model of diabetes mellitus. Santana RB and Trackman PC, Int J Oral Maxillofac Implants. 2006 Sep-Oct;21(5):711-8.
92. Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury. Sapieha PS, etal., Mol Cell Neurosci. 2003 Nov;24(3):656-72.
93. Prevention of gastric ulcer relapse induced by indomethacin in rats by a mutein of basic fibroblast growth factor. Satoh H, etal., Jpn J Pharmacol. 1997 Mar;73(3):229-41.
94. Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction. Shimizu T, etal., JCI Insight. 2017 Jul 6;2(13). pii: 93187. doi: 10.1172/jci.insight.93187.
95. Endothelial cells overexpressing basic fibroblast growth factor (FGF-2) induce vascular tumors in immunodeficient mice. Sola F, etal., Angiogenesis. 1997;1(1):102-116.
96. Diabetic retinopathy: VEGF, bFGF and retinal vascular pathology. Song E, etal., Chin Med J (Engl). 2004 Feb;117(2):247-51.
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98. Expression of oncogene products HER2/Neu and Ras and fibrosis-related growth factors bFGF, TGF-beta, and PDGF in bile from biliary malignancies and inflammatory disorders. Su WC, etal., Dig Dis Sci. 2001 Jul;46(7):1387-92.
99. Angiogenesis and angiogenic growth factors in middle ear cholesteatoma. Sudhoff H, etal., Am J Otol. 2000 Nov;21(6):793-8.
100. Effect of basic fibroblast growth factor incorporating gelatin microspheres on erectile function in the diabetic rat. Suetomi T, etal., J Urol. 2005 Apr;173(4):1423-8.
101. Fibroblast growth factor 2: roles of regulation of lens cell proliferation and epithelial-mesenchymal transition in response to injury. Tanaka T, etal., Mol Vis. 2004 Jul 15;10:462-7.
102. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
103. Cellular uptake and activity of heparin functionalised cerium oxide nanoparticles in monocytes. Ting SR, etal., Biomaterials. 2013 Jun;34(17):4377-86. doi: 10.1016/j.biomaterials.2013.02.042. Epub 2013 Mar 7.
104. Vascular endothelial growth factor and basic fibroblast growth factor differentially modulate early postnatal coronary angiogenesis. Tomanek RJ, etal., Circ Res. 2001 Jun 8;88(11):1135-41.
105. Clinical efficacy of basic fibroblast growth factor (bFGF) for diabetic ulcer. UCHI H, etal., Eur J Dermatol. 2009 Sep-Oct;19(5):461-8. Epub 2009 Jul 29.
106. Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor. Unoki K and LaVail MM, Invest Ophthalmol Vis Sci. 1994 Mar;35(3):907-15.
107. Effect of anti-basic fibroblast growth factor (Anti-bFGF) on in vitro embryonic development in rat. Unur E, etal., Anat Histol Embryol. 2009 Aug;38(4):241-5. Epub 2009 May 19.
108. Expression of angiogenic growth factors in dural arteriovenous fistula. Uranishi R, etal., J Neurosurg. 1999 Nov;91(5):781-6.
109. Human mesenchymal stem cells modulate inflammatory cytokines after spinal cord injury in rat. Urdzíková LM, etal., Int J Mol Sci. 2014 Jun 25;15(7):11275-93. doi: 10.3390/ijms150711275.
110. Role of basic fibroblast growth factor (FGF-2) in diabetic nephropathy and mechanisms of its induction by hyperglycemia in human renal fibroblasts. Vasko R, etal., Am J Physiol Renal Physiol. 2009 Jun;296(6):F1452-63. Epub 2009 Mar 11.
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113. MicroRNA-155 inversely correlates with esophageal cancer progression through regulating tumor-associated macrophage FGF2 expression. Wang P, etal., Biochem Biophys Res Commun. 2018 Sep 5;503(2):452-458. doi: 10.1016/j.bbrc.2018.04.094. Epub 2018 Jun 30.
114. Expression and localization of basic fibroblast growth factor in diabetic rat prostate. Wang Z, etal., BJU Int. 2000 May;85(7):945-52.
115. Growth factors in the collateral circulation of chronic total coronary occlusions: relation to duration of occlusion and collateral function. Werner GS, etal., Circulation. 2004 Oct 5;110(14):1940-5. Epub 2004 Sep 27.
116. Fibroblast growth factors (FGF) in human myometrium and uterine leiomyomas in various stages of tumour growth. Wolanska M and Bankowski E, Biochimie. 2006 Feb;88(2):141-6. Epub 2005 Aug 22.
117. Overaccumulation of transforming growth factor-beta1 and basic fibroblast growth factor in lens epithelial cells of congenital cataract. Xiao Y, etal., Can J Ophthalmol. 2009 Apr;44(2):189-92. doi: 10.3129/i09-006.
118. Fibroblast growth factor-2 determines severity of joint disease in adjuvant-induced arthritis in rats. Yamashita A, etal., J Immunol 2002 Jan 1;168(1):450-7.
119. Expression of basic fibroblast growth factor (FGF-2)-associated with tumour proliferation in human pancreatic carcinoma. Yamazaki K, etal., Virchows Arch. 1997 Aug;431(2):95-101.
120. The angiogenic peptide vascular endothelial growth factor-basic fibroblast growth factor signaling is up-regulated in a rat pressure ulcer model. Yang JJ, etal., Anat Rec (Hoboken). 2013 Aug;296(8):1161-8. doi: 10.1002/ar.22676. Epub 2013 Jun 6.
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124. Diabetes can alter the signal transduction pathways in the lens of rats. Zatechka DS Jr, etal., Diabetes. 2003 Apr;52(4):1014-22.
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126. Increased basic fibroblast growth factor in plasma from multiple endocrine neoplasia type 1: relation to pituitary tumor. Zimering MB, etal., J Clin Endocrinol Metab. 1993 May;76(5):1182-7.
127. Basic fibroblast growth factor (bFGF, FGF-2) potentiates leukocyte recruitment to inflammation by enhancing endothelial adhesion molecule expression. Zittermann SI and Issekutz AC, Am J Pathol. 2006 Mar;168(3):835-46.
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Genomics

Comparative Map Data
Fgf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82122,164,454 - 122,218,796 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2122,164,454 - 122,224,493 (+)EnsemblGRCr8
mRatBN7.22120,236,328 - 120,290,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,236,328 - 120,291,221 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2126,799,241 - 126,853,523 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,911,739 - 124,966,029 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,540,703 - 119,594,985 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02124,081,072 - 124,134,133 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2124,081,072 - 124,134,681 (+)Ensemblrn6Rnor6.0
Rnor_5.02143,689,407 - 143,742,070 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42123,893,314 - 123,947,136 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2115,183,003 - 115,237,310 (+)NCBICelera
RGSC_v3.12123,838,275 - 123,897,453 (+)NCBI
RH 3.4 Map2677.29RGD
Cytogenetic Map2q25NCBI
FGF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384122,826,682 - 122,898,236 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4122,826,682 - 122,898,236 (+)Ensemblhg38GRCh38
GRCh374123,747,837 - 123,819,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,967,313 - 124,038,840 (+)NCBIBuild 36Build 36hg18NCBI36
Build 344124,105,467 - 124,176,995NCBI
Celera4121,130,707 - 121,202,234 (+)NCBICelera
Cytogenetic Map4q28.1NCBI
HuRef4119,474,437 - 119,545,817 (+)NCBIHuRef
CHM1_14123,724,372 - 123,795,895 (+)NCBICHM1_1
T2T-CHM13v2.04126,130,781 - 126,202,343 (+)NCBIT2T-CHM13v2.0
Fgf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39337,402,616 - 37,464,255 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl337,402,495 - 37,464,257 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38337,348,477 - 37,410,106 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,348,346 - 37,410,108 (+)Ensemblmm10GRCm38
MGSCv37337,247,575 - 37,303,752 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36337,540,399 - 37,596,346 (+)NCBIMGSCv36mm8
Celera337,228,587 - 37,279,676 (+)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.41NCBI
Fgf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542817,840,628 - 17,894,773 (-)Ensembl
ChiLan1.0NW_00495542817,840,554 - 17,894,779 (-)NCBIChiLan1.0ChiLan1.0
FGF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23120,604,078 - 120,675,314 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14120,869,886 - 120,941,139 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04115,005,136 - 115,076,369 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14126,149,750 - 126,220,774 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4126,149,813 - 126,214,942 (+)EnsemblpanPan2panpan1.1
FGF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11917,403,288 - 17,463,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1916,994,661 - 17,463,151 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1917,610,808 - 17,690,535 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01917,510,798 - 17,588,734 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1917,164,097 - 17,578,900 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11917,466,635 - 17,533,082 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01917,745,360 - 17,822,472 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01918,217,074 - 18,293,705 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
FGF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8101,278,885 - 101,343,916 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18101,278,877 - 101,344,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,489,442 - 108,508,875 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1770,089,394 - 70,157,423 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603749,060,630 - 49,133,030 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247773,268,953 - 3,321,145 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247773,268,674 - 3,321,424 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fgf2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13116,628,556 - 116,681,857 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fgf2
205 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:92
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000023388
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2120039407151869825Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
RH94418  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22120,291,028 - 120,291,198 (+)MAPPERmRatBN7.2
Rnor_6.02124,134,489 - 124,134,658NCBIRnor6.0
Rnor_5.02143,742,426 - 143,742,595UniSTSRnor5.0
RGSC_v3.42123,947,492 - 123,947,661UniSTSRGSC3.4
Celera2115,237,678 - 115,237,847UniSTS
RH 3.4 Map2677.29UniSTS
Cytogenetic Map2q25UniSTS
RH130030  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera2115,237,546 - 115,237,729UniSTS
RH 3.4 Map2667.5UniSTS
Cytogenetic Map2q25UniSTS


Related Rat Strains
The following Strains have been annotated to Fgf2
LEW    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 12 60 150 67 66 35 30 35 6 236 122 9 130 60 88 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000023388   ⟹   ENSRNOP00000023388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2122,164,454 - 122,218,796 (+)Ensembl
mRatBN7.2 Ensembl2120,236,328 - 120,291,221 (+)Ensembl
Rnor_6.0 Ensembl2124,081,072 - 124,134,681 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119158   ⟹   ENSRNOP00000088479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2122,195,865 - 122,218,796 (+)Ensembl
mRatBN7.2 Ensembl2120,267,741 - 120,291,221 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000143209   ⟹   ENSRNOP00000109903
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2122,164,454 - 122,224,493 (+)Ensembl
RefSeq Acc Id: NM_019305   ⟹   NP_062178
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82122,164,454 - 122,218,796 (+)NCBI
mRatBN7.22120,236,328 - 120,290,673 (+)NCBI
Rnor_6.02124,081,072 - 124,134,133 (+)NCBI
Rnor_5.02143,689,407 - 143,742,070 (+)NCBI
RGSC_v3.42123,893,314 - 123,947,136 (+)RGD
Celera2115,183,003 - 115,237,310 (+)RGD
Sequence:
RefSeq Acc Id: NP_062178   ⟸   NM_019305
- UniProtKB: P13109 (UniProtKB/Swiss-Prot),   A0A7U3JW58 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023388   ⟸   ENSRNOT00000023388
Ensembl Acc Id: ENSRNOP00000088479   ⟸   ENSRNOT00000119158
Ensembl Acc Id: ENSRNOP00000109903   ⟸   ENSRNOT00000143209

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13109-F1-model_v2 AlphaFold P13109 1-154 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691296
Promoter ID:EPDNEW_R1821
Type:single initiation site
Name:Fgf2_1
Description:fibroblast growth factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02124,081,170 - 124,081,230EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2609 AgrOrtholog
BioCyc Gene G2FUF-53305 BioCyc
Ensembl Genes ENSRNOG00000017392 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023388 ENTREZGENE
  ENSRNOT00000023388.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot
InterPro Fibroblast_GF_fam UniProtKB/Swiss-Prot
  IL1/FGF UniProtKB/Swiss-Prot
KEGG Report rno:54250 UniProtKB/Swiss-Prot
NCBI Gene 54250 ENTREZGENE
PANTHER PTHR11486 UniProtKB/Swiss-Prot
Pfam FGF UniProtKB/Swiss-Prot
PhenoGen Fgf2 PhenoGen
PRINTS HBGFFGF UniProtKB/Swiss-Prot
  IL1HBGF UniProtKB/Swiss-Prot
PROSITE HBGF_FGF UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017392 RatGTEx
SMART FGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot
TIGR TC230999
UniProt A0A2U1_RAT UniProtKB/TrEMBL
  A0A7U3JW58 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GG97_RAT UniProtKB/TrEMBL
  A0ABK0LGH7_RAT UniProtKB/TrEMBL
  A6II05_RAT UniProtKB/TrEMBL
  A6II06_RAT UniProtKB/TrEMBL
  FGF2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Fgf2  Fibroblast growth factor 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization colocalizes with FGFR1 protein in transcriptionally active chormatin of astrocytes and has also been observed in the perinuclear region and cytoplasm of activated astrocytes in response to CNS injury 625526
gene_disease up-regulated in adjuvant-induced arthritis synovial joints 70481
gene_disease may function in rheumatoid arthritis joint disease to modulate disease progression 70481
gene_expression expressed in astrocytes and discrete neuronal populations in brain 625526
gene_expression expressed in many tissues including testis 628487
gene_function a FGF receptor 1 (FGFR1) ligand 625526
gene_pathway decreases elastin gene expression through activation of the ERK1/2, resulting in the translocation of ERK1/2, and causes the induction of Fra-1 mRNA and protein 628487
gene_process a potent gliogenic and neurotrophic factor that may be involved in the regulation of central nervous system (CNS) injury responses 625565
gene_process may be active in CNS injury responses like transformation of reactive astrocytes, angiogenesis, scar formation and promotion of neurotrophic activities 625526
gene_process negative regulator of elastin transcription in contact-inhibited fibroblast cultures 628487
gene_product 22, 21 and 18 kDa proteins 625526
gene_regulation increase in expression seen after brain injury 625526