RGD Reference Report - Vascular endothelial growth factor and basic fibroblast growth factor in exudative age-related macular degeneration and diffuse diabetic macular edema. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Vascular endothelial growth factor and basic fibroblast growth factor in exudative age-related macular degeneration and diffuse diabetic macular edema.

Authors: Jonas, JB  Neumaier, M 
Citation: Jonas JB and Neumaier M, Ophthalmic Res. 2007;39(3):139-42. Epub 2007 May 15.
RGD ID: 8655594
Pubmed: PMID:17505145   (View Abstract at PubMed)
DOI: DOI:10.1159/000102935   (Journal Full-text)

BACKGROUND: To evaluate the concentrations of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in neovascular or edematous retinal diseases. METHODS: In the clinical comparative interventional study, VEGF and bFGF concentrations in aqueous humor samples of 35 patients with exudative age-related macular degeneration (AMD), 21 patients with diabetic macular edema and 24 patients of a control group were measured using a solid-phase chemiluminescence immunoassay. RESULTS: Concentrations of VEGF and bFGF, respectively, were significantly higher in the diabetic group (184.7 +/- 107.0 and 5.0 +/- 10.2 pg/l) than in the AMD group (107.7 +/- 73.0 pg/l, p = 0.002; 2.2 +/- 7.4 pg/l, p = 0.002) and the control group (71.5 +/- 94.7 pg/l, p = 0.001; 0.00 pg/l, p = 0.001). The two latter groups did not vary significantly (p = 0.10). CONCLUSIONS: VEGF and bFGF are present in considerably higher concentrations in eyes with diabetic macular edema than in eyes with exudative AMD or normal eyes. The differences were more marked for VEGF than for bFGF.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
macular retinal edema  IEP 8655594; 8655594associated with Diabetes Mellitus and protein:increased expression:aqueous humorRGD 
macular retinal edema  ISOFGF2 (Homo sapiens)8655594; 8655594associated with Diabetes Mellitus and protein:increased expression:aqueous humorRGD 
macular retinal edema  ISOVEGFA (Homo sapiens)8655594; 8655594associated with Diabetes Mellitus and protein:increased expression:aqueous humorRGD 

Objects Annotated

Genes (Rattus norvegicus)
Fgf2  (fibroblast growth factor 2)
Vegfa  (vascular endothelial growth factor A)

Genes (Mus musculus)
Fgf2  (fibroblast growth factor 2)
Vegfa  (vascular endothelial growth factor A)

Genes (Homo sapiens)
FGF2  (fibroblast growth factor 2)
VEGFA  (vascular endothelial growth factor A)


Additional Information