RGD Reference Report - Angiogenesis and capillary maturation phenotypes associated with the Edpm3 locus on rat chromosome 3. - Rat Genome Database

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Angiogenesis and capillary maturation phenotypes associated with the Edpm3 locus on rat chromosome 3.

Authors: Pandey, J  Wendell, DL 
Citation: Pandey J and Wendell DL, Mamm Genome. 2006 Jan;17(1):49-57. Epub 2006 Jan 13.
RGD ID: 1581610
Pubmed: PMID:16416090   (View Abstract at PubMed)
DOI: DOI:10.1007/s00335-005-2450-4   (Journal Full-text)

The quantitative trait locus (QTL) Edpm3 is one of a group of additively acting QTL \responsible for the difference in estrogen-induced pituitary tumor growth between the tumor-susceptible F344 and tumor-resistant BN rat strains. The F344.BN-Edpm3(BN) rat strain was produced by moving the segment of rat Chr 3 between D3Mgh7 and D3Mgh13, which contains the Edpm3 QTL, from the BN strain into the F344 genetic background. In a previous study, we used this congenic line to find that the BN allele of the Edpm3 QTL reduces tissue mass and S-phase fraction in the estrogen-induced rat pituitary tumor. We now report on the use of this congenic line to investigate the linkage of Edpm3 to tumor angiogenesis. Contrary to expectation, the F344.BN-Edpm3(BN) strain has significantly greater angiogenic activity than does F344 in both treated and untreated rats. Microvessel count (MVC), perivascular space, and number of nonattached pericytes/pericapillary fibroblasts are all elevated in the pituitary by chronic estrogen treatment and their values are significantly greater in F344.BN-Edpm3(BN) than F344. Thus, although there is greater angiogenic activity in the pituitary of estrogen-treated F344.BN-Edpm3(BN) rats, there is a deficiency in capillary maturation compared with F344.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pituitary adenoma inducedIAGPdiethylstilbestrol1581610; 1581610 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
increased capillary density  IAGP 1581610compared to F344/NHsdRGD 
increased capillary density inducedIAGPdiethylstilbestrol1581610compared to F344.BN-D3Mgh13-D3Mgh7/Dlw and diethylstilbestrol treated F344/NHsdRGD 
increased capillary density inducedIAGPdiethylstilbestrol1581610compared to F344/NHsdRGD 
increased lactotroph cell number inducedIAGPdiethylstilbestrol1581610compared to F344.BN-D3Mgh13-D3Mgh7/DlwRGD 
increased lactotroph cell number inducedIAGPdiethylstilbestrol1581610compared to F344/NHsd and diethylstilbestrol treated F344.BN-D3Mgh13-D3Mgh7/DlwRGD 
increased lactotroph cell number  IAGP 1581610compared to F344.BN-D3Mgh13-D3Mgh7/DlwRGD 
increased tumor nonattached pericyte number  IAGP 1581610compared to F344/NHsdRGD 
increased tumor nonattached pericyte number inducesIAGPdiethylstilbestrol1581610compared to diethylstilbestrol treated F344/NHsdRGD 
increased tumor nonattached pericyte number inducesIAGPdiethylstilbestrol1581610compared to F344/NHsdRGD 
increased tumor perivascular space size  IAGP 1581610compared to F344/NHsdRGD 
increased tumor perivascular space size inducesIAGPdiethylstilbestrol1581610compared to diethylstilbestrol treated F344/NHsdRGD 

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Objects Annotated

Genes (Rattus norvegicus)
Nrp1  (neuropilin 1)

Strains
F344.BN-(D3Mgh13-D3Mgh7)/Dlw  (NA)
F344/NHsd  (F344/NHsd)

Objects referenced in this article
QTL Edpm3 Estrogen-dependent pituitary mass QTL 3 Rattus norvegicus
Gene Fgf1 fibroblast growth factor 1 Rattus norvegicus
Gene Fgf2 fibroblast growth factor 2 Rattus norvegicus
Gene Fgf7 fibroblast growth factor 7 Rattus norvegicus
Gene Hgf hepatocyte growth factor Rattus norvegicus

Additional Information