Fgf2 (fibroblast growth factor 2) - Rat Genome Database

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Pathways
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Gene: Fgf2 (fibroblast growth factor 2) Chinchilla lanigera
Analyze
Symbol: Fgf2
Name: fibroblast growth factor 2
RGD ID: 8788599
Description: ENCODES a protein that exhibits chemoattractant activity (ortholog); chemokine binding (ortholog); cytokine activity (ortholog); INVOLVED IN angiogenesis (ortholog); angiogenesis involved in coronary vascular morphogenesis (ortholog); branching involved in ureteric bud morphogenesis (ortholog); PARTICIPATES IN cerium oxide nanoparticle response pathway; fibroblast growth factor signaling pathway; glypican signaling pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); Arteriovenous Fistula (ortholog); biliary tract disease (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: fibroblast growth factor 2 (basic)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542817,840,628 - 17,894,773 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542817,840,554 - 17,894,779 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Animal Mammary Neoplasms  (ISO)
Arteriovenous Fistula  (ISO)
biliary tract disease  (ISO)
bladder disease  (ISO)
bone disease  (ISO)
Bone Fractures  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Cardiomegaly  (ISO)
cataract  (ISO)
cholangiocarcinoma  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (ISO)
chronic ulcer of skin  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
decubitus ulcer  (ISO)
Delayed Hypersensitivity  (ISO)
demyelinating disease  (ISO)
depressive disorder  (ISO)
dermatitis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
Disease Progression  (ISO)
endometrial cancer  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
esophageal cancer  (ISO)
essential thrombocythemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Eye Injuries  (ISO)
Femoral Fractures  (ISO)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
Gliosis  (ISO)
high grade glioma  (ISO)
Hypercholesterolemia  (ISO)
Hyperoxic Lung Injury  (ISO)
hypertension  (ISO)
Hypoglossal Nerve Injuries  (ISO)
impotence  (ISO)
Inflammation  (ISO)
Invasive Pulmonary Aspergillosis  (ISO)
Kaposiform Hemangioendothelioma  (ISO)
kidney disease  (ISO)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
long QT syndrome  (ISO)
macular retinal edema  (ISO)
Mesothelioma  (ISO)
middle cerebral artery infarction  (ISO)
multiple endocrine neoplasia type 1  (ISO)
Myocardial Ischemia  (ISO)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Neointima  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephrosclerosis  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
neurodevelopmental disorder with hearing loss, seizures, and brain abnormalities  (ISO)
Neurodevelopmental Disorders  (ISO)
Optic Nerve Injuries  (ISO)
oral submucous fibrosis  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinsonism  (ISO)
Penetrating Eye Injuries  (ISO)
periapical periodontitis  (ISO)
polyarteritis nodosa  (ISO)
Pregnancy in Diabetics  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
prostate adenocarcinoma  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Infections  (ISO)
pterygium  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
retinal vein occlusion  (ISO)
Spinal Cord Compression  (ISO)
Spinal Cord Injuries  (ISO)
transitional cell carcinoma  (ISO)
Tympanic Membrane Perforation  (ISO,ISS)
type 2 diabetes mellitus  (ISO)
Ulcer  (ISO)
urinary bladder cancer  (ISO)
Wound Infection  (ISO)
Wounds and Injuries  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
angiogenesis involved in coronary vascular morphogenesis  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
canonical Wnt signaling pathway  (ISO)
cell migration involved in sprouting angiogenesis  (ISO)
cell population proliferation  (ISO)
cellular response to mechanical stimulus  (ISO)
cerebellar granule cell precursor proliferation  (ISO)
chondroblast differentiation  (ISO)
corticotropin hormone secreting cell differentiation  (ISO)
embryo development ending in birth or egg hatching  (ISO)
endothelial cell migration  (ISO)
endothelial cell proliferation  (ISO)
epithelial cell proliferation  (ISO)
ERK1 and ERK2 cascade  (ISO)
fibroblast growth factor receptor signaling pathway  (ISO)
glial cell differentiation  (ISO)
growth factor dependent regulation of skeletal muscle satellite cell proliferation  (ISO)
hyaluronan catabolic process  (ISO)
inner ear auditory receptor cell differentiation  (ISO)
lung development  (ISO)
lymphatic endothelial cell migration  (ISO)
mammary gland epithelial cell differentiation  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of fibroblast migration  (ISO)
negative regulation of stem cell proliferation  (ISO)
negative regulation of wound healing  (ISO)
neuroblast proliferation  (ISO)
neuroepithelial cell differentiation  (ISO)
organ induction  (ISO)
osteoblast differentiation  (ISO)
paracrine signaling  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell fate specification  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cerebellar granule cell precursor proliferation  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of endothelial cell chemotaxis  (ISO)
positive regulation of endothelial cell chemotaxis to fibroblast growth factor  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial tube formation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inner ear auditory receptor cell differentiation  (ISO)
positive regulation of lens fiber cell differentiation  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of neuroepithelial cell differentiation  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of stem cell differentiation  (ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
regulation of cell cycle  (ISO)
regulation of endothelial cell chemotaxis to fibroblast growth factor  (ISO)
regulation of retinal cell programmed cell death  (ISO)
release of sequestered calcium ion into cytosol  (ISO)
response to axon injury  (ISO)
stem cell development  (ISO)
stem cell differentiation  (ISO)
stem cell proliferation  (ISO)
substantia nigra development  (ISO)
thyroid-stimulating hormone-secreting cell differentiation  (ISO)
transcription by RNA polymerase II  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. Repair of chronic tympanic membrane perforations with fibroblast growth factor. Kato M and Jackler RK, Otolaryngol Head Neck Surg. 1996 Dec;115(6):538-47.
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Fgf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542817,840,628 - 17,894,773 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542817,840,554 - 17,894,779 (-)NCBIChiLan1.0ChiLan1.0
FGF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384122,826,682 - 122,898,236 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4122,826,682 - 122,898,236 (+)EnsemblGRCh38hg38GRCh38
GRCh374123,747,837 - 123,819,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,967,313 - 124,038,840 (+)NCBINCBI36Build 36hg18NCBI36
Build 344124,105,467 - 124,176,995NCBI
Celera4121,130,707 - 121,202,234 (+)NCBICelera
Cytogenetic Map4q28.1NCBI
HuRef4119,474,437 - 119,545,817 (+)NCBIHuRef
CHM1_14123,724,372 - 123,795,895 (+)NCBICHM1_1
T2T-CHM13v2.04126,130,781 - 126,202,343 (+)NCBIT2T-CHM13v2.0
Fgf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39337,402,616 - 37,464,255 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl337,402,495 - 37,464,257 (+)EnsemblGRCm39 Ensembl
GRCm38337,348,477 - 37,410,106 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,348,346 - 37,410,108 (+)EnsemblGRCm38mm10GRCm38
MGSCv37337,247,575 - 37,303,752 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36337,540,399 - 37,596,346 (+)NCBIMGSCv36mm8
Celera337,228,587 - 37,279,676 (+)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.41NCBI
Fgf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82122,164,454 - 122,218,796 (+)NCBIGRCr8
mRatBN7.22120,236,328 - 120,290,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,236,328 - 120,291,221 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2126,799,241 - 126,853,523 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,911,739 - 124,966,029 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,540,703 - 119,594,985 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02124,081,072 - 124,134,133 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2124,081,072 - 124,134,681 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02143,689,407 - 143,742,070 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,893,314 - 123,947,136 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12123,838,275 - 123,897,453 (+)NCBI
Celera2115,183,003 - 115,237,310 (+)NCBICelera
RH 3.4 Map2677.29RGD
Cytogenetic Map2q25NCBI
FGF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23120,604,078 - 120,675,314 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14120,869,886 - 120,941,139 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04115,005,136 - 115,076,369 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14126,149,750 - 126,220,774 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4126,149,813 - 126,214,942 (+)Ensemblpanpan1.1panPan2
FGF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11917,403,288 - 17,463,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1916,994,661 - 17,463,151 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1917,610,808 - 17,690,535 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01917,510,798 - 17,588,734 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11917,466,635 - 17,533,082 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01917,745,360 - 17,822,472 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01918,217,074 - 18,293,705 (-)NCBIUU_Cfam_GSD_1.0
FGF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8101,278,885 - 101,343,916 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18101,278,877 - 101,344,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,489,442 - 108,508,875 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1770,089,394 - 70,157,423 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603749,060,630 - 49,133,030 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247773,268,953 - 3,321,145 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247773,268,674 - 3,321,424 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000004783   ⟹   ENSCLAP00000004697
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542817,840,628 - 17,894,773 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000004784   ⟹   ENSCLAP00000004698
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542817,840,628 - 17,864,731 (-)Ensembl
RefSeq Acc Id: XM_013515320   ⟹   XP_013370774
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542817,840,554 - 17,894,779 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013370774 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000004697
  ENSCLAP00000004697.1
  ENSCLAP00000004698.1
Reference Protein Sequences
RefSeq Acc Id: XP_013370774   ⟸   XM_013515320
- UniProtKB: A0A8C2UTV0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000004697   ⟸   ENSCLAT00000004783
RefSeq Acc Id: ENSCLAP00000004698   ⟸   ENSCLAT00000004784


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000003340 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000004783 ENTREZGENE
  ENSCLAT00000004783.1 UniProtKB/TrEMBL
  ENSCLAT00000004784.1 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/TrEMBL
InterPro Fibroblast_GF_fam UniProtKB/TrEMBL
  IL1/FGF UniProtKB/TrEMBL
NCBI Gene Fgf2 ENTREZGENE
PANTHER PTHR11486 UniProtKB/TrEMBL
  PTHR11486:SF83 UniProtKB/TrEMBL
Pfam FGF UniProtKB/TrEMBL
PRINTS HBGFFGF UniProtKB/TrEMBL
  IL1HBGF UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/TrEMBL
SMART FGF UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/TrEMBL
UniProt A0A8C2UTV0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2UWG1_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Fgf2  fibroblast growth factor 2    fibroblast growth factor 2 (basic)  Symbol and/or name change 5135510 APPROVED