RGD Reference Report - [A preliminary study on the changes of expression of PDGF-beta, PDGFR-beta, TGF-beta 1, TGFR, bFGF and its relationship with the wound age in wound healing] - Rat Genome Database

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[A preliminary study on the changes of expression of PDGF-beta, PDGFR-beta, TGF-beta 1, TGFR, bFGF and its relationship with the wound age in wound healing]

Authors: Wang, HJ  Ruan, HG  Huang, GZ 
Citation: Wang HJ, etal., Fa Yi Xue Za Zhi. 2001 Nov;17(4):198-201, 204.
RGD ID: 2292211
Pubmed: PMID:12533868   (View Abstract at PubMed)

OBJECTIVE: To explore the relationship between the expression change of cytokines and the wound age during the healing process of rats skin wound. METHODS: Immunohistochemical and image-analysis methods were performed on vital skin wounds(after incision 0.5-168 h am) and postmortem damage(after incision 0.5-6 h pm). RESULTS: The expression of the cytokines PDGF-beta, PDGFR-beta, TGF-beta 1, and bFGF in the epithelial cells was already enhanced since 0.5 h am after damage and their strongest expression reaction was seen at 24-96 h am. In addition, the expression of PDGF-beta, PDGFR-beta, TGF-beta 1 and bFGF was also found in the macrophages and the fibroblasts of the granulation tissue, and the expression changes in the postmortem damage group showed that the skin tissue within 0.5-3 h after incision showed immunohistochemical changes but weakly expression and 3 h thereafter no any change was found. CONCLUSION: The expression characteristics of the above mentioned cytokines in wound repair should be related to the wound age and it reminds therefore that they may be used as immunohistochemical criteria for accurate determining the wound age.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Wounds and Injuries  ISOFgf2 (Rattus norvegicus)2292211; 2292211protein:increased expression:skinRGD 
Wounds and Injuries  IEP 2292211; 2292211; 2292211; 2292211protein:increased expression:skinRGD 
Wounds and Injuries  ISOPdgfb (Rattus norvegicus)2292211; 2292211protein:increased expression:skinRGD 
Wounds and Injuries  ISOPdgfrb (Rattus norvegicus)2292211; 2292211protein:increased expression:skinRGD 
Wounds and Injuries  ISOTgfb1 (Rattus norvegicus)2292211; 2292211protein:increased expression:skinRGD 

Objects Annotated

Genes (Rattus norvegicus)
Fgf2  (fibroblast growth factor 2)
Pdgfb  (platelet derived growth factor subunit B)
Pdgfrb  (platelet derived growth factor receptor beta)
Tgfb1  (transforming growth factor, beta 1)

Genes (Mus musculus)
Fgf2  (fibroblast growth factor 2)
Pdgfb  (platelet derived growth factor, B polypeptide)
Pdgfrb  (platelet derived growth factor receptor, beta polypeptide)
Tgfb1  (transforming growth factor, beta 1)

Genes (Homo sapiens)
FGF2  (fibroblast growth factor 2)
PDGFB  (platelet derived growth factor subunit B)
PDGFRB  (platelet derived growth factor receptor beta)
TGFB1  (transforming growth factor beta 1)


Additional Information