CERIUM OXIDE NANOPARTICLE RESPONSE PATHWAY (PW:0001439)

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Description

Nanoparticles (NP) are increasingly being used in a wide range of applications, including biomedical and environmental. The potential hazard they may present is the focus of current nanotoxicology research. Nanoparticles with unusual properties that may translate into beneficial medical applications are cerium oxide NP or nanoceria (NC). Cerium (Ce), a rare earth lanthanide, can cycle between the cerous (III) and the ceric (IV) oxidation states. While the physico-chemical properties of nanoceria

Pathway Diagram:

Ariadne Genomics Inc. cerium oxide ---| cancer cells cancer cells NC differentially expressed genes PC12 cells gene expression cerium oxide ---- Fgf2 cerium oxide ---- heparin heparin BaF32 cells cell proliferation Fgf2 ---- Fgfr1 Fgfr1 Fgf2 cerium oxide cerium oxide --+> cell proliferation cerium oxide ---> NC differentially expressed genes cerium oxide ---> ROS modulation Ce(IV) oxide ---> hydrogen peroxide Ce(III) oxide ---> superoxide radical Ce(III) oxide Ce(IV) oxide hydrogen peroxide Diabetes Mellitus Macular Degeneration superoxide radical ROS generation senescence ROS modulation cerium oxide ---| Diabetes Mellitus cerium oxide ---| senescence cytotoxicity dopamine biosynthetic pathway ROS catabolism cerium oxide ---| Macular Degeneration cerium oxide --+> ROS catabolism cerium oxide --+> dopamine biosynthetic pathway cerium oxide ---> cytotoxicity cerium oxide ---| ROS generation cerium oxide ---> gene expression
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cerium oxide nanoparticle response pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:7364779
G Fgfr1 Fibroblast growth factor receptor 1 JBrowse link 16 71,265,390 71,319,046 RGD:7364779

Pathway Gene Annotations

Disease Annotations Associated with Genes in the cerium oxide nanoparticle response pathway
Disease TermsGene Symbols
AcrocephalosyndactyliaFgfr1
Alzheimer DiseaseFgfr1
ANTLEY-BIXLER SYNDROME WITHOUT GENITAL ANOMALIES OR DISORDERED STEROIDOGENESISFgfr1
Arteriovenous FistulaFgf2
Arthritis, ExperimentalFgfr1
AstrocytomaFgfr1
Biliary Tract DiseasesFgf2
Bone DiseasesFgf2
Brain InfarctionFgf2
Brain InjuriesFgf2
Breast NeoplasmsFgf2 , Fgfr1
BurnsFgfr1
Carcinoma, Non-Small-Cell LungFgfr1
Carcinoma, Pancreatic DuctalFgf2
Carcinoma, Renal CellFgf2 , Fgfr1
Carcinoma, Squamous CellFgfr1
Carcinoma, Transitional CellFgf2
CardiomegalyFgf2
CataractFgf2
CholangiocarcinomaFgf2
Cholesteatoma, Middle EarFgf2
Choroidal NeovascularizationFgf2
Cleft LipFgf2 , Fgfr1
Cleft PalateFgf2 , Fgfr1
Cocaine-Related DisordersFgf2
Corneal NeovascularizationFgf2
Coronary Artery DiseaseFgf2
Coronary DiseaseFgf2
Craniofacial AbnormalitiesFgfr1
CraniosynostosesFgfr1
Dementia, VascularFgfr1
Demyelinating DiseasesFgf2 , Fgfr1
Depressive DisorderFgf2 , Fgfr1
DermatitisFgf2
Diabetes Mellitus, ExperimentalFgf2
Diabetes Mellitus, Type 2Fgf2 , Fgfr1
Diabetes, GestationalFgf2
Diabetic NephropathiesFgf2
Diabetic NeuropathiesFgf2
Diabetic RetinopathyFgf2
Disease ProgressionFgf2
Encephalocraniocutaneous LipomatosisFgfr1
Encephalomyelitis, Autoimmune, ExperimentalFgf2
Endometrial NeoplasmsFgf2
Epilepsy, Tonic-ClonicFgf2
Erectile DysfunctionFgf2
Eye InjuriesFgf2
Eye Injuries, PenetratingFgf2
Femoral FracturesFgf2 , Fgfr1
Foot Deformities, CongenitalFgfr1
Fractures, BoneFgf2
Gallbladder NeoplasmsFgf2
GliomaFgf2 , Fgfr1
GliosisFgf2
Head Injuries, PenetratingFgfr1
Hernia, DiaphragmaticFgf2
Hernia, UmbilicalFgfr1
HoloprosencephalyFgfr1
Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip/PalateFgfr1
HypercholesterolemiaFgf2
Hyperoxic Lung InjuryFgf2
Hypersensitivity, DelayedFgf2
HypertensionFgf2
Hypertension, PulmonaryFgf2 , Fgfr1
Hypoglossal Nerve InjuriesFgf2 , Fgfr1
HypogonadismFgfr1
Hypogonadotropic Hypogonadism and Anosmia, Autosomal DominantFgfr1
Idiopathic Hypogonadotropic HypogonadismFgfr1
InflammationFgf2
Invasive Pulmonary AspergillosisFgf2
Ischemic Attack, TransientFgfr1
Jackson-Weiss SyndromeFgfr1
Kallmann SyndromeFgfr1
Kaposiform HemangioendotheliomaFgf2
Kidney DiseasesFgf2
LeiomyomaFgf2
Leukemia, ExperimentalFgfr1
Leukemia, MyeloidFgfr1
Leukemia, Myeloid, AcuteFgfr1
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL NegativeFgfr1
Limb IschemiaFgfr1
Liver CirrhosisFgf2
Liver Cirrhosis, ExperimentalFgf2
Long QT SyndromeFgf2
Lung NeoplasmsFgfr1
Lymphoma, T-CellFgfr1
Macular EdemaFgf2
Mammary Neoplasms, AnimalFgf2
Mesangial Proliferative GlomerulonephritisFgfr1
MesotheliomaFgf2
Mouth DiseasesFgfr1
Multiple Endocrine Neoplasia Type 1Fgf2
Myeloproliferative DisordersFgfr1
Myocardial InfarctionFgfr1
Myocardial IschemiaFgf2
Nasal PolypsFgf2
NecrosisFgf2
NeointimaFgf2 , Fgfr1
Nephrotic SyndromeFgf2
Nerve DegenerationFgf2
Neurocognitive DisordersFgf2
Neuroma, AcousticFgfr1
ObesityFgfr1
Optic Nerve InjuriesFgf2
Oral Submucous FibrosisFgf2
OsteoarthritisFgfr1
Osteoarthritis, ExperimentalFgfr1
Osteoglophonic DwarfismFgfr1
Ovarian NeoplasmsFgf2
Pancreatic NeoplasmsFgf2
Periapical PeriodontitisFgf2
Pfeiffer Type AcrocephalosyndactylyFgfr1
Polyarteritis NodosaFgf2
Pregnancy in DiabeticsFgf2
Prenatal Exposure Delayed EffectsFgf2
Pressure UlcerFgf2
Prostatic NeoplasmsFgf2
PterygiumFgf2
Puberty, DelayedFgfr1
Pulmonary FibrosisFgf2
Reperfusion InjuryFgf2
Retina Reperfusion InjuryFgf2
Retinal DetachmentFgfr1
Retinal Vein OcclusionFgf2
SchizophreniaFgfr1
Sciatic NeuropathyFgfr1
SeizuresFgf2 , Fgfr1
Skin UlcerFgf2
Small Cell Lung CarcinomaFgfr1
Spinal Cord CompressionFgf2
Stargardt Disease 3Fgfr1
Stomach UlcerFgf2
Thrombocythemia, EssentialFgf2
Trigonocephaly 1Fgfr1
Trigonocephaly 2Fgfr1
Trigonocephaly, NonsyndromicFgfr1
Tympanic Membrane PerforationFgf2 , Fgfr1
UlcerFgf2
Urinary Bladder DiseasesFgf2
Urinary Bladder NeoplasmsFgf2
Vitreoretinopathy, ProliferativeFgf2
Wound InfectionFgf2
Wounds and InjuriesFgf2
Pathway Annotations Associated with Genes in the cerium oxide nanoparticle response pathway

References Associated with the cerium oxide nanoparticle response pathway:

Ontology Path Diagram:

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