Camk2a (calcium/calmodulin-dependent protein kinase II alpha) - Rat Genome Database

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Gene: Camk2a (calcium/calmodulin-dependent protein kinase II alpha) Rattus norvegicus
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Symbol: Camk2a
Name: calcium/calmodulin-dependent protein kinase II alpha
RGD ID: 2261
Description: Enables GTPase activating protein binding activity and calcium/calmodulin-dependent protein kinase activity. Involved in ionotropic glutamate receptor signaling pathway; neurotransmitter receptor transport to plasma membrane; and regulation of protein localization to membrane. Located in axon; dendrite cytoplasm; and neuronal cell body. Is active in several cellular components, including postsynaptic cytosol; postsynaptic density; and presynaptic cytosol. Biomarker of middle cerebral artery infarction and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 53 and autosomal recessive intellectual developmental disorder 63. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; fibroblast growth factor signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha CaM kinase II; Ca2+/calmodulin-dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase II alpha subunit; calcium/calmodulin-dependent protein kinase II, alpha; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase type II subunit alpha; caM kinase II subunit alpha; caM-kinase II alpha chain; caMK-II subunit alpha; PK2CDD; PKCCD
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81856,648,779 - 56,711,505 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1856,649,025 - 56,711,504 (+)EnsemblGRCr8
mRatBN7.21854,378,642 - 54,441,120 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,378,784 - 54,438,994 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1856,467,554 - 56,526,074 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,182,163 - 57,240,684 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,002,670 - 55,061,881 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,193,978 - 56,295,869 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,193,978 - 56,295,869 (+)Ensemblrn6Rnor6.0
Rnor_5.01855,514,559 - 55,529,045 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01855,428,487 - 55,463,016 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41856,879,247 - 56,948,537 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1852,533,226 - 52,592,130 (+)NCBICelera
RGSC_v3.11856,951,478 - 57,020,769 (+)NCBI
Cytogenetic Map18q12.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (ISO)
(S)-nicotine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7-chlorokynurenic acid  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alcohol  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azamethiphos  (EXP)
Bay-K-8644  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
calciol  (EXP)
calcium carbonate  (EXP)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (EXP)
chlorpyrifos  (EXP,ISO)
cisplatin  (EXP)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (EXP)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (ISO)
decabromodiphenyl ether  (EXP,ISO)
diarsenic trioxide  (ISO)
dieldrin  (EXP)
diethyl malate  (ISO)
diethylstilbestrol  (ISO)
dizocilpine maleate  (EXP)
dopamine  (EXP)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
flurotyl  (EXP)
FPL 64176  (EXP)
Glutathione ethyl ester  (ISO)
glyphosate  (ISO)
haloperidol  (EXP)
heptachlor  (EXP)
ibuprofen  (EXP)
ionomycin  (EXP)
ivermectin  (ISO)
kainic acid  (ISO)
KN-93  (EXP,ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
lipoic acid  (ISO)
losartan  (ISO)
malathion  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
melatonin  (EXP)
memantine  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
microcystin-LR  (ISO)
Moniliformin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (EXP)
morphine  (ISO)
N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol  (EXP)
N-nitrosodiethylamine  (ISO)
nicardipine  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
nifedipine  (EXP,ISO)
ochratoxin A  (EXP)
olanzapine  (EXP)
paclitaxel  (EXP)
paracetamol  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phencyclidine  (ISO)
phenylephrine  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
quercetin  (EXP,ISO)
resveratrol  (ISO)
risperidone  (EXP)
rotenone  (ISO)
S-allylcysteine  (ISO)
sarin  (EXP)
SCH 23390  (EXP)
silicon dioxide  (EXP)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium benzoate  (EXP)
sodium fluoride  (ISO)
streptozocin  (EXP,ISO)
sulfur dioxide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (EXP)
trifluoperazine  (EXP)
tris(2-chloroethyl) phosphate  (EXP)
U-73122  (EXP)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
verapamil  (EXP)
vinclozolin  (EXP)
VX nerve agent  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiotensin-activated signaling pathway  (IEA,ISO)
calcium ion transport  (ISO,ISS)
cellular response to interferon-beta  (IEA,ISO,ISS)
cellular response to type II interferon  (IEA,ISO)
dendrite morphogenesis  (ISO)
dendritic spine development  (IEA,ISO,ISS)
G1/S transition of mitotic cell cycle  (ISO,ISS)
ionotropic glutamate receptor signaling pathway  (IDA)
negative regulation of ferroptosis  (ISO,ISS)
negative regulation of hydrolase activity  (ISO)
neurotransmitter receptor transport to plasma membrane  (IMP)
peptidyl-serine phosphorylation  (IDA,ISO)
peptidyl-threonine autophosphorylation  (ISO)
positive regulation of calcium ion transport  (ISO,ISS)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO,ISS)
positive regulation of receptor signaling pathway via JAK-STAT  (IEA,ISO,ISS)
protein autophosphorylation  (IDA,ISO)
protein phosphorylation  (IDA)
regulation of endocannabinoid signaling pathway  (ISO,ISS)
regulation of mitochondrial membrane permeability involved in apoptotic process  (ISO,ISS)
regulation of neuron migration  (IEA,ISO,ISS)
regulation of neuronal synaptic plasticity  (IBA,ISO,ISS)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (IDA,IMP)
regulation of neurotransmitter secretion  (ISO,ISS)
regulation of protein localization to plasma membrane  (IBA,IEA,IGI)
regulation of synaptic vesicle docking  (ISO)
response to ischemia  (ISO,ISS)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. Ashpole NM, etal., J Biol Chem. 2012 Jun 8;287(24):19856-69. doi: 10.1074/jbc.M111.322537. Epub 2012 Apr 18.
2. Autophosphorylated CaMKIIalpha acts as a scaffold to recruit proteasomes to dendritic spines. Bingol B, etal., Cell. 2010 Feb 19;140(4):567-78. doi: 10.1016/j.cell.2010.01.024.
3. Localization of CaMKIIalpha in rat primary sensory neurons: increase in inflammation. Carlton SM Brain Res. 2002 Aug 30;947(2):252-9.
4. Mechanisms for regulation of calmodulin kinase IIalpha by Ca(2+)/calmodulin and autophosphorylation of threonine 286. Chin D and Means AR, Biochemistry 2002 Nov 26;41(47):14001-9.
5. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Cho KO, etal., Neuron 1992 Nov;9(5):929-42.
6. CaMKII regulation in information processing and storage. Coultrap SJ and Bayer KU, Trends Neurosci. 2012 Oct;35(10):607-18. doi: 10.1016/j.tins.2012.05.003. Epub 2012 Jun 19.
7. Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. De Felice FG, etal., Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1971-6. doi: 10.1073/pnas.0809158106. Epub 2009 Feb 2.
8. Loss of control over the ethanol consumption: differential transcriptional regulation in prefrontal cortex. de Paiva Lima C, etal., J Neurogenet. 2017 Sep;31(3):170-177. doi: 10.1080/01677063.2017.1349121. Epub 2017 Jul 17.
9. The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. Dhavan R, etal., J Neurosci. 2002 Sep 15;22(18):7879-91.
10. Surface dynamics of GluN2B-NMDA receptors controls plasticity of maturing glutamate synapses. Dupuis JP, etal., EMBO J. 2014 Apr 16;33(8):842-61. doi: 10.1002/embj.201386356. Epub 2014 Mar 3.
11. PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity. Esteban JA, etal., Nat Neurosci. 2003 Feb;6(2):136-43.
12. CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction. Gardoni F, etal., J Biol Chem 2003 Nov 7;278(45):44745-52. Epub 2003 Aug 21.
13. Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex. Gardoni F, etal., J Biol Chem. 2001 Mar 9;276(10):7609-13. Epub 2000 Dec 4.
14. Hippocampal synaptic plasticity involves competition between Ca2+/calmodulin-dependent protein kinase II and postsynaptic density 95 for binding to the NR2A subunit of the NMDA receptor. Gardoni F, etal., J Neurosci. 2001 Mar 1;21(5):1501-9.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. CaMKIIalpha interacts with M4 muscarinic receptors to control receptor and psychomotor function. Guo ML, etal., EMBO J. 2010 Jun 16;29(12):2070-81. doi: 10.1038/emboj.2010.93. Epub 2010 May 11.
17. Calcium/calmodulin-dependent protein kinase II-delta isoform regulation of vascular smooth muscle cell proliferation. House SJ, etal., Am J Physiol Cell Physiol. 2007 Jun;292(6):C2276-87. Epub 2007 Jan 31.
18. Circulating MicroRNAs in Extracellular Vesicles as Potential Biomarkers of Alcohol-Induced Neuroinflammation in Adolescence: Gender Differences. Ibáñez F, etal., Int J Mol Sci. 2020 Sep 14;21(18):6730. doi: 10.3390/ijms21186730.
19. Modulation of CaV2.1 channels by Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain. Jiang X, etal., Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):341-6. Epub 2007 Dec 27.
20. Secondary hyperalgesia in the postoperative pain model is dependent on spinal calcium/calmodulin-dependent protein kinase II alpha activation. Jones TL, etal., Anesth Analg. 2007 Dec;105(6):1650-6, table of contents.
21. Mechanisms of CaMKII action in long-term potentiation. Lisman J, etal., Nat Rev Neurosci. 2012 Feb 15;13(3):169-82. doi: 10.1038/nrn3192.
22. Synaptic targeting of AMPA receptors is regulated by a CaMKII site in the first intracellular loop of GluA1. Lu W, etal., Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22266-71. doi: 10.1073/pnas.1016289107. Epub 2010 Dec 6.
23. Protein kinase C-gamma and calcium/calmodulin-dependent protein kinase II-alpha are persistently translocated to cell membranes of the rat brain during and after middle cerebral artery occlusion. Matsumoto S, etal., J Cereb Blood Flow Metab 2004 Jan;24(1):54-61.
24. Autophosphorylated calcium/calmodulin-dependent protein kinase II alpha induced by cerebral ischemia immediately targets and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in hippocampus of rats. Meng F and Zhang G, Neurosci Lett 2002 Nov 15;333(1):59-63.
25. Phosphorylation state, solubility, and activity of calcium/calmodulin-dependent protein kinase II alpha in transient focal ischemia in mouse brain. Mengesdorf T, etal., Neurochem Res. 2002 Jun;27(6):477-84.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma. Nair JS, etal., Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):5971-6. doi: 10.1073/pnas.052159099. Epub 2002 Apr 23.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat. Obaid AA, etal., J Trace Elem Med Biol. 2023 May 24;79:127221. doi: 10.1016/j.jtemb.2023.127221.
30. Specific distribution of Ca2+/calmodulin-dependent protein kinase II alpha and beta isoforms in some structures of the rat forebrain. Ochiishi T, etal., Brain Res. 1994 Oct 3;659(1-2):179-93.
31. CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin. Opazo P, etal., Neuron. 2010 Jul 29;67(2):239-52. doi: 10.1016/j.neuron.2010.06.007.
32. Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP. Petrini EM, etal., Nat Commun. 2014 Jun 4;5:3921. doi: 10.1038/ncomms4921.
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
35. Pharmacological interactions between calcium/calmodulin-dependent kinase II alpha and TRPV1 receptors in rat trigeminal sensory neurons. Price TJ, etal., Neurosci Lett. 2005 Dec 2;389(2):94-8.
36. GOA pipeline RGD automated data pipeline
37. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2. Robison AJ, etal., J Biol Chem. 2005 Oct 21;280(42):35329-36. Epub 2005 Aug 24.
40. Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation. Shen K and Meyer T, Science. 1999 Apr 2;284(5411):162-6.
41. Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats. Song B, etal., Neurosci Lett. 2003 Oct 9;349(3):183-6.
42. Structure and composition of the postsynaptic density during development. Swulius MT, etal., J Comp Neurol. 2010 Oct 15;518(20):4243-60. doi: 10.1002/cne.22451.
43. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
44. Changes in the distribution of calcium calmodulin-dependent protein kinase II at the presynaptic bouton after depolarization. Tao-Cheng JH, etal., Brain Cell Biol. 2006 Jun;35(2-3):117-24. doi: 10.1007/s11068-007-9012-5. Epub 2007 Sep 20.
45. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
46. Trichostatin A protects against cisplatin-induced ototoxicity by regulating expression of genes related to apoptosis and synaptic function. Wang P, etal., Neurotoxicology. 2013 Jul;37:51-62. doi: 10.1016/j.neuro.2013.03.007. Epub 2013 Apr 1.
47. The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology. Wang YJ, etal., Brain Res. 2005 Jan 7;1031(1):101-8. doi: 10.1016/j.brainres.2004.10.061.
48. Developmentally regulated expression of CaMKII and iGluRs in the rat retina. Xue J, etal., Brain Res Dev Brain Res 2002 Sep 20;138(1):61-70.
49. [Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions] Yamamoto H Tanpakushitsu Kakusan Koso 2002 Mar;47(3):241-7.
50. Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit. Yong XLH, etal., Cell Rep. 2021 Jul 6;36(1):109338. doi: 10.1016/j.celrep.2021.109338.
51. A 63 signature genes prediction system is effective for glioblastoma prognosis. Zhang Y, etal., Int J Mol Med. 2018 Apr;41(4):2070-2078. doi: 10.3892/ijmm.2018.3422. Epub 2018 Jan 25.
52. Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Zhu JJ, etal., Cell. 2002 Aug 23;110(4):443-55.
Additional References at PubMed
PMID:1328883   PMID:2153289   PMID:2842767   PMID:2856087   PMID:3037704   PMID:3475713   PMID:8280084   PMID:8598227   PMID:10347170   PMID:11036263   PMID:11160423   PMID:11264466  
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PMID:15044062   PMID:15292517   PMID:15312654   PMID:15375008   PMID:15383398   PMID:15494036   PMID:15574738   PMID:15607978   PMID:15649892   PMID:15659234   PMID:15664178   PMID:15673434  
PMID:15714506   PMID:15775983   PMID:15964981   PMID:15994560   PMID:16214364   PMID:16277604   PMID:16436603   PMID:16501029   PMID:16627565   PMID:16632208   PMID:16648177   PMID:16709720  
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PMID:25644714   PMID:25682687   PMID:25701274   PMID:25944900   PMID:26086939   PMID:26110816   PMID:26174594   PMID:26291163   PMID:26742808   PMID:26779588   PMID:26809094   PMID:26821292  
PMID:27477489   PMID:27611779   PMID:28130356   PMID:28230177   PMID:28236215   PMID:28536695   PMID:28553222   PMID:28573136   PMID:28638088   PMID:28717010   PMID:28730575   PMID:28754591  
PMID:28865231   PMID:28940879   PMID:28957669   PMID:29100089   PMID:29184507   PMID:29273596   PMID:29279520   PMID:29476059   PMID:29604406   PMID:29806529   PMID:30053369   PMID:30142538  
PMID:30177751   PMID:30299584   PMID:30520144   PMID:30526621   PMID:30919283   PMID:31100477   PMID:31874853   PMID:31935048   PMID:32005763   PMID:32238193   PMID:32303334   PMID:32357304  
PMID:32716967   PMID:32841609   PMID:32920522   PMID:33393454   PMID:34775982   PMID:36424866   PMID:38199412  


Genomics

Comparative Map Data
Camk2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81856,648,779 - 56,711,505 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1856,649,025 - 56,711,504 (+)EnsemblGRCr8
mRatBN7.21854,378,642 - 54,441,120 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,378,784 - 54,438,994 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1856,467,554 - 56,526,074 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,182,163 - 57,240,684 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,002,670 - 55,061,881 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,193,978 - 56,295,869 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,193,978 - 56,295,869 (+)Ensemblrn6Rnor6.0
Rnor_5.01855,514,559 - 55,529,045 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01855,428,487 - 55,463,016 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41856,879,247 - 56,948,537 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1852,533,226 - 52,592,130 (+)NCBICelera
RGSC_v3.11856,951,478 - 57,020,769 (+)NCBI
Cytogenetic Map18q12.1NCBI
CAMK2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385150,219,491 - 150,290,130 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5150,219,491 - 150,290,093 (-)Ensemblhg38GRCh38
GRCh375149,599,054 - 149,669,693 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365149,579,248 - 149,649,529 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345149,579,247 - 149,649,529NCBI
Celera5145,680,447 - 145,750,799 (-)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5144,747,170 - 144,817,356 (-)NCBIHuRef
CHM1_15149,031,647 - 149,101,993 (-)NCBICHM1_1
T2T-CHM13v2.05150,756,093 - 150,826,669 (-)NCBIT2T-CHM13v2.0
Camk2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,058,704 - 61,121,224 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,058,690 - 61,121,224 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381860,925,307 - 60,988,152 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1860,925,618 - 60,988,152 (+)Ensemblmm10GRCm38
MGSCv371861,085,286 - 61,147,806 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361861,051,001 - 61,113,513 (+)NCBIMGSCv36mm8
Celera1862,212,530 - 62,274,768 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.41NCBI
Camk2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554154,247,014 - 4,307,458 (+)Ensembl
ChiLan1.0NW_0049554154,247,307 - 4,307,402 (+)NCBIChiLan1.0ChiLan1.0
CAMK2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24145,448,477 - 145,518,496 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15143,588,026 - 143,658,043 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05145,644,164 - 145,714,143 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15151,649,062 - 151,719,373 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5151,649,062 - 151,719,373 (-)EnsemblpanPan2panpan1.1
CAMK2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,800,818 - 58,865,830 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,800,813 - 58,865,830 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha458,567,052 - 58,631,982 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0459,281,664 - 59,346,612 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl459,281,703 - 59,346,615 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1459,070,398 - 59,135,346 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,184,686 - 59,249,804 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,715,947 - 59,780,872 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Camk2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213143,064,159 - 143,126,577 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365044,638,176 - 4,700,984 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365044,636,863 - 4,700,887 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAMK2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2151,248,358 - 151,308,706 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12151,248,356 - 151,353,907 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22158,335,771 - 158,396,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CAMK2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12352,829,438 - 52,899,428 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2352,829,350 - 52,899,375 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603424,817,181 - 24,887,318 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Camk2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247749,526,323 - 9,585,649 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247749,526,323 - 9,585,647 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Camk2a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11570,959,958 - 71,023,712 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Camk2a
544 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:179
Count of miRNA genes:118
Interacting mature miRNAs:133
Transcripts:ENSRNOT00000041533
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184891705460064728Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185384517561982387Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184918722662647720Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185449080168120379Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
1331806Bp229Blood pressure QTL 2294.36484arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat

Markers in Region
D18Got54  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21854,401,652 - 54,401,849 (+)MAPPERmRatBN7.2
Rnor_6.01856,216,839 - 56,217,035NCBIRnor6.0
Rnor_5.01855,451,263 - 55,451,459UniSTSRnor5.0
Celera1852,556,111 - 52,556,307UniSTS
RH 3.4 Map18530.2RGD
RH 3.4 Map18530.2UniSTS
RH 2.0 Map18383.9RGD
Cytogenetic Map18q11UniSTS
RH143135  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21854,424,382 - 54,424,523 (+)MAPPERmRatBN7.2
Rnor_6.01856,282,221 - 56,282,361NCBIRnor6.0
Rnor_5.01855,515,397 - 55,515,537UniSTSRnor5.0
RGSC_v3.41856,934,889 - 56,935,029UniSTSRGSC3.4
Celera1852,578,482 - 52,578,622UniSTS
Cytogenetic Map18q11UniSTS
BF399379  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21854,403,634 - 54,403,764 (+)MAPPERmRatBN7.2
Rnor_6.01856,218,821 - 56,218,950NCBIRnor6.0
Rnor_5.01855,453,245 - 55,453,374UniSTSRnor5.0
Celera1852,558,093 - 52,558,222UniSTS
RH 3.4 Map18534.5UniSTS
Cytogenetic Map18q11UniSTS
RH137986  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21854,424,283 - 54,424,453 (+)MAPPERmRatBN7.2
Rnor_6.01856,282,122 - 56,282,291NCBIRnor6.0
Rnor_5.01855,515,298 - 55,515,467UniSTSRnor5.0
RGSC_v3.41856,934,790 - 56,934,959UniSTSRGSC3.4
Celera1852,578,383 - 52,578,552UniSTS
RH 3.4 Map18530.3UniSTS
Cytogenetic Map18q11UniSTS
RH138447  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21854,424,381 - 54,424,523 (+)MAPPERmRatBN7.2
Rnor_6.01856,282,220 - 56,282,361NCBIRnor6.0
Rnor_5.01855,515,396 - 55,515,537UniSTSRnor5.0
RGSC_v3.41856,934,888 - 56,935,029UniSTSRGSC3.4
Celera1852,578,481 - 52,578,622UniSTS
RH 3.4 Map18530.3UniSTS
Cytogenetic Map18q11UniSTS
BE119266  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21854,423,405 - 54,423,556 (+)MAPPERmRatBN7.2
Rnor_6.01856,281,244 - 56,281,394NCBIRnor6.0
Rnor_5.01855,514,420 - 55,514,570UniSTSRnor5.0
RGSC_v3.41856,933,193 - 56,933,343UniSTSRGSC3.4
Celera1852,577,505 - 52,577,655UniSTS
RH 3.4 Map18530.1UniSTS
Cytogenetic Map18q11UniSTS
UniSTS:225275  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81856,710,887 - 56,711,041 (+)Marker Load Pipeline
mRatBN7.21854,440,499 - 54,440,654 (+)MAPPERmRatBN7.2
Rnor_6.01856,298,335 - 56,298,489NCBIRnor6.0
Rnor_5.01855,531,511 - 55,531,665UniSTSRnor5.0
RGSC_v3.41856,951,003 - 56,951,157UniSTSRGSC3.4
Celera1852,594,596 - 52,594,750UniSTS
Cytogenetic Map18q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 12 67 155 88 88 57 90 57 6 337 189 11 133 69 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000041533   ⟹   ENSRNOP00000041940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1856,649,074 - 56,685,375 (+)Ensembl
mRatBN7.2 Ensembl1854,378,784 - 54,438,030 (+)Ensembl
Rnor_6.0 Ensembl1856,193,978 - 56,295,869 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080177   ⟹   ENSRNOP00000069249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1856,649,025 - 56,708,146 (+)Ensembl
mRatBN7.2 Ensembl1854,378,784 - 54,437,755 (+)Ensembl
Rnor_6.0 Ensembl1856,194,019 - 56,295,594 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098023   ⟹   ENSRNOP00000094280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1856,649,025 - 56,708,146 (+)Ensembl
mRatBN7.2 Ensembl1854,378,784 - 54,437,755 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101374   ⟹   ENSRNOP00000093893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1856,649,074 - 56,711,504 (+)Ensembl
mRatBN7.2 Ensembl1854,378,784 - 54,438,994 (+)Ensembl
RefSeq Acc Id: NM_012920   ⟹   NP_037052
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,649,180 - 56,708,421 (+)NCBI
mRatBN7.21854,378,784 - 54,438,030 (+)NCBI
Rnor_6.01856,193,978 - 56,295,869 (+)NCBI
Rnor_5.01855,428,487 - 55,463,016 (+)NCBI
Rnor_5.01855,514,559 - 55,529,045 (+)NCBI
RGSC_v3.41856,879,247 - 56,948,537 (+)RGD
Celera1852,533,226 - 52,592,130 (+)RGD
Sequence:
RefSeq Acc Id: XM_039096592   ⟹   XP_038952520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,648,779 - 56,711,505 (+)NCBI
mRatBN7.21854,378,642 - 54,441,120 (+)NCBI
RefSeq Acc Id: XM_039096593   ⟹   XP_038952521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,649,036 - 56,708,146 (+)NCBI
mRatBN7.21854,378,642 - 54,437,755 (+)NCBI
RefSeq Acc Id: NP_037052   ⟸   NM_012920
- UniProtKB: P11275 (UniProtKB/Swiss-Prot),   A6IXE8 (UniProtKB/TrEMBL),   A0A8I6AHE3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069249   ⟸   ENSRNOT00000080177
Ensembl Acc Id: ENSRNOP00000041940   ⟸   ENSRNOT00000041533
RefSeq Acc Id: XP_038952520   ⟸   XM_039096592
- Peptide Label: isoform X1
- UniProtKB: F1LZG4 (UniProtKB/TrEMBL),   A0A0G2JUV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952521   ⟸   XM_039096593
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AHE3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094280   ⟸   ENSRNOT00000098023
Ensembl Acc Id: ENSRNOP00000093893   ⟸   ENSRNOT00000101374
Protein Domains
Calcium/calmodulin-dependent protein kinase II   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11275-F1-model_v2 AlphaFold P11275 1-478 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2261 AgrOrtholog
BioCyc Gene G2FUF-7351 BioCyc
Ensembl Genes ENSRNOG00000018712 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000080177 ENTREZGENE
  ENSRNOT00000101374 ENTREZGENE
Gene3D-CATH 3.10.450.50 UniProtKB/Swiss-Prot
  6.10.140.620 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Ca/CaM-dep_prot_kinase-assoc UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  NTF2-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:25400 UniProtKB/Swiss-Prot
NCBI Gene 25400 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam CaMKII_AD UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Camk2a PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018712 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54427 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
TIGR TC228753
UniProt A0A0G2JUV8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AHE3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AKH1_RAT UniProtKB/TrEMBL
  A6IXE8 ENTREZGENE, UniProtKB/TrEMBL
  A6IXE9_RAT UniProtKB/TrEMBL
  A6IXF0_RAT UniProtKB/TrEMBL
  A6IXF1_RAT UniProtKB/TrEMBL
  F1LZG4 ENTREZGENE, UniProtKB/TrEMBL
  KCC2A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q924T0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-11 Camk2a  calcium/calmodulin-dependent protein kinase II alpha  Camk2a  calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-24 Camk2a  calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha  Camk2a  calcium/calmodulin-dependent protein kinase II, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Camk2a  calcium/calmodulin-dependent protein kinase II, alpha    calcium/calmodulin-dependent protein kinase II alpha subunit  Name updated 1299863 APPROVED
2002-11-06 Camk2a  calcium/calmodulin-dependent protein kinase II alpha subunit    Ca2+/calmodulin-dependent protein kinase II alpha  Name updated 625702 APPROVED
2002-06-10 Camk2a  Ca2+/calmodulin-dependent protein kinase II alpha      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression in hippocampal cells strongly induced upon ischemic insult 634689
gene_expression expressed at high levels in neurons 1299829
gene_function kinase subunit 634689
gene_function phosphorylates N-methyl-D-aspartate receptor subunit 2B on serine 634689
gene_function autophosphorylates on threonine (T286) 1299829
gene_physical_interaction binds to and is activated by calcium/calmodulin 1299829
gene_process may play a role in the development of the retina 634688
gene_process may regulate channel properties of N-methyl-D-aspartate receptor subunit 2B during ischemia via phosphorylation 634689
gene_process transduces cellular signals corresponding to fluctuations in intracellular calcium levels in conjuction with calmodulin 1299829
gene_process important in learning and memory 1299829
gene_regulation activity is regulated by calcium/calmodulin binding and autophosphorylation 1299829