Tgfb2 (transforming growth factor, beta 2) - Rat Genome Database

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Gene: Tgfb2 (transforming growth factor, beta 2) Rattus norvegicus
Analyze
Symbol: Tgfb2
Name: transforming growth factor, beta 2
RGD ID: 70491
Description: Enables identical protein binding activity. Involved in several processes, including negative regulation of release of sequestered calcium ion into cytosol; regulation of apoptotic process; and skeletal system morphogenesis. Located in several cellular components, including cell surface; secretory granule; and trans-Golgi network. Biomarker of diabetic neuropathy; myocardial infarction; and osteochondrodysplasia. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 4; colorectal cancer; and pancreatic adenosquamous carcinoma. Orthologous to human TGFB2 (transforming growth factor beta 2); PARTICIPATES IN glypican signaling pathway; Hedgehog signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH (R)-lipoic acid; (R)-noradrenaline; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: TGF beta 2 protein; TGF-B2; TGF-beta-2; transforming growth factor beta-2; transforming growth factor beta-2 proprotein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813100,691,540 - 100,793,227 (-)NCBIGRCr8
mRatBN7.21398,160,075 - 98,261,771 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1398,160,087 - 98,261,405 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13100,678,931 - 100,778,632 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013102,066,560 - 102,165,910 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01399,261,239 - 99,360,947 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013105,039,639 - 105,142,010 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13105,039,853 - 105,141,030 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013109,679,866 - 109,792,609 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413102,718,703 - 102,818,768 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113102,907,748 - 103,007,811 (-)NCBI
Celera1397,669,691 - 97,769,426 (-)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Tgfb2RatAberrant Crypt Foci treatmentIEP 13432080 RGD 
Tgfb2Ratcolon carcinoma  ISOTgfb2 (Mus musculus)13432084 RGD 
Tgfb2Ratcolon carcinoma disease_progressionISOTGFB2 (Homo sapiens)13432074 RGD 
Tgfb2Ratcolorectal cancer disease_progressionISOTGFB2 (Homo sapiens)13432086 RGD 
Tgfb2Ratcolorectal cancer treatmentISOTGFB2 (Homo sapiens)13432081 RGD 
Tgfb2RatColorectal Neoplasms  ISOTGFB2 (Homo sapiens)13432077associated with Inflammatory Bowel Diseases and DNA:hypermethylationRGD 
Tgfb2Ratdiabetic neuropathy  IEP 2302086associated with Diabetes Mellitus more ...RGD 
Tgfb2RatExperimental Autoimmune Encephalomyelitis  IEP 2302088mRNA and protein:decreased expression:central nervous systemRGD 
Tgfb2RatExperimental Diabetes Mellitus  IEP 2302087protein:increased expression:parotid glandRGD 
Tgfb2Ratliver cirrhosis  ISOTGFB2 (Homo sapiens)14985228 RGD 
Tgfb2Ratmyocardial infarction  IEP 2302107 RGD 
Tgfb2Ratosteochondrodysplasia  IEP 2302024 RGD 
Tgfb2Ratpancreatic adenosquamous carcinoma amelioratesISOTGFB2 (Homo sapiens)155630611human cells in a mouse modelRGD 
Tgfb2Ratpancreatic ductal adenocarcinoma amelioratesISOTGFB2 (Homo sapiens)155630628protein:decreased expression:pancreas (human)RGD 
Tgfb2RatSpinal Cord Injuries  IMP 2302103 RGD 
Tgfb2RatWallerian Degeneration  IEP 2302105protein:decreased expression:sciatic nerveRGD 
Tgfb2RatWounds and Injuries  IMP 2302090 RGD 
Tgfb2RatWounds and Injuries  IEP 2292158 RGD 
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Original Reference(s)
Tgfb2Rataortic aneurysm  ISOTGFB2 (Homo sapiens)8554872ClinVar Annotator: match by term: Aortic aneurysmClinVarPMID:22772371 more ...
Tgfb2Rataortic disease  ISOTGFB2 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial aortopathyClinVarPMID:22772368 more ...
Tgfb2Ratatrial heart septal defect 1  ISOTGFB2 (Homo sapiens)8554872ClinVar Annotator: match by term: Atrial septal defect 1ClinVar 
Tgfb2Ratconnective tissue disease  ISOTGFB2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 and PMID:28492532
Tgfb2RatEhlers-Danlos syndrome  ISOTGFB2 (Homo sapiens)8554872ClinVar Annotator: match by term: Ehlers-Danlos syndromeClinVarPMID:22772371 more ...
Tgfb2Ratgastrointestinal stromal tumor  ISOTGFB2 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Tgfb2Ratgenetic disease  ISOTGFB2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Tgfb2RatHirschsprung Disease 1  ISOTGFB2 (Homo sapiens)8554872ClinVar Annotator: match by term: Hirschsprung disease 1ClinVarPMID:25741868 more ...
Tgfb2RatHirschsprung's disease  ISOTGFB2 (Homo sapiens)8554872ClinVar Annotator: match by term: Hirschsprung disease more ...ClinVarPMID:25741868 more ...
Tgfb2RatHolt-Oram syndrome  ISOTGFB2 (Homo sapiens)8554872ClinVar Annotator: match by term: Holt-Oram syndromeClinVarPMID:24465802 more ...
Tgfb2RatLoeys-Dietz syndrome  ISOTGFB2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10611753 more ...
Tgfb2RatLoeys-Dietz syndrome  ISOTGFB2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10611753 more ...
Tgfb2RatLoeys-Dietz syndrome 4  ISOTGFB2 (Homo sapiens)8554872ClinVar Annotator: match by term: Loeys-Dietz syndrome 4ClinVarPMID:10611753 more ...
Tgfb2Ratlung adenocarcinoma  ISOTGFB2 (Homo sapiens)8554872ClinVar Annotator: match by term: Lung adenocarcinomaClinVarPMID:27993330
Tgfb2RatMartsolf Syndrome  ISOTGFB2 (Homo sapiens)8554872ClinVar Annotator: match by term: Martsolf syndromeClinVarPMID:23420520 and PMID:28492532
Tgfb2Ratmethylmalonic aciduria due to methylmalonyl-CoA mutase deficiency  ISOTGFB2 (Homo sapiens)8554872ClinVar Annotator: match by term: Methylmalonic aciduria and mut typeClinVarPMID:22772368 more ...
Tgfb2Ratparathyroid carcinoma  ISOTGFB2 (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Tgfb2Ratthoracic aortic aneurysm  ISOTGFB2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10611753 more ...
Tgfb2Ratthoracic aortic aneurysm  ISOTGFB2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10611753 more ...
Tgfb2Ratthoracic aortic aneurysm  ISOTGFB2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10611753 more ...
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Original Reference(s)
Tgfb2Rataortic valve insufficiency  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21216836
Tgfb2Ratautoimmune disease  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25055964
Tgfb2Ratbasal cell carcinoma  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:36428691
Tgfb2Ratbone development disease  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9217007
Tgfb2Ratcholangitis  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25055964
Tgfb2Ratcleft palate  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25450421
Tgfb2Ratcongenital heart disease  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9217007
Tgfb2RatCongenital Limb Deformities  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9217007
Tgfb2RatCraniofacial Abnormalities  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9217007
Tgfb2RatCyanosis  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9217007
Tgfb2Ratendometriosis  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20864642
Tgfb2RatEye Abnormalities  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9217007
Tgfb2Ratglaucoma  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20375339
Tgfb2Rathepatocellular carcinoma  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:33010264
Tgfb2RatLoeys-Dietz syndrome  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22772368
Tgfb2Ratmalignant mesothelioma  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25756049
Tgfb2RatMusculoskeletal Abnormalities  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9217007
Tgfb2RatRespiratory System Abnormalities  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9217007
Tgfb2Ratthoracic aortic aneurysm  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22772368 and PMID:22772371
Tgfb2Ratureteral obstruction  ISOTGFB2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17164399
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Tgfb2RatLoeys-Dietz syndrome  ISSTgfb2 (Mus musculus)13592920 MouseDO 
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Tgfb2RatLoeys-Dietz syndrome 4  ISOTGFB2 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Tgfb2Rat(1->4)-beta-D-glucan multiple interactionsISOTgfb2 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of TGFB2 mRNACTDPMID:36331819
Tgfb2Rat(R)-lipoic acid multiple interactionsEXP 6480464[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TGFB2 mRNA and [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of TGFB2 mRNACTDPMID:23830814 and PMID:31068541
Tgfb2Rat(R)-noradrenaline increases expressionEXP 6480464Norepinephrine results in increased expression of TGFB2 mRNA and Norepinephrine results in increased expression of TGFB2 proteinCTDPMID:15326086
Tgfb2Rat(R)-noradrenaline multiple interactionsEXP 6480464Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB2 mRNA]CTDPMID:15326086
Tgfb2Rat1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactionsEXP 64804642 more ...CTDPMID:19414516
Tgfb2Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases expressionISOTGFB2 (Homo sapiens)6480464o and p'-DDT results in decreased expression of TGFB2 mRNACTDPMID:19371625
Tgfb2Rat1,1-dichloroethene increases expressionISOTgfb2 (Mus musculus)6480464vinylidene chloride results in increased expression of TGFB2 mRNACTDPMID:26682919
Tgfb2Rat1,2-dichloroethane decreases expressionISOTgfb2 (Mus musculus)6480464ethylene dichloride results in decreased expression of TGFB2 mRNACTDPMID:28960355
Tgfb2Rat1,2-dimethylhydrazine increases expressionISOTgfb2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of TGFB2 mRNACTDPMID:22206623
Tgfb2Rat1-naphthyl isothiocyanate multiple interactionsISOTgfb2 (Mus musculus)6480464FGG protein affects the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA] more ...CTDPMID:24633426 more ...
Tgfb2Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of TGFB2 mRNACTDPMID:23558518
Tgfb2Rat1-naphthyl isothiocyanate increases expressionISOTgfb2 (Mus musculus)64804641-Naphthylisothiocyanate results in increased expression of TGFB2 mRNACTDPMID:24633426 more ...
Tgfb2Rat17alpha-ethynylestradiol affects expressionISOTGFB2 (Homo sapiens)6480464Ethinyl Estradiol affects the expression of TGFB2 mRNACTDPMID:20170705
Tgfb2Rat17alpha-ethynylestradiol decreases expressionISOTGFB2 (Homo sapiens)6480464Ethinyl Estradiol results in decreased expression of TGFB2 mRNACTDPMID:18936297
Tgfb2Rat17beta-estradiol affects expressionISOTGFB2 (Homo sapiens)6480464Estradiol affects the expression of TGFB2 mRNACTDPMID:14699072
Tgfb2Rat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TGFB2 mRNACTDPMID:32741896
Tgfb2Rat17beta-estradiol increases expressionISOTgfb2 (Mus musculus)6480464Estradiol results in increased expression of TGFB2 mRNACTDPMID:19484750 and PMID:8390853
Tgfb2Rat17beta-estradiol increases expressionISOTGFB2 (Homo sapiens)6480464Estradiol results in increased expression of TGFB2 mRNACTDPMID:11813992 and PMID:19484750
Tgfb2Rat17beta-estradiol decreases expressionISOTGFB2 (Homo sapiens)6480464Estradiol results in decreased expression of TGFB2 mRNACTDPMID:16474171 more ...
Tgfb2Rat17beta-estradiol multiple interactionsISOTgfb2 (Mus musculus)6480464Dronabinol promotes the reaction [Estradiol results in increased expression of TGFB2 mRNA]CTDPMID:8390853

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Biological Process
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Original Reference(s)
Tgfb2Ratactivation-induced cell death of T cells acts_upstream_ofISOTgfb2 (Mus musculus)1624291 PMID:8206089RGDPMID:8206089
Tgfb2Ratactivation-induced cell death of T cells acts_upstream_ofIEAUniProtKB:P27090 and ensembl:ENSMUSP000000438491600115GO_REF:0000107EnsemblGO_REF:0000107
Tgfb2Ratanimal organ morphogenesis involved_inIEAARBA:ARBA000280671600115GO_REF:0000117UniProtGO_REF:0000117
Tgfb2Ratascending aorta morphogenesis involved_inISOTgfb2 (Mus musculus)1624291 PMID:9217007RGDPMID:9217007
Tgfb2Ratascending aorta morphogenesis involved_inIEAUniProtKB:P27090 and ensembl:ENSMUSP000000438491600115GO_REF:0000107EnsemblGO_REF:0000107
Tgfb2Ratatrial septum morphogenesis involved_inISOTgfb2 (Mus musculus)1624291 PMID:9217007RGDPMID:9217007
Tgfb2Ratatrial septum morphogenesis involved_inIEAUniProtKB:P27090 and ensembl:ENSMUSP000000438491600115GO_REF:0000107EnsemblGO_REF:0000107
Tgfb2Ratatrial septum primum morphogenesis involved_inISOTgfb2 (Mus musculus)1624291 PMID:11390347RGDPMID:11390347
Tgfb2Ratatrial septum primum morphogenesis involved_inIEAUniProtKB:P27090 and ensembl:ENSMUSP000000438491600115GO_REF:0000107EnsemblGO_REF:0000107
Tgfb2Ratatrioventricular valve morphogenesis involved_inISOTgfb2 (Mus musculus)1624291 PMID:9217007RGDPMID:9217007
Tgfb2Ratatrioventricular valve morphogenesis involved_inIEAUniProtKB:P27090 and ensembl:ENSMUSP000000438491600115GO_REF:0000107EnsemblGO_REF:0000107
Tgfb2Rataxon guidance acts_upstream_of_or_withinIEAUniProtKB:P27090 and ensembl:ENSMUSP000000438491600115GO_REF:0000107EnsemblGO_REF:0000107
Tgfb2Rataxon guidance acts_upstream_of_or_withinISOTgfb2 (Mus musculus)1624291MGI:1888389 PMID:15528466RGDPMID:15528466
Tgfb2Ratblood vessel development acts_upstream_of_or_withinIEAUniProtKB:P27090 and ensembl:ENSMUSP000000438491600115GO_REF:0000107EnsemblGO_REF:0000107
Tgfb2Ratblood vessel development acts_upstream_of_or_withinISOTgfb2 (Mus musculus)1624291MGI:1888389 PMID:15528466RGDPMID:15528466
Tgfb2Ratblood vessel remodeling acts_upstream_of_or_withinISOTgfb2 (Mus musculus)1624291MGI:1888389 PMID:12393102RGDPMID:12393102
Tgfb2Ratblood vessel remodeling acts_upstream_of_or_withinIEAUniProtKB:P27090 and ensembl:ENSMUSP000000438491600115GO_REF:0000107EnsemblGO_REF:0000107
Tgfb2Ratcardiac epithelial to mesenchymal transition involved_inISOTGFB2 (Homo sapiens)1624291 PMID:10092230RGDPMID:10092230
Tgfb2Ratcardiac epithelial to mesenchymal transition involved_inIEAUniProtKB:P61812 and ensembl:ENSP000003558971600115GO_REF:0000107EnsemblGO_REF:0000107
Tgfb2Ratcardiac epithelial to mesenchymal transition involved_inISSUniProtKB:P618121600115GO_REF:0000024UniProtGO_REF:0000024
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Cellular Component
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Tgfb2Rataxon located_inISSUniProtKB:P270901600115GO_REF:0000024UniProtGO_REF:0000024
Tgfb2Rataxon located_inISOTgfb2 (Mus musculus)1624291 PMID:16257223RGDPMID:16257223
Tgfb2Rataxon located_inIEAUniProtKB:P27090 and ensembl:ENSMUSP000000438491600115GO_REF:0000107EnsemblGO_REF:0000107
Tgfb2Ratbasement membrane  IDA 2302094 RGD 
Tgfb2Ratcell surface  IDA 1579782 RGD 
Tgfb2Ratcollagen-containing extracellular matrix located_inISOTGFB2 (Homo sapiens)1624291 PMID:18049952RGDPMID:18049952
Tgfb2Ratendosome located_inISOTgfb2 (Mus musculus)1624291 PMID:21266196RGDPMID:21266196
Tgfb2Ratendosome located_inIEAUniProtKB:P27090 and ensembl:ENSMUSP000000438491600115GO_REF:0000107EnsemblGO_REF:0000107
Tgfb2Ratextracellular matrix located_inISSUniProtKB:P618121600115GO_REF:0000024AgBaseGO_REF:0000024
Tgfb2Ratextracellular region located_inISOTGFB2 (Homo sapiens)1624291 PMID:16227582RGDPMID:16227582
Tgfb2Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Tgfb2Ratextracellular region located_inIEAInterPro:IPR0156151600115GO_REF:0000002InterProGO_REF:0000002
Tgfb2Ratextracellular region located_inIEAUniProtKB:P61812 and ensembl:ENSP000003558971600115GO_REF:0000107EnsemblGO_REF:0000107
Tgfb2Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Tgfb2Ratextracellular region located_inISSUniProtKB:P618121600115GO_REF:0000024AgBaseGO_REF:0000024
Tgfb2Ratextracellular space  IDA 1579782 RGD 
Tgfb2Ratextracellular space located_inIEAUniProtKB:P27090 and ensembl:ENSMUSP000000438491600115GO_REF:0000107EnsemblGO_REF:0000107
Tgfb2Ratextracellular space located_inIEAUniRule:UR0009547511600115GO_REF:0000104UniProtGO_REF:0000104
Tgfb2Ratextracellular space located_inISOTgfb2 (Mus musculus)1624291 PMID:8164195RGDPMID:8164195
Tgfb2Ratextracellular space located_inIEAUniProtKB:P61812 and ensembl:ENSP000003558971600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Tgfb2Ratamyloid-beta binding enablesISSUniProtKB:P618121600115GO_REF:0000024AgBaseGO_REF:0000024
Tgfb2Ratamyloid-beta binding enablesIEAUniProtKB:P61812 and ensembl:ENSP000003558971600115GO_REF:0000107EnsemblGO_REF:0000107
Tgfb2Ratamyloid-beta binding enablesISOTGFB2 (Homo sapiens)1624291 PMID:16227582RGDPMID:16227582
Tgfb2Ratcytokine activity enablesIBAMGI:1346047 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tgfb2Ratgrowth factor activity enablesIEAUniProtKB-KW:KW-03391600115GO_REF:0000043UniProtGO_REF:0000043
Tgfb2Ratgrowth factor activity enablesIEAInterPro:IPR001839 and InterPro:IPR0179481600115GO_REF:0000002InterProGO_REF:0000002
Tgfb2Ratgrowth factor activity enablesIEAUniRule:UR0009547511600115GO_REF:0000104UniProtGO_REF:0000104
Tgfb2Ratidentical protein binding  IPITgfb2 (Rattus norvegicus)2302086homodimerizationRGD 
Tgfb2Ratprotein binding enablesISOTgfb2 (Mus musculus)1624291PR:Q07475 more ...RGDPMID:14985127 more ...
Tgfb2Ratprotein binding enablesISOTGFB2 (Homo sapiens)1624291UniProtKB:P05067 more ...RGDPMID:10930463 more ...
Tgfb2Ratprotein homodimerization activity enablesISSUniProtKB:P618121600115GO_REF:0000024AgBaseGO_REF:0000024
Tgfb2Ratprotein homodimerization activity enablesIEAUniProtKB:P61812 and ensembl:ENSP000003558971600115GO_REF:0000107EnsemblGO_REF:0000107
Tgfb2Ratprotein homodimerization activity enablesISOTGFB2 (Homo sapiens)1624291 PMID:2119582RGDPMID:2119582
Tgfb2Ratprotein-containing complex binding  IDA 2302086heterodimerizationRGD 
Tgfb2Ratsignaling receptor binding enablesISSUniProtKB:P618121600115GO_REF:0000024AgBaseGO_REF:0000024
Tgfb2Ratsignaling receptor binding enablesIEAUniProtKB:P61812 and ensembl:ENSP000003558971600115GO_REF:0000107EnsemblGO_REF:0000107
Tgfb2Ratsignaling receptor binding enablesISOTGFB2 (Homo sapiens)1624291 PMID:16227582RGDPMID:16227582
Tgfb2Rattransforming growth factor beta receptor binding  TAS 70296 RGD 
Tgfb2Rattransforming growth factor beta receptor binding enablesIEAUniProtKB:P61812 and ensembl:ENSP000003558971600115GO_REF:0000107EnsemblGO_REF:0000107
Tgfb2Rattransforming growth factor beta receptor binding enablesISOTGFB2 (Homo sapiens)1624291 PMID:10092230 and PMID:16227582RGDPMID:10092230 and PMID:16227582
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RGD Manual Annotations


  
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Source
Original Reference(s)
Tgfb2Rattransforming growth factor-beta Smad dependent signaling pathway   ISOTgfb2 (Mus musculus)2298921 RGD 

Imported Annotations - KEGG (archival)

1 to 19 of 19 rows
1 to 19 of 19 rows

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tgfb2Ratglypican signaling pathway  ISOTGFB2 (Homo sapiens)6484113 PIDPID:200026
Tgfb2RatHedgehog signaling pathway   ISOTGFB2 (Homo sapiens)6484113 PIDPID:200168
Tgfb2Rattransforming growth factor-beta Smad dependent signaling pathway   ISOTGFB2 (Homo sapiens)6484113 PIDPID:200227

1 to 20 of 68 rows
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Reference Title
Reference Citation
1. Tgf-beta1, Tgf-beta2, Tgf-beta3 and Msx2 expression is elevated during frontonasal suture morphogenesis and during active postnatal facial growth. Adab K, etal., Orthod Craniofac Res. 2002 Nov;5(4):227-37.
2. TGFbeta2 mediates the effects of hedgehog on hypertrophic differentiation and PTHrP expression. Alvarez J, etal., Development. 2002 Apr;129(8):1913-24.
3. Transforming growth factor-beta induces cellular injury in experimental diabetic neuropathy. Anjaneyulu M, etal., Exp Neurol. 2008 Jun;211(2):469-79. Epub 2008 Mar 2.
4. The effect of antibodies to TGF-beta1 and TGF-beta2 at a site of sciatic nerve repair. Atkins S, etal., J Peripher Nerv Syst. 2006 Dec;11(4):286-93.
5. Novel methylation panel for the early detection of neoplasia in high-risk ulcerative colitis and Crohn's colitis patients. Azuara D, etal., Inflamm Bowel Dis. 2013 Jan;19(1):165-73. doi: 10.1002/ibd.22994.
6. Differential expression of transforming growth factors-beta1, -beta2 and -beta3 in human colon carcinoma. Bellone G, etal., Eur J Cancer. 2001 Jan;37(2):224-33.
7. TGFbeta Type III and TGFbeta Type II receptors have distinct activities during epithelial-mesenchymal cell transformation in the embryonic heart. Boyer AS and Runyan RB, Dev Dyn. 2001 Aug;221(4):454-9.
8. Expression of transforming growth factor beta isoforms and their roles in tendon healing. Chan KM, etal., Wound Repair Regen. 2008 May-Jun;16(3):399-407.
9. Retinal neurons regulate proliferation of postnatal progenitors and Muller glia in the rat retina via TGF beta signaling. Close JL, etal., Development. 2005 Jul;132(13):3015-26.
10. Effects of high dose retinoic acid on TGF-beta2 expression during pancreatic organogenesis. Colakoglu N, etal., J Mol Histol. 2005 Sep;36(6-7):413-8. Epub 2006 Feb 15.
11. Ontogenic expression of TGFbeta 1, 2, and 3 and its receptors in the rat gastric mucosa. de Andrade Sa ER, etal., Dev Dyn. 2003 Jul;227(3):450-7.
12. Effect of propranolol on cardiac cytokine expression after myocardial infarction in rats. Deten A, etal., Mol Cell Biochem. 2003 Sep;251(1-2):127-37.
13. Astrocyte-derived transforming growth factor-{beta} mediates the neuroprotective effects of 17{beta}-estradiol: involvement of nonclassical genomic signaling pathways. Dhandapani KM, etal., Endocrinology. 2005 Jun;146(6):2749-59. Epub 2005 Mar 3.
14. The phosphodiesterase inhibitor, pentoxifylline, alters rat intestinal epithelial cell proliferation via changes in the expression of transforming growth factors. Diab-Assef M, etal., Scand J Gastroenterol. 2002 Feb;37(2):206-14.
15. Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis. Engle SJ, etal., Cancer Res. 1999 Jul 15;59(14):3379-86.
16. Microarray analysis of mechanical shear effects on flexor tendon cells. Fong KD, etal., Plast Reconstr Surg. 2005 Oct;116(5):1393-404; discussion 1405-6.
17. Inhibition of ALK5 signaling induces physeal dysplasia in rats. Frazier K, etal., Toxicol Pathol. 2007;35(2):284-95.
18. Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival. Friess H, etal., Gastroenterology. 1993 Dec;105(6):1846-56. doi: 10.1016/0016-5085(93)91084-u.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Dynamic expression patterns of transforming growth factor-beta(2) and transforming growth factor-beta receptors in experimental glomerulonephritis. Hartner A, etal., J Mol Med. 2003 Jan;81(1):32-42. Epub 2002 Dec 14.
1 to 20 of 68 rows
PMID:1333888   PMID:2119582   PMID:7852346   PMID:8133057   PMID:8164195   PMID:8167376   PMID:8206089   PMID:8486763   PMID:8509457   PMID:8565825   PMID:9217007   PMID:10092230  
PMID:10433821   PMID:10899565   PMID:11157754   PMID:11390347   PMID:11784073   PMID:12393102   PMID:12411310   PMID:12477932   PMID:12646048   PMID:12733949   PMID:12773577   PMID:14707111  
PMID:14717916   PMID:14960316   PMID:15122060   PMID:15375625   PMID:15528466   PMID:15531369   PMID:15744664   PMID:15896309   PMID:15955085   PMID:16034134   PMID:16257223   PMID:16891397  
PMID:16943770   PMID:17068209   PMID:17192487   PMID:17217916   PMID:17401695   PMID:17516499   PMID:17960115   PMID:17999987   PMID:18039789   PMID:18040277   PMID:18049952   PMID:18080134  
PMID:18223299   PMID:18358889   PMID:18378961   PMID:18391505   PMID:18431253   PMID:18498113   PMID:18505915   PMID:18597229   PMID:18790002   PMID:19161227   PMID:19200954   PMID:19342245  
PMID:19434765   PMID:19457129   PMID:19567205   PMID:19656380   PMID:20573232   PMID:20653032   PMID:20875417   PMID:21266196   PMID:21780244   PMID:21865583   PMID:21984612   PMID:24006456  
PMID:24263861   PMID:24838936   PMID:25217442   PMID:25448845   PMID:25639665   PMID:26637070   PMID:26957638   PMID:27049496   PMID:27855367   PMID:28361415   PMID:28694529   PMID:28977001  
PMID:31835434   PMID:34246804   PMID:35028925   PMID:38409639  



Tgfb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813100,691,540 - 100,793,227 (-)NCBIGRCr8
mRatBN7.21398,160,075 - 98,261,771 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1398,160,087 - 98,261,405 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13100,678,931 - 100,778,632 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013102,066,560 - 102,165,910 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01399,261,239 - 99,360,947 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013105,039,639 - 105,142,010 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13105,039,853 - 105,141,030 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013109,679,866 - 109,792,609 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413102,718,703 - 102,818,768 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113102,907,748 - 103,007,811 (-)NCBI
Celera1397,669,691 - 97,769,426 (-)NCBICelera
Cytogenetic Map13q26NCBI
TGFB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381218,345,336 - 218,444,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1218,345,336 - 218,444,619 (+)EnsemblGRCh38hg38GRCh38
GRCh371218,518,678 - 218,617,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361216,586,491 - 216,681,596 (+)NCBINCBI36Build 36hg18NCBI36
Build 341214,908,262 - 215,003,365NCBI
Celera1191,735,848 - 191,834,418 (+)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1189,186,842 - 189,286,057 (+)NCBIHuRef
CHM1_11219,791,024 - 219,890,484 (+)NCBICHM1_1
T2T-CHM13v2.01217,580,100 - 217,679,392 (+)NCBIT2T-CHM13v2.0
Tgfb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,354,984 - 186,441,504 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1186,354,989 - 186,438,186 (-)EnsemblGRCm39 Ensembl
GRCm381186,622,787 - 186,709,697 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,622,792 - 186,705,989 (-)EnsemblGRCm38mm10GRCm38
MGSCv371188,447,065 - 188,529,871 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361188,324,430 - 188,406,777 (-)NCBIMGSCv36mm8
Celera1193,563,609 - 193,649,724 (-)NCBICelera
Cytogenetic Map1H5NCBI
cM Map189.95NCBI
Tgfb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955406172,814 - 249,248 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955406174,949 - 249,248 (-)NCBIChiLan1.0ChiLan1.0
TGFB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2130,962,733 - 31,060,610 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1130,925,280 - 31,023,656 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01193,907,398 - 194,005,800 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11198,758,718 - 198,856,853 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1198,758,751 - 198,859,041 (+)Ensemblpanpan1.1panPan2
TGFB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13813,430,832 - 13,511,655 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3813,429,148 - 13,510,242 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3813,472,728 - 13,552,654 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03813,464,207 - 13,544,357 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3813,464,807 - 13,545,256 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13813,473,487 - 13,553,481 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03813,819,811 - 13,899,809 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03814,128,921 - 14,209,014 (+)NCBIUU_Cfam_GSD_1.0
Tgfb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934458,300,141 - 58,383,975 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936628308,691 - 394,007 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936628310,720 - 394,002 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl108,305,539 - 8,390,341 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1108,306,136 - 8,435,307 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21010,353,794 - 10,476,143 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap10p16NCBI
TGFB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12511,163,651 - 11,259,868 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2511,163,100 - 11,258,470 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605511,574,533 - 11,672,282 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgfb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248352,363,139 - 2,437,643 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248352,363,059 - 2,436,536 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Tgfb2
585 total Variants

Predicted Target Of
Summary Value
Count of predictions:99
Count of miRNA genes:89
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000003313
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 11 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat

1 to 10 of 11 rows
RH135195  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21398,260,777 - 98,260,958 (+)MAPPERmRatBN7.2
Rnor_6.013105,140,324 - 105,140,504NCBIRnor6.0
Rnor_5.013109,791,120 - 109,791,300UniSTSRnor5.0
RGSC_v3.413102,818,312 - 102,818,492UniSTSRGSC3.4
Celera1397,768,970 - 97,769,150UniSTS
RH 3.4 Map13666.0UniSTS
Cytogenetic Map13q26UniSTS
G39607  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21398,231,469 - 98,231,772 (+)MAPPERmRatBN7.2
Rnor_6.013105,111,026 - 105,111,328NCBIRnor6.0
Rnor_5.013109,761,807 - 109,762,109UniSTSRnor5.0
RGSC_v3.413102,788,984 - 102,789,286UniSTSRGSC3.4
Celera1397,739,652 - 97,739,954UniSTS
Cytogenetic Map13q26UniSTS
UniSTS:224971  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21398,261,133 - 98,261,281 (+)MAPPERmRatBN7.2
Rnor_6.013105,140,680 - 105,140,827NCBIRnor6.0
Rnor_5.013109,791,476 - 109,791,623UniSTSRnor5.0
RGSC_v3.413102,818,668 - 102,818,815UniSTSRGSC3.4
Celera1397,769,326 - 97,769,473UniSTS
Cytogenetic Map13q26UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000003313   ⟹   ENSRNOP00000003313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1398,160,087 - 98,261,191 (-)Ensembl
Rnor_6.0 Ensembl13105,039,853 - 105,141,030 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087023   ⟹   ENSRNOP00000074059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13105,042,274 - 105,140,473 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111585   ⟹   ENSRNOP00000086888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1398,259,354 - 98,261,405 (-)Ensembl
RefSeq Acc Id: NM_031131   ⟹   NP_112393
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813100,692,953 - 100,792,685 (-)NCBI
mRatBN7.21398,161,488 - 98,261,234 (-)NCBI
Rnor_6.013105,041,052 - 105,140,780 (-)NCBI
Rnor_5.013109,679,866 - 109,792,609 (-)NCBI
RGSC_v3.413102,718,703 - 102,818,768 (-)RGD
Celera1397,669,691 - 97,769,426 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250448   ⟹   XP_006250510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813100,691,540 - 100,793,227 (-)NCBI
mRatBN7.21398,160,075 - 98,261,771 (-)NCBI
Rnor_6.013105,039,639 - 105,142,010 (-)NCBI
Rnor_5.013109,679,866 - 109,792,609 (-)NCBI
Sequence:
RefSeq Acc Id: NP_112393   ⟸   NM_031131
- Peptide Label: precursor
- UniProtKB: Q9WUQ8 (UniProtKB/Swiss-Prot),   Q9R2B8 (UniProtKB/Swiss-Prot),   Q9R298 (UniProtKB/Swiss-Prot),   Q9R281 (UniProtKB/Swiss-Prot),   Q9QW26 (UniProtKB/Swiss-Prot),   Q63574 (UniProtKB/Swiss-Prot),   Q07257 (UniProtKB/Swiss-Prot),   G3V6B1 (UniProtKB/TrEMBL),   A6JGS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250510   ⟸   XM_006250448
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000074059   ⟸   ENSRNOT00000087023
Ensembl Acc Id: ENSRNOP00000003313   ⟸   ENSRNOT00000003313
Ensembl Acc Id: ENSRNOP00000086888   ⟸   ENSRNOT00000111585
TGF-beta family profile   TGF-beta propeptide

Name Modeler Protein Id AA Range Protein Structure
AF-Q07257-F1-model_v2 AlphaFold Q07257 1-442 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699097
Promoter ID:EPDNEW_R9622
Type:multiple initiation site
Name:Tgfb2_1
Description:transforming growth factor, beta 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013105,140,964 - 105,141,024EPDNEW


1 to 40 of 46 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-16959 BioCyc
Ensembl Genes ENSRNOG00000002418 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000003313 ENTREZGENE
  ENSRNOT00000136296 ENTREZGENE
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
  2.60.120.970 UniProtKB/Swiss-Prot
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  TGF-b_C UniProtKB/Swiss-Prot
  TGF-b_propeptide UniProtKB/Swiss-Prot
  TGF-beta UniProtKB/Swiss-Prot
  TGF-beta-rel UniProtKB/Swiss-Prot
  TGFb2 UniProtKB/Swiss-Prot
  TGFb_CS UniProtKB/Swiss-Prot
KEGG Report rno:81809 UniProtKB/Swiss-Prot
NCBI Gene 81809 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot
  TRANSFORMING GROWTH FACTOR BETA-2 PROPROTEIN UniProtKB/Swiss-Prot
Pfam TGF_beta UniProtKB/Swiss-Prot
  TGFb_propeptide UniProtKB/Swiss-Prot
PhenoGen Tgfb2 PhenoGen
PIRSF TGF-beta UniProtKB/Swiss-Prot
PRINTS TGFBETA UniProtKB/Swiss-Prot
  TGFBETA2 UniProtKB/Swiss-Prot
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot
  TGF_BETA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002418 RatGTEx
SMART TGFB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt A6JGS5 ENTREZGENE, UniProtKB/TrEMBL
  A6JGS6 ENTREZGENE, UniProtKB/TrEMBL
  G3V6B1 ENTREZGENE, UniProtKB/TrEMBL
  Q07257 ENTREZGENE
  Q496Y8_RAT UniProtKB/TrEMBL
  Q63574 ENTREZGENE
  Q9QW26 ENTREZGENE
  Q9R281 ENTREZGENE
  Q9R298 ENTREZGENE
  Q9R2B8 ENTREZGENE
  Q9WUQ8 ENTREZGENE
  TGFB2_RAT UniProtKB/Swiss-Prot
1 to 40 of 46 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Tgfb2  transforming growth factor, beta 2      Symbol and Name status set to approved 629479 APPROVED
2002-06-10 Tgfb2  transforming growth factor, beta 2      Symbol and Name status set to provisional 70585 PROVISIONAL

Note Type Note Reference
gene_expression lacking in young rat prostates but present in both the stroma and epithelium of aging prostates 70812
gene_process stimulates proliferation of fetal lung epithelial cells 70317
gene_process stimulates proliferation of fetal lung epithelial cells 70812
gene_process stimulates cell growth 70317
gene_process stimulates cell growth 70812
gene_process stimulates lactotroph cell growth possibly by enhancing prolactin secretion through increased number of lactotroph cells and stimulates vascular endothelial growth factor (Vegf) in pituitary cells 625677
gene_process may modulate growth and function of endocrine pituitary cells including intrapituitary vascular permeablility, intergrity and angiogenesis 625677
gene_product member of Tgf beta superfamily 625677