RGD Reference Report - Expression of TGFbeta family in the developing internal ear of rat embryos. - Rat Genome Database

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Expression of TGFbeta family in the developing internal ear of rat embryos.

Authors: Kim, HJ  Kang, KY  Baek, JG  Jo, HC  Kim, H 
Citation: Kim HJ, etal., J Korean Med Sci. 2006 Feb;21(1):136-42.
RGD ID: 2302094
Pubmed: PMID:16479080   (View Abstract at PubMed)
PMCID: PMC2733962   (View Article at PubMed Central)
DOI: DOI:10.3346/jkms.2006.21.1.136   (Journal Full-text)

In order to investigate the expression patterns of the transforming growth factor (TGF)beta isoforms in the internal ear, an immunohistochemical study of rat embryos was performed. Rat embryos were taken on the 13th, 15th, 17th, and 19th day after conception and their internal ears were immunohistochemically stained against TGF beta1, beta2, and beta3. As a result, the 13-day-old embryo showed a very weak positivity to TGF beta1. After the 15th day of pregnancy, no reactivity to TGF beta1 was defected. Immunoreactivity to TGF beta2 was observed from the 15th day of pregnancy throughout the rest of the period. The ampulla of the semicircular canal and the cochlear duct showed a notably strong immunohistochemical reaction. A strong reaction to TGF beta3 was observed on the 15th day of pregnancy. However, no positive reactions were observed thereafter. A strong immunoreactivity was observed especially on the apical cytoplasms, the surfaces of the epithelial cells, and basement membranes of the cochlear duct, as well as the semicircular canals of the developing internal ear of rat embryo.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
inner ear development  IEP 2302094; 2302094; 2302094 RGD 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
basement membrane  IDA 2302094 RGD 
cell surface  IDA 2302094 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tgfb1  (transforming growth factor, beta 1)
Tgfb2  (transforming growth factor, beta 2)
Tgfb3  (transforming growth factor, beta 3)


Additional Information